{"id":"https://openalex.org/W174969858","doi":null,"title":"Functional analysis of ATP binding cassette (ABC) transporters in Caenorhabditis Elegans","display_name":"Functional analysis of ATP binding cassette (ABC) transporters in Caenorhabditis Elegans","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W174969858","mag":"174969858"},"language":"en","primary_location":{"id":"pmh:oai:summit.sfu.ca:5118","doi":null,"is_oa":true,"landing_page_url":"http://summit.sfu.ca/item/5118","pdf_url":"http://summit.sfu.ca/item/5118","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://summit.sfu.ca/item/5118","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033328883","display_name":"Zhongying Zhao","orcid":"https://orcid.org/0000-0003-2743-9008","observed_orcids":["https://orcid.org/0000-0003-2743-9008"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zhongying Zhao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2743-9008","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033328883"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.8999999761581421},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9559999704360962},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.4819999933242798},{"id":"https://openalex.org/keywords/tandem-gene-duplication","display_name":"tandem gene duplication","score":0.7059999704360962},{"id":"https://openalex.org/keywords/promoter-analysis","display_name":"promoter analysis","score":0.4090000092983246},{"id":"https://openalex.org/keywords/excretory-cells","display_name":"excretory cells","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.722000002861023},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/nuclear-transport","display_name":"nuclear transport","score":0.8100000023841858},{"id":"https://openalex.org/keywords/germline","display_name":"germline","score":0.7250000238418579},{"id":"https://openalex.org/keywords/vulva","display_name":"vulva","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.8911025524139404},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.8292540907859802},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5223739743232727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4441917836666107},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4279560148715973},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33330315351486206},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3058090806007385},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16869398951530457}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:summit.sfu.ca:5118","doi":null,"is_oa":true,"landing_page_url":"http://summit.sfu.ca/item/5118","pdf_url":"http://summit.sfu.ca/item/5118","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:summit.sfu.ca:node-5118","doi":null,"is_oa":false,"landing_page_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/5118/etd1610.pdf","pdf_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/5118/etd1610.pdf","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:174969858","doi":null,"is_oa":false,"landing_page_url":"https://summit.sfu.ca/item/5118","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:summit.sfu.ca:5118","doi":null,"is_oa":true,"landing_page_url":"http://summit.sfu.ca/item/5118","pdf_url":"http://summit.sfu.ca/item/5118","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W174969858.pdf","grobid_xml":"https://content.openalex.org/works/W174969858.grobid-xml"},"referenced_works_count":110,"referenced_works":["https://openalex.org/W84412087","https://openalex.org/W163498145","https://openalex.org/W165254100","https://openalex.org/W1484529414","https://openalex.org/W1486665544","https://openalex.org/W1494416165","https://openalex.org/W1499500424","https://openalex.org/W1567517848","https://openalex.org/W1582655487","https://openalex.org/W1587397381","https://openalex.org/W1604959358","https://openalex.org/W1647075334","https://openalex.org/W1905840509","https://openalex.org/W1921244251","https://openalex.org/W1964918240","https://openalex.org/W1967053372","https://openalex.org/W1969770714","https://openalex.org/W1971707621","https://openalex.org/W1971950332","https://openalex.org/W1973384895","https://openalex.org/W1975482089","https://openalex.org/W1982542571","https://openalex.org/W1983099693","https://openalex.org/W1983906182","https://openalex.org/W1984847838","https://openalex.org/W1989952069","https://openalex.org/W1992151847","https://openalex.org/W1992170226","https://openalex.org/W1994876071","https://openalex.org/W1997616950","https://openalex.org/W1999192371","https://openalex.org/W2000250937","https://openalex.org/W2000646355","https://openalex.org/W2001921072","https://openalex.org/W2005581710","https://openalex.org/W2006700952","https://openalex.org/W2008646367","https://openalex.org/W2009966494","https://openalex.org/W2010488171","https://openalex.org/W2010623159","https://openalex.org/W2013057753","https://openalex.org/W2014250634","https://openalex.org/W2017612025","https://openalex.org/W2018119138","https://openalex.org/W2020930773","https://openalex.org/W2027652933","https://openalex.org/W2030988632","https://openalex.org/W2031576290","https://openalex.org/W2032579724","https://openalex.org/W2035425096","https://openalex.org/W2038492783","https://openalex.org/W2039361749","https://openalex.org/W2039599894","https://openalex.org/W2040565334","https://openalex.org/W2041245661","https://openalex.org/W2047550476","https://openalex.org/W2049772927","https://openalex.org/W2050767064","https://openalex.org/W2050917153","https://openalex.org/W2056182546","https://openalex.org/W2056471774","https://openalex.org/W2059399555","https://openalex.org/W2060814715","https://openalex.org/W2064384066","https://openalex.org/W2064879068","https://openalex.org/W2067171614","https://openalex.org/W2067703397","https://openalex.org/W2068233575","https://openalex.org/W2071006116","https://openalex.org/W2072828263","https://openalex.org/W2073159328","https://openalex.org/W2082926700","https://openalex.org/W2088367672","https://openalex.org/W2090415636","https://openalex.org/W2092135843","https://openalex.org/W2094031081","https://openalex.org/W2097382368","https://openalex.org/W2097706568","https://openalex.org/W2100221195","https://openalex.org/W2105599787","https://openalex.org/W2106013076","https://openalex.org/W2106742994","https://openalex.org/W2107424557","https://openalex.org/W2108401170","https://openalex.org/W2119468178","https://openalex.org/W2122023966","https://openalex.org/W2124656134","https://openalex.org/W2128491398","https://openalex.org/W2134484762","https://openalex.org/W2135256255","https://openalex.org/W2140115103","https://openalex.org/W2141885858","https://openalex.org/W2142437744","https://openalex.org/W2152075687","https://openalex.org/W2152875974","https://openalex.org/W2157811652","https://openalex.org/W2159559878","https://openalex.org/W2162097287","https://openalex.org/W2164154631","https://openalex.org/W2166187656","https://openalex.org/W2167869241","https://openalex.org/W2168733346","https://openalex.org/W2181935187","https://openalex.org/W2201333915","https://openalex.org/W2226301921","https://openalex.org/W2344473764","https://openalex.org/W2419136270","https://openalex.org/W2976039853","https://openalex.org/W6991195499","https://openalex.org/W7055455646"],"related_works":["https://openalex.org/W2056471774","https://openalex.org/W7096682564","https://openalex.org/W2107063284","https://openalex.org/W7095721477","https://openalex.org/W2010404725","https://openalex.org/W2070561132","https://openalex.org/W2473307024","https://openalex.org/W1975577463","https://openalex.org/W2322259245","https://openalex.org/W7125697600"],"abstract_inverted_index":{"This":[0,262],"thesis":[1],"deals":[2],"with":[3],"functional":[4],"analysis":[5,228,281],"of":[6,17,57,91,109,128,144,174,186,246,270,273,282],"ABC":[7,13,26,59,92,112,167,188],"transporter":[8],"genes":[9,27,81,93,113,147],"in":[10,22,73,85,94,103,148,218,225,277,294,312],"Caenorhabditis":[11],"elegans.":[12,24,279],"transporters":[14],"constitute":[15],"one":[16,185],"the":[18,55,58,70,110,126,129,132,187,219,231,250,271,274,283,309],"largest":[19],"gene":[20,168,252,276,284],"families":[21],"C.":[23,44,47,107,278],"Sixty":[25],"have":[28,170],"been":[29,171,255],"identified":[30],"and":[31,46,78,97,106,121,207,222,296,298,315],"classified":[32],"into":[33],"eight":[34],"different":[35,149],"subfamilies.":[36],"Fifty-seven":[37],"orthologous":[38],"pairs":[39],"can":[40],"be":[41,267],"found":[42],"between":[43],"elegans":[45],"briggsae.":[48],"As":[49],"an":[50,191,258],"initial":[51],"step":[52],"toward":[53],"understanding":[54],"functions":[56,234,311],"genes,":[60,117,189],"I":[61,87,183],"generated":[62],"transgenic":[63],"animals":[64],"containing":[65],"prornoter::GFP/DsRed":[66],"fusion":[67],"constructs":[68],"for":[69,101,161,238,290],"whole":[71],"family":[72],"order":[74],"to":[75,195,266],"address":[76],"when":[77],"where":[79],"these":[80,145],"are":[82,114,176],"turned":[83],"on":[84],"vivo.":[86],"observed":[88],"frequent":[89],"expression":[90],"intestine,":[95],"pharynx":[96],"excretory":[98,192,220,239],"cell,":[99],"especially":[100],"those":[102],"subfamilies":[104],"B":[105],"Sixteen":[108],"60":[111],"tandemly":[115],"duplicated":[116,146,162],"forming":[118],"two":[119],"4-gene":[120],"four":[122],"2-gene":[123],"clusters.":[124],"Interestingly,":[125],"majority":[127],"promoters":[130],"from":[131],"same":[133],"clusters":[134],"drive":[135],"temporally":[136],"andfor":[137],"spatially":[138],"differential":[139],"expressions,":[140],"suggesting":[141],"active":[142],"function":[143,300],"tissues":[150],"or":[151],"stages":[152],"rather":[153],"than":[154],"their":[155],"being":[156],"inactivated,":[157],"as":[158,235,257,301],"is":[159,215,249,264,288],"typical":[160],"genes.":[163],"Currently":[164],"18":[165],"single":[166],"mutants":[169],"created.":[172],"All":[173],"them":[175],"wild":[177],"type":[178],"under":[179],"normal":[180],"laboratory":[181],"conditions.":[182],"used":[184],"pgp-12,":[190],"cell-expressing":[193],"gene,":[194],"characterize":[196],"its":[197,208],"transcriptional":[198],"regulation.":[199],"A":[200],"10":[201],"base":[202],"pair":[203],"(bp)":[204],"cis-element,":[205],"Ex-1":[206],"binding":[209],"protein":[210,233,310],"C26C6.5a,":[211],"were":[212],"isolated.":[213],"C26C6.5a":[214,232],"also":[216],"expressed":[217],"cell":[221,240],"binds":[223],"Ex-l":[224],"vitro.":[226],"RNAi":[227,305],"revealed":[229],"that":[230,253,286,308],"a":[236,302],"trans-activator":[237],"specific":[241],"expression.":[242],"The":[243],"only":[244],"member":[245],"subfamily":[247],"E":[248],"ABCE":[251],"has":[254],"annotated":[256],"RNase":[259],"L":[260],"inhibitor.":[261],"annotation":[263],"unlikely":[265],"correct":[268],"because":[269],"lack":[272],"inhibitor":[275],"Functional":[280],"reveals":[285],"it":[287],"essential":[289],"life,":[291],"possibly":[292],"involved":[293],"transcription":[295],"translation,":[297],"may":[299],"nucleocytoplasrnic":[303],"transporter.":[304],"data":[306],"implies":[307],"both":[313],"germline":[314],"vulvae.":[316]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}