{"id":"https://openalex.org/W1748872307","doi":null,"title":"Intestinal helminths: a clue explaining the low incidence of inflammatory bowel diseases in Subsaharan Africa? Potential benefits and hazards of helminth therapy.","display_name":"Intestinal helminths: a clue explaining the low incidence of inflammatory bowel diseases in Subsaharan Africa? Potential benefits and hazards of helminth therapy.","publication_year":2006,"publication_date":"2006-10-01","ids":{"openalex":"https://openalex.org/W1748872307","mag":"1748872307","pmid":"https://pubmed.ncbi.nlm.nih.gov/17343086"},"language":"en","primary_location":{"id":"pmid:17343086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17343086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta gastro-enterologica Belgica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066330523","display_name":"Ren\u00e9 Fiasse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315288073","display_name":"Cliniques Universitaires Saint-Luc","ror":"https://ror.org/03s4khd80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I1315288073"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ren\u00e9 Fiasse","raw_affiliation_strings":["Department of Gastroenterology, University Hospital St-Luc, Universit\u00e9 catholique de Louvain, Brussels, Belgium. rene.fiasse@gaen.ucl.ac.be"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, University Hospital St-Luc, Universit\u00e9 catholique de Louvain, Brussels, Belgium. rene.fiasse@gaen.ucl.ac.be","institution_ids":["https://openalex.org/I1315288073","https://openalex.org/I95674353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111485136","display_name":"Dominique Latinne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dominique Latinne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7478,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.64323035,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"69","issue":"4","first_page":"418","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.13279999792575836,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-helminths","display_name":"intestinal helminths","score":0.9900000095367432},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9629999995231628},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.8309999704360962},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/hygiene-hypothesis","display_name":"hygiene hypothesis","score":0.890999972820282},{"id":"https://openalex.org/keywords/sub-saharan-africa","display_name":"sub-Saharan Africa","score":0.6290000081062317},{"id":"https://openalex.org/keywords/anthelmintic-treatment","display_name":"anthelmintic treatment","score":0.722000002861023},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/th1-th2-balance","display_name":"Th1/Th2 balance","score":0.8199999928474426},{"id":"https://openalex.org/keywords/immune-anergy","display_name":"immune anergy","score":0.656000018119812},{"id":"https://openalex.org/keywords/ethiopian-jews","display_name":"Ethiopian Jews","score":0.6039999723434448},{"id":"https://openalex.org/keywords/nontuberculous-mycobacteria","display_name":"nontuberculous mycobacteria","score":0.8389999866485596},{"id":"https://openalex.org/keywords/lactobacilli","display_name":"lactobacilli","score":0.9430000185966492}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7455359101295471},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.6587702035903931},{"id":"https://openalex.org/C78635009","wikidata":"https://www.wikidata.org/wiki/Q2109172","display_name":"Hygiene hypothesis","level":3,"score":0.6186672449111938},{"id":"https://openalex.org/C2777461070","wikidata":"https://www.wikidata.org/wiki/Q1345770","display_name":"Deworming","level":3,"score":0.5984795093536377},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.54425048828125},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5242041349411011},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45377662777900696},{"id":"https://openalex.org/C2779726973","wikidata":"https://www.wikidata.org/wiki/Q578994","display_name":"Helminthiasis","level":2,"score":0.45277196168899536},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4449804425239563},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4388638734817505},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.43854591250419617},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4376751482486725},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.41845715045928955},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35886305570602417},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.19403725862503052},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1449551284313202},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000349","descriptor_name":"Africa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006373","descriptor_name":"Helminthiasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006373","descriptor_name":"Helminthiasis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006376","descriptor_name":"Helminths","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D006376","descriptor_name":"Helminths","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:17343086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17343086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta gastro-enterologica Belgica","raw_type":"Journal Article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:10890","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2078.1/10890","pdf_url":null,"source":{"id":"https://openalex.org/S4306400166","display_name":"Digital Access to Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800384882","host_organization_name":"Harris County Public Library","host_organization_lineage":["https://openalex.org/I2800384882"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta gastro-enterologica Belgica, Vol. 69, no. 4, p. 418-22 (2006)","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1748872307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17343086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1530611653","https://openalex.org/W2183180771","https://openalex.org/W4392504059","https://openalex.org/W161948656","https://openalex.org/W2030413123","https://openalex.org/W2088420174","https://openalex.org/W2316165639","https://openalex.org/W3025834742","https://openalex.org/W7097031769","https://openalex.org/W2588434935"],"abstract_inverted_index":{"In":[0],"their":[1],"review,":[2],"the":[3,7,29,33,42,76,105,120,192,211],"authors":[4],"state":[5,165],"that":[6,40,159],"very":[8],"low":[9],"incidence":[10,34],"and":[11,31,102,113,117,128,154,197],"prevalence":[12],"of":[13,28,35,41,75,91,107,122,136,166,176,178,215],"IBD":[14],"in":[15,25,52,67,145,185,191],"sub-Saharan":[16,53],"Africa":[17],"cannot":[18],"be":[19],"explained":[20],"by":[21],"genetic":[22],"factors":[23],"since":[24,210],"Black":[26],"populations":[27],"U.S.A.":[30],"U.K.,":[32],"these":[36,83],"diseases":[37,124,130],"is":[38,50,71],"approaching":[39],"white":[43],"populations.":[44],"Beside":[45],"helminths":[46,138,216],"whose":[47],"intestinal":[48,137],"infestation":[49,162],"frequent":[51],"Africa,":[54],"other":[55],"micro-organisms":[56,84],"such":[57],"as":[58,87],"atypical":[59],"mycobacteria,":[60],"lactobacilli,":[61],"etc,":[62],"might":[63],"have":[64,142,157],"been":[65,143],"reduced":[66],"Western":[68],"population.":[69],"This":[70],"a":[72,164,201],"new":[73],"variant":[74],"Hygiene":[77],"hypothesis.":[78],"After":[79],"Rook":[80],"et":[81],"al.,":[82],"were":[85],"acting":[86],"adjuvants":[88],"for":[89],"induction":[90],"T":[92,109],"regulatory":[93],"cells":[94,99,110],"which,":[95],"associated":[96],"with":[97,170,200],"antigen-presenting":[98],"secrete":[100],"IL-10":[101],"TGF-beta,":[103],"inhibiting":[104],"maturation":[106],"CD4":[108],"to":[111,149],"Th1":[112],"Th2":[114],"effector":[115],"cells,":[116],"consequently":[118],"reducing":[119],"occurrence":[121],"Th1-mediated":[123],"like":[125,131],"Crohn's":[126,195],"disease":[127,196],"Th2-mediated":[129],"ulcerative":[132,198],"colitis.":[133],"The":[134],"effects":[135,214],"on":[139,217],"host":[140],"immunity":[141],"studied":[144],"Ethiopian":[146],"Jews":[147],"emigrated":[148],"Israel.":[150],"Thorough":[151],"studies":[152],"before":[153],"after":[155,173],"deworming":[156],"demonstrated":[158],"chronic":[160,167],"helminth":[161,182],"provokes":[163],"immune":[168],"activation":[169],"anergy,":[171],"reversible":[172],"deworming.":[174],"Administration":[175],"ova":[177],"Trichuris":[179],"suis,":[180],"an":[181],"non":[183],"pathogenic":[184],"man,":[186],"has":[187],"given":[188],"encouraging":[189],"results":[190],"treatment":[193],"o":[194],"colitis":[199],"good":[202],"safety":[203],"record":[204],"but":[205],"long-term":[206],"trials":[207],"are":[208],"needed":[209],"potentially":[212],"harmful":[213],"immunity.":[218]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
