{"id":"https://openalex.org/W17474223","doi":"https://doi.org/10.1007/978-3-0348-7259-1_12","title":"5-HT1P Receptors in the Bowel: G Protein Coupling, Localization, and Function","display_name":"5-HT1P Receptors in the Bowel: G Protein Coupling, Localization, and Function","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W17474223","doi":"https://doi.org/10.1007/978-3-0348-7259-1_12","mag":"17474223"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-0348-7259-1_12","doi":"https://doi.org/10.1007/978-3-0348-7259-1_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-0348-7259-1_12","pdf_url":null,"source":{"id":"https://openalex.org/S4306462920","display_name":"Birkh\u00e4user Basel eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Serotonin: Molecular Biology, Receptors and Functional Effects","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W289821420","display_name":"Serotonin: Molecular Biology, Receptors and Functional Effects"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019329770","display_name":"Michael David Gershon","orcid":"https://orcid.org/0000-0002-5893-7643","observed_orcids":["https://orcid.org/0000-0002-5893-7643"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. D. Gershon","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. R. Wade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. R. Wade","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079036604","display_name":"Elena Fiorica\u2010Howells","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Fiorica-Howells","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111962039","display_name":"Annette L. Kirchgessner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. L. Kirchgessner","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110449522","display_name":"H. Tamir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Tamir","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.877,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.92079208,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"133","last_page":"143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.5092999935150146,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.5092999935150146,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.4611999988555908,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-receptors","display_name":"serotonin receptors","score":0.8349999785423279},{"id":"https://openalex.org/keywords/g-protein-coupling","display_name":"G protein coupling","score":0.7379999756813049},{"id":"https://openalex.org/keywords/myenteric-plexus","display_name":"myenteric plexus","score":0.8360000252723694},{"id":"https://openalex.org/keywords/enteric-neurons","display_name":"enteric neurons","score":0.7710000276565552},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.8410000205039978},{"id":"https://openalex.org/keywords/renzapride","display_name":"renzapride","score":0.8629999756813049},{"id":"https://openalex.org/keywords/anti-idiotypic-antibodies","display_name":"anti-idiotypic antibodies","score":0.8640000224113464},{"id":"https://openalex.org/keywords/5-ht3-receptor","display_name":"5-HT3 receptor","score":0.7459999918937683},{"id":"https://openalex.org/keywords/5-ht4-receptor","display_name":"5-HT4 receptor","score":0.8119999766349792},{"id":"https://openalex.org/keywords/5-ht2-receptor","display_name":"5-HT2 receptor","score":0.8610000014305115},{"id":"https://openalex.org/keywords/gastrointestinal-motility","display_name":"gastrointestinal motility","score":0.7689999938011169},{"id":"https://openalex.org/keywords/receptor-localization","display_name":"receptor localization","score":0.46700000762939453},{"id":"https://openalex.org/keywords/gtpgammas-binding","display_name":"GTPgammaS binding","score":0.6579999923706055},{"id":"https://openalex.org/keywords/tropisetron","display_name":"tropisetron","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7233304381370544},{"id":"https://openalex.org/C2776907353","wikidata":"https://www.wikidata.org/wiki/Q1890233","display_name":"Myenteric plexus","level":3,"score":0.605806291103363},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.5727647542953491},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5633118152618408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5445232391357422},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.5265586376190186},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.524807333946228},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.48985669016838074},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.48260223865509033},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.45614099502563477},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.42252978682518005},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.3974374532699585},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2652973234653473},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19530752301216125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09220993518829346},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.09042385220527649},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-0348-7259-1_12","doi":"https://doi.org/10.1007/978-3-0348-7259-1_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-0348-7259-1_12","pdf_url":null,"source":{"id":"https://openalex.org/S4306462920","display_name":"Birkh\u00e4user Basel eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Serotonin: Molecular Biology, Receptors and Functional Effects","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W139443835","https://openalex.org/W177747808","https://openalex.org/W1508582984","https://openalex.org/W1597053236","https://openalex.org/W1597460974","https://openalex.org/W1869902845","https://openalex.org/W1979647423","https://openalex.org/W1985066920","https://openalex.org/W1987836188","https://openalex.org/W1995604771","https://openalex.org/W2002131365","https://openalex.org/W2002852335","https://openalex.org/W2008257828","https://openalex.org/W2013930024","https://openalex.org/W2037543907","https://openalex.org/W2048367253","https://openalex.org/W2053468878","https://openalex.org/W2055753133","https://openalex.org/W2059772079","https://openalex.org/W2072150726","https://openalex.org/W2075540132","https://openalex.org/W2091609408","https://openalex.org/W2105136745","https://openalex.org/W2177901546","https://openalex.org/W2232346553","https://openalex.org/W2283485861","https://openalex.org/W2294340540","https://openalex.org/W2312729008","https://openalex.org/W2473892876","https://openalex.org/W6641647953","https://openalex.org/W6641984347","https://openalex.org/W6675951111"],"related_works":["https://openalex.org/W11223074","https://openalex.org/W2002852335","https://openalex.org/W2227901931","https://openalex.org/W51337228","https://openalex.org/W1454893841","https://openalex.org/W4224258094","https://openalex.org/W2066626481","https://openalex.org/W2294340540","https://openalex.org/W2438112567","https://openalex.org/W205767632"],"abstract_inverted_index":{"Although":[0],"serotinin":[1],"(5-HT)":[2],"has":[3],"been":[4,41],"demonstrated":[5,223],"to":[6,50,73,89,136,145,164,167,200,224,226,238,262,275,279,308,324,371],"mediate":[7],"slow":[8],"exicitatory":[9],"postsynaptic":[10],"potentials":[11],"in":[12,23,43,71,150,326,346,403],"neurons":[13,273,345,378,408],"of":[14,18,26,37,83,93,148,152,190,217,251,260,267,288,295,315,329,333,357,374,382,390,406],"the":[15,19,24,44,57,78,91,96,128,131,161,172,179,241,249,268,289,312,327,388,396,404,410],"myenteric":[16,154,347,377],"plexus":[17,356],"bowel,":[20],"its":[21],"role":[22,402],"physiology":[25],"gastrointestinal":[27],"motility":[28],"and":[29,62,81,116,230,246,255,298,348,366,387],"secretion":[30],"is":[31,134,393],"not":[32,214,233,342],"well":[33],"understood.":[34],"Five":[35],"subtypes":[36,216],"5-HT":[38,140,165,191,218,252,263,296,317],"receptor":[39,48,98,133,318,362],"have":[40],"reported":[42],"gut.":[45],"The":[46,66,188,258,284,303],"5-HT2":[47],"appears":[49],"be":[51,198,309],"present":[52,67],"on":[53,192,344,353],"smooth":[54],"muscle,":[55],"while":[56,114],"others,":[58],"5-HT1A,":[59],"5-HT1P\u201e":[60],"5-HT3,":[61,231],"5-HT4":[63,203],"are":[64,125,340],"neuronal.":[65],"experiments":[68],"were":[69,120,208,222,291,306,322,369],"undertaken":[70],"order":[72],"obtain":[74],"more":[75,110],"information":[76],"about":[77],"location,":[79],"action,":[80],"function":[82],"5-HT1P":[84,97,132,173,256,285,338,361,391],"receptors.":[85,204,235,257],"GTP-\u03b3-S,":[86],"was":[87,103,109,142,169,270],"found":[88,144,307,370],"inhibit":[90],"binding":[92],"3H-5-HT":[94],"by":[95,171,293,299,379],"(the":[99],"IC50":[100],"for":[101,311],"GTP-\u03b3-S":[102,108],"1.8":[104],"\u00b1":[105],"0.4":[106],"\u03bcM).":[107,302],"potent":[111],"than":[112],"GTP,":[113],"ATP":[115],"GMP":[117],"(100":[118],"\u03bcM)":[119],"without":[121],"effect.":[122],"These":[123,220],"observations":[124],"compatible":[126],"with":[127,395],"hypothesis":[129],"that":[130,210,264,337,398],"coupled":[135],"a":[137,354,401],"G":[138],"protein.":[139],"(0.1\u201310\u03bcM)":[141],"also":[143,157,352],"elevate":[146],"levels":[147],"cAMP":[149],"preparations":[151],"isolated":[153],"ganglia.":[155],"Renzapride":[156],"increased":[158],"cAMP,":[159,194],"but":[160,213,232,351],"response":[162],"neither":[163],"nor":[166],"renzapride":[168,300],"inhibited":[170],"antagonist,":[174,181],"N-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan":[175],"amide":[176],"(5-HTP-DP)":[177],"or":[178,202,281,376],"5-HT3/5-HT4":[180],"ICS":[182],"205\u2013930,":[183],"even":[184],"at":[185,253],"10":[186],"\u03bcM.":[187],"action":[189],"ganglionic":[193],"therefore,":[195],"cannot":[196],"now":[197],"attributed":[199],"5-HT1P,":[201,229],"Polyclonal":[205],"anti-idiotypic":[206,242,304,367],"antibodies":[207,221,243,290,305,335],"raised":[209],"recognize":[211],"some,":[212],"all,":[215],"receptor.":[219],"bind":[225],"5-HT2,":[227],"5-HT1C,":[228],"5-HT1A":[234],"When":[236],"applied":[237,323],"enteric":[239,407],"neurons,":[240],"transiently":[244],"mimicked":[245],"then":[247],"blocked":[248],"actions":[250,287],"5-HT3":[254],"blockage":[259],"responses":[261],"followed":[265],"application":[266,381],"antibody":[269],"specific,":[271],"since":[272],"continued":[274],"respond":[276],"as":[277],"before":[278],"carbachol":[280],"substance":[282],"P.":[283],"agonist-like":[286],"prevented":[292],"desensitization":[294],"receptors":[297,339],"(1":[301],"useful":[310],"immunocytochemical":[313],"localization":[314,389],"specific":[316],"subtypes,":[319],"if":[320],"they":[321,399],"tissues":[325],"presence":[328],"appropriate":[330],"antagonists.":[331],"Use":[332],"these":[334],"indicated":[336],"located,":[341],"only":[343],"submucosal":[349,375],"ganglia,":[350],"subepithelial":[355],"nerve":[358],"fibers.":[359],"Finally,":[360],"antagonists":[363],"(5-HTP-DP,":[364],"renzapride,":[365],"antibodies),":[368],"prevent":[372],"excitation":[373,405],"mucosal":[380],"cholera":[383],"toxin.":[384],"This":[385],"observation,":[386],"receptors,":[392],"consistent":[394],"idea":[397],"play":[400],"during":[409],"peristaltic":[411],"reflex.":[412]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}
