{"id":"https://openalex.org/W1746889600","doi":null,"title":"Beneficial effect of antioxidants in retinopathies: a new hypothesis.","display_name":"Beneficial effect of antioxidants in retinopathies: a new hypothesis.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1746889600","mag":"1746889600","pmid":"https://pubmed.ncbi.nlm.nih.gov/24600629","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3939726"},"language":"en","primary_location":{"id":"pmh:oai:www.mehdijournal.com:article/51","doi":null,"is_oa":true,"landing_page_url":"http://mehdijournal.com/index.php/mehdiophthalmol/article/view/51","pdf_url":"http://mehdijournal.com/index.php/mehdiophthalmol/article/view/51/11","source":{"id":"https://openalex.org/S4210181860","display_name":"Medical Hypothesis Discovery & Innovation in Ophthalmology","issn_l":"2322-3219","issn":["2322-3219","2322-4436"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2322-3219","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://mehdijournal.com/index.php/mehdiophthalmol/article/view/51/11","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081002776","display_name":"Isabella Panfoli","orcid":"https://orcid.org/0000-0002-6261-1128","observed_orcids":["https://orcid.org/0000-0002-6261-1128"]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Isabella Panfoli","raw_affiliation_strings":["Department of Pharmacy-DIFAR, Biochemistry Lab. University of Genoa, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy-DIFAR, Biochemistry Lab. University of Genoa, Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081002776"],"corresponding_institution_ids":["https://openalex.org/I83816512"],"apc_list":null,"apc_paid":null,"fwci":1.1292,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.76384621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"1","issue":"4","first_page":"76","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.19599999487400055,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.984000027179718},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.7730000019073486},{"id":"https://openalex.org/keywords/rod-outer-segments","display_name":"rod outer segments","score":0.7459999918937683},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8769999742507935},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9710000157356262},{"id":"https://openalex.org/keywords/photoreceptor-degeneration","display_name":"photoreceptor degeneration","score":0.7229999899864197},{"id":"https://openalex.org/keywords/mitochondrial-electron-transport-chain","display_name":"mitochondrial electron transport chain","score":0.9179999828338623},{"id":"https://openalex.org/keywords/f0f1-atp-synthase","display_name":"F0F1-ATP synthase","score":0.984000027179718},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.9729999899864197},{"id":"https://openalex.org/keywords/phototransduction","display_name":"phototransduction","score":0.75},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.8899999856948853},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/retinitis-pigmentosa","display_name":"retinitis pigmentosa","score":0.9959999918937683},{"id":"https://openalex.org/keywords/retinal-detachment","display_name":"retinal detachment","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C2781114197","wikidata":"https://www.wikidata.org/wiki/Q847057","display_name":"Retinitis pigmentosa","level":3,"score":0.7992769479751587},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6425755023956299},{"id":"https://openalex.org/C131667965","wikidata":"https://www.wikidata.org/wiki/Q445081","display_name":"Visual phototransduction","level":3,"score":0.6278549432754517},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.592710554599762},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.578045129776001},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.5618454813957214},{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.5319818258285522},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.5124757885932922},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4631158113479614},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4597414433956146},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.41293537616729736},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.4106369614601135},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35052841901779175},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3321758508682251},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3288775086402893},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3005332350730896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29801714420318604},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.2811777591705322}],"mesh":[],"locations_count":7,"locations":[{"id":"pmh:oai:www.mehdijournal.com:article/51","doi":null,"is_oa":true,"landing_page_url":"http://mehdijournal.com/index.php/mehdiophthalmol/article/view/51","pdf_url":"http://mehdijournal.com/index.php/mehdiophthalmol/article/view/51/11","source":{"id":"https://openalex.org/S4210181860","display_name":"Medical Hypothesis Discovery & Innovation in Ophthalmology","issn_l":"2322-3219","issn":["2322-3219","2322-4436"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2322-3219","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:2928296","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3939726","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24600629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24600629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical hypothesis, discovery & innovation ophthalmology journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3939726","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3939726/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Med Hypothesis Discov Innov Ophthalmol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.797.9003","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.797.9003","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/68/c0/mehdiophth-1-076.PMC3939726.pdf","raw_type":"text"},{"id":"pmh:oai:iris.unige.it:11567/782998","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11567/782998","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1746889600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24600629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.mehdijournal.com:article/51","doi":null,"is_oa":true,"landing_page_url":"http://mehdijournal.com/index.php/mehdiophthalmol/article/view/51","pdf_url":"http://mehdijournal.com/index.php/mehdiophthalmol/article/view/51/11","source":{"id":"https://openalex.org/S4210181860","display_name":"Medical Hypothesis Discovery & Innovation in Ophthalmology","issn_l":"2322-3219","issn":["2322-3219","2322-4436"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2322-3219","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1746889600.pdf","grobid_xml":"https://content.openalex.org/works/W1746889600.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W172348664","https://openalex.org/W199142598","https://openalex.org/W936972680","https://openalex.org/W1661422265","https://openalex.org/W1909383564","https://openalex.org/W1964513960","https://openalex.org/W1966483924","https://openalex.org/W1969301686","https://openalex.org/W1974649871","https://openalex.org/W1977335152","https://openalex.org/W1979039714","https://openalex.org/W1982803107","https://openalex.org/W1983557667","https://openalex.org/W1983653244","https://openalex.org/W1988230638","https://openalex.org/W1988917929","https://openalex.org/W1992890710","https://openalex.org/W1997354645","https://openalex.org/W1997816482","https://openalex.org/W2005221463","https://openalex.org/W2005767645","https://openalex.org/W2007448480","https://openalex.org/W2008846006","https://openalex.org/W2012230565","https://openalex.org/W2012321872","https://openalex.org/W2025295875","https://openalex.org/W2028476182","https://openalex.org/W2033748396","https://openalex.org/W2034195388","https://openalex.org/W2041978412","https://openalex.org/W2046662655","https://openalex.org/W2064170412","https://openalex.org/W2064839214","https://openalex.org/W2070001955","https://openalex.org/W2073339596","https://openalex.org/W2073775232","https://openalex.org/W2077738024","https://openalex.org/W2078739917","https://openalex.org/W2084034472","https://openalex.org/W2085514362","https://openalex.org/W2093070234","https://openalex.org/W2109045394","https://openalex.org/W2115337518","https://openalex.org/W2116707380","https://openalex.org/W2118249767","https://openalex.org/W2120113019","https://openalex.org/W2130191947","https://openalex.org/W2137331743","https://openalex.org/W2138308486","https://openalex.org/W2144839999"],"related_works":["https://openalex.org/W7099717577","https://openalex.org/W3154658579","https://openalex.org/W7215611946","https://openalex.org/W3088080130","https://openalex.org/W4306408092","https://openalex.org/W7135500286","https://openalex.org/W3095122271","https://openalex.org/W7123747040","https://openalex.org/W4323529355","https://openalex.org/W1109639756"],"abstract_inverted_index":{"The":[0],"retina":[1],"is":[2,51,139,215],"the":[3,9,33,39,48,61,76,84,96,142,146,155,158,174,195,207,212,220,230],"most":[4,94],"oxygen":[5,80,170,199],"consuming":[6],"tissue":[7],"of":[8,60,75,78,95,149,233],"body.":[10],"Rod":[11],"and":[12,109],"cone":[13],"photoreceptors":[14],"efficiently":[15],"carry":[16],"out":[17],"visual":[18],"cascades,":[19],"which":[20,50,64,211],"are":[21,120],"energetically":[22],"costly":[23],"processes.":[24],"Data":[25],"has":[26,88],"recently":[27],"been":[28,89],"published":[29],"that":[30,32,141],"suggests":[31],"metabolic":[34],"support":[35],"to":[36,53,70,91,93,182],"phototransduction":[37],"in":[38,47,123,134,151,165,185,202],"rod":[40,62,186,213],"outer":[41],"segment":[42],"(OS)":[43],"may":[44],"originate":[45],"directly":[46,82],"OS,":[49,63],"able":[52],"conduct":[54],"aerobic":[55],"metabolism.":[56],"This":[57],"oxygen-handling":[58],"activity":[59],"was":[65],"never":[66],"suspected":[67],"before,":[68],"appears":[69],"be":[71,163],"a":[72,227],"primary":[73],"cause":[74],"generation":[77],"reactive":[79,169,198],"species":[81,171,200],"inside":[83],"OS.":[85],"Oxidative":[86],"stress":[87],"hypothesised":[90],"contribute":[92],"neurodegenerative":[97],"retinal":[98,114,159,238],"pathologies,":[99],"such":[100],"as":[101],"diabetic":[102],"retinopathy,":[103],"age-related":[104],"macular":[105],"degeneration,":[106],"retinitis":[107],"pigmentosa":[108],"photoreceptor":[110,132],"cell":[111],"death":[112],"after":[113],"detachment.":[115],"Many":[116],"natural":[117],"antioxidant":[118],"compounds":[119],"routinely":[121],"used":[122],"experimental":[124],"or":[125,130,153],"human":[126],"therapies":[127,234],"for":[128,145,229,237],"preventing":[129,152],"delaying":[131],"degeneration":[133],"those":[135],"pathologies.":[136],"Here":[137],"it":[138],"proposed":[140],"ultimate":[143],"reason":[144],"beneficial":[147],"actions":[148],"antioxidants":[150,236],"retarding":[154],"effect":[156],"on":[157,168,206],"degenerative":[160,239],"pathologies":[161],"can":[162,204],"found":[164],"their":[166],"action":[167],"generated":[172],"by":[173],"ectopic":[175],"mitochondrial":[176],"electron":[177],"transport":[178],"chain":[179],"(ETC)":[180],"coupled":[181],"FoF1-ATP":[183],"synthase":[184],"OS":[187,214],"disks.":[188],"In":[189],"fact,":[190],"if":[191],"not":[192],"adequately":[193],"coupled,":[194],"ETC":[196],"generates":[197],"that,":[201],"turn,":[203],"act":[205],"polyunsaturated":[208],"fatty":[209],"acids":[210],"rich":[216],"in.":[217],"If":[218],"correct,":[219],"mechanism":[221],"put":[222],"forward":[223],"here":[224],"would":[225],"provide":[226],"potential":[228],"molecular":[231],"basis":[232],"with":[235],"diseases.":[240]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
