{"id":"https://openalex.org/W174659950","doi":null,"title":"Abnormalities of oxidative phosphorylation due to excess of deficiency of thyroid hormones.","display_name":"Abnormalities of oxidative phosphorylation due to excess of deficiency of thyroid hormones.","publication_year":1980,"publication_date":"1980-07-01","ids":{"openalex":"https://openalex.org/W174659950","mag":"174659950","pmid":"https://pubmed.ncbi.nlm.nih.gov/7433860"},"language":"en","primary_location":{"id":"pmid:7433860","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7433860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinologie","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080155767","display_name":"Dorel Ionel Popovici","orcid":"https://orcid.org/0000-0002-2772-7547","observed_orcids":["https://orcid.org/0000-0002-2772-7547"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Popovici","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"N Mihai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Mihai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035257136","display_name":"Vaidotas Urbanavi\u010dius","orcid":"https://orcid.org/0000-0002-8601-4563","observed_orcids":["https://orcid.org/0000-0002-8601-4563"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Urbanavicius","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.01381693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"3","first_page":"143","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.06449999660253525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.8870000243186951},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.984000027179718},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.8529999852180481},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7799999713897705},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.7429999709129333},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.6639999747276306},{"id":"https://openalex.org/keywords/lactate-accumulation","display_name":"lactate accumulation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/nadph","display_name":"NADPH","score":0.718999981880188},{"id":"https://openalex.org/keywords/atpase","display_name":"ATPase","score":0.6000000238418579},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.865047812461853},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.6622864007949829},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.6564083695411682},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5494076013565063},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5128633975982666},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5072252750396729},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4856063723564148},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.4473068118095398},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4453665018081665},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4064655005931854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3302403688430786},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.32284533977508545},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06763488054275513}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010725","descriptor_name":"Phosphocreatine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7433860","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7433860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinologie","raw_type":"Journal Article"},{"id":"mag:174659950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7433860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W59377606","https://openalex.org/W1965505826","https://openalex.org/W2415319586","https://openalex.org/W2001636951","https://openalex.org/W2073716930","https://openalex.org/W4239976960","https://openalex.org/W3210905450","https://openalex.org/W2046105635","https://openalex.org/W2005221039","https://openalex.org/W2306756622"],"abstract_inverted_index":{"ATP":[0,12,41,79,104,124],"synthesis":[1],"requires":[2],"the":[3,14,89,127,130],"presence":[4],"of":[5,54,59,84,99,132,142],"thyroid":[6],"hormones":[7],"that":[8],"activate":[9],"oxidative":[10,85],"phosphorylation.":[11],"supports":[13],"energy":[15],"consuming":[16],"reactions":[17],"such":[18],"as":[19],"actin-myosin":[20],"interaction,":[21],"calcium":[22],"and":[23,66,72,101,103,140],"sodium":[24],"pump,":[25],"which":[26,43,121],"are":[27],"essential":[28],"in":[29],"a":[30,95],"normal":[31],"heart":[32],"function.":[33],"Thyroid":[34],"insufficiency":[35],"depresses":[36],"mitochondrial":[37,67],"oxidation,":[38],"leading":[39],"to":[40,57],"depletion":[42],"can":[44],"not":[45],"be":[46],"compensated":[47],"by":[48,82,134],"activated":[49],"glycolysis.":[50],"Glycolysis":[51],"under":[52],"conditions":[53],"hypoxia":[55],"due":[56],"accumulation":[58],"lactate":[60],"or":[61],"NADPH,":[62],"impairs":[63],"membrane":[64],"permeability":[65],"function,":[68],"causing":[69],"enzyme":[70,119],"release":[71,139],"pump":[73],"failure.":[74],"In":[75],"severe":[76],"hyperthyroidism":[77],"an":[78],"deficiency":[80],"occurs":[81],"uncoupling":[83],"phosphorylation,":[86],"T4":[87,133],"stimulating":[88,135],"extra-mitochondrial":[90],"metabolic":[91],"pathways.":[92],"There":[93],"is":[94],"disproportion":[96],"between":[97],"consumption":[98],"O2":[100],"nutrients":[102],"production.":[105],"The":[106],"T4--T3":[107],"excess":[108,131],"via":[109],"trace":[110],"metal":[111],"(magnesium,":[112],"copper,":[113],"zinc,":[114],"iron,":[115],"etc.)":[116],"chelation":[117],"inhibits":[118],"activity":[120],"had":[122],"impaired":[123],"synthesis.":[125],"At":[126],"same":[128],"time":[129],"ATP-ase":[136],"causes":[137],"heat":[138],"dissipation":[141],"ATP,":[143],"favouring":[144],"cardiothyreosis.":[145]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
