{"id":"https://openalex.org/W1745549119","doi":"https://doi.org/10.18632/oncotarget.3494","title":"Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer","display_name":"Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer","publication_year":2015,"publication_date":"2015-03-30","ids":{"openalex":"https://openalex.org/W1745549119","doi":"https://doi.org/10.18632/oncotarget.3494","mag":"1745549119","pmid":"https://pubmed.ncbi.nlm.nih.gov/25869206","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4494960"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.3494","doi":"https://doi.org/10.18632/oncotarget.3494","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.3494","pdf_url":"https://www.oncotarget.com/article/3494/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.oncotarget.com/article/3494/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084499108","display_name":"Stefan J. Barfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Stefan J. Barfeld","raw_affiliation_strings":["Prostate Research Group, Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prostate Research Group, Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034110828","display_name":"Ladan Fazli","orcid":"https://orcid.org/0009-0005-0731-0583","observed_orcids":["https://orcid.org/0009-0005-0731-0583","https://orcid.org/0000-0001-6488-4245"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405261103","display_name":"Vancouver Prostate Centre","ror":"https://ror.org/04skhpe58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405261103"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ladan Fazli","raw_affiliation_strings":["The Vancouver Prostate Centre, University of British Columbia, Canada","The Vancouver Prostate Centre, University of British Columbia, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Vancouver Prostate Centre, University of British Columbia, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405261103"]},{"raw_affiliation_string":"The Vancouver Prostate Centre, University of British Columbia, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405261103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027674575","display_name":"Margareta Persson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Margareta Persson","raw_affiliation_strings":["Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074709836","display_name":"Lisette Marjavaara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lisette Marjavaara","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics, Molecular Infection Medicine Sweden (MIMS), Nordic EMBL Partnership, University of Ume\u00e5, Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, Molecular Infection Medicine Sweden (MIMS), Nordic EMBL Partnership, University of Ume\u00e5, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028961632","display_name":"Alfonso Urbanucci","orcid":"https://orcid.org/0000-0003-2931-3652","observed_orcids":["https://orcid.org/0000-0003-2931-3652"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Alfonso Urbanucci","raw_affiliation_strings":["Prostate Research Group, Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prostate Research Group, Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023639693","display_name":"Kirsi M. Kaukoniemi","orcid":"https://orcid.org/0000-0003-3458-7527","observed_orcids":["https://orcid.org/0000-0003-3458-7527"]},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]},{"id":"https://openalex.org/I4210133601","display_name":"Fimlab (Finland)","ror":"https://ror.org/031y6w871","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210133601"]},{"id":"https://openalex.org/I4387153886","display_name":"University of Tampere","ror":"https://ror.org/05p6qqk79","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kirsi M. Kaukoniemi","raw_affiliation_strings":["Institute of Biosciences and Medical Technology, University of Tampere and Fimlab Laboratories, Tampere University Hospital, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biosciences and Medical Technology, University of Tampere and Fimlab Laboratories, Tampere University Hospital, Tampere, Finland","institution_ids":["https://openalex.org/I4210126318","https://openalex.org/I4210133601","https://openalex.org/I4387153886"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113514052","display_name":"Paul S. Rennie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405261103","display_name":"Vancouver Prostate Centre","ror":"https://ror.org/04skhpe58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405261103"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Paul S. Rennie","raw_affiliation_strings":["The Vancouver Prostate Centre, University of British Columbia, Canada","The Vancouver Prostate Centre, University of British Columbia, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Vancouver Prostate Centre, University of British Columbia, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405261103"]},{"raw_affiliation_string":"The Vancouver Prostate Centre, University of British Columbia, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405261103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087403158","display_name":"Yvonne Ceder","orcid":"https://orcid.org/0000-0002-8705-8293","observed_orcids":["https://orcid.org/0000-0002-8705-8293"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Yvonne Ceder","raw_affiliation_strings":["Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006041544","display_name":"Andrei Chabes","orcid":"https://orcid.org/0000-0003-1708-8259","observed_orcids":["https://orcid.org/0000-0003-1708-8259"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Andrei Chabes","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics, Molecular Infection Medicine Sweden (MIMS), Nordic EMBL Partnership, University of Ume\u00e5, Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, Molecular Infection Medicine Sweden (MIMS), Nordic EMBL Partnership, University of Ume\u00e5, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085775392","display_name":"Tapio Visakorpi","orcid":"https://orcid.org/0000-0002-5004-0364","observed_orcids":["https://orcid.org/0000-0002-5004-0364"]},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]},{"id":"https://openalex.org/I4210133601","display_name":"Fimlab (Finland)","ror":"https://ror.org/031y6w871","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210133601"]},{"id":"https://openalex.org/I4387153886","display_name":"University of Tampere","ror":"https://ror.org/05p6qqk79","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tapio Visakorpi","raw_affiliation_strings":["Institute of Biosciences and Medical Technology, University of Tampere and Fimlab Laboratories, Tampere University Hospital, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biosciences and Medical Technology, University of Tampere and Fimlab Laboratories, Tampere University Hospital, Tampere, Finland","institution_ids":["https://openalex.org/I4210126318","https://openalex.org/I4210133601","https://openalex.org/I4387153886"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082768586","display_name":"Ian Geoffrey Mills","orcid":"https://orcid.org/0000-0001-5347-5083","observed_orcids":["https://orcid.org/0000-0001-5347-5083"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ian G. Mills","raw_affiliation_strings":["Department of Cancer Prevention, Oslo University Hospital, Oslo, Norway","Department of Urology, Oslo University Hospital, Oslo, Norway","Prostate Research Group, Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Prevention, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Department of Urology, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Prostate Research Group, Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7999,"has_fulltext":true,"cited_by_count":79,"citation_normalized_percentile":{"value":0.85015596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"6","issue":"14","first_page":"12587","last_page":"12602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.15760000050067902,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8489999771118164},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.746999979019165},{"id":"https://openalex.org/keywords/purine-biosynthesis","display_name":"purine biosynthesis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nucleolar-stress","display_name":"nucleolar stress","score":0.902999997138977},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.6710000038146973},{"id":"https://openalex.org/keywords/impdh2","display_name":"IMPDH2","score":0.7789999842643738},{"id":"https://openalex.org/keywords/paics","display_name":"PAICS","score":0.8339999914169312},{"id":"https://openalex.org/keywords/mycophenolic-acid","display_name":"mycophenolic acid","score":0.968999981880188},{"id":"https://openalex.org/keywords/impdh-inhibitors","display_name":"IMPDH inhibitors","score":0.8479999899864197},{"id":"https://openalex.org/keywords/antiandrogen-therapy","display_name":"antiandrogen therapy","score":0.5580000281333923},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5720000267028809},{"id":"https://openalex.org/keywords/xmp","display_name":"XMP","score":0.531000018119812},{"id":"https://openalex.org/keywords/nucleotide-metabolism","display_name":"nucleotide metabolism","score":0.6430000066757202},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.3619999885559082},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5789999961853027},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.414000004529953},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6325741410255432},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46888941526412964},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3741381764411926},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3568873703479767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3045054078102112}],"mesh":[{"descriptor_ui":"D002466","descriptor_name":"Cell Nucleolus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007168","descriptor_name":"IMP Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.18632/oncotarget.3494","doi":"https://doi.org/10.18632/oncotarget.3494","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.3494","pdf_url":"https://www.oncotarget.com/article/3494/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmid:25869206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25869206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4494960","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4494960/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmh:oai:pure.qub.ac.uk/portal:openaire/a73247d2-1708-4e5b-886a-b0cbd591d84c","doi":null,"is_oa":true,"landing_page_url":"https://pure.qub.ac.uk/en/publications/a73247d2-1708-4e5b-886a-b0cbd591d84c","pdf_url":null,"source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Barfeld, S J, Fazli, L, Persson, M, Marjavaara, L, Urbanucci, A, Kaukoniemi, K M, Rennie, P S, Ceder, Y, Chabes, A, Visakorpi, T & Mills, I G 2015, 'Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer', Oncotarget, vol. 6, no. 14, pp. 12587-602. https://doi.org/10.18632/oncotarget.3494","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:tampub.uta.fi:10024/99681","doi":null,"is_oa":true,"landing_page_url":"http://tampub.uta.fi/handle/10024/99681","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"publishedVersion"},{"id":"pmh:oai:DiVA.org:umu-101879","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-101879","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lup.lub.lu.se:db3ca0fd-051d-4b94-b270-3984a7c5a66f","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/5342006","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1949-2553","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:trepo.tuni.fi:10024/99681","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/99681","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"publishedVersion"},{"id":"pmh:oai:www.duo.uio.no:10852/48257","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/48257","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.3494","doi":"https://doi.org/10.18632/oncotarget.3494","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.3494","pdf_url":"https://www.oncotarget.com/article/3494/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320323260","display_name":"Universitetet i Oslo","ror":"https://ror.org/01xtthb56"},{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1745549119.pdf","grobid_xml":"https://content.openalex.org/works/W1745549119.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W115721195","https://openalex.org/W1495871951","https://openalex.org/W1619791548","https://openalex.org/W1740737174","https://openalex.org/W1833017940","https://openalex.org/W1842649350","https://openalex.org/W1919512980","https://openalex.org/W1966559042","https://openalex.org/W1969689238","https://openalex.org/W1972778166","https://openalex.org/W1979843175","https://openalex.org/W1988294855","https://openalex.org/W1996646041","https://openalex.org/W1997614722","https://openalex.org/W1998867125","https://openalex.org/W2004344128","https://openalex.org/W2005658600","https://openalex.org/W2006588532","https://openalex.org/W2008498145","https://openalex.org/W2013730471","https://openalex.org/W2020123502","https://openalex.org/W2021784588","https://openalex.org/W2041719533","https://openalex.org/W2044680827","https://openalex.org/W2046505220","https://openalex.org/W2046694248","https://openalex.org/W2055255976","https://openalex.org/W2055346449","https://openalex.org/W2055829752","https://openalex.org/W2057463560","https://openalex.org/W2066808338","https://openalex.org/W2070889512","https://openalex.org/W2070895376","https://openalex.org/W2074664629","https://openalex.org/W2083158631","https://openalex.org/W2085213714","https://openalex.org/W2088393064","https://openalex.org/W2090029033","https://openalex.org/W2090944178","https://openalex.org/W2091154312","https://openalex.org/W2093426285","https://openalex.org/W2093941725","https://openalex.org/W2094252220","https://openalex.org/W2094941740","https://openalex.org/W2095517704","https://openalex.org/W2095873383","https://openalex.org/W2097580481","https://openalex.org/W2099692224","https://openalex.org/W2104488717","https://openalex.org/W2104624195","https://openalex.org/W2107482095","https://openalex.org/W2107633226","https://openalex.org/W2107857423","https://openalex.org/W2120583266","https://openalex.org/W2121846636","https://openalex.org/W2126895807","https://openalex.org/W2135254264","https://openalex.org/W2135798683","https://openalex.org/W2138799354","https://openalex.org/W2141451721","https://openalex.org/W2155445409","https://openalex.org/W2157517801","https://openalex.org/W2158107632","https://openalex.org/W2159448513","https://openalex.org/W2166771233","https://openalex.org/W4245453995"],"related_works":["https://openalex.org/W2104773254","https://openalex.org/W4408372771","https://openalex.org/W4280566607","https://openalex.org/W2607622220","https://openalex.org/W2738571701","https://openalex.org/W2588930356","https://openalex.org/W2300438298","https://openalex.org/W2901618857","https://openalex.org/W1919512980","https://openalex.org/W2604778717"],"abstract_inverted_index":{"//":[0],"Stefan":[1,155],"J.":[2,156],"Barfeld":[3],"1":[4,20,50],",":[5,9,13,17,21,26,31,35,39,43],"Ladan":[6],"Fazli":[7],"2":[8,30,68],"Margareta":[10],"Persson":[11],"3":[12,34,78],"Lisette":[14],"Marjavaara":[15],"4":[16,38,91],"Alfonso":[18],"Urbanucci":[19],"Kirsi":[22],"M.":[23],"Kaukoniemi":[24],"5":[25,42,111],"Paul":[27],"S.":[28],"Rennie":[29],"Yvonne":[32],"Ceder":[33],"Andrei":[36],"Chabes":[37],"Tapio":[40],"Visakorpi":[41],"Ian":[44,150],"G.":[45,151],"Mills":[46],"1,":[47],"6,":[48],"7":[49,139],"Prostate":[51,71],"Research":[52],"Group,":[53],"Centre":[54],"for":[55],"Molecular":[56,98],"Medicine":[57,100],"Norway":[58,67,138,147],"(NCMM),":[59],"Nordic":[60,103],"EMBL":[61,104],"Partnership,":[62,105],"University":[63,73,106,118,125,135,144],"of":[64,74,80,84,93,107,113,119,131,141,191,194,236,272,295],"Oslo,":[65,66,137,146],"The":[69,179],"Vancouver":[70],"Centre,":[72],"British":[75],"Columbia,":[76],"Canada":[77],"Department":[79,92,130,140],"Laboratory":[81],"Medicine,":[82],"Division":[83],"Clinical":[85],"Chemistry,":[86],"Lund":[87],"University,":[88],"Malm\u00f6,":[89],"Sweden":[90,101,110],"Medical":[94,116],"Biochemistry":[95],"and":[96,115,121,232,259,270,280,291,327,342],"Biophysics,":[97],"Infection":[99],"(MIMS),":[102],"Ume\u00e5,":[108,109],"Institute":[112],"Biosciences":[114],"Technology,":[117],"Tampere":[120,124],"Fimlab":[122],"Laboratories,":[123],"Hospital,":[126,136,145],"Tampere,":[127],"Finland":[128],"6":[129],"Cancer":[132],"Prevention,":[133],"Oslo":[134,143],"Urology,":[142],"Correspondence":[148],"to:":[149],"Mills,":[152],"e-mail:":[153,158],"ian.mills@ncmm.uio.no":[154],"Barfeld,":[157],"stefan.barfeld@ncmm.uio.no":[159],"Keywords:":[160],"prostate,":[161],"cancer,":[162],"nucleotide,":[163],"transcription,":[164],"metabolism":[165,341],"Received:":[166],"September":[167],"28,":[168],"2014":[169],"Accepted:":[170],"March":[171],"07,":[172],"2015":[173,177],"Published:":[174],"April":[175],"01,":[176],"ABSTRACT":[178],"androgen":[180],"receptor":[181],"is":[182,215,265],"a":[183,216,301,314],"key":[184],"transcription":[185,201],"factor":[186],"contributing":[187],"to":[188,263,313,338],"the":[189,228,260,283],"development":[190],"all":[192],"stages":[193],"prostate":[195],"cancer":[196],"(PCa).":[197],"In":[198,246,330],"addition,":[199],"other":[200,221,244],"factors":[202],"have":[203,224],"been":[204],"associated":[205],"with":[206,300,310],"poor":[207],"prognosis":[208],"in":[209,219,243,252,288,298,317],"PCa,":[210],"amongst":[211],"which":[212],"c-Myc":[213],"(MYC)":[214],"well-established":[217],"oncogene":[218],"many":[220,235],"cancers.":[222,245],"We":[223,275],"previously":[225],"reported":[226],"that":[227,251],"AR":[229,273],"promotes":[230],"glycolysis":[231],"anabolic":[233],"metabolism;":[234],"these":[237],"metabolic":[238],"pathways":[239],"are":[240],"also":[241],"MYC-regulated":[242],"this":[247],"study,":[248],"we":[249],"report":[250,292],"PCa":[253,286,340],"cells":[254],"de":[255],"novo":[256],"purine":[257,333],"biosynthesis":[258,334],"subsequent":[261],"conversion":[262],"XMP":[264],"tightly":[266],"regulated":[267],"by":[268,324],"MYC":[269],"independent":[271],"activity.":[274],"characterized":[276],"two":[277],"enzymes,":[278],"PAICS":[279],"IMPDH2,":[281],"within":[282],"pathway":[284],"as":[285],"biomarkers":[287],"tissue":[289],"samples":[290],"increased":[293],"efficacy":[294],"established":[296],"anti-androgens":[297],"combination":[299],"clinically":[302],"approved":[303],"IMPDH":[304],"inhibitor,":[305],"mycophenolic":[306],"acid":[307],"(MPA).":[308],"Treatment":[309],"MPA":[311],"led":[312],"significant":[315],"reduction":[316],"cellular":[318],"guanosine":[319],"triphosphate":[320],"(GTP)":[321],"levels":[322],"accompanied":[323],"nucleolar":[325],"stress":[326,346],"p53":[328],"stabilization.":[329],"conclusion,":[331],"targeting":[332],"provides":[335],"an":[336],"opportunity":[337],"perturb":[339],"enhance":[343],"tumour":[344],"suppressive":[345],"responses.":[347]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}