{"id":"https://openalex.org/W174547157","doi":null,"title":"Rhizobium purine metabolism and its role in infection of legumes","display_name":"Rhizobium purine metabolism and its role in infection of legumes","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W174547157","mag":"174547157"},"language":"en","primary_location":{"id":"pmh:oai:epublications.marquette.edu:dissertations-1665","doi":null,"is_oa":false,"landing_page_url":"https://epublications.marquette.edu/dissertations/AAI9318928","pdf_url":null,"source":{"id":"https://openalex.org/S4306401682","display_name":"e-Publications@Marquette (Marquette University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102461120","host_organization_name":"Marquette University","host_organization_lineage":["https://openalex.org/I102461120"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations (1962 - 2010) Access via Proquest Digital Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041465207","display_name":"Jeffrey D. Newman","orcid":"https://orcid.org/0000-0003-0495-4840","observed_orcids":["https://orcid.org/0000-0003-0495-4840"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jeffrey D. Newman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0495-4840","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041465207"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11470","display_name":"Legume Nitrogen Fixing Symbiosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11470","display_name":"Legume Nitrogen Fixing Symbiosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhizobium","display_name":"Rhizobium","score":0.9100000262260437},{"id":"https://openalex.org/keywords/purine-metabolism","display_name":"purine metabolism","score":0.8939999938011169},{"id":"https://openalex.org/keywords/purine-auxotrophy","display_name":"purine auxotrophy","score":0.9810000061988831},{"id":"https://openalex.org/keywords/legume-rhizobium-symbiosis","display_name":"legume-rhizobium symbiosis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/root-nodulation","display_name":"root nodulation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/aica-riboside","display_name":"AICA riboside","score":0.8870000243186951},{"id":"https://openalex.org/keywords/aicar","display_name":"AICAR","score":0.9470000267028809},{"id":"https://openalex.org/keywords/purine-biosynthesis","display_name":"purine biosynthesis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/rhizobium-leguminosarum-biovar-phaseoli","display_name":"Rhizobium leguminosarum biovar phaseoli","score":0.902999997138977},{"id":"https://openalex.org/keywords/nitrogen-fixation","display_name":"nitrogen fixation","score":0.3919999897480011},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.4429999887943268},{"id":"https://openalex.org/keywords/auxotrophic-mutants","display_name":"auxotrophic mutants","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C2780434414","wikidata":"https://www.wikidata.org/wiki/Q830142","display_name":"Rhizobium","level":3,"score":0.7155486345291138},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.5702224373817444},{"id":"https://openalex.org/C169586020","wikidata":"https://www.wikidata.org/wiki/Q3780159","display_name":"Purine metabolism","level":3,"score":0.5025272369384766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4934495985507965},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3660363256931305},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3421698212623596},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3057776987552643},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17398428916931152},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06768706440925598}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:epublications.marquette.edu:dissertations-1665","doi":null,"is_oa":false,"landing_page_url":"https://epublications.marquette.edu/dissertations/AAI9318928","pdf_url":null,"source":{"id":"https://openalex.org/S4306401682","display_name":"e-Publications@Marquette (Marquette University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102461120","host_organization_name":"Marquette University","host_organization_lineage":["https://openalex.org/I102461120"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations (1962 - 2010) Access via Proquest Digital Dissertations","raw_type":"text"},{"id":"pmh:oai:epublications.marquette.edu:dissertations_mu-2697","doi":null,"is_oa":false,"landing_page_url":"https://epublications.marquette.edu/dissertations_mu/1684","pdf_url":null,"source":{"id":"https://openalex.org/S4306401682","display_name":"e-Publications@Marquette (Marquette University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102461120","host_organization_name":"Marquette University","host_organization_lineage":["https://openalex.org/I102461120"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations (1934 -)","raw_type":"text"},{"id":"mag:174547157","doi":null,"is_oa":false,"landing_page_url":"https://epublications.marquette.edu/cgi/viewcontent.cgi?article=1665&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.40450000762939453,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1891513010","https://openalex.org/W2071345459","https://openalex.org/W26662010","https://openalex.org/W2156823152","https://openalex.org/W2328725084","https://openalex.org/W2059039478","https://openalex.org/W2751442467","https://openalex.org/W2102000124","https://openalex.org/W2487313019","https://openalex.org/W1992670157"],"abstract_inverted_index":{"A.":[0],"Rationale.":[1],"Bacteria":[2],"of":[3,43,51,144,174,212,225,240,268,288],"the":[4,16,28,49,56,142,150,157,171,175,200,213,223,237,265,269,280,289],"family":[5],"Rhizobiaceae":[6],"enter":[7],"into":[8],"a":[9,40,52,272],"symbiotic":[10,69,266],"relationship":[11],"with":[12,166,251],"legumes":[13],"in":[14,31,48,61,285],"which":[15,244,286,311],"bacterial":[17,241],"partner":[18],"reduces":[19],"atmospheric":[20],"nitrogen":[21],"to":[22,27,67,149,199,278,298,305],"ammonia":[23],"that":[24,46,138,186,202,218,231],"is":[25,162,204,245],"supplied":[26],"host":[29],"plant":[30,54],"exchange":[32],"for":[33,206],"reduced":[34],"carbon":[35],"sources.":[36],"This":[37],"occurs":[38],"following":[39],"complex":[41],"series":[42],"developmental":[44],"steps":[45,284],"culminate":[47],"formation":[50],"specialized":[53],"organ,":[55],"root":[57,151],"nodule.":[58],"Purine":[59],"auxotrophy":[60],"Rhizobium":[62,115,214],"has":[63,135,153],"consistently":[64],"been":[65,136],"found":[66],"cause":[68],"defects":[70],"(Chen":[71],"et":[72,76,80,92,96,110,127,131,181],"al.,":[73,77,81,93,97,111,128,132,182],"1985;":[74],"Dickstein":[75],"1991;":[78],"Djordjevic":[79],"1988;":[82,90,94,98,129],"Fedorov":[83],"and":[84,88,102,106,254,262,303],"Zaretskaya,":[85],"1979;":[86,100],"Kerppola":[87],"Kahn,":[89],"Kim":[91],"Noel":[95],"Pain,":[99],"Pankhurst":[101],"Schwinghamer,":[103],"1974;":[104],"Scherrer":[105],"Denarie,":[107],"1971;":[108],"VandenBosch":[109,130],"1985).":[112,133],"On":[113],"bean,":[114],"leguminosarum":[116],"biovar":[117],"phaseoli":[118],"purine":[119,147,176,215,242,260,282],"auxotrophs":[120,216,290],"elicit":[121],"uninfected,":[122],"poorly":[123],"developed":[124],"nodules":[125],"(Noel":[126,180],"It":[134],"reported":[137],"while":[139],"purines":[140],"support":[141],"growth":[143],"these":[145],"mutants,":[146],"addition":[148],"medium":[152],"no":[154],"effect":[155],"on":[156,249],"nodulation":[158],"phenotype.":[159],"However,":[160],"infection":[161,187,207],"restored":[163],"by":[164,191,196,236,310],"supplementation":[165],"5-aminoimidazole-4-":[167],"carboxamide":[168],"(AICA)":[169],"riboside,":[170,193],"unphosphorylated":[172],"form":[173],"biosynthetic":[177,283],"intermediate":[178],"AICAR":[179,203],"1988).":[183],"The":[184],"finding":[185],"can":[188],"be":[189,234],"promoted":[190],"AICA":[192,300,312],"but":[194],"not":[195,233],"purines,":[197],"led":[198],"hypothesis":[201],"required":[205],"thread":[208],"development":[209],"While":[210],"characterization":[211],"indicated":[217],"all":[219],"were":[220],"blocked":[221],"before":[222],"production":[224],"AICAR,":[226],"several":[227],"mutants":[228,270],"had":[229],"phenotypes":[230],"could":[232,314],"explained":[235],"current":[238],"understanding":[239],"metabolism,":[243],"based":[246],"almost":[247],"entirely":[248],"studies":[250],"Escherichia":[252],"coli":[253],"Salmonella":[255],"typhimurium.":[256],"To":[257],"detennine":[258],"whether":[259],"auxotrophy,":[261],"possibly":[263],"also":[264],"defect,":[267],"was":[271,276,291,296],"pleiotropic":[273],"effect,":[274],"it":[275,295],"desirable":[277],"identify":[279],"specific":[281],"each":[287],"blocked.":[292],"In":[293],"addition,":[294],"necessary":[297],"characterize":[299],"riboside":[301,313],"transport":[302],"utilization":[304],"narrow":[306],"down":[307],"possible":[308],"mechanisms":[309],"promote":[315],"infection...":[316]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}