{"id":"https://openalex.org/W1744707441","doi":null,"title":"Thyroid hormone, metabolism and the brain","display_name":"Thyroid hormone, metabolism and the brain","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1744707441","mag":"1744707441"},"language":"en","primary_location":{"id":"pmh:knaw:oai:pure.knaw.nl:publications/3078eeb5-10ff-47c1-a8e1-e664fbcd9f9e","doi":null,"is_oa":false,"landing_page_url":"https://pure.knaw.nl/portal/en/publications/3078eeb5-10ff-47c1-a8e1-e664fbcd9f9e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/other"},"volume":null,"type":"other","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058958340","display_name":"Lars P. Klieverik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lars P. Klieverik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058958340"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.8220000267028809},{"id":"https://openalex.org/keywords/thyrotoxicosis","display_name":"thyrotoxicosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.8330000042915344},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/fatty-acid-uptake","display_name":"fatty acid uptake","score":0.7609999775886536},{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":0.8669999837875366},{"id":"https://openalex.org/keywords/total-energy-expenditure","display_name":"total energy expenditure","score":0.7039999961853027},{"id":"https://openalex.org/keywords/resting-energy-expenditure","display_name":"resting energy expenditure","score":0.9649999737739563},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.8859999775886536},{"id":"https://openalex.org/keywords/substrate-metabolism","display_name":"substrate metabolism","score":0.4580000042915344},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.4180000126361847},{"id":"https://openalex.org/keywords/methimazole","display_name":"methimazole","score":0.5249999761581421},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.6970000267028809},{"id":"https://openalex.org/keywords/albumin-bound-fatty-acids","display_name":"albumin-bound fatty acids","score":0.7110000252723694},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.7139999866485596},{"id":"https://openalex.org/keywords/muscle","display_name":"muscle","score":0.5320000052452087},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.6690000295639038},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.8330000042915344},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.898655354976654},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8840597867965698},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6154171824455261},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5879368782043457},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.5772775411605835},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.5762730240821838},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.5646129250526428},{"id":"https://openalex.org/C139566807","wikidata":"https://www.wikidata.org/wiki/Q25324083","display_name":"Resting energy expenditure","level":3,"score":0.5210273265838623},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4973595440387726},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.49008262157440186},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.43785709142684937},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4153693616390228},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28045815229415894},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.19850975275039673},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.19502496719360352}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:knaw:oai:pure.knaw.nl:publications/3078eeb5-10ff-47c1-a8e1-e664fbcd9f9e","doi":null,"is_oa":false,"landing_page_url":"https://pure.knaw.nl/portal/en/publications/3078eeb5-10ff-47c1-a8e1-e664fbcd9f9e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/other"},{"id":"pmh:oai:dare.uva.nl:openaire_cris_publications/62385e8d-b05a-49fb-973a-4b00eaa827e5","doi":null,"is_oa":false,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/thyroid-hormone-metabolism-and-the-brain(62385e8d-b05a-49fb-973a-4b00eaa827e5).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Klieverik, L P 2009, 'Thyroid hormone, metabolism and the brain', Doctor of Philosophy, Universiteit van Amsterdam.","raw_type":"info:eu-repo/semantics/other"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/b1d283eb-8f43-4069-a0f5-e44582b5ed8c","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/b1d283eb-8f43-4069-a0f5-e44582b5ed8c","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Klieverik, L P 2009, 'Thyroid hormone, metabolism and the brain', University of Amsterdam.","raw_type":"info:eu-repo/semantics/other"},{"id":"pmh:uvapub:oai:dare.uva.nl:publications/62385e8d-b05a-49fb-973a-4b00eaa827e5","doi":null,"is_oa":false,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/thyroid-hormone-metabolism-and-the-brain(62385e8d-b05a-49fb-973a-4b00eaa827e5).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:1744707441","doi":null,"is_oa":false,"landing_page_url":"http://www.kalsbeekgroup.nl/mediapool/133/1333280/data/thesis_Klieverik_2009.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W405619859","https://openalex.org/W1646110612","https://openalex.org/W1888479777","https://openalex.org/W1964532167","https://openalex.org/W1970570371","https://openalex.org/W1971669504","https://openalex.org/W1972586446","https://openalex.org/W1973828005","https://openalex.org/W1977672570","https://openalex.org/W1984228599","https://openalex.org/W1984542063","https://openalex.org/W1985126656","https://openalex.org/W1987475341","https://openalex.org/W1988357092","https://openalex.org/W1988377203","https://openalex.org/W1994930939","https://openalex.org/W2006889378","https://openalex.org/W2007558589","https://openalex.org/W2008327763","https://openalex.org/W2011081765","https://openalex.org/W2011137594","https://openalex.org/W2015333103","https://openalex.org/W2015381438","https://openalex.org/W2018607158","https://openalex.org/W2021411159","https://openalex.org/W2024217772","https://openalex.org/W2030951856","https://openalex.org/W2030959315","https://openalex.org/W2046186891","https://openalex.org/W2048245477","https://openalex.org/W2054125205","https://openalex.org/W2061084753","https://openalex.org/W2063465801","https://openalex.org/W2066023103","https://openalex.org/W2067984291","https://openalex.org/W2070995469","https://openalex.org/W2071408780","https://openalex.org/W2078060668","https://openalex.org/W2079383298","https://openalex.org/W2082905592","https://openalex.org/W2083150841","https://openalex.org/W2084307511","https://openalex.org/W2090543544","https://openalex.org/W2090816106","https://openalex.org/W2094842041","https://openalex.org/W2102993391","https://openalex.org/W2106237215","https://openalex.org/W2108234530","https://openalex.org/W2108994825","https://openalex.org/W2112104834","https://openalex.org/W2116365106","https://openalex.org/W2118441870","https://openalex.org/W2119238604","https://openalex.org/W2122267743","https://openalex.org/W2126879257","https://openalex.org/W2131501155","https://openalex.org/W2134096679","https://openalex.org/W2135960244","https://openalex.org/W2138100786","https://openalex.org/W2139248824","https://openalex.org/W2150684723","https://openalex.org/W2151336952","https://openalex.org/W2151484167","https://openalex.org/W2157822195","https://openalex.org/W2160166542","https://openalex.org/W2167716419","https://openalex.org/W2170816999","https://openalex.org/W2180081857"],"related_works":["https://openalex.org/W2170084132","https://openalex.org/W2419169720","https://openalex.org/W1528419212","https://openalex.org/W1976499539","https://openalex.org/W2413046478","https://openalex.org/W2132855785","https://openalex.org/W2946160592","https://openalex.org/W2319381132","https://openalex.org/W2032075543","https://openalex.org/W2440778059"],"abstract_inverted_index":{"The":[0,223],"effects":[1,24],"of":[2,25,66,221],"thyroid":[3],"hormone":[4],"(TH)":[5],"status":[6,27,111,217],"on":[7,28],"energy":[8,29,74,81],"metabolism":[9,30,229],"and":[10,31,46,56,87,100,149,177,182,210,248],"tissue-specific":[11,32,233],"substrate":[12],"supply":[13],"in":[14,51,135,139,147,159,175,180,184,196,198,207,212,225,235,239],"vivo":[15],"are":[16,230],"incompletely":[17],"understood":[18],"at":[19],"present.":[20],"To":[21],"study":[22],"the":[23],"TH":[26,110,216],"fatty":[33],"acid":[34],"(FA)":[35],"fluxes,":[36],"we":[37],"used":[38],"metabolic":[39],"cages":[40],"as":[41,43],"well":[42],"14C-labelled":[44],"FA":[45,131,145,166,171,192,237],"3H-labeled":[47],"triglyceride":[48],"(TG)":[49],"infusion":[50],"rats":[52],"treated":[53],"with":[54,200,241],"methimazole":[55],"either":[57],"0":[58],"(hypothyroidism),":[59],"1.5":[60],"(euthyroidism)":[61],"or":[62],"16.0":[63],"(thyrotoxicosis)":[64],"\u03bcg/100g*day":[65],"thyroxine":[67],"for":[68],"11":[69],"days.":[70],"Thyrotoxicosis":[71,119,142],"increased":[72,120,134,143,174,195,201],"total":[73],"expenditure":[75,82],"(TEE)":[76],"by":[77,84,90,232,246],"38%":[78],"(p=0.02),":[79],"resting":[80],"(REE)":[83],"61%":[85],"(p=0.002)":[86],"food":[88,108],"intake":[89],"18%":[91],"(p=0.004).":[92],"Hypothyroidism":[93],"tended":[94],"to":[95],"decrease":[96],"TEE":[97],"(10%;":[98],"p=0.064),":[99],"REE":[101],"(12%;":[102],"p=0.025),":[103],"but":[104,137,205],"did":[105,112],"not":[106,113,138],"affect":[107,114],"intake.":[109],"spontaneous":[115],"physical":[116],"activity":[117],"(SPA).":[118],"fat":[121],"oxidation":[122,128],"(p=0.006),":[123],"whereas":[124,154],"hypothyroidism":[125,155,190],"decreased":[126,183,211],"glucose":[127],"(p=0.035).":[129],"Plasma":[130],"concentration":[132],"was":[133,173,194],"thyrotoxic,":[136],"hypothyroid":[140],"rats.":[141],"albumin-bound":[144,165],"uptake":[146,172,193,238],"muscle":[148,176],"white":[150],"adipose":[151,186],"tissue":[152,161],"(WAT),":[153],"had":[156],"no":[157],"effect":[158],"any":[160],"studied,":[162],"suggesting":[163],"mass-driven":[164],"uptake.":[167],"During":[168],"thyrotoxicosis,":[169],"TG-derived":[170,191,236],"heart,":[178],"unaffected":[179,206],"WAT,":[181],"brown":[185],"tissue.":[187],"Conversely,":[188],"during":[189],"WAT":[197],"association":[199],"lipoprotein":[202],"lipase":[203],"activity,":[204],"oxidative":[208],"tissues":[209],"liver.":[213],"In":[214],"conclusion,":[215],"determines":[218],"EE":[219],"independently":[220],"SPA.":[222],"changes":[224,234],"whole":[226],"body":[227],"lipid":[228],"accompanied":[231],"accordance":[240],"hyperand":[242],"hypometabolic":[243],"states":[244],"induced":[245],"thyrotoxicosis":[247],"hypothyroidism,":[249],"respectively.":[250],"28":[251,254],"proefschrift":[252],"Klieverik.indb":[253],"4-8-2009":[255],"15:22:28":[256]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
