{"id":"https://openalex.org/W1743903282","doi":null,"title":"Alkylresorcinols as a biomarker for whole grain rye and wheat intake in the finnish diabetes prevention trial","display_name":"Alkylresorcinols as a biomarker for whole grain rye and wheat intake in the finnish diabetes prevention trial","publication_year":2015,"publication_date":"2015-09-16","ids":{"openalex":"https://openalex.org/W1743903282","mag":"1743903282"},"language":"en","primary_location":{"id":"mag:1743903282","doi":null,"is_oa":false,"landing_page_url":"https://stud.epsilon.slu.se/8485/1/nordin_e_150916.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024430052","display_name":"Elise Nordin","orcid":"https://orcid.org/0000-0001-5317-3261","observed_orcids":["https://orcid.org/0000-0001-5317-3261"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Elise Nordin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5317-3261","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5024430052"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0726451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10140","display_name":"Food composition and properties","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10140","display_name":"Food composition and properties","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.14259999990463257,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alkylresorcinols","display_name":"alkylresorcinols","score":0.9980000257492065},{"id":"https://openalex.org/keywords/whole-grain-intake","display_name":"whole grain intake","score":0.8379999995231628},{"id":"https://openalex.org/keywords/rye","display_name":"rye","score":0.8619999885559082},{"id":"https://openalex.org/keywords/wheat","display_name":"wheat","score":0.9950000047683716},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8930000066757202},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.7020000219345093},{"id":"https://openalex.org/keywords/finnish-diabetes-prevention-study","display_name":"Finnish Diabetes Prevention Study","score":0.7390000224113464},{"id":"https://openalex.org/keywords/lifestyle-intervention","display_name":"lifestyle intervention","score":0.8320000171661377},{"id":"https://openalex.org/keywords/dietary-fiber","display_name":"dietary fiber","score":0.7260000109672546},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.734000027179718},{"id":"https://openalex.org/keywords/phenolic-lipids","display_name":"phenolic lipids","score":0.8009999990463257},{"id":"https://openalex.org/keywords/rye-bread","display_name":"rye bread","score":0.7749999761581421},{"id":"https://openalex.org/keywords/diabetes-prevention","display_name":"diabetes prevention","score":0.5270000100135803},{"id":"https://openalex.org/keywords/dietary-adherence","display_name":"dietary adherence","score":0.32600000500679016},{"id":"https://openalex.org/keywords/food-frequency-questionnaire","display_name":"food frequency questionnaire","score":0.367000013589859},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.4339999854564667},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C3017554442","wikidata":"https://www.wikidata.org/wiki/Q1938952","display_name":"Whole grains","level":2,"score":0.6225113272666931},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6114175319671631},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5856962203979492},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5283613801002502},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.506037175655365},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.42146021127700806},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.41325029730796814},{"id":"https://openalex.org/C2780609358","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Impaired glucose tolerance","level":4,"score":0.4101380407810211},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19756856560707092},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18373975157737732},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08587127923965454}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1743903282","doi":null,"is_oa":false,"landing_page_url":"https://stud.epsilon.slu.se/8485/1/nordin_e_150916.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912},{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6735000014305115}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1787025020","https://openalex.org/W1852941094","https://openalex.org/W1902657801","https://openalex.org/W1922978388","https://openalex.org/W1964295420","https://openalex.org/W1965559891","https://openalex.org/W1969749680","https://openalex.org/W1973593366","https://openalex.org/W1975227808","https://openalex.org/W1976059582","https://openalex.org/W1996293056","https://openalex.org/W2008403623","https://openalex.org/W2013652987","https://openalex.org/W2020267609","https://openalex.org/W2024756081","https://openalex.org/W2026986667","https://openalex.org/W2030237021","https://openalex.org/W2033895856","https://openalex.org/W2042324494","https://openalex.org/W2042847509","https://openalex.org/W2056862173","https://openalex.org/W2058401170","https://openalex.org/W2072418914","https://openalex.org/W2086801771","https://openalex.org/W2087083444","https://openalex.org/W2089500158","https://openalex.org/W2089650200","https://openalex.org/W2093375035","https://openalex.org/W2094699931","https://openalex.org/W2102203027","https://openalex.org/W2110340092","https://openalex.org/W2113785501","https://openalex.org/W2124558473","https://openalex.org/W2127086353","https://openalex.org/W2130177558","https://openalex.org/W2130717716","https://openalex.org/W2133988179","https://openalex.org/W2133994619","https://openalex.org/W2138878573","https://openalex.org/W2147055838","https://openalex.org/W2156077595","https://openalex.org/W2162425231","https://openalex.org/W2164715193","https://openalex.org/W2167447098","https://openalex.org/W2332951586","https://openalex.org/W2497657435","https://openalex.org/W2520432709"],"related_works":["https://openalex.org/W2413679611","https://openalex.org/W2297482748","https://openalex.org/W7100271044","https://openalex.org/W2033895856","https://openalex.org/W2147055838","https://openalex.org/W1947868131","https://openalex.org/W2780756012","https://openalex.org/W2013652987","https://openalex.org/W2027924736","https://openalex.org/W2758820724"],"abstract_inverted_index":{"Type":[0],"2":[1],"diabetes":[2,162,303],"(T2D)":[3],"is":[4,14,92,367,449,467],"a":[5,19,36,95,149,164,208,328,387,421,434],"public":[6],"health":[7],"problem":[8],"of":[9,83,97,140,166,171,210,264,278,341,347,359,383,424,459,469],"great":[10],"concern.":[11],"Globally":[12],"it":[13,17,366,441],"increasing":[15],"and":[16,25,44,57,64,85,102,123,158,196,205,214,235,255,272,295,307,323,377,395,401],"generates":[18],"huge":[20],"economic":[21],"burden":[22],"to":[23,34,117,144,183,225,355,397],"society":[24],"problems":[26],"for":[27,100,471],"the":[28,80,115,172,175,292,320,345,351,363,391,402,405,462],"individuals.":[29],"Whole":[30],"grain":[31,99,153,188,212,343,426,447],"has":[32],"shown":[33],"have":[35,61],"protective":[37],"role":[38],"against":[39],"T2D":[40,130,398,429],"in":[41,67,75,79,112,131,151,174,186,222,287,316,331,344,461],"epide-miological":[42],"studies":[43],"underlying":[45],"mechanisms":[46],"are":[47,71],"poorly":[48],"understood,":[49],"but":[50,465],"de-creased":[51],"energy":[52],"intake,":[53,436],"higher":[54,410],"insulin":[55],"sensitivity":[56],"improved":[58],"glucose":[59,135],"tolerance":[60,136],"been":[62],"suggested":[63],"partly":[65],"confirmed":[66,454],"studies.":[68],"Alkylresorcinols":[69],"(AR)":[70],"phenolic":[72],"lipids":[73],"found":[74,286],"different":[76],"homologs":[77],"only":[78],"outer":[81],"parts":[82],"wheat":[84,103,215,378],"rye":[86,101,213,348,376,427,448],"among":[87,156],"commonly":[88],"consumed":[89],"foods.":[90],"It":[91],"used":[93,206],"as":[94,207],"biomarker":[96],"whole":[98,152,187,211,342,425,446],"intake.":[104,216],"The":[105,138,179,262,335,380],"Finnish":[106,336],"Diabetes":[107],"Prevention":[108],"Study":[109],"(DPS)":[110,176],"started":[111],"1993":[113],"with":[114,133,232,239,251,257,372,420,433,455],"purpose":[116],"evaluate":[118],"if":[119,146,311],"an":[120],"intensive":[121],"diet-":[122],"exercise":[124],"program":[125],"could":[126],"pre-vent":[127],"or":[128,298,437],"delay":[129],"persons":[132],"impaired":[134],"(IGT).":[137],"aim":[139,180],"this":[141,371,384,472],"study":[142,385,464],"was":[143,148,177,181,203,285,313,327,409],"investigate":[145,184],"there":[147,312,326],"difference":[150,284,315],"cereal":[154],"intake":[155,189,333,423],"non-diabetics":[157,412],"people":[159],"who":[160,192,198,301],"developed":[161,302],"under":[163],"period":[165],"8":[167],"years.":[168],"A":[169],"fraction":[170],"subjects":[173,300,352],"studied.":[178],"also":[182],"differences":[185],"between":[190,273,291,299,390],"participants":[191],"got":[193],"lifestyle":[194,293,321,364],"intervention":[195],"those":[197,432],"did":[199,370],"not.":[200],"Plasma":[201],"AR":[202,229,244,289,318,392,406],"measured":[204],"proxy":[209],"Quality":[217],"control":[218,296,324],"samples":[219],"were":[220,230,245,269,353,386],"included":[221],"each":[223],"batch":[224],"ensure":[226],"adequate":[227],"precision.":[228],"extracted":[231],"diethyl":[233],"ether":[234],"further":[236],"cleaned":[237],"up":[238,306],"solid":[240],"phase":[241],"extraction":[242],"(SPE).":[243],"made":[246],"more":[247,456],"volatile":[248],"through":[249],"derivat-isation":[250],"trifluoroacetic":[252],"anhydride":[253],"(TFAA)":[254],"analyzed":[256],"gas":[258],"chromatog-raphy-mass":[259],"spectrometry":[260],"(GC-MS).":[261],"coefficient":[263],"variation":[265],"(CV)":[266],"within":[267,411],"batch-es":[268],"\u2264":[270,275],"9%":[271],"batches":[274],"15%":[276],"except":[277],"one":[279],"homolog,":[280],"C25.":[281],"No":[282],"signifi-cant":[283],"total":[288],"concentration":[290],"interven-tion":[294],"groups":[297,325],"during":[304,362],"follow":[305],"non-diabetic":[308],"controls.":[309],"Even":[310],"no":[314],"plasma":[317],"be-tween":[319],"intervention-":[322],"significant":[329],"differ-ence":[330],"fiber":[332,361],"(p=0.001).":[334],"population":[337],"consumes":[338],"large":[339],"amounts":[340],"form":[346],"bread.":[349],"When":[350],"advised":[354],"raise":[356],"their":[357],"consumption":[358],"dietary":[360],"intervention,":[365],"likely":[368],"they":[369],"other":[373],"foods":[374],"than":[375,413,431],"sources.":[379],"main":[381],"findings":[382],"positive":[388],"correlation":[389],"C17/C21":[393,407],"ratio":[394,408],"time":[396],"diagno-sis":[399],"(p=0.027)":[400],"fact":[403],"that":[404,418,445,466],"diabetics":[414],"(p=0.025).":[415],"This":[416,451],"indicates":[417],"individuals":[419],"high":[422],"develop":[428],"later":[430],"low":[435],"does":[438],"not":[439],"de-velop":[440],"at":[442],"all,":[443],"i.e.":[444],"protective.":[450],"should":[452],"be":[453],"sophisticated":[457],"analysis":[458],"data":[460],"present":[463],"out":[468],"scope":[470],"study.":[473]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}