{"id":"https://openalex.org/W174336008","doi":"https://doi.org/10.1080/10790268.2000.11753520","title":"Review of Immune Function, Healing of Pressure Ulcers, and Nutritional Status in Patients with Spinal Cord Injury","display_name":"Review of Immune Function, Healing of Pressure Ulcers, and Nutritional Status in Patients with Spinal Cord Injury","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W174336008","doi":"https://doi.org/10.1080/10790268.2000.11753520","mag":"174336008","pmid":"https://pubmed.ncbi.nlm.nih.gov/10914354"},"language":"en","primary_location":{"id":"doi:10.1080/10790268.2000.11753520","doi":"https://doi.org/10.1080/10790268.2000.11753520","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10790268.2000.11753520","pdf_url":null,"source":{"id":"https://openalex.org/S192059556","display_name":"Journal of Spinal Cord Medicine","issn_l":"1079-0268","issn":["1079-0268","2045-7723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Spinal Cord Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108591334","display_name":"Julius M. Cruse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Cruse","raw_affiliation_strings":["Department of Pathology, University of Mississippi Medical Center, Jackson 39216, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Mississippi Medical Center, Jackson 39216, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072416990","display_name":"Robert E. Lewis","orcid":"https://orcid.org/0000-0002-3616-2971","observed_orcids":["https://orcid.org/0000-0002-3616-2971","https://orcid.org/0009-0005-0177-220X"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. E. Lewis","raw_affiliation_strings":["Department of Pathology, The University of Mississippi Medical Center, Jackson, Mississippi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Mississippi Medical Center, Jackson, Mississippi","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049798545","display_name":"Smaroula Dilioglou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Dilioglou","raw_affiliation_strings":["Department of Pathology, The University of Mississippi Medical Center, Jackson, Mississippi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Mississippi Medical Center, Jackson, Mississippi","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D. L. Roe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. L. Roe","raw_affiliation_strings":["Department of Pathology, The University of Mississippi Medical Center, Jackson, Mississippi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Mississippi Medical Center, Jackson, Mississippi","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":null,"display_name":"W. F. Wallace","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. F. Wallace","raw_affiliation_strings":["Department of Pathology, The University of Mississippi Medical Center, Jackson, Mississippi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Mississippi Medical Center, Jackson, Mississippi","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074377041","display_name":"R.S. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. S. Chen","raw_affiliation_strings":["Department of Pathology, The University of Mississippi Medical Center, Jackson, Mississippi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Mississippi Medical Center, Jackson, Mississippi","institution_ids":["https://openalex.org/I29606459"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I29606459"],"apc_list":null,"apc_paid":null,"fwci":1.642,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.81972595,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"2","first_page":"129","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11670","display_name":"Pressure Ulcer Prevention and Management","score":0.0430000014603138,"subfield":{"id":"https://openalex.org/subfields/3609","display_name":"Occupational Therapy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":1.0},{"id":"https://openalex.org/keywords/immune-function","display_name":"immune function","score":0.7900000214576721},{"id":"https://openalex.org/keywords/pressure-ulcers","display_name":"pressure ulcers","score":0.9150000214576721},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.972000002861023},{"id":"https://openalex.org/keywords/lymphocyte-surface-markers","display_name":"lymphocyte surface markers","score":0.8479999899864197},{"id":"https://openalex.org/keywords/granulocytes","display_name":"granulocytes","score":0.8199999928474426},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.902999997138977},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.9459999799728394},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/neuroendocrine-immune-interaction","display_name":"neuroendocrine-immune interaction","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.7465872764587402},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7390937209129333},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.5879093408584595},{"id":"https://openalex.org/C53122370","wikidata":"https://www.wikidata.org/wiki/Q2458503","display_name":"CD18","level":4,"score":0.5474822521209717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5427113175392151},{"id":"https://openalex.org/C62084212","wikidata":"https://www.wikidata.org/wiki/Q3648604","display_name":"CD11a","level":5,"score":0.5160765051841736},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5023746490478516},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4563271999359131},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4473671615123749},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4383087456226349},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4114598035812378},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4108010530471802},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.39102619886398315},{"id":"https://openalex.org/C171779818","wikidata":"https://www.wikidata.org/wiki/Q3799301","display_name":"Integrin alpha M","level":3,"score":0.26016199588775635},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003668","descriptor_name":"Pressure Ulcer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009752","descriptor_name":"Nutritional Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/10790268.2000.11753520","doi":"https://doi.org/10.1080/10790268.2000.11753520","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10790268.2000.11753520","pdf_url":null,"source":{"id":"https://openalex.org/S192059556","display_name":"Journal of Spinal Cord Medicine","issn_l":"1079-0268","issn":["1079-0268","2045-7723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Spinal Cord Medicine","raw_type":"journal-article"},{"id":"pmid:10914354","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10914354","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of spinal cord medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W145150268","https://openalex.org/W1586297195","https://openalex.org/W1599924272","https://openalex.org/W1989261420","https://openalex.org/W2098345014","https://openalex.org/W2160796211","https://openalex.org/W2412038904","https://openalex.org/W2416324400"],"related_works":["https://openalex.org/W2112756064","https://openalex.org/W1988466317","https://openalex.org/W1973102472","https://openalex.org/W10116116","https://openalex.org/W4224981842","https://openalex.org/W2083942108","https://openalex.org/W2327544510","https://openalex.org/W1588417310","https://openalex.org/W1989261420","https://openalex.org/W53418300"],"abstract_inverted_index":{"The":[0],"immune,":[1],"neural,":[2],"and":[3,19,35,51,59,80,85,92,147],"endocrine":[4],"systems":[5,21],"do":[6],"not":[7],"act":[8],"autonomously;":[9],"rather,":[10],"multiple":[11],"communicative":[12],"pathways":[13],"exist":[14],"among":[15],"the":[16,67,103,107,113,126,140],"nervous,":[17],"endocrine,":[18],"immune":[20,37,136],"that":[22,129],"facilitate":[23],"physiological":[24],"immunoregulation.":[25],"Patients":[26],"with":[27,46,121,131],"spinal":[28],"cord":[29],"injury":[30],"(SCI)":[31],"have":[32,133],"decreased":[33,101,118,135,149],"natural":[34],"adaptive":[36],"responses":[38],"by":[39],"2":[40],"weeks":[41],"after":[42],"injury.":[43],"In":[44,65],"patients":[45,130],"SCI,":[47],"adrenocorticotropic":[48],"hormone":[49],"(ACTH)":[50],"urine-free":[52],"cortisol":[53],"levels":[54,61],"were":[55,62,99],"increased":[56],"while":[57],"zinc":[58],"albumin":[60],"decreased,":[63],"respectively.":[64],"addition,":[66],"surface":[68,94],"markers":[69,95],"alpha":[70,72,74,86,88],"2,":[71],"3,":[73,87],"4,":[75,89],"CD11a,":[76,90],"CD11b,":[77],"CD18,":[78,91],"CD54,":[79],"CD8":[81,93],"found":[82,96],"on":[83,97],"lymphocytes":[84],"granulocytes":[98],"also":[100,117],"in":[102,112],"patient":[104],"population.":[105],"Finally,":[106],"adhesion":[108,152],"molecules":[109],"binding":[110],"ability":[111],"SCI":[114,132,141],"group":[115],"was":[116],"when":[119],"compared":[120],"a":[122,134,148],"control":[123],"group.":[124],"Overall,":[125],"investigation":[127],"showed":[128],"function,":[137],"especially":[138],"succeeding":[139],"injury,":[142],"an":[143],"impaired":[144],"nutrition":[145],"status,":[146],"number":[150],"of":[151,155],"molecules,":[153],"all":[154],"which":[156],"contribute":[157],"to":[158],"delayed":[159],"wound":[160],"healing.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}