{"id":"https://openalex.org/W174306153","doi":"https://doi.org/10.1016/s0031-3955(16)36512-9","title":"Pharmacologic Considerations in the Treatment of Acute Lymphoblastic Leukemia","display_name":"Pharmacologic Considerations in the Treatment of Acute Lymphoblastic Leukemia","publication_year":1988,"publication_date":"1988-08-01","ids":{"openalex":"https://openalex.org/W174306153","doi":"https://doi.org/10.1016/s0031-3955(16)36512-9","mag":"174306153","pmid":"https://pubmed.ncbi.nlm.nih.gov/3047656"},"language":"en","primary_location":{"id":"doi:10.1016/s0031-3955(16)36512-9","doi":"https://doi.org/10.1016/s0031-3955(16)36512-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0031-3955(16)36512-9","pdf_url":null,"source":{"id":"https://openalex.org/S68151621","display_name":"Pediatric Clinics of North America","issn_l":"0031-3955","issn":["0031-3955","1557-8240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Clinics of North America","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024249524","display_name":"Frank M. Balis","orcid":"https://orcid.org/0000-0002-8117-6926","observed_orcids":["https://orcid.org/0000-0002-8117-6926"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Frank M. Balis","raw_affiliation_strings":["National Cancer Institute, Bethesda, Maryland","Investigator, Pediatric Branch, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Investigator, Pediatric Branch, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024249524"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":null,"fwci":0.5485,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.67025163,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"4","first_page":"835","last_page":"851"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":1.0},{"id":"https://openalex.org/keywords/clinical-pharmacology","display_name":"clinical pharmacology","score":0.8230000138282776},{"id":"https://openalex.org/keywords/antileukemic-drugs","display_name":"antileukemic drugs","score":0.8379999995231628},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/pediatric-oncology","display_name":"pediatric oncology","score":0.7139999866485596},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.4749999940395355},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6579999923706055},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9598813056945801},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.7086160182952881},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6235237717628479},{"id":"https://openalex.org/C63433958","wikidata":"https://www.wikidata.org/wiki/Q1774688","display_name":"Clinical pharmacology","level":2,"score":0.563020646572113},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5237878561019897},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5187997221946716},{"id":"https://openalex.org/C2781107101","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Acute lymphocytic leukemia","level":4,"score":0.4802839457988739},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.41449493169784546},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35387858748435974},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.293651282787323},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2353326380252838},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23070001602172852}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007945","descriptor_name":"Leukemia, Lymphoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008577","descriptor_name":"Meningeal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0031-3955(16)36512-9","doi":"https://doi.org/10.1016/s0031-3955(16)36512-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0031-3955(16)36512-9","pdf_url":null,"source":{"id":"https://openalex.org/S68151621","display_name":"Pediatric Clinics of North America","issn_l":"0031-3955","issn":["0031-3955","1557-8240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Clinics of North America","raw_type":"journal-article"},{"id":"pmid:3047656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3047656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric clinics of North America","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W164449364","https://openalex.org/W196621111","https://openalex.org/W581386893","https://openalex.org/W599022200","https://openalex.org/W614456250","https://openalex.org/W1424161198","https://openalex.org/W1490545395","https://openalex.org/W1507403192","https://openalex.org/W1508893005","https://openalex.org/W1549755081","https://openalex.org/W1552988224","https://openalex.org/W1559344958","https://openalex.org/W1574173284","https://openalex.org/W1591744739","https://openalex.org/W1660272883","https://openalex.org/W1799197699","https://openalex.org/W1864393549","https://openalex.org/W1876684013","https://openalex.org/W1902563404","https://openalex.org/W1907295631","https://openalex.org/W1909437603","https://openalex.org/W1931698261","https://openalex.org/W1939017986","https://openalex.org/W1947817766","https://openalex.org/W1953387859","https://openalex.org/W1965688215","https://openalex.org/W1966108600","https://openalex.org/W1966641649","https://openalex.org/W1971035689","https://openalex.org/W1974721564","https://openalex.org/W2000967575","https://openalex.org/W2011525939","https://openalex.org/W2014915566","https://openalex.org/W2025639667","https://openalex.org/W2026558658","https://openalex.org/W2027766462","https://openalex.org/W2028055736","https://openalex.org/W2031561085","https://openalex.org/W2032918444","https://openalex.org/W2033403055","https://openalex.org/W2033600000","https://openalex.org/W2037125325","https://openalex.org/W2038832793","https://openalex.org/W2044118975","https://openalex.org/W2049320217","https://openalex.org/W2058471639","https://openalex.org/W2066250067","https://openalex.org/W2066943324","https://openalex.org/W2072032394","https://openalex.org/W2072912951","https://openalex.org/W2081702317","https://openalex.org/W2082251738","https://openalex.org/W2082749146","https://openalex.org/W2083523629","https://openalex.org/W2095240869","https://openalex.org/W2103790960","https://openalex.org/W2145999470","https://openalex.org/W2146226392","https://openalex.org/W2146765441","https://openalex.org/W2148150929","https://openalex.org/W2149090375","https://openalex.org/W2159737052","https://openalex.org/W2171404959","https://openalex.org/W2216897043","https://openalex.org/W2243824947","https://openalex.org/W2244173686","https://openalex.org/W2265594607","https://openalex.org/W2328999771","https://openalex.org/W2406692965","https://openalex.org/W2410122496","https://openalex.org/W2411554573","https://openalex.org/W2412338107","https://openalex.org/W2413290861","https://openalex.org/W2418748705","https://openalex.org/W2422485301","https://openalex.org/W2432166350","https://openalex.org/W2462779651","https://openalex.org/W3043800854","https://openalex.org/W4301020558","https://openalex.org/W4301410953","https://openalex.org/W4317926315","https://openalex.org/W6717639816"],"related_works":["https://openalex.org/W2162853560","https://openalex.org/W56893981","https://openalex.org/W70912246","https://openalex.org/W1967805478","https://openalex.org/W2322337010","https://openalex.org/W7033234945","https://openalex.org/W2401326656","https://openalex.org/W7027350216","https://openalex.org/W1967913849","https://openalex.org/W2414054913"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}