{"id":"https://openalex.org/W174284652","doi":"https://doi.org/10.1016/s0193-953x(18)30206-5","title":"The Genetics of Obsessive Compulsive Disorder and Gilles De La Tourette\u2019s Syndrome","display_name":"The Genetics of Obsessive Compulsive Disorder and Gilles De La Tourette\u2019s Syndrome","publication_year":1992,"publication_date":"1992-12-01","ids":{"openalex":"https://openalex.org/W174284652","doi":"https://doi.org/10.1016/s0193-953x(18)30206-5","mag":"174284652","pmid":"https://pubmed.ncbi.nlm.nih.gov/1461793"},"language":"en","primary_location":{"id":"doi:10.1016/s0193-953x(18)30206-5","doi":"https://doi.org/10.1016/s0193-953x(18)30206-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0193-953x(18)30206-5","pdf_url":null,"source":{"id":"https://openalex.org/S121233926","display_name":"Psychiatric Clinics of North America","issn_l":"0193-953X","issn":["0193-953X","1558-3147"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatric Clinics of North America","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0193-953x(18)30206-5","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032615209","display_name":"David L. Pauls","orcid":"https://orcid.org/0000-0002-8107-345X","observed_orcids":["https://orcid.org/0000-0002-8107-345X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David L. Pauls","raw_affiliation_strings":["From the Child Study Center, Yale University School of Medicine, New Haven, Connecticut","Child Study Center, Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Child Study Center, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Child Study Center, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032615209"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":{"value":2900,"currency":"USD","value_usd":2900},"fwci":1.5655,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.81177725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"4","first_page":"759","last_page":"766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11132","display_name":"Psychoanalysis and Psychopathology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obsessive-compulsive-disorder","display_name":"obsessive-compulsive disorder","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tourette-syndrome","display_name":"Tourette syndrome","score":0.9829999804496765},{"id":"https://openalex.org/keywords/genetics","display_name":"genetics","score":0.6159999966621399},{"id":"https://openalex.org/keywords/familial-aggregation","display_name":"familial aggregation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/autosomal-dominant-inheritance","display_name":"autosomal dominant inheritance","score":0.8999999761581421},{"id":"https://openalex.org/keywords/genetic-transmission","display_name":"genetic transmission","score":0.593999981880188},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C3017582312","wikidata":"https://www.wikidata.org/wiki/Q178190","display_name":"Obsessive compulsive","level":2,"score":0.6721175909042358},{"id":"https://openalex.org/C2777026814","wikidata":"https://www.wikidata.org/wiki/Q191779","display_name":"Tourette syndrome","level":2,"score":0.628057062625885},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5900954008102417},{"id":"https://openalex.org/C2909837681","wikidata":"https://www.wikidata.org/wiki/Q7836907","display_name":"Tourette's syndrome","level":2,"score":0.5332381725311279},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.441173791885376}],"mesh":[{"descriptor_ui":"D004200","descriptor_name":"Diseases in Twins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004200","descriptor_name":"Diseases in Twins","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005879","descriptor_name":"Tourette Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005879","descriptor_name":"Tourette Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005879","descriptor_name":"Tourette Syndrome","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014429","descriptor_name":"Twins, Dizygotic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014429","descriptor_name":"Twins, Dizygotic","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D014430","descriptor_name":"Twins, Monozygotic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014430","descriptor_name":"Twins, Monozygotic","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0193-953x(18)30206-5","doi":"https://doi.org/10.1016/s0193-953x(18)30206-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0193-953x(18)30206-5","pdf_url":null,"source":{"id":"https://openalex.org/S121233926","display_name":"Psychiatric Clinics of North America","issn_l":"0193-953X","issn":["0193-953X","1558-3147"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatric Clinics of North America","raw_type":"journal-article"},{"id":"pmid:1461793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1461793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Psychiatric clinics of North America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0193-953x(18)30206-5","doi":"https://doi.org/10.1016/s0193-953x(18)30206-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0193-953x(18)30206-5","pdf_url":null,"source":{"id":"https://openalex.org/S121233926","display_name":"Psychiatric Clinics of North America","issn_l":"0193-953X","issn":["0193-953X","1558-3147"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatric Clinics of North America","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2042906835","display_name":null,"funder_award_id":"MH00508","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4198012477","display_name":"A Genetic Study of GTS, OCD and ADHD","funder_award_id":"R01NS016648","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G736192395","display_name":null,"funder_award_id":"NS-16648","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W33535093","https://openalex.org/W140548115","https://openalex.org/W614741797","https://openalex.org/W1591182101","https://openalex.org/W1679486966","https://openalex.org/W1965774235","https://openalex.org/W1971573337","https://openalex.org/W1973126456","https://openalex.org/W1979344662","https://openalex.org/W1982462985","https://openalex.org/W1985907410","https://openalex.org/W1988186546","https://openalex.org/W1994619477","https://openalex.org/W2009362311","https://openalex.org/W2015676070","https://openalex.org/W2033813352","https://openalex.org/W2035897560","https://openalex.org/W2056769840","https://openalex.org/W2063753810","https://openalex.org/W2068306013","https://openalex.org/W2070233693","https://openalex.org/W2073148845","https://openalex.org/W2074149961","https://openalex.org/W2090210495","https://openalex.org/W2095933386","https://openalex.org/W2103573870","https://openalex.org/W2114492826","https://openalex.org/W2125181006","https://openalex.org/W2126359651","https://openalex.org/W2142185958","https://openalex.org/W2146471748","https://openalex.org/W2147965707","https://openalex.org/W2163595270","https://openalex.org/W2166089383","https://openalex.org/W2319080528","https://openalex.org/W2325940811","https://openalex.org/W2418023577","https://openalex.org/W2422610708","https://openalex.org/W2423973223","https://openalex.org/W2426404470","https://openalex.org/W2950007988"],"related_works":["https://openalex.org/W1973126456","https://openalex.org/W2054712298","https://openalex.org/W29289234","https://openalex.org/W2937799278","https://openalex.org/W2230621156","https://openalex.org/W2083315084","https://openalex.org/W2319080528","https://openalex.org/W4387607559","https://openalex.org/W1710014040","https://openalex.org/W2982162224"],"abstract_inverted_index":{"This":[0],"article":[1],"reviews":[2],"the":[3,53,62,68],"evidence":[4],"that":[5,25,27],"obsessive":[6],"compulsive":[7],"disorder":[8],"(OCD)":[9],"and":[10,20,44,51,59],"Gilles":[11],"de":[12],"la":[13],"Tourette's":[14],"syndrome":[15],"(GTS)":[16],"are":[17,23,33,42,65],"both":[18],"familial":[19,43],"genetic.":[21],"Studies":[22],"summarized":[24],"suggest":[26],"(1)":[28],"some":[29,38],"forms":[30,39],"of":[31,40,55,57,70],"OCD":[32,41,60],"related":[34,48],"to":[35,49],"GTS,":[36,50],"(2)":[37],"may":[45],"not":[46],"be":[47],"(3)":[52],"patterns":[54],"inheritance":[56],"GTS":[58],"within":[61],"same":[63],"families":[64],"consistent":[66],"with":[67],"transmission":[69],"an":[71],"autosomal":[72],"dominant":[73],"genetic":[74],"locus.":[75]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}