{"id":"https://openalex.org/W174168798","doi":null,"title":"Identification of new subgroups and prognostic markers in pediatric B cell precursor acute lymphoblastic leukemia by gene expression profiling","display_name":"Identification of new subgroups and prognostic markers in pediatric B cell precursor acute lymphoblastic leukemia by gene expression profiling","publication_year":2010,"publication_date":"2010-01-30","ids":{"openalex":"https://openalex.org/W174168798","mag":"174168798"},"language":"en","primary_location":{"id":"pmh:oai:www.research.unipd.it:11577/3423224","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11577/3423224","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11577/3423224","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016402287","display_name":"Elena Vendramini","orcid":"https://orcid.org/0000-0002-9705-7083","observed_orcids":["https://orcid.org/0000-0002-9705-7083"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Elena Vendramini","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9705-7083","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016402287"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-b-cell-precursor-acute-lymphoblastic-leukemia","display_name":"pediatric B-cell precursor acute lymphoblastic leukemia","score":0.9020000100135803},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7979999780654907},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.7149999737739563},{"id":"https://openalex.org/keywords/microrna-signature","display_name":"microRNA signature","score":0.6700000166893005},{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.8730000257492065},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5690000057220459},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.7269999980926514},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.6493968963623047},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.5907589197158813},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.480969101190567},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4349396228790283},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41955065727233887},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4120035171508789},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.40869271755218506},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35015812516212463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3491169810295105},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3268566131591797},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29872429370880127},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2799486517906189},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1373380720615387},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.research.unipd.it:11577/3423224","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11577/3423224","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:174168798","doi":null,"is_oa":false,"landing_page_url":"http://paduaresearch.cab.unipd.it/3981/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.research.unipd.it:11577/3423224","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11577/3423224","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":168,"referenced_works":["https://openalex.org/W8223099","https://openalex.org/W15453418","https://openalex.org/W59733412","https://openalex.org/W80054229","https://openalex.org/W131497487","https://openalex.org/W141830811","https://openalex.org/W1505782089","https://openalex.org/W1531583547","https://openalex.org/W1538470262","https://openalex.org/W1558665965","https://openalex.org/W1563458559","https://openalex.org/W1577577364","https://openalex.org/W1578821331","https://openalex.org/W1603432390","https://openalex.org/W1767192282","https://openalex.org/W1824047490","https://openalex.org/W1855059633","https://openalex.org/W1904793007","https://openalex.org/W1924090634","https://openalex.org/W1929295557","https://openalex.org/W1964662687","https://openalex.org/W1966547883","https://openalex.org/W1967659031","https://openalex.org/W1967892265","https://openalex.org/W1968895134","https://openalex.org/W1973983272","https://openalex.org/W1975317091","https://openalex.org/W1977499961","https://openalex.org/W1977918192","https://openalex.org/W1981226387","https://openalex.org/W1982357299","https://openalex.org/W1984065010","https://openalex.org/W1984522634","https://openalex.org/W1984714707","https://openalex.org/W1986529423","https://openalex.org/W1987294127","https://openalex.org/W1987552300","https://openalex.org/W1987959125","https://openalex.org/W1988161609","https://openalex.org/W1988377311","https://openalex.org/W1989115199","https://openalex.org/W1993017155","https://openalex.org/W1994219810","https://openalex.org/W1996837459","https://openalex.org/W2001613293","https://openalex.org/W2002451995","https://openalex.org/W2002800994","https://openalex.org/W2003096566","https://openalex.org/W2004503198","https://openalex.org/W2005156143","https://openalex.org/W2005479935","https://openalex.org/W2010955626","https://openalex.org/W2014345967","https://openalex.org/W2014534727","https://openalex.org/W2014743999","https://openalex.org/W2014881329","https://openalex.org/W2016533346","https://openalex.org/W2016833582","https://openalex.org/W2017396574","https://openalex.org/W2018910109","https://openalex.org/W2022523272","https://openalex.org/W2024996887","https://openalex.org/W2025420184","https://openalex.org/W2027090034","https://openalex.org/W2030352564","https://openalex.org/W2036999612","https://openalex.org/W2037896121","https://openalex.org/W2038476365","https://openalex.org/W2040329520","https://openalex.org/W2041355362","https://openalex.org/W2042184886","https://openalex.org/W2045977586","https://openalex.org/W2046906378","https://openalex.org/W2047509412","https://openalex.org/W2047696308","https://openalex.org/W2049131636","https://openalex.org/W2049963512","https://openalex.org/W2050869737","https://openalex.org/W2052908684","https://openalex.org/W2057106513","https://openalex.org/W2059020331","https://openalex.org/W2061802055","https://openalex.org/W2063207305","https://openalex.org/W2063380435","https://openalex.org/W2064613430","https://openalex.org/W2068355068","https://openalex.org/W2068517117","https://openalex.org/W2069709802","https://openalex.org/W2069731288","https://openalex.org/W2070328448","https://openalex.org/W2070533443","https://openalex.org/W2071700698","https://openalex.org/W2072462194","https://openalex.org/W2074181164","https://openalex.org/W2074503465","https://openalex.org/W2076889248","https://openalex.org/W2077280636","https://openalex.org/W2078358187","https://openalex.org/W2078491157","https://openalex.org/W2080791654","https://openalex.org/W2085933860","https://openalex.org/W2086770774","https://openalex.org/W2089632625","https://openalex.org/W2090340916","https://openalex.org/W2090946356","https://openalex.org/W2090969569","https://openalex.org/W2091454369","https://openalex.org/W2092434419","https://openalex.org/W2093341871","https://openalex.org/W2096875118","https://openalex.org/W2100025372","https://openalex.org/W2100261035","https://openalex.org/W2100753831","https://openalex.org/W2101487056","https://openalex.org/W2103838304","https://openalex.org/W2105423509","https://openalex.org/W2106919258","https://openalex.org/W2107277218","https://openalex.org/W2109377963","https://openalex.org/W2110065044","https://openalex.org/W2111008003","https://openalex.org/W2111599440","https://openalex.org/W2112085178","https://openalex.org/W2116634113","https://openalex.org/W2116951187","https://openalex.org/W2119967034","https://openalex.org/W2122128999","https://openalex.org/W2122147796","https://openalex.org/W2122683221","https://openalex.org/W2129003172","https://openalex.org/W2130410032","https://openalex.org/W2131635408","https://openalex.org/W2132473369","https://openalex.org/W2133131759","https://openalex.org/W2134030033","https://openalex.org/W2136941630","https://openalex.org/W2138218344","https://openalex.org/W2140065103","https://openalex.org/W2141316782","https://openalex.org/W2145968395","https://openalex.org/W2146267463","https://openalex.org/W2149052195","https://openalex.org/W2149430154","https://openalex.org/W2150116340","https://openalex.org/W2150536104","https://openalex.org/W2151069914","https://openalex.org/W2154174652","https://openalex.org/W2155459663","https://openalex.org/W2157688021","https://openalex.org/W2157838058","https://openalex.org/W2158473241","https://openalex.org/W2158501712","https://openalex.org/W2158556487","https://openalex.org/W2161409973","https://openalex.org/W2162341356","https://openalex.org/W2164959344","https://openalex.org/W2165207521","https://openalex.org/W2165609679","https://openalex.org/W2166667170","https://openalex.org/W2169291909","https://openalex.org/W2169592090","https://openalex.org/W2169808956","https://openalex.org/W2170708028","https://openalex.org/W2170989872","https://openalex.org/W2255191999","https://openalex.org/W2313577290","https://openalex.org/W2409862460","https://openalex.org/W2579646442"],"related_works":["https://openalex.org/W2138218344","https://openalex.org/W2596977918","https://openalex.org/W3160305245","https://openalex.org/W4310107765","https://openalex.org/W2024996887","https://openalex.org/W2559542173","https://openalex.org/W2146748994","https://openalex.org/W2009427006","https://openalex.org/W2607424741","https://openalex.org/W2527684850"],"abstract_inverted_index":{"Treatment":[0],"of":[1,13,18,33,46,106,119,126,133,154,166,186,207,219,229,240,253,260,277,287,294,321,339,342,346,354,380,470,480,489,507,527,592,613,617,631,637,656,673,703,725,744,761,800,811,847,863,877,952,1013],"pediatric":[2,879],"acute":[3],"lymphoblastic":[4],"leukemia":[5,458,704,745,779,888],"(ALL)":[6],"is":[7,102,198,300,315,323,335,365,453,929],"increasingly":[8],"successful,":[9],"achieving":[10],"cure":[11],"rates":[12],"over":[14,217,238,654,855],"80%.":[15],"Early":[16],"identification":[17,45,1010],"patients":[19,34,92,160,167,189,601,623,661,674,937],"with":[20,194,237,308,377,562,651,662,913,938,955],"high":[21,301,914,926,986],"risk":[22,42,120,680,915,927,987],"for":[23,298,627,634,685,735,750,778,860,892,916,980,984],"relapse":[24,36,940],"has":[25],"led":[26],"to":[27,67,72,76,112,200,290,525,553,682,711,740,747,764,783,887,901,963,999],"improved":[28],"outcome,":[29],"however,":[30],"two":[31],"third":[32],"encountering":[35],"were":[37,475,493,577,976],"initially":[38],"stratified":[39,676],"into":[40,603,883],"low-intermediate":[41],"groups.":[43],"The":[44,257,464,904,925],"better":[47],"upfront":[48],"prognostic":[49,115,590,923],"factors":[50,116],"remains":[51],"an":[52,130,211,378,670,942],"important":[53,671],"challenge":[54],"in":[55,81,104,107,110,162,191,232,242,266,303,306,328,401,441,456,461,502,519,536,548,597,649,677,713,736,824,941,995,1006],"childhood":[56],"ALL.":[57],"In":[58,179,332,640,753,829],"this":[59,180,208,355,593,641,830,956],"thesis,":[60],"gene":[61,134,151,413,797,933],"expression":[62,139,152,170,205,218,228,239,359,414,479,565,629,655,798,947],"profiling":[63,149,171,206,948],"(GEP)":[64],"was":[65,399,408,538,625,890,910],"applied":[66],"different":[68,425,788],"research":[69,1003],"approaches":[70],"aiming":[71],"dissect":[73],"subgroups":[74],"and":[75,117,135,140,161,172,197,225,274,284,317,383,406,420,433,446,460,500,511,523,544,589,633,695,715,739,770,821,851,1011],"find":[77],"novel":[78,531],"therapeutic":[79,982],"targets":[80,979],"B":[82],"cell":[83,718,974],"precursor":[84],"ALL":[85,159,267,305,322,356,364,375,404,419,422,473,560,599,622,660,707,804,880],"(BCP":[86],"ALL).":[87],"Among":[88],"BCP":[89,158,598,621,659],"ALL,":[90],"the":[91,99,243,254,275,278,291,319,329,402,428,438,443,447,457,471,481,503,508,520,558,571,587,604,611,628,635,646,678,689,722,726,742,759,774,790,796,825,835,840,845,848,864],"lacking":[93],"major":[94],"genomic":[95,340,390],"aberrations":[96,265,490,576],"(B-others)":[97],"represent":[98],"subgroup":[100],"that":[101,184,349,362,417,449,468,542,557,624,645,834,873,907,935],"most":[103],"need":[105,681],"depth":[108],"investigations":[109],"order":[111],"indentify":[113],"new":[114,595,921],"improve":[118],"stratification.":[121],"To":[122],"advance":[123],"biological":[124],"knowledge":[125],"B-others":[127,157,188],"we":[128,182,584,643,757,771,832],"performed":[129],"integrated":[131],"study":[132,147,181,338,465,612,642,756,831,872,905],"non":[136,581,619],"coding":[137],"RNAs":[138],"genetic":[141],"aberrancies.":[142],"Chapter":[143,333,608,754,867],"1":[144],"reports":[145,869],"a":[146,163,192,201,282,337,343,366,373,394,450,495,512,530,614,663,700,784,861,871,920,932,950,960,1001],"on":[148,870],"by":[150,216,477,692,931],"arrays":[153],"145":[155],"Italian":[156,187,600],"representative":[164,615],"subcohort":[165],"microRNAs":[168],"(miRNAs)":[169],"genome-wide":[173],"DNA":[174,381],"copy":[175,250],"number":[176,251,743],"variation":[177],"analysis.":[178],"found":[183,578,644],"25%":[185],"fits":[190],"group":[193,209,345],"unique":[195,212,374],"signature":[196,214,405,934],"associated":[199,912,954],"favourable":[202],"outcome.":[203],"MicroRNAs":[204],"revealed":[210,361,467,949],"miRNAs":[213],"characterized":[215,476],"hsa-miR-125b,":[220],"-125b-2*,":[221],"-99a,":[222],"-100,":[223],"-125a-3p":[224],"has-miR-491-5p.":[226],"Over":[227],"cluster":[230],"miR-125b-2":[231],"region":[233,280,505],"21q21.1":[234,255,279],"goes":[235],"along":[236],"genes":[241,289,386,953],"same":[244],"chromosomal":[245],"region.":[246,256],"Genome-wide":[247],"analysis":[248,341,360,694],"excluded":[249],"alteration":[252],"frequent":[258],"involvement":[259,276],"human":[261,842],"chromosome":[262],"21":[263,314],"(Hsa21)":[264],"(e.g.":[268],"hyperdiploidy":[269],"(HD),":[270],"t(12;21)":[271],"or":[272],"iAmp21)":[273],"suggest":[281],"direct":[283],"functional":[285],"contribution":[286],"Hsa21":[288,396],"malignant":[292],"transformation":[293],"hematopoietic":[295],"cells.":[296],"There":[297],"there":[299],"interest":[302],"studying":[304],"children":[307,561],"Down":[309],"Syndrome":[310],"(DS),":[311],"where":[312,318],"trisomy":[313,435,444,452],"constitutional":[316,432,451],"incidence":[320,588],"approximately":[324],"20-fold":[325],"higher":[326],"than":[327],"general":[330],"population.":[331],"2":[334],"presented":[336],"large":[344],"DS":[347,363,403,418,472,559,582,620],"ALLs":[348],"characterizes":[350],"molecular":[351,1015],"abnormalities":[352],"specific":[353],"group.":[357],"Gene":[358,946],"highly":[367],"heterogeneous":[368,723],"disease":[369],"not":[370],"definable":[371],"as":[372,437,808,810,897],"subtype":[376,1007],"enrichment":[379],"damage":[382],"BCL6":[384],"responsive":[385],"suggesting":[387,556],"B-cell":[388],"lymphocytic":[389],"instability.":[391],"Surprisingly,":[392],"only":[393,409],"single":[395],"gene,":[397],"SON":[398],"included":[400],"it":[407],"slightly":[410],"upregulated.":[411],"Furthermore":[412,529],"data":[415],"suggested":[416],"HD":[421],"are":[423,709,731],"very":[424,664],"leukemias,":[426],"reflecting":[427],"fundamental":[429],"differences":[430],"between":[431],"acquired":[434],"such":[436],"developmental":[439],"stage":[440],"which":[442],"occurs":[445],"fact":[448],"present":[454],"both":[455],"cells":[459,555,746,781],"their":[462,766,812],"microenvironment.":[463],"further":[466,585],"62%":[469],"samples":[474,708,763,805,816,881],"aberrant":[478,564],"type":[482],"I":[483],"cytokine":[484,550],"receptor":[485],"CRLF2.":[486,528],"Two":[487],"kind":[488],"involving":[491,498,971],"CRLF2":[492,501,537,543,563,575,632,638,657],"identified:":[494],"cryptic":[496],"translocation":[497],"IGH@":[499],"pseudoautosomal":[504],"(PAR1)":[506],"sex":[509],"chromosomes":[510],"deletion":[513],"within":[514],"PAR1.":[515],"This":[516],"aberration":[517],"resulted":[518],"P2RY8-CRLF2":[521,647],"fusion":[522],"leads":[524],"overexpression":[526],"activating":[532],"somatic":[533],"mutation,":[534],"F232C,":[535],"identified.":[539],"We":[540,794],"demonstrated":[541,833],"mutated":[545],"JAK2":[546],"cooperate":[547],"conferring":[549],"independent":[551,922,943],"growth":[552,975],"pro-B":[554],"may":[566],"benefit":[567],"from":[568,789,899],"therapy":[569],"blocking":[570],"CRLF2-JAK2":[572],"pathway.":[573],"Since":[574],"also":[579],"among":[580,668],"patients,":[583],"analyzed":[586,626],"impact":[591],"potential":[594,961],"marker":[596],"enrolled":[602],"AIEOP-BFM":[605],"ALL2000":[606],"study.":[607],"3,":[609],"presents":[610],"cohort":[616],"464":[618],"levels":[630],"occurrence":[636],"rearrangements.":[639],"rearrangements":[648],"association":[650],"20":[652],"times":[653],"identifies":[658],"poor":[665],"prognosis":[666],"and,":[667],"them,":[669],"subset":[672],"currently":[675,716],"intermediate":[679],"be":[683,748,1000],"considered":[684],"treatment":[686],"adaptation.":[687],"Investigating":[688],"pathways":[690,970],"highlighted":[691],"GEP":[693,997],"testing":[696,738],"drug":[697],"effects":[698],"require":[699],"substantial":[701],"availability":[702],"samples.":[705],"Primary":[706],"difficult":[710],"culture":[712],"vitro":[714],"available":[717],"lines":[719],"poorly":[720],"reflect":[721],"nature":[724],"disease.":[727],"Mouse":[728],"xenotransplantation":[729],"models":[730],"therefore":[732],"widely":[733],"used":[734,749],"vivo":[737],"amplify":[741],"various":[751],"analyses.":[752],"4":[755],"assessed":[758],"capability":[760],"xenografted":[762],"recapitulate":[765],"respective":[767,813],"primary":[768,802,841,849],"leukemia,":[769],"investigated":[772,874],"whether":[773],"murine":[775],"microenvironment":[776],"selects":[777],"initiating":[780],"leading":[782],"bulk":[785],"tumor":[786],"markedly":[787],"diagnostic":[791],"patient":[792,894,944],"sample.":[793],"analysed":[795],"profiles":[799],"7":[801],"paediatric":[803],"at":[806],"diagnosis":[807],"well":[809],"xenograft":[814],"leukaemia":[815],"after":[817,992],"serial":[818,856],"primary,":[819],"secondary":[820],"tertiary":[822],"passages":[823,857],"NOD/SCID/huALL":[826,836],"transplant":[827,837,900],"model.":[828],"model":[838],"recapitulates":[839],"leukaemia,":[843],"mimics":[844],"features":[846],"malignancy":[850],"retains":[852],"these":[853,965,985],"characteristics":[854],"without":[858],"selection":[859],"subclone":[862],"initial":[865],"leukaemia.":[866],"5":[868],"engraftment":[875],"properties":[876],"50":[878],"transplanted":[882],"NOD/SCID":[884],"mice.":[885],"Time":[886],"(TTL)":[889],"determined":[891],"each":[893],"sample":[895],"engrafted":[896],"weeks":[898],"overt":[902],"leukemia.":[903],"shows":[906],"short":[908],"TTL":[909],"strongly":[911],"early":[917,939],"relapse,":[918],"identifying":[919],"factor.":[924],"phenotype":[928,958],"reflected":[930],"identified":[936],"cohort.":[945],"set":[951],"aggressive":[957],"providing":[959,978],"strategy":[962],"identify":[964],"high-risk":[966],"patients.":[967,988],"Most":[968],"importantly,":[969],"mTOR":[972],"regulating":[973],"identified,":[977],"alternative":[981],"strategies":[983],"Concluding,":[989],"ten":[990],"years":[991],"its":[993],"introduction":[994],"oncohematology,":[996],"constitutes":[998],"valuable":[1002],"tool,":[1004],"efficacious":[1005],"discovery,":[1008],"biomarkers":[1009],"discoveries":[1012],"deregulated":[1014],"pathways.":[1016]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
