{"id":"https://openalex.org/W174012016","doi":"https://doi.org/10.1385/1-59259-967-2:363","title":"In Vivo Models for Studying Mast Cell-Dependent Responses to Bacterial Infection","display_name":"In Vivo Models for Studying Mast Cell-Dependent Responses to Bacterial Infection","publication_year":2005,"publication_date":"2005-08-18","ids":{"openalex":"https://openalex.org/W174012016","doi":"https://doi.org/10.1385/1-59259-967-2:363","mag":"174012016","pmid":"https://pubmed.ncbi.nlm.nih.gov/16110170"},"language":"en","primary_location":{"id":"doi:10.1385/1-59259-967-2:363","doi":"https://doi.org/10.1385/1-59259-967-2:363","is_oa":false,"landing_page_url":"https://doi.org/10.1385/1-59259-967-2:363","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mast Cells","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4234590975","display_name":"Mast Cells"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087100299","display_name":"Christopher P. Shelburne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher P. Shelburne","raw_affiliation_strings":["Department of Pathology, Duke University, Durham, NC, USA","Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke University","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091202762","display_name":"James B. McLachlan","orcid":"https://orcid.org/0000-0001-7741-391X","observed_orcids":["https://orcid.org/0000-0001-7741-391X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James B. McLachlan","raw_affiliation_strings":["Department of Pathology, Duke University, Durham","Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Duke University, Durham","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke University","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030259389","display_name":"Soman N. Abraham","orcid":"https://orcid.org/0000-0002-1662-2096","observed_orcids":["https://orcid.org/0000-0002-1662-2096"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soman N. Abraham","raw_affiliation_strings":["Department of Pathology, Molecular Genetics and Microbiology and Immunology, Duke University Medical Center, Durham","Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Molecular Genetics and Microbiology and Immunology, Duke University Medical Center, Durham","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4756,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.83173496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"315","issue":null,"first_page":"363","last_page":"382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":1.0},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mast-cell-deficient-mice","display_name":"mast cell-deficient mice","score":0.843999981880188},{"id":"https://openalex.org/keywords/uropathogenic-escherichia-coli","display_name":"uropathogenic Escherichia coli","score":0.9599999785423279},{"id":"https://openalex.org/keywords/gram-negative-pathogens","display_name":"Gram-negative pathogens","score":0.6330000162124634},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6990000009536743},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.7428908348083496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6303092241287231},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6057990193367004},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5777536034584045},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.502333402633667},{"id":"https://openalex.org/C2778536324","wikidata":"https://www.wikidata.org/wiki/Q1030169","display_name":"Peritoneal cavity","level":2,"score":0.4529399871826172},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4511331021785736},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.44501200318336487},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4292917549610138},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.41016528010368347},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.39056164026260376},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34277433156967163},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10443457961082458},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.049739331007003784},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D005528","descriptor_name":"Foot","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010529","descriptor_name":"Peritoneal Cavity","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010529","descriptor_name":"Peritoneal Cavity","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1385/1-59259-967-2:363","doi":"https://doi.org/10.1385/1-59259-967-2:363","is_oa":false,"landing_page_url":"https://doi.org/10.1385/1-59259-967-2:363","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mast Cells","raw_type":"book-chapter"},{"id":"pmid:16110170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16110170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2372016454","display_name":null,"funder_award_id":"DK50814","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G520453448","display_name":"Caveolae Mediated Bacterial Uptake in the Urinary Tract","funder_award_id":"R01AI050021","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309508","display_name":"Sandler Foundation","ror":"https://ror.org/05f1ftz34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W146090589","https://openalex.org/W167584193","https://openalex.org/W1542115737","https://openalex.org/W1644900513","https://openalex.org/W1967700295","https://openalex.org/W1982709334","https://openalex.org/W2003924825","https://openalex.org/W2007990557","https://openalex.org/W2024900877","https://openalex.org/W2034222095","https://openalex.org/W2056927031","https://openalex.org/W2061443292","https://openalex.org/W2063153913","https://openalex.org/W2081166085","https://openalex.org/W2127565001","https://openalex.org/W2134860029","https://openalex.org/W2139403735","https://openalex.org/W2149304859","https://openalex.org/W2156627022","https://openalex.org/W2161948102","https://openalex.org/W2164740721","https://openalex.org/W2172263281","https://openalex.org/W2402309447","https://openalex.org/W4313306007"],"related_works":["https://openalex.org/W2793487548","https://openalex.org/W2206978421","https://openalex.org/W2034203371","https://openalex.org/W1965541595","https://openalex.org/W121157519","https://openalex.org/W2070895906","https://openalex.org/W2886359275","https://openalex.org/W2060502995","https://openalex.org/W2088129903","https://openalex.org/W2141820117"],"abstract_inverted_index":{"Mast":[0],"cells":[1,15,94],"are":[2],"a":[3],"critical":[4],"component":[5],"of":[6,13,24,31,36,55,74,86,92,99,107,118],"host":[7],"defense":[8],"against":[9],"bacterial":[10,57,80,119],"infections.":[11],"Activation":[12],"these":[14],"during":[16,79],"infection":[17,58],"induces":[18],"both":[19],"innate":[20],"and":[21,34,103,115],"adaptive":[22],"aspects":[23],"protective":[25],"immunity":[26],"needed":[27],"for":[28,42,71],"the":[29,32,37,43,72,84,90,97,104,112],"elimination":[30],"bacteria":[33],"survival":[35],"host.":[38],"These":[39,82],"functional":[40],"roles":[41],"mast":[44,75,87,93,108],"cell":[45],"have":[46],"been":[47],"principally":[48],"characterized":[49],"using":[50],"two":[51],"in":[52,95,111],"vivo":[53],"models":[54,117],"acute":[56],"featuring":[59],"Gram-negative":[60],"pathogens":[61],"such":[62],"as":[63],"Escherichia":[64],"coli.":[65],"Here,":[66],"we":[67],"present":[68],"basic":[69,105],"protocols":[70],"identification":[73,91],"cell-dependent":[76,109],"biological":[77],"functions":[78,110],"infection.":[81],"include":[83],"use":[85],"cell-deficient":[88],"mice,":[89],"tissue,":[96],"culture":[98],"uropathogenic":[100],"E.":[101],"coli,":[102],"analysis":[106],"peritoneal":[113],"cavity":[114],"footpad":[116],"pathogenesis.":[120]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
