{"id":"https://openalex.org/W17382240","doi":null,"title":"Clonidine suppression of noradrenergic hyperactivity during morphine withdrawal by clonidine: biochemical studies in rodents and primates.","display_name":"Clonidine suppression of noradrenergic hyperactivity during morphine withdrawal by clonidine: biochemical studies in rodents and primates.","publication_year":1982,"publication_date":"1982-06-01","ids":{"openalex":"https://openalex.org/W17382240","mag":"17382240","pmid":"https://pubmed.ncbi.nlm.nih.gov/6806253"},"language":"en","primary_location":{"id":"pmid:6806253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6806253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113176320","display_name":"R.H. Roth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R H Roth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027557843","display_name":"John D. Elsworth","orcid":"https://orcid.org/0000-0002-0323-0886","observed_orcids":["https://orcid.org/0000-0002-0323-0886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J D Elsworth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029378428","display_name":"Donald Eugene Redmond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D E Redmond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0444,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.68890752,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"43","issue":"6 Pt 2","first_page":"42","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5464000105857849,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5464000105857849,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.35010001063346863,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.06289999932050705,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonidine","display_name":"clonidine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/morphine-withdrawal","display_name":"morphine withdrawal","score":0.9919999837875366},{"id":"https://openalex.org/keywords/noradrenergic-hyperactivity","display_name":"noradrenergic hyperactivity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mhpg","display_name":"MHPG","score":0.7549999952316284},{"id":"https://openalex.org/keywords/noradrenaline-turnover","display_name":"noradrenaline turnover","score":0.9100000262260437},{"id":"https://openalex.org/keywords/naloxone-precipitated-withdrawal","display_name":"naloxone-precipitated withdrawal","score":0.9259999990463257},{"id":"https://openalex.org/keywords/locus-coeruleus","display_name":"locus coeruleus","score":0.8169999718666077},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.6909999847412109},{"id":"https://openalex.org/keywords/vervet-monkey","display_name":"vervet monkey","score":0.6840000152587891},{"id":"https://openalex.org/keywords/noradrenaline-metabolism","display_name":"noradrenaline metabolism","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2778399450","wikidata":"https://www.wikidata.org/wiki/Q412221","display_name":"Clonidine","level":2,"score":0.9671860337257385},{"id":"https://openalex.org/C2778468602","wikidata":"https://www.wikidata.org/wiki/Q1470452","display_name":"Locus coeruleus","level":3,"score":0.9175534248352051},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.6519404649734497},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.6424683928489685},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5590603351593018},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5426298975944519},{"id":"https://openalex.org/C2777972943","wikidata":"https://www.wikidata.org/wiki/Q409587","display_name":"Naltrexone","level":4,"score":0.5281548500061035},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.40489113330841064},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.3513528108596802},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3451792001724243},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2473321259021759},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06138581037521362}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003000","descriptor_name":"Clonidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008734","descriptor_name":"Methoxyhydroxyphenylglycol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009021","descriptor_name":"Morphine Dependence","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009021","descriptor_name":"Morphine Dependence","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6806253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6806253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Journal Article"},{"id":"mag:17382240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6806253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1982563712","https://openalex.org/W2028031473","https://openalex.org/W1983400812","https://openalex.org/W2007870053","https://openalex.org/W2089748306","https://openalex.org/W2052930197","https://openalex.org/W1997256496","https://openalex.org/W1954611182","https://openalex.org/W2063437158","https://openalex.org/W7095724436"],"abstract_inverted_index":{"In":[0,42,100],"rodents,":[1],"naloxone-precipitated":[2],"withdrawal":[3,124,200],"of":[4,19,58,70,79,88,90,96,105,116,131,147,163,205],"morphine-dependent":[5,101],"animals":[6],"causes":[7,109],"an":[8,110],"increase":[9,23,111,119],"in":[10,16,24,55,61,93,112,120,134,167,182,191],"NE":[11,25,59,94,165,194,206],"turnover":[12,26],"and":[13,27,137,144,201],"MHPG":[14,28,80,121,132,157],"accumulation":[15,29],"certain":[17],"regions":[18],"the":[20,56,62,67,76,97,113,177,188],"brain.":[21],"This":[22],"is":[30,125,208],"suppressed":[31,126,209],"by":[32,49,127,210],"clonidine":[33],"to":[34,52],"a":[35,39,85,160],"dose-dependent":[36],"degree":[37],"via":[38],"naloxone-insensitive":[40],"mechanism.":[41],"general,":[43],"drugs":[44],"which":[45],"have":[46],"been":[47],"shown":[48],"electrophysiological":[50],"studies":[51,73,173],"cause":[53],"changes":[54],"activity":[57],"neurons":[60,95],"locus":[63,98],"coeruleus":[64],"also":[65],"alter":[66],"brain":[68,77,114,164,193],"levels":[69,78,115,130],"MHPG.":[71,117,148],"These":[72,149],"suggest":[74,151],"that":[75,152,190,202],"may":[81],"be":[82],"used":[83],"as":[84],"biochemical":[86],"measure":[87,162],"alterations":[89],"impulse":[91],"flow":[92],"coeruleus.":[99],"vervet":[102],"monkeys,":[103],"administration":[104],"naloxone":[106],"or":[107],"naltrexone":[108],"The":[118],"observed":[122],"during":[123,198],"clonidine.":[128,211],"Brain":[129],"measured":[133],"both":[135],"drug-treated":[136],"control":[138],"monkeys":[139],"correlate":[140],"significantly":[141],"with":[142,176,187],"plasma":[143,156],"CSF":[145],"measures":[146],"observations":[150,180],"under":[153],"controlled":[154],"conditions":[155],"can":[158],"provide":[159],"reasonable":[161],"metabolism":[166],"primates.":[168],"Pilot":[169],"data":[170],"from":[171],"clinical":[172],"taken":[174],"together":[175],"more":[178],"direct":[179],"made":[181],"non-human":[183],"primates":[184],"are":[185],"consistent":[186],"hypothesis":[189],"humans":[192],"systems":[195,207],"become":[196],"hyperactive":[197],"opiate":[199],"this":[203],"hyperactivity":[204]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
