{"id":"https://openalex.org/W17374740","doi":null,"title":"An Optimization Model for Achieving Sparsity of Gene Regulatory Networks","display_name":"An Optimization Model for Achieving Sparsity of Gene Regulatory Networks","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W17374740","mag":"17374740"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.377.7720","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.377.7720","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.aporc.org/LNOR/6/ISORA2006F33.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jinshan Li","orcid":"https://orcid.org/0000-0002-6894-9760","observed_orcids":["https://orcid.org/0000-0002-6894-9760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinshan Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6894-9760","affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Yu Xia","orcid":"https://orcid.org/0000-0002-5596-5518","observed_orcids":["https://orcid.org/0000-0002-5596-5518"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Xia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5596-5518","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00134371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-regulatory-network-inference","display_name":"gene regulatory network inference","score":0.9729999899864197},{"id":"https://openalex.org/keywords/network-sparsity","display_name":"network sparsity","score":0.8159999847412109},{"id":"https://openalex.org/keywords/optimization-model","display_name":"optimization model","score":0.8230000138282776},{"id":"https://openalex.org/keywords/linear-ordinary-differential-equations","display_name":"linear ordinary differential equations","score":0.9229999780654907},{"id":"https://openalex.org/keywords/gene-expression-profiles","display_name":"gene expression profiles","score":0.7979999780654907},{"id":"https://openalex.org/keywords/breast-cancer-metastasis","display_name":"breast cancer metastasis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/microarray-data","display_name":"microarray data","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5979190468788147},{"id":"https://openalex.org/C33676613","wikidata":"https://www.wikidata.org/wiki/Q13415176","display_name":"Dimension (graph theory)","level":2,"score":0.5462281107902527},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5293047428131104},{"id":"https://openalex.org/C2776372474","wikidata":"https://www.wikidata.org/wiki/Q508291","display_name":"Simplicity","level":2,"score":0.47043320536613464},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.4564622938632965},{"id":"https://openalex.org/C2780586882","wikidata":"https://www.wikidata.org/wiki/Q7520643","display_name":"Simple (philosophy)","level":2,"score":0.45137161016464233},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.4476640224456787},{"id":"https://openalex.org/C51544822","wikidata":"https://www.wikidata.org/wiki/Q465274","display_name":"Ordinary differential equation","level":3,"score":0.43293461203575134},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.33931753039360046},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33319783210754395},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3219267725944519},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.30649685859680176},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.22181755304336548},{"id":"https://openalex.org/C78045399","wikidata":"https://www.wikidata.org/wiki/Q11214","display_name":"Differential equation","level":2,"score":0.21331796050071716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21157634258270264},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.1672883927822113},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13241097331047058},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.377.7720","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.377.7720","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.aporc.org/LNOR/6/ISORA2006F33.pdf","raw_type":"text"},{"id":"mag:17374740","doi":null,"is_oa":false,"landing_page_url":"http://www.aporc.org/LNOR/6/ISORA2006F33.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1547034405","https://openalex.org/W1594028072","https://openalex.org/W1970156673","https://openalex.org/W2003266876","https://openalex.org/W2008107402","https://openalex.org/W2058221907","https://openalex.org/W2058704592","https://openalex.org/W2082982706","https://openalex.org/W2108579152","https://openalex.org/W2113305236","https://openalex.org/W2114382052","https://openalex.org/W2130721915","https://openalex.org/W2132647070","https://openalex.org/W2136988691","https://openalex.org/W2163076211","https://openalex.org/W2163296862","https://openalex.org/W2348273077","https://openalex.org/W2611370172"],"related_works":["https://openalex.org/W7100728459","https://openalex.org/W1987979031","https://openalex.org/W658857384","https://openalex.org/W7096428692","https://openalex.org/W2000692739","https://openalex.org/W7125885598","https://openalex.org/W4309135126","https://openalex.org/W2004608252","https://openalex.org/W7097398635","https://openalex.org/W2149635958"],"abstract_inverted_index":{"Abstract":[0],"Dimension":[1],"problem":[2],"is":[3,42],"the":[4,35,55,73],"main":[5],"difficulty":[6],"in":[7,17,77,83],"inferring":[8],"gene":[9,37,45,87],"regulatory":[10,38,88],"networks":[11],"and":[12,54,80],"has":[13,62],"not":[14],"been":[15],"solved":[16],"substance.":[18],"Grounded":[19],"on":[20],"linear":[21],"ordinary":[22],"differential":[23],"equation,":[24],"we":[25],"propose":[26],"a":[27],"simple":[28],"optimization":[29],"model":[30,41,61,74],"for":[31,34],"achieving":[32],"sparseness":[33],"derived":[36],"networks.":[39],"The":[40,70],"applied":[43],"to":[44,50,64],"expression":[46],"profile":[47],"data":[48],"related":[49],"breast":[51],"cancer":[52],"metastasis,":[53],"computational":[56],"outcome":[57],"shows":[58],"that":[59],"this":[60],"potential":[63],"find":[65],"solution":[66],"with":[67],"biological":[68],"plausibility.":[69],"advantage":[71],"of":[72],"lies":[75],"also":[76],"its":[78],"simplicity":[79],"time":[81],"saving":[82],"computation.":[84],"Keywords":[85],"optimization;":[86],"networks;":[89],"microarray":[90],"technique":[91],"1":[92]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
