{"id":"https://openalex.org/W1736726786","doi":"https://doi.org/10.1046/j.1365-2125.2003.01977.x","title":"Effect of food on the relative bioavailability of two oral formulations of posaconazole in healthy adults","display_name":"Effect of food on the relative bioavailability of two oral formulations of posaconazole in healthy adults","publication_year":2003,"publication_date":"2003-10-09","ids":{"openalex":"https://openalex.org/W1736726786","doi":"https://doi.org/10.1046/j.1365-2125.2003.01977.x","mag":"1736726786","pmid":"https://pubmed.ncbi.nlm.nih.gov/14748822","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1884431"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2125.2003.01977.x","doi":"https://doi.org/10.1046/j.1365-2125.2003.01977.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2125.2003.01977.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2125.2003.01977.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2125.2003.01977.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112255294","display_name":"Rachel Courtney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rachel Courtney","raw_affiliation_strings":["Early Clinical Research and Experimental Medicine, Schering-Plough Research Institute, K-15-4-4455, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. rachel.courtney@spcorp.com","Early Clinical Research and Experimental Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Clinical Research and Experimental Medicine, Schering-Plough Research Institute, K-15-4-4455, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. rachel.courtney@spcorp.com","institution_ids":[]},{"raw_affiliation_string":"Early Clinical Research and Experimental Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060475451","display_name":"David B. Wexler","orcid":"https://orcid.org/0000-0003-4121-8973","observed_orcids":["https://orcid.org/0000-0003-4121-8973"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Wexler","raw_affiliation_strings":["Drug Metabolism and Pharmacokinetics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Metabolism and Pharmacokinetics and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013466966","display_name":"Elaine Radwanski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elaine Radwanski","raw_affiliation_strings":["Project Planning, Schering-Plough Research Institute, Kenilworth, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Project Planning, Schering-Plough Research Institute, Kenilworth, New Jersey, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108196229","display_name":"Josephine M. Lim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Josephine Lim","raw_affiliation_strings":["Drug Metabolism and Pharmacokinetics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Metabolism and Pharmacokinetics and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111813211","display_name":"Mark A Laughlin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Laughlin","raw_affiliation_strings":["Early Clinical Research and Experimental Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Clinical Research and Experimental Medicine,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112255294"],"corresponding_institution_ids":[],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":4.3251,"has_fulltext":true,"cited_by_count":332,"citation_normalized_percentile":{"value":0.94852599,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"57","issue":"2","first_page":"218","last_page":"222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.5713000297546387,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.5713000297546387,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.1550000011920929,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.1039000004529953,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/posaconazole","display_name":"posaconazole","score":1.0},{"id":"https://openalex.org/keywords/food-effect","display_name":"food effect","score":0.6549999713897705},{"id":"https://openalex.org/keywords/relative-bioavailability","display_name":"relative bioavailability","score":0.9150000214576721},{"id":"https://openalex.org/keywords/oral-formulations","display_name":"oral dosage forms","score":0.6589999794960022},{"id":"https://openalex.org/keywords/suspension-formulation","display_name":"suspension formulation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/high-fat-meal","display_name":"high-fat meal","score":0.871999979019165},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.5989999771118164},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.7889999747276306},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9539999961853027}],"concepts":[{"id":"https://openalex.org/C2778566413","wikidata":"https://www.wikidata.org/wiki/Q906453","display_name":"Posaconazole","level":4,"score":0.9253770112991333},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.8861015439033508},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.8168161511421204},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.7154119610786438},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6905619502067566},{"id":"https://openalex.org/C2778345441","wikidata":"https://www.wikidata.org/wiki/Q6460735","display_name":"Meal","level":2,"score":0.6812485456466675},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5151664018630981},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5051952004432678},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4303607940673828},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3252410888671875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22715696692466736},{"id":"https://openalex.org/C2777071850","wikidata":"https://www.wikidata.org/wiki/Q411229","display_name":"Itraconazole","level":3,"score":0.06344211101531982},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.06056821346282959},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.0},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005502","descriptor_name":"Food","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D018565","descriptor_name":"Food-Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1365-2125.2003.01977.x","doi":"https://doi.org/10.1046/j.1365-2125.2003.01977.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2125.2003.01977.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2125.2003.01977.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1884431","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1884431","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},{"id":"pmid:14748822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14748822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1046/j.1365-2125.2003.01977.x","doi":"https://doi.org/10.1046/j.1365-2125.2003.01977.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2125.2003.01977.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2125.2003.01977.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1736726786.pdf","grobid_xml":"https://content.openalex.org/works/W1736726786.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1981516536","https://openalex.org/W2004434620","https://openalex.org/W2034615747","https://openalex.org/W2045726697","https://openalex.org/W2063611602","https://openalex.org/W2072416057","https://openalex.org/W2097822381","https://openalex.org/W2128483390","https://openalex.org/W2138866540","https://openalex.org/W2138937494","https://openalex.org/W2155071468","https://openalex.org/W2156860818","https://openalex.org/W2164728060","https://openalex.org/W2502670554"],"related_works":["https://openalex.org/W1883163115","https://openalex.org/W1995377218","https://openalex.org/W4313649238","https://openalex.org/W4390604634","https://openalex.org/W2117813373","https://openalex.org/W2969608688","https://openalex.org/W2330130059","https://openalex.org/W1984228185","https://openalex.org/W2067101775","https://openalex.org/W2119982081"],"abstract_inverted_index":{"AIMS:":[0],"This":[1,41],"randomized,":[2,44],"crossover,":[3,47],"single-dose":[4,48],"study":[5,20,49],"evaluated":[6,57],"the":[7,19,34,110,154,157,173,205,226,231],"relative":[8,203,222],"oral":[9,64],"bioavailability":[10,107,223],"of":[11,37,66,153,172,188,197,212,235],"posaconazole":[12,26,67,87,100,213,236],"suspension":[13,68,101,155,174,210],"and":[14,124,138,194,220,233],"coprecipitate":[15],"tablet":[16,111],"formulations.":[17],"Additionally,":[18],"determined":[21],"whether":[22],"systemic":[23,218],"exposure":[24,219],"to":[25,204],"was":[27,42,214],"affected":[28],"by":[29,33],"prandial":[30],"status":[31],"or":[32,80,86],"fat":[35],"content":[36],"a":[38,43,62,74,77,82,95,103,147,176],"meal.":[39,97],"METHODS:":[40],"open-label,":[45],"four-way":[46],"in":[50,106,113,135,156,182,185,195,238],"20":[51],"healthy":[52,239],"men.":[53],"Posaconazole":[54],"pharmacokinetics":[55],"were":[56,141],"over":[58],"72":[59],"h":[60,84],"following":[61],"single":[63],"dose":[65],"(200":[69],"mg/5":[70],"ml)":[71],"administered":[72,93,145],"with":[73,94,109,146,151,175,216,225],"high-fat":[75,96,148],"meal,":[76],"nonfat":[78,177],"breakfast,":[79],"after":[81],"10":[83],"fast,":[85],"tablets":[88],"(2":[89],"x":[90],"100":[91],"mg)":[92],"RESULTS:":[98],"The":[99,132,209],"showed":[102],"significant":[104],"increase":[105,184],"compared":[108,150,224],"(increase":[112],"AUC(0,72":[114,136,186],"h)":[115,137,161,187],"=":[116,126],"137%":[117],"(90%":[118,128,190,199],"confidence":[119],"interval":[120],"(CI)":[121],"119%,":[122],"156%":[123],"Cmax":[125,139,166,196],"123%":[127],"CI":[129,163,168,191,200],"104%,":[130],"146%).":[131],"mean":[133],"increases":[134],"values":[140],"about":[142],"400%":[143],"when":[144],"meal":[149,178],"administration":[152],"fasting":[158],"state":[159],"(AUC(0,72":[160],"90%":[162,167],"343%,":[164],"448%;":[165],"352%,":[169],"493%).":[170],"Administration":[171],"enhanced":[179,217,230],"exposure,":[180],"resulting":[181],"an":[183],"264%":[189],"231%,":[192],"302%)":[193],"296%":[198],"250%,":[201],"350%)":[202],"fasted":[206],"state.":[207],"CONCLUSIONS:":[208],"formulation":[211],"associated":[215],"increased":[221],"tablet.":[227],"Food":[228],"substantially":[229],"rate":[232],"extent":[234],"absorption":[237],"subjects.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}