{"id":"https://openalex.org/W173631979","doi":null,"title":"From genes to therapy: A study on how genetics can help identifying novel targets for alcohol dependence","display_name":"From genes to therapy: A study on how genetics can help identifying novel targets for alcohol dependence","publication_year":2009,"publication_date":"2009-10-27","ids":{"openalex":"https://openalex.org/W173631979","mag":"173631979"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/36368","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/36368","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dspace.library.uu.nl:8080/handle/1874/36368","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055874141","display_name":"Marjolein S. Kops","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"M.S. Kops","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5055874141"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.5210000276565552,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.5210000276565552,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.2728999853134155,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.09920000284910202,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/candidate-genes","display_name":"candidate genes","score":0.8389999866485596},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.7689999938011169},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.8230000138282776},{"id":"https://openalex.org/keywords/oprm1","display_name":"OPRM1","score":0.7889999747276306},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.7360000014305115},{"id":"https://openalex.org/keywords/naltrexone","display_name":"naltrexone","score":0.7900000214576721},{"id":"https://openalex.org/keywords/acetaldehyde-accumulation","display_name":"acetaldehyde accumulation","score":0.6819999814033508},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.703000009059906},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.4869999885559082},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5739414691925049},{"id":"https://openalex.org/C2779436514","wikidata":"https://www.wikidata.org/wiki/Q4713263","display_name":"Alcohol dependence","level":3,"score":0.5017542839050293},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4973016083240509},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4409175217151642},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4130095839500427},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.35058140754699707},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/36368","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/36368","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},{"id":"mag:173631979","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/bitstream/handle/1874/36368/0455091_thesis.pdf.pdf;sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/36368","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/36368","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W612904245","https://openalex.org/W1553583298","https://openalex.org/W1559609624","https://openalex.org/W1586529577","https://openalex.org/W1604627024","https://openalex.org/W1963498395","https://openalex.org/W1970367888","https://openalex.org/W1971697874","https://openalex.org/W1974488383","https://openalex.org/W1976502754","https://openalex.org/W1977467968","https://openalex.org/W1980941647","https://openalex.org/W1984296918","https://openalex.org/W1985244817","https://openalex.org/W1990027430","https://openalex.org/W1991475702","https://openalex.org/W1998674360","https://openalex.org/W2000043887","https://openalex.org/W2002255191","https://openalex.org/W2004771951","https://openalex.org/W2017482780","https://openalex.org/W2025108897","https://openalex.org/W2026900956","https://openalex.org/W2033500251","https://openalex.org/W2034147908","https://openalex.org/W2035088954","https://openalex.org/W2043187808","https://openalex.org/W2050616769","https://openalex.org/W2052005967","https://openalex.org/W2053806428","https://openalex.org/W2054597549","https://openalex.org/W2056121498","https://openalex.org/W2059434400","https://openalex.org/W2068483269","https://openalex.org/W2074406420","https://openalex.org/W2082229496","https://openalex.org/W2083690780","https://openalex.org/W2087994176","https://openalex.org/W2088829922","https://openalex.org/W2089086385","https://openalex.org/W2095894512","https://openalex.org/W2102891083","https://openalex.org/W2103690575","https://openalex.org/W2104755990","https://openalex.org/W2107964123","https://openalex.org/W2116707453","https://openalex.org/W2120611321","https://openalex.org/W2133838422","https://openalex.org/W2135057136","https://openalex.org/W2141244087","https://openalex.org/W2141536473","https://openalex.org/W2153532459","https://openalex.org/W2154058918","https://openalex.org/W2154807729","https://openalex.org/W2155090722","https://openalex.org/W2165975149","https://openalex.org/W2169085718","https://openalex.org/W2413881794","https://openalex.org/W3211520585","https://openalex.org/W4414004094"],"related_works":["https://openalex.org/W2083033369","https://openalex.org/W1938434640","https://openalex.org/W2559968502","https://openalex.org/W2087928436","https://openalex.org/W1266576800","https://openalex.org/W2082880404","https://openalex.org/W2085202511","https://openalex.org/W1571417609","https://openalex.org/W1566960339","https://openalex.org/W3212456759"],"abstract_inverted_index":{"Alcohol":[0],"addiction":[1],"is":[2,22,126,175,223],"a":[3,119,180,184],"major":[4],"public":[5],"health":[6],"burden.":[7],"Treatment":[8],"strategies":[9],"available":[10],"for":[11,38,48,95,252],"alcoholism":[12,253],"are":[13,115],"limited":[14],"in":[15,101,244],"number":[16],"and":[17,30,60,75,111,196,202,262],"efficacy.":[18],"This":[19],"current":[20],"review":[21],"focused":[23],"on":[24,154,193,259],"how":[25],"genetic":[26,228,264,269],"studies":[27,229],"can":[28,230],"contribute":[29,231],"have":[31,118],"contributed":[32],"to":[33,117,133,205,212,233,247,273,277],"finding":[34],"novel":[35],"workable":[36],"therapies":[37],"alcoholism.":[39],"I":[40,225],"address":[41],"five":[42],"candidate":[43,145],"genes":[44,55,82,114,198],"with":[45,50,86,173],"strong":[46,84,134],"evidence":[47],"associations":[49,85],"alcohol":[51,87,97,140],"dependence:":[52],"two":[53],"ethanol-metabolizing":[54,124],"(alcohol":[56],"dehydrogenase":[57,62],"enzyme,":[58],"ADH1B,":[59],"aldehyde":[61],"enzyme":[63],"ALDH2),":[64],"one":[65,70,76],"opioid":[66],"receptor":[67,72,168],"gene":[68,73,79,146,165],"(OPRM1),":[69],"dopamine":[71],"(DRD2),":[74],"GABA":[77],"\\nreceptor":[78],"(GABRA2).":[80],"These":[81],"show":[83],"dependence.":[88],"Some":[89],"functional":[90],"polymorphisms":[91],"predispose":[92],"an":[93],"individual":[94],"developing":[96,234],"dependence,":[98],"like":[99],"those":[100],"the":[102,109,112,123,163,167,194,200,216,245,260,263,274],"DRD2":[103,195],"receptor.":[104],"In":[105],"contrast,":[106],"variants":[107],"of":[108,162,182,187,215,218,257,268],"ADH1B":[110],"ALDH2":[113],"believed":[116],"protective":[120],"effect,":[121],"since":[122],"process":[125],"altered":[127],"such":[128,170],"that":[129,149,171,227],"accumulated":[130],"acetaldehyde":[131],"leads":[132],"intoxication":[135],"responses":[136],"shortly":[137],"after":[138],"drinking":[139],"(alcohol-induced":[141],"flushing":[142],"trait).":[143],"One":[144],"displays":[147],"qualities":[148],"allow":[150],"patient-tailored":[151],"treatment":[152,172],"based":[153],"their":[155],"individual\u2019s":[156],"genotype.":[157],"The":[158],"Asp40":[159],"variant":[160],"allele":[161],"OPRM1":[164],"improves":[166],"ability":[169],"naltrexone":[174],"more":[176],"efficient,":[177],"thus":[178],"giving":[179],"subgroup":[181],"alcoholics":[183],"better":[185],"chance":[186],"withstanding":[188],"relapse.":[189],"Despite":[190],"discovering":[191],"haplotypes":[192],"GABR2":[197],"associating":[199],"dopaminergic":[201],"GABAergic":[203],"system":[204],"alcoholism,":[206],"drug":[207,235,250,278],"treatments":[208,251],"almost":[209],"always":[210],"lead":[211],"side-effects":[213],"because":[214],"complexity":[217],"these":[219],"pathways.":[220],"Further":[221],"research":[222],"required.":[224],"feel":[226],"profoundly":[232],"treatments.":[236],"With":[237],"pharmacogenetic":[238],"studies,":[239],"it":[240],"may":[241],"be":[242],"possible":[243],"future":[246],"develop":[248],"personalized":[249],"by":[254],"making":[255],"use":[256],"information":[258],"genotype":[261],"predisposition":[265],"(the":[266],"contribution":[267],"versus":[270],"environment)":[271],"related":[272],"expected":[275],"response":[276],"treatment.":[279]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
