{"id":"https://openalex.org/W173622182","doi":null,"title":"Adaptor Proteins in Regulation of Receptor Endocytosis","display_name":"Adaptor Proteins in Regulation of Receptor Endocytosis","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W173622182","mag":"173622182"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-4477","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4477","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4477","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102157797","display_name":"Katarzyna Kowanetz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Katarzyna Kowanetz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5102157797"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.9399999976158142},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cbl-ubiquitin-ligase","display_name":"Cbl ubiquitin ligase","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cin85","display_name":"CIN85","score":0.9309999942779541},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.8709999918937683},{"id":"https://openalex.org/keywords/sh3-domain","display_name":"SH3 domain","score":0.6079999804496765},{"id":"https://openalex.org/keywords/endophilin","display_name":"endophilin","score":0.8619999885559082},{"id":"https://openalex.org/keywords/asap1","display_name":"ASAP1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dab2","display_name":"Dab2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sts-1","display_name":"STS-1","score":0.9490000009536743},{"id":"https://openalex.org/keywords/sts-2","display_name":"STS-2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/receptor-downregulation","display_name":"receptor down-regulation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/signal-termination","display_name":"signal termination","score":0.6679999828338623},{"id":"https://openalex.org/keywords/adaptor-proteins","display_name":"adaptor proteins","score":0.6200000047683716},{"id":"https://openalex.org/keywords/mitogenic-signaling","display_name":"mitogenic signaling","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.8059333562850952},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.7134836316108704},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5865676999092102},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4897325038909912},{"id":"https://openalex.org/C117943116","wikidata":"https://www.wikidata.org/wiki/Q1135604","display_name":"Receptor-mediated endocytosis","level":4,"score":0.46150070428848267},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3842530846595764},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3249138593673706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3117421269416809},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2278214991092682},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18149328231811523}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-4477","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4477","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:173622182","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/ETH/8617","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-4477","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4477","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":169,"referenced_works":["https://openalex.org/W170428794","https://openalex.org/W1490624051","https://openalex.org/W1494477854","https://openalex.org/W1513014113","https://openalex.org/W1543768950","https://openalex.org/W1553799143","https://openalex.org/W1564784444","https://openalex.org/W1565471250","https://openalex.org/W1571287379","https://openalex.org/W1574831557","https://openalex.org/W1589502992","https://openalex.org/W1596079370","https://openalex.org/W1601571585","https://openalex.org/W1605218758","https://openalex.org/W1780544763","https://openalex.org/W1892578325","https://openalex.org/W1930762285","https://openalex.org/W1931780528","https://openalex.org/W1938129101","https://openalex.org/W1964261321","https://openalex.org/W1964321121","https://openalex.org/W1964504843","https://openalex.org/W1964745905","https://openalex.org/W1964966535","https://openalex.org/W1965028987","https://openalex.org/W1965150594","https://openalex.org/W1967343277","https://openalex.org/W1967391569","https://openalex.org/W1969958451","https://openalex.org/W1970954185","https://openalex.org/W1972172786","https://openalex.org/W1972242729","https://openalex.org/W1974925709","https://openalex.org/W1975545716","https://openalex.org/W1976197008","https://openalex.org/W1977253956","https://openalex.org/W1977951612","https://openalex.org/W1978279440","https://openalex.org/W1979274256","https://openalex.org/W1980217369","https://openalex.org/W1981096579","https://openalex.org/W1981515958","https://openalex.org/W1983089513","https://openalex.org/W1983523339","https://openalex.org/W1983921682","https://openalex.org/W1984168124","https://openalex.org/W1984418041","https://openalex.org/W1984967137","https://openalex.org/W1986812906","https://openalex.org/W1988651629","https://openalex.org/W1990662798","https://openalex.org/W1992139451","https://openalex.org/W1993355802","https://openalex.org/W1995574514","https://openalex.org/W1997719326","https://openalex.org/W1999041896","https://openalex.org/W1999679029","https://openalex.org/W2000630926","https://openalex.org/W2003979167","https://openalex.org/W2004396935","https://openalex.org/W2005722151","https://openalex.org/W2007962912","https://openalex.org/W2009018171","https://openalex.org/W2011625746","https://openalex.org/W2013355944","https://openalex.org/W2014868351","https://openalex.org/W2015961921","https://openalex.org/W2016162029","https://openalex.org/W2019103273","https://openalex.org/W2019286212","https://openalex.org/W2019987740","https://openalex.org/W2020292268","https://openalex.org/W2020952581","https://openalex.org/W2023131365","https://openalex.org/W2024272753","https://openalex.org/W2025327960","https://openalex.org/W2026055716","https://openalex.org/W2027533965","https://openalex.org/W2028415754","https://openalex.org/W2031098987","https://openalex.org/W2032157793","https://openalex.org/W2033021180","https://openalex.org/W2034796157","https://openalex.org/W2034947351","https://openalex.org/W2036644816","https://openalex.org/W2037635704","https://openalex.org/W2042776102","https://openalex.org/W2046540619","https://openalex.org/W2050251450","https://openalex.org/W2050505054","https://openalex.org/W2052354634","https://openalex.org/W2052590422","https://openalex.org/W2052799365","https://openalex.org/W2052934075","https://openalex.org/W2053100392","https://openalex.org/W2054160631","https://openalex.org/W2055786440","https://openalex.org/W2057071478","https://openalex.org/W2057975573","https://openalex.org/W2063273434","https://openalex.org/W2067216245","https://openalex.org/W2067917889","https://openalex.org/W2068829311","https://openalex.org/W2069444054","https://openalex.org/W2070655784","https://openalex.org/W2071033930","https://openalex.org/W2071102056","https://openalex.org/W2071877471","https://openalex.org/W2072508525","https://openalex.org/W2074877259","https://openalex.org/W2075097866","https://openalex.org/W2076984266","https://openalex.org/W2078369440","https://openalex.org/W2079051863","https://openalex.org/W2082773871","https://openalex.org/W2082797919","https://openalex.org/W2083087230","https://openalex.org/W2092561515","https://openalex.org/W2093351885","https://openalex.org/W2093429365","https://openalex.org/W2094630875","https://openalex.org/W2095340557","https://openalex.org/W2095467264","https://openalex.org/W2101849511","https://openalex.org/W2102201607","https://openalex.org/W2108489580","https://openalex.org/W2108586733","https://openalex.org/W2110522042","https://openalex.org/W2114628856","https://openalex.org/W2116023341","https://openalex.org/W2116398087","https://openalex.org/W2118929373","https://openalex.org/W2121634203","https://openalex.org/W2124504624","https://openalex.org/W2125285895","https://openalex.org/W2126297518","https://openalex.org/W2128963767","https://openalex.org/W2129448282","https://openalex.org/W2130448025","https://openalex.org/W2131361386","https://openalex.org/W2132497596","https://openalex.org/W2133987610","https://openalex.org/W2136203552","https://openalex.org/W2137035181","https://openalex.org/W2141475443","https://openalex.org/W2142925367","https://openalex.org/W2142939427","https://openalex.org/W2144444784","https://openalex.org/W2145625720","https://openalex.org/W2147476448","https://openalex.org/W2148414191","https://openalex.org/W2148527073","https://openalex.org/W2149854941","https://openalex.org/W2151312020","https://openalex.org/W2151624014","https://openalex.org/W2153800130","https://openalex.org/W2153991959","https://openalex.org/W2158588008","https://openalex.org/W2159422521","https://openalex.org/W2159452410","https://openalex.org/W2159642177","https://openalex.org/W2161832828","https://openalex.org/W2167806590","https://openalex.org/W2169290377","https://openalex.org/W2171164575","https://openalex.org/W2176719787","https://openalex.org/W2330922316","https://openalex.org/W2335540407","https://openalex.org/W2474157163"],"related_works":["https://openalex.org/W2106626264","https://openalex.org/W1967368177","https://openalex.org/W2005106186","https://openalex.org/W65105544","https://openalex.org/W1992214979","https://openalex.org/W2164093749","https://openalex.org/W2125285895","https://openalex.org/W2168709504","https://openalex.org/W7099452259","https://openalex.org/W2171862581"],"abstract_inverted_index":{"Ligand-induced":[0,228],"endocytosis":[1],"of":[2,23,36,49,68,73,98,117,124,160,173,181,202,207,224,232,241,247,267,270,292,296],"receptor":[3,76,91,182,226,242,248,274],"tyrosine":[4],"kinases":[5],"(RTKs)":[6],"is":[7,19,27],"a":[8,20,44,104,196,264],"dynamic":[9],"process":[10],"governed":[11],"by":[12,51,251,283],"numerous":[13,141],"protein-protein":[14],"and":[15,26,56,135,148,166,185,215,221,229,244,261],"protein-lipid":[16],"interactions.":[17],"This":[18],"major":[21],"mechanism":[22],"signal":[24],"termination":[25],"also":[28],"frequently":[29],"impaired":[30],"in":[31,47,75,103,133,178,187,200,205,273],"cancer.":[32],"The":[33,94,121,157],"Cbl":[34,74,86,134,271],"family":[35],"ubiquitin":[37],"ligases":[38],"has":[39,63],"been":[40],"shown":[41],"to":[42,65,164,239,287],"play":[43],"key":[45],"role":[46],"downregulation":[48,206],"RTKs,":[50],"directing":[52],"their":[53,154],"ligand-induced":[54],"ubiquitination":[55],"subsequent":[57,171,245],"lysosomal":[58],"degradation.":[59],"My":[60],"thesis":[61,279],"work":[62],"led":[64,238],"the":[66,81,179,188],"identification":[67],"novel,":[69],"ubiquitin-ligase":[70],"independent,":[71],"functions":[72,194,272],"endocytosis.":[77,275],"We":[78,190],"demonstrated":[79],"that":[80,140,192,259],"adaptor":[82,217],"protein":[83],"CIN85":[84,99,125,152,161,193],"links":[85],"with":[87,101,151],"epidermal":[88],"growth":[89],"factor":[90],"(EGFR)":[92],"internalization.":[93],"three":[95],"SH3":[96,122,158],"domains":[97,123,159],"interact":[100,150],"Cbl/Cbl-b":[102],"phosphotyrosine":[105],"dependent":[106],"manner,":[107],"whereas":[108],"its":[109,168,288],"proline-rich":[110],"region":[111],"constitutively":[112],"binds":[113],"endophilins,":[114],"known":[115],"regulators":[116,269],"plasma":[118],"membrane":[119],"invagination.":[120],"recognize":[126],"an":[127],"atypical":[128],"proline-arginine":[129],"(PxxxPR)":[130],"motif":[131],"present":[132],"Cbl-b.":[136],"Moreover,":[137],"we":[138,210],"showed":[139],"endocytic":[142],"regulatory":[143],"proteins,":[144],"among":[145],"them":[146],"ASAP1":[147],"Dab2,":[149],"via":[153],"PxxxPR":[155],"motifs.":[156],"are":[162,300],"able":[163],"cluster":[165],"exchange":[167],"effectors":[169],"at":[170],"stages":[172],"EGFR":[174,236],"endocytosis,":[175],"thus":[176],"participating":[177],"control":[180,201],"internalization,":[183],"recycling":[184],"degradation":[186,249],"lysosome.":[189],"proposed":[191],"as":[195,304,306],"scaffold":[197],"molecule":[198],"implicated":[199],"multiple":[203],"steps":[204],"RTKs.":[208,293],"Furthermore,":[209],"identified":[211],"two":[212],"novel":[213,281],"Cbl-":[214],"ubiquitin-interacting":[216],"proteins":[218],"named":[219],"Sts-1":[220,260],"Sts-2":[222,262],"(Suppressors":[223],"T-cell":[225],"signaling).":[227],"Cbl-mediated":[230],"recruitment":[231],"Sts-1/Sts-2":[233],"into":[234],"activated":[235],"complexes":[237],"inhibition":[240],"internalization":[243],"block":[246],"followed":[250],"prolonged":[252],"mitogenic":[253],"signaling":[254],"pathways.":[255],"Our":[256],"results":[257],"indicate":[258],"represent":[263],"new":[265],"class":[266],"negative":[268],"In":[276],"conclusion,":[277],"this":[278],"describes":[280],"mechanisms":[282],"which":[284],"Cbl,":[285],"coupled":[286],"effectors,":[289],"orchestrates":[290],"trafficking":[291],"Detailed":[294],"understanding":[295],"how":[297],"these":[298],"processes":[299],"controlled":[301],"under":[302,307],"physiological":[303],"well":[305],"pathological":[308],"conditions":[309],"may":[310],"be":[311],"important":[312],"for":[313],"future":[314],"therapeutic":[315],"approaches.":[316]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
