{"id":"https://openalex.org/W1736202","doi":null,"title":"Inhibition of histamine release from human mast cells by natural chymase inhibitors.","display_name":"Inhibition of histamine release from human mast cells by natural chymase inhibitors.","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W1736202","mag":"1736202","pmid":"https://pubmed.ncbi.nlm.nih.gov/15169639"},"language":"en","primary_location":{"id":"pmid:15169639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15169639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110311024","display_name":"Shao-Heng He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32574673","display_name":"Shantou University","ror":"https://ror.org/01a099706","country_code":"CN","type":"education","lineage":["https://openalex.org/I32574673"]},{"id":"https://openalex.org/I4210120522","display_name":"Shantou University Medical College","ror":"https://ror.org/02gxych78","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shao-Heng He","raw_affiliation_strings":["Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China. shoahenghe@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China. shoahenghe@hotmail.com","institution_ids":["https://openalex.org/I32574673","https://openalex.org/I4210120522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109857677","display_name":"HuaXie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Xie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053853871","display_name":"Xiao-junZHANG","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Jun Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079396845","display_name":"Xian-jieWANG","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xian-Jie Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8052,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.68643721,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"25","issue":"6","first_page":"822","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histamine-release","display_name":"histamine release","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.9570000171661377},{"id":"https://openalex.org/keywords/chymase-inhibitors","display_name":"chymase inhibitors","score":0.9779999852180481},{"id":"https://openalex.org/keywords/secretory-leukocyte-protease-inhibitor","display_name":"secretory leukocyte protease inhibitor","score":0.9909999966621399},{"id":"https://openalex.org/keywords/alpha-1-antitrypsin","display_name":"alpha-1-antitrypsin","score":0.9430000185966492},{"id":"https://openalex.org/keywords/a23187","display_name":"A23187","score":0.9639999866485596},{"id":"https://openalex.org/keywords/lung-mast-cells","display_name":"lung mast cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/skin-mast-cells","display_name":"skin mast cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/allergy","display_name":"allergy","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.9449081420898438},{"id":"https://openalex.org/C2780614898","wikidata":"https://www.wikidata.org/wiki/Q5118578","display_name":"Chymase","level":3,"score":0.860802173614502},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.6817693710327148},{"id":"https://openalex.org/C2777090344","wikidata":"https://www.wikidata.org/wiki/Q18031590","display_name":"SLPI","level":3,"score":0.5721957087516785},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5720953345298767},{"id":"https://openalex.org/C30862142","wikidata":"https://www.wikidata.org/wiki/Q288382","display_name":"Histamine H4 receptor","level":5,"score":0.5618072152137756},{"id":"https://openalex.org/C2779419017","wikidata":"https://www.wikidata.org/wiki/Q180569","display_name":"Tonsil","level":2,"score":0.5588981509208679},{"id":"https://openalex.org/C2781406822","wikidata":"https://www.wikidata.org/wiki/Q904140","display_name":"Tryptase","level":3,"score":0.5541561841964722},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49334827065467834},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4473798871040344},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4433116316795349},{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.4181545674800873},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3465624749660492},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3248465061187744},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3089257776737213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2956767976284027},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1947801411151886},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18748891353607178},{"id":"https://openalex.org/C34400551","wikidata":"https://www.wikidata.org/wiki/Q311568","display_name":"Histamine H2 receptor","level":4,"score":0.14091557264328003},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.11696341633796692},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0820041298866272},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.0630786120891571},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.056165844202041626}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000515","descriptor_name":"alpha 1-Antitrypsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000888","descriptor_name":"Antibodies, Anti-Idiotypic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007476","descriptor_name":"Ionophores","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014066","descriptor_name":"Palatine Tonsil","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053481","descriptor_name":"Secretory Leukocyte Peptidase Inhibitor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053491","descriptor_name":"Proteinase Inhibitory Proteins, Secretory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053818","descriptor_name":"Chymases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15169639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15169639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},{"id":"mag:1554212834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15169639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:1736202","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/95561A/200406/9980233.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306542255","display_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u62a5\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u62a5\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W197129590","https://openalex.org/W2008517611","https://openalex.org/W2013851053","https://openalex.org/W2024997444","https://openalex.org/W2030355559","https://openalex.org/W2037658703","https://openalex.org/W2040792654","https://openalex.org/W2050800572","https://openalex.org/W2059841687","https://openalex.org/W2095730707","https://openalex.org/W2126518898","https://openalex.org/W2126833964"],"related_works":["https://openalex.org/W2472989191","https://openalex.org/W2393213796","https://openalex.org/W2130450426","https://openalex.org/W1524564313","https://openalex.org/W2413838572","https://openalex.org/W2398777712","https://openalex.org/W2466316529","https://openalex.org/W2031166753","https://openalex.org/W2378424427","https://openalex.org/W2221203568"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"investigate":[2],"the":[3,36,41],"ability":[4],"of":[5,40],"natural":[6,42],"chymase":[7,43],"inhibitors":[8,44],"to":[9,72,93,107,137,183],"modulate":[10],"histamine":[11,53,59,96,125,141,162],"release":[12,54,60,126,142,163],"from":[13,21,61,98,127,143,164],"human":[14,22,166],"mast":[15,66,103,132,147,171,189],"cells.":[16,148],"METHODS:":[17],"Enzymatically":[18],"dispersed":[19,165],"cells":[20,67,104,172],"lung,":[23,62,99,128,167],"tonsil,":[24,63,168],"and":[25,50,64,77,101,113,130,145,152,158,169],"skin":[26,65,102,131,170],"were":[27,68,135,181],"challenged":[28],"with":[29,83],"anti-IgE":[30],"or":[31,38],"calcium":[32,139,159],"ionophore":[33],"A23187":[34],"in":[35,173,188],"absence":[37],"presence":[39],"secretory":[45],"leukocyte":[46],"protease":[47],"inhibitor":[48],"(SLPI)":[49],"alpha(1)-antitrypsin,":[51],"then":[52],"was":[55,90],"determined.":[56],"RESULTS:":[57],"IgE-dependent":[58,157],"inhibited":[69],"by":[70,105,122],"up":[71,106],"70":[73],"%,":[74,76,79,110,112,115],"61":[75],"62":[78],"respectively":[80],"following":[81],"incubation":[82],"alpha(1)-antitrypsin":[84,119],"(5000":[85],"nmol/L).":[86],"SLPI":[87,121,153],"5000":[88],"nmol/L":[89],"also":[91],"able":[92,136],"inhibit":[94,138,156],"anti-IgE-dependent":[95],"released":[97],"tonsil":[100,129,146],"approximately":[108],"72":[109],"67":[111],"58":[114],"respectively.":[116],"While":[117],"neither":[118],"nor":[120],"themselves":[123],"altered":[124],"cells,":[133],"they":[134,180],"ionophore-induced":[140],"lung":[144],"CONCLUSION:":[149],"Both":[150],"micro(1)-antitrypsin":[151],"could":[154],"potently":[155],"ionophore-":[160],"induced":[161],"a":[174,185],"concentration-dependent":[175],"manner,":[176],"which":[177],"suggested":[178],"that":[179],"likely":[182],"play":[184],"protective":[186],"role":[187],"cell":[190],"associated":[191],"diseases":[192],"including":[193],"allergy.":[194]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
