{"id":"https://openalex.org/W173591244","doi":"https://doi.org/10.1016/b978-0-12-397176-0.00013-3","title":"Design of the anti-HIV protease inhibitor darunavir","display_name":"Design of the anti-HIV protease inhibitor darunavir","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W173591244","doi":"https://doi.org/10.1016/b978-0-12-397176-0.00013-3","mag":"173591244"},"language":"en","primary_location":{"id":"doi:10.1016/b978-0-12-397176-0.00013-3","doi":"https://doi.org/10.1016/b978-0-12-397176-0.00013-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-397176-0.00013-3","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Introduction to Biological and Small Molecule Drug Research and Development","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4242166059","display_name":"Introduction to Biological and Small Molecule Drug Research and Development"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041773055","display_name":"Arun Kumar Ghosh","orcid":"https://orcid.org/0000-0003-2472-1841","observed_orcids":["https://orcid.org/0000-0003-2472-1841"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arun K. Ghosh","raw_affiliation_strings":["Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA","Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024727289","display_name":"Bruno D. Chapsal","orcid":"https://orcid.org/0009-0004-0504-5053","observed_orcids":["https://orcid.org/0009-0004-0504-5053"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruno D. Chapsal","raw_affiliation_strings":["Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":null,"apc_paid":null,"fwci":3.7724,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.93099199,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"355","last_page":"384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/darunavir","display_name":"darunavir","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hiv-protease-inhibitors","display_name":"HIV protease inhibitors","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hiv-1-protease","display_name":"HIV-1 protease","score":0.9810000061988831},{"id":"https://openalex.org/keywords/structure-based-drug-design","display_name":"structure-based drug design","score":0.9129999876022339},{"id":"https://openalex.org/keywords/p2-ligands","display_name":"P2 ligands","score":0.7139999866485596},{"id":"https://openalex.org/keywords/hiv-drug-resistance","display_name":"HIV drug resistance","score":0.8759999871253967},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.8709999918937683},{"id":"https://openalex.org/keywords/antiviral-drug-discovery","display_name":"antiviral drug discovery","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2779182219","wikidata":"https://www.wikidata.org/wiki/Q3765251","display_name":"Darunavir","level":5,"score":0.9845055341720581},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.7001973390579224},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5839595794677734},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5557776093482971},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5446930527687073},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5052264332771301},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4606807827949524},{"id":"https://openalex.org/C2781143361","wikidata":"https://www.wikidata.org/wiki/Q55761529","display_name":"Protease inhibitor (pharmacology)","level":5,"score":0.45512813329696655},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4229589104652405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39871323108673096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36777395009994507},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30401891469955444},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.2807164788246155},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.24259915947914124},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20438921451568604},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.15766757726669312},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1363075077533722},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12766507267951965}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-0-12-397176-0.00013-3","doi":"https://doi.org/10.1016/b978-0-12-397176-0.00013-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-397176-0.00013-3","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Introduction to Biological and Small Molecule Drug Research and Development","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000252667","display_name":null,"funder_award_id":"GM53386","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W626810566","https://openalex.org/W1488273275","https://openalex.org/W1495629930","https://openalex.org/W1564884101","https://openalex.org/W1577096885","https://openalex.org/W1590620260","https://openalex.org/W1858568413","https://openalex.org/W1966952510","https://openalex.org/W1969406694","https://openalex.org/W1971020159","https://openalex.org/W1972227391","https://openalex.org/W1974224443","https://openalex.org/W1974488819","https://openalex.org/W1974713194","https://openalex.org/W1975177202","https://openalex.org/W1976295381","https://openalex.org/W1977249481","https://openalex.org/W1977482746","https://openalex.org/W1981491253","https://openalex.org/W1981669483","https://openalex.org/W1983499495","https://openalex.org/W1986457945","https://openalex.org/W1986916945","https://openalex.org/W1986986717","https://openalex.org/W1989837529","https://openalex.org/W1991696252","https://openalex.org/W1992716708","https://openalex.org/W1998419999","https://openalex.org/W1999018540","https://openalex.org/W2000933604","https://openalex.org/W2010751579","https://openalex.org/W2014772558","https://openalex.org/W2019691224","https://openalex.org/W2023819168","https://openalex.org/W2026034630","https://openalex.org/W2031040219","https://openalex.org/W2035095394","https://openalex.org/W2038099508","https://openalex.org/W2038275196","https://openalex.org/W2039965018","https://openalex.org/W2043120072","https://openalex.org/W2044581646","https://openalex.org/W2048192508","https://openalex.org/W2051039960","https://openalex.org/W2051455246","https://openalex.org/W2054955019","https://openalex.org/W2056079193","https://openalex.org/W2058499983","https://openalex.org/W2064073012","https://openalex.org/W2073036247","https://openalex.org/W2076492757","https://openalex.org/W2076553573","https://openalex.org/W2077472737","https://openalex.org/W2091926467","https://openalex.org/W2093217552","https://openalex.org/W2101080301","https://openalex.org/W2104270610","https://openalex.org/W2106448315","https://openalex.org/W2109604183","https://openalex.org/W2113909045","https://openalex.org/W2115405122","https://openalex.org/W2118245054","https://openalex.org/W2120338717","https://openalex.org/W2128479544","https://openalex.org/W2139167304","https://openalex.org/W2140534639","https://openalex.org/W2141474275","https://openalex.org/W2152531984","https://openalex.org/W2152921548","https://openalex.org/W2153478782","https://openalex.org/W2153868685","https://openalex.org/W2155523204","https://openalex.org/W2157791496","https://openalex.org/W2157856009","https://openalex.org/W2165732545","https://openalex.org/W2168270411","https://openalex.org/W2168620139","https://openalex.org/W2170573838","https://openalex.org/W2171764043","https://openalex.org/W2312613954","https://openalex.org/W2318289184","https://openalex.org/W2477742046","https://openalex.org/W2949318797","https://openalex.org/W2949730222","https://openalex.org/W2952919357","https://openalex.org/W6629913487","https://openalex.org/W6634651372","https://openalex.org/W6685052560"],"related_works":["https://openalex.org/W1986986717","https://openalex.org/W1991696252","https://openalex.org/W2767487215","https://openalex.org/W4302761482","https://openalex.org/W1566920585","https://openalex.org/W2171764043","https://openalex.org/W3175679680","https://openalex.org/W2955192928","https://openalex.org/W2946727343","https://openalex.org/W2606056265"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}