{"id":"https://openalex.org/W1733969783","doi":"https://doi.org/10.1212/wnl.82.10_supplement.p4.086","title":"A Clinical Demonstration Of An EEG Brain-Computer Interface (BCI) For ALS Patients (VA Cooperative Study #567): Enrollment, Retention, And Adherence (P4.086)","display_name":"A Clinical Demonstration Of An EEG Brain-Computer Interface (BCI) For ALS Patients (VA Cooperative Study #567): Enrollment, Retention, And Adherence (P4.086)","publication_year":2014,"publication_date":"2014-04-08","ids":{"openalex":"https://openalex.org/W1733969783","doi":"https://doi.org/10.1212/wnl.82.10_supplement.p4.086","mag":"1733969783"},"language":"nl","primary_location":{"id":"doi:10.1212/wnl.82.10_supplement.p4.086","doi":"https://doi.org/10.1212/wnl.82.10_supplement.p4.086","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1212/wnl.82.10_supplement.p4.086","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102998448","display_name":"Richard Bedlack","orcid":"https://orcid.org/0000-0003-4666-7495","observed_orcids":["https://orcid.org/0000-0003-4666-7495"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210139568","display_name":"Durham VA Medical Center","ror":"https://ror.org/034adnw64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119589","https://openalex.org/I4210139568","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Bedlack","raw_affiliation_strings":["Neurology Duke University Durham NC United States","Neurology Durham VA Medical Center Durham NC United States","3Neurology Duke University Durham NC United States","4Neurology Durham VA Medical Center Durham NC United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Duke University Durham NC United States","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Neurology Durham VA Medical Center Durham NC United States","institution_ids":["https://openalex.org/I4210139568"]},{"raw_affiliation_string":"3Neurology Duke University Durham NC United States","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"4Neurology Durham VA Medical Center Durham NC United States","institution_ids":["https://openalex.org/I4210139568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109229048","display_name":"Robert Louis Ruff","orcid":"https://orcid.org/0000-0003-3562-6591","observed_orcids":["https://orcid.org/0000-0003-3562-6591"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Ruff","raw_affiliation_strings":["Dept of Veterans Affairs Cleveland OH United States","2Dept of Veterans Affairs Cleveland OH United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Veterans Affairs Cleveland OH United States","institution_ids":["https://openalex.org/I1322918889"]},{"raw_affiliation_string":"2Dept of Veterans Affairs Cleveland OH United States","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079669862","display_name":"Domenic J. Reda","orcid":"https://orcid.org/0000-0003-1831-4270","observed_orcids":["https://orcid.org/0000-0003-1831-4270"]},"institutions":[{"id":"https://openalex.org/I2802230104","display_name":"Edward Hines, Jr. VA Hospital","ror":"https://ror.org/02223wv31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802230104","https://openalex.org/I4210115976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Domenic Reda","raw_affiliation_strings":["CSP Coordinating Center Hines VA Hospital Hines IL United States","5CSP Coordinating Center Hines VA Hospital Hines IL United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSP Coordinating Center Hines VA Hospital Hines IL United States","institution_ids":["https://openalex.org/I2802230104"]},{"raw_affiliation_string":"5CSP Coordinating Center Hines VA Hospital Hines IL United States","institution_ids":["https://openalex.org/I2802230104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027440225","display_name":"Theresa M. Vaughan","orcid":"https://orcid.org/0000-0002-9548-0371","observed_orcids":["https://orcid.org/0000-0002-9548-0371"]},"institutions":[{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa Vaughan","raw_affiliation_strings":["Laboratory of Neural Injury and Repair Wadsworth Center Albany NY United States","8Laboratory of Neural Injury and Repair Wadsworth Center Albany NY United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neural Injury and Repair Wadsworth Center Albany NY United States","institution_ids":["https://openalex.org/I1339417872"]},{"raw_affiliation_string":"8Laboratory of Neural Injury and Repair Wadsworth Center Albany NY United States","institution_ids":["https://openalex.org/I1339417872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079034258","display_name":"Helen Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802230104","display_name":"Edward Hines, Jr. VA Hospital","ror":"https://ror.org/02223wv31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802230104","https://openalex.org/I4210115976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen Shi","raw_affiliation_strings":["CSP Coordinating Center Hines VA Hospital Hines IL United States","5CSP Coordinating Center Hines VA Hospital Hines IL United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSP Coordinating Center Hines VA Hospital Hines IL United States","institution_ids":["https://openalex.org/I2802230104"]},{"raw_affiliation_string":"5CSP Coordinating Center Hines VA Hospital Hines IL United States","institution_ids":["https://openalex.org/I2802230104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083960164","display_name":"Katya J. Hill","orcid":"https://orcid.org/0000-0002-2399-1690","observed_orcids":["https://orcid.org/0000-0002-2399-1690"]},"institutions":[{"id":"https://openalex.org/I4210133905","display_name":"VA Pittsburgh Healthcare System","ror":"https://ror.org/02qm18h86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katya Hill","raw_affiliation_strings":["VA Pittsburgh Healthcare System Pittsburgh PA United States","7VA Pittsburgh Healthcare System Pittsburgh PA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VA Pittsburgh Healthcare System Pittsburgh PA United States","institution_ids":["https://openalex.org/I4210133905"]},{"raw_affiliation_string":"7VA Pittsburgh Healthcare System Pittsburgh PA United States","institution_ids":["https://openalex.org/I4210133905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091022902","display_name":"Robert J. Ringer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108867","display_name":"Raymond G. Murphy VA Medical Center","ror":"https://ror.org/01z1n5c47","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210108867","https://openalex.org/I4210138663","https://openalex.org/I4210154741"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Ringer","raw_affiliation_strings":["Clinical Research Pharmacy Coordinating Center Albuquerque VA Medical Center Albuquerque NM United States","1Clinical Research Pharmacy Coordinating Center Albuquerque VA Medical Center Albuquerque NM United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Pharmacy Coordinating Center Albuquerque VA Medical Center Albuquerque NM United States","institution_ids":["https://openalex.org/I4210108867"]},{"raw_affiliation_string":"1Clinical Research Pharmacy Coordinating Center Albuquerque VA Medical Center Albuquerque NM United States","institution_ids":["https://openalex.org/I4210108867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066537554","display_name":"Patricia G. Banks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110978","display_name":"Louis Stokes Cleveland VA Medical Center","ror":"https://ror.org/01vrybr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110978","https://openalex.org/I4210127612"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Banks","raw_affiliation_strings":["Neurology Louis Stokes VA Medical Center Cleveland OH United States","6Neurology Louis Stokes VA Medical Center Cleveland OH United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Louis Stokes VA Medical Center Cleveland OH United States","institution_ids":["https://openalex.org/I4210110978"]},{"raw_affiliation_string":"6Neurology Louis Stokes VA Medical Center Cleveland OH United States","institution_ids":["https://openalex.org/I4210110978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038763207","display_name":"Tamara Paine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802230104","display_name":"Edward Hines, Jr. VA Hospital","ror":"https://ror.org/02223wv31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802230104","https://openalex.org/I4210115976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamara Paine","raw_affiliation_strings":["CSP Coordinating Center Hines VA Hospital Hines IL United States","5CSP Coordinating Center Hines VA Hospital Hines IL United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSP Coordinating Center Hines VA Hospital Hines IL United States","institution_ids":["https://openalex.org/I2802230104"]},{"raw_affiliation_string":"5CSP Coordinating Center Hines VA Hospital Hines IL United States","institution_ids":["https://openalex.org/I2802230104"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049156533","display_name":"Jonathan R. Wolpaw","orcid":"https://orcid.org/0000-0003-0805-1315","observed_orcids":["https://orcid.org/0000-0003-0805-1315"]},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Wolpaw","raw_affiliation_strings":["Wadsworth Ctr/ NY State Dept of Health Albany NY United States","9Wadsworth Ctr/ NY State Dept of Health Albany NY United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wadsworth Ctr/ NY State Dept of Health Albany NY United States","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"raw_affiliation_string":"9Wadsworth Ctr/ NY State Dept of Health Albany NY United States","institution_ids":["https://openalex.org/I1298060332"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06833003,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"10_supplement","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12207","display_name":"Assistive Technology in Communication and Mobility","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/3609","display_name":"Occupational Therapy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11707","display_name":"Gaze Tracking and Assistive Technology","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1709","display_name":"Human-Computer Interaction"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/study-enrollment","display_name":"study enrollment","score":0.6510000228881836},{"id":"https://openalex.org/keywords/subject-retention","display_name":"subject retention","score":0.7400000095367432},{"id":"https://openalex.org/keywords/protocol-adherence","display_name":"protocol adherence","score":0.9869999885559082},{"id":"https://openalex.org/keywords/veterans","display_name":"veterans","score":0.5230000019073486},{"id":"https://openalex.org/keywords/home-based-research","display_name":"home-based research","score":0.5550000071525574},{"id":"https://openalex.org/keywords/caregiver-availability","display_name":"caregiver availability","score":0.4519999921321869},{"id":"https://openalex.org/keywords/protocol-deviations","display_name":"protocol deviations","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C173201364","wikidata":"https://www.wikidata.org/wiki/Q897410","display_name":"Brain\u2013computer interface","level":3,"score":0.9322342872619629},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.639541745185852},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.5006616115570068},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.4411288797855377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37148571014404297},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3667839765548706},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3545413315296173},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3237610459327698},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.26698893308639526},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.14478132128715515},{"id":"https://openalex.org/C129307140","wikidata":"https://www.wikidata.org/wiki/Q6795880","display_name":"Maximum bubble pressure method","level":3,"score":0.0},{"id":"https://openalex.org/C157915830","wikidata":"https://www.wikidata.org/wiki/Q2928001","display_name":"Bubble","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.82.10_supplement.p4.086","doi":"https://doi.org/10.1212/wnl.82.10_supplement.p4.086","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1212/wnl.82.10_supplement.p4.086","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2810837951","https://openalex.org/W2034168596","https://openalex.org/W2119206024","https://openalex.org/W2074143647","https://openalex.org/W4406266796","https://openalex.org/W2902309040","https://openalex.org/W1980310825","https://openalex.org/W4298366170","https://openalex.org/W2742781500","https://openalex.org/W2112050930"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"describe":[2],"study":[3,133,175,235],"enrollment,":[4],"retention,":[5],"and":[6,22,49,72,77,101,106,153,157,193,206,269,294],"adherence.":[7,24],"BACKGROUND:":[8],"Patients":[9,40],"with":[10,47,60,238,250,286],"advanced":[11,239,252,287],"ALS":[12,48,61,288],"are":[13,289,297],"rarely":[14],"studied":[15],"due":[16,203,208,225,276],"to":[17,29,90,97,102,204,209,227,244,260,277],"difficulties":[18],"in":[19,41,122,173],"recruitment,":[20],"retention":[21,293],"protocol":[23,218,295],"We":[25,57],"recruited":[26],"such":[27],"patients":[28,237,249,256],"test":[30],"independent":[31],"home":[32,86,123],"use":[33],"of":[34,45,191,236,248,284],"a":[35,74,78,112],"novel":[36],"EEG-based":[37],"BCI.":[38],"DESIGN/METHODS:":[39],"the":[42,50,92,99,104,131,150,159,164,174],"National":[43],"Registry":[44],"Veterans":[46],"investigators\u2019":[51],"clinics":[52],"were":[53,88,120,140,143,200,221,271],"sent":[54],"an":[55],"advertisement.":[56],"consented":[58],"veterans":[59],"who:":[62],"had":[63,73,149],"lost":[64],"verbal":[65],"or":[66,213,229,263,274,279],"written":[67],"communication;":[68],"could":[69],"communicate":[70],"yes/no;":[71],"significant":[75,210],"other":[76],"BCI":[79,95,151],"system":[80],"operator":[81],"(SO).":[82],"Following":[83],"consent,":[84],"2-6":[85],"visits":[87,124,199,224,270],"conducted":[89],"screen":[91],"subject":[93,105,292],"for":[94,183,246],"ability,":[96],"install":[98],"BCI,":[100],"train":[103],"SO.":[107],"The":[108],"subjects":[109,166],"then":[110],"entered":[111,158],"12-18":[113,179],"month":[114],"data-collection":[115,160],"phase":[116],"during":[117],"which":[118],"outcomes":[119],"measured":[121],"every":[125],"3":[126],"months.":[127],"RESULTS:":[128],"Enrollment:":[129],"Across":[130],"5":[132],"sites":[134],"over":[135],"8":[136],"months,":[137],"42":[138],"people":[139,285],"consented,":[141],"37(88%)":[142],"screened,":[144],"29(69%)":[145],"passed":[146],"screening,":[147],"28(67%)":[148],"installed,":[152],"20(48%)":[154],"completed":[155],"training":[156],"phase.":[161],"Retention:":[162],"Of":[163,216],"20":[165],"who":[167],"began":[168],"data":[169,261],"collection,":[170],"9(45%)":[171],"remained":[172],"at":[176],"its":[177,267],"conclusion":[178],"months":[180],"later.":[181],"Reasons":[182],"dropout":[184],"included":[185],"death,":[186],"rapidly":[187],"progressing":[188],"illness,":[189],"lack":[190],"interest,":[192],"SO":[194,214,230,280],"unavailability.":[195,215,231,281],"Adherence:":[196],"24":[197],"3-month":[198,223],"missed,":[201],"16(67%)":[202],"illness":[205,228,278],"6(25%)":[207],"other,":[211],"caregiver,":[212],"23":[217],"deviations,":[219],"19(83%)":[220],"delayed":[222,275],"mainly":[226],"CONCLUSIONS:":[232],"In":[233],"this":[234],"ALS,":[240],"enrollment":[241],"was":[242],"comparable":[243],"that":[245],"studies":[247,283],"less":[251],"disease.":[253],"However,":[254],"many":[255],"did":[257],"not":[258],"progress":[259],"collection":[262],"dropped":[264],"out":[265],"before":[266],"completion,":[268],"often":[272],"missed":[273],"Chronic":[282],"possible,":[290],"but":[291],"adherence":[296],"challenging.":[298]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}