{"id":"https://openalex.org/W1732419787","doi":"https://doi.org/10.1378/chest.14-2546","title":"Prostacyclin and Oral Vasodilator Therapy in Sarcoidosis-Associated Pulmonary Hypertension","display_name":"Prostacyclin and Oral Vasodilator Therapy in Sarcoidosis-Associated Pulmonary Hypertension","publication_year":2015,"publication_date":"2015-10-01","ids":{"openalex":"https://openalex.org/W1732419787","doi":"https://doi.org/10.1378/chest.14-2546","mag":"1732419787","pmid":"https://pubmed.ncbi.nlm.nih.gov/26437815","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4594624"},"language":"en","primary_location":{"id":"doi:10.1378/chest.14-2546","doi":"https://doi.org/10.1378/chest.14-2546","is_oa":true,"landing_page_url":"https://doi.org/10.1378/chest.14-2546","pdf_url":"http://journal.chestnet.org/article/S001236921550295X/pdf","source":{"id":"https://openalex.org/S76900504","display_name":"CHEST Journal","issn_l":"0012-3692","issn":["0012-3692","1931-3543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://journal.chestnet.org/article/S001236921550295X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017089109","display_name":"Catherine A. Bonham","orcid":"https://orcid.org/0000-0001-9132-4083","observed_orcids":["https://orcid.org/0000-0001-9132-4083"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Catherine A. Bonham","raw_affiliation_strings":["Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL. Electronic address: catherine.bonham@uchospitals.edu","Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL. Electronic address: catherine.bonham@uchospitals.edu","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009091055","display_name":"Justin M. Oldham","orcid":"https://orcid.org/0000-0003-4957-8869","observed_orcids":["https://orcid.org/0000-0003-4957-8869"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin M. Oldham","raw_affiliation_strings":["Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035496455","display_name":"Mardi Gomberg\u2010Maitland","orcid":"https://orcid.org/0000-0003-0482-4560","observed_orcids":["https://orcid.org/0000-0003-0482-4560"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mardi Gomberg-Maitland","raw_affiliation_strings":["Section of Cardiology, University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardiology, University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019589703","display_name":"Rekha Vij","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rekha Vij","raw_affiliation_strings":["Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017089109"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":4160,"currency":"USD","value_usd":4160},"apc_paid":null,"fwci":6.8557,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.97314278,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"148","issue":"4","first_page":"1055","last_page":"1062"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcoidosis-associated-pulmonary-hypertension","display_name":"sarcoidosis-associated pulmonary hypertension","score":0.9350000023841858},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.8209999799728394},{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.8560000061988831},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5960000157356262},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.6060000061988831},{"id":"https://openalex.org/keywords/pulmonary-vascular-resistance","display_name":"pulmonary vascular resistance","score":0.753000020980835},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.6629999876022339},{"id":"https://openalex.org/keywords/n-terminal-pro-b-type-natriuretic-peptide","display_name":"N-terminal pro-brain natriuretic peptide","score":0.9049999713897705},{"id":"https://openalex.org/keywords/functional-class","display_name":"functional class","score":0.5709999799728394},{"id":"https://openalex.org/keywords/oxygen-demand","display_name":"oxygen requirement","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.917681097984314},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.7091363668441772},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.6195157766342163},{"id":"https://openalex.org/C2781301800","wikidata":"https://www.wikidata.org/wiki/Q193894","display_name":"Sarcoidosis","level":2,"score":0.5985207557678223},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5495520830154419},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5494588613510132},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5161727070808411},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.49127835035324097},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.424148291349411},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.38029494881629944}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011669","descriptor_name":"Pulmonary Wedge Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017565","descriptor_name":"Sarcoidosis, Pulmonary","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D017565","descriptor_name":"Sarcoidosis, Pulmonary","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1378/chest.14-2546","doi":"https://doi.org/10.1378/chest.14-2546","is_oa":true,"landing_page_url":"https://doi.org/10.1378/chest.14-2546","pdf_url":"http://journal.chestnet.org/article/S001236921550295X/pdf","source":{"id":"https://openalex.org/S76900504","display_name":"CHEST Journal","issn_l":"0012-3692","issn":["0012-3692","1931-3543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4000088","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4594624","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4594624","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4594624","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"Text"},{"id":"pmid:26437815","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26437815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1378/chest.14-2546","doi":"https://doi.org/10.1378/chest.14-2546","is_oa":true,"landing_page_url":"https://doi.org/10.1378/chest.14-2546","pdf_url":"http://journal.chestnet.org/article/S001236921550295X/pdf","source":{"id":"https://openalex.org/S76900504","display_name":"CHEST Journal","issn_l":"0012-3692","issn":["0012-3692","1931-3543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8799999952316284}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G9000873713","display_name":"Research training in respiratory biology","funder_award_id":"T32HL007605","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1732419787.pdf","grobid_xml":"https://content.openalex.org/works/W1732419787.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1564936805","https://openalex.org/W1571127508","https://openalex.org/W1572586951","https://openalex.org/W1963720544","https://openalex.org/W1972784084","https://openalex.org/W1988814005","https://openalex.org/W2048492291","https://openalex.org/W2095934572","https://openalex.org/W2097131961","https://openalex.org/W2100211265","https://openalex.org/W2104130883","https://openalex.org/W2106521635","https://openalex.org/W2125096444","https://openalex.org/W2132971674","https://openalex.org/W2135546982","https://openalex.org/W2161483623","https://openalex.org/W2167735678","https://openalex.org/W2183644045","https://openalex.org/W2330481161","https://openalex.org/W2465401158","https://openalex.org/W2582602949","https://openalex.org/W4210995779"],"related_works":["https://openalex.org/W7161552576","https://openalex.org/W7161546509","https://openalex.org/W1572586951","https://openalex.org/W4379600337","https://openalex.org/W4387981459","https://openalex.org/W2132971674","https://openalex.org/W2560351435","https://openalex.org/W2125096444","https://openalex.org/W2130339381","https://openalex.org/W3046314330"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}