{"id":"https://openalex.org/W173196971","doi":null,"title":"Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats.","display_name":"Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats.","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W173196971","mag":"173196971","pmid":"https://pubmed.ncbi.nlm.nih.gov/11749824"},"language":"en","primary_location":{"id":"pmid:11749824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11749824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Z Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Z Chen","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310031, China. chenzfl@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310031, China. chenzfl@hotmail.com","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063877153","display_name":"J Q Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Q Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069544817","display_name":"Chiaki KAMEI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Kamei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4676,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.58229744,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"22","issue":"7","first_page":"609","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.701200008392334,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.701200008392334,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.09529999643564224,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.06769999861717224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histamine-h1-receptor-antagonists","display_name":"histamine H1 receptor antagonists","score":0.953000009059906},{"id":"https://openalex.org/keywords/histamine-h1-receptor","display_name":"histamine H1 receptor","score":0.9399999976158142},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.9890000224113464},{"id":"https://openalex.org/keywords/8-arm-radial-maze","display_name":"8-arm radial maze","score":0.9049999713897705},{"id":"https://openalex.org/keywords/diphenhydramine","display_name":"diphenhydramine","score":0.9660000205039978},{"id":"https://openalex.org/keywords/mepyramine","display_name":"mepyramine","score":1.0},{"id":"https://openalex.org/keywords/epinastine","display_name":"epinastine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tacrine","display_name":"tacrine","score":0.996999979019165},{"id":"https://openalex.org/keywords/memory-retrieval","display_name":"memory retrieval","score":0.7639999985694885},{"id":"https://openalex.org/keywords/memory-acquisition","display_name":"memory acquisition","score":0.75},{"id":"https://openalex.org/keywords/cholinergic-neurons","display_name":"cholinergic neurons","score":0.7730000019073486},{"id":"https://openalex.org/keywords/histaminergic-neurons","display_name":"histaminergic neurons","score":0.8859999775886536},{"id":"https://openalex.org/keywords/spatial-cognition","display_name":"spatial cognition","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C2910759140","wikidata":"https://www.wikidata.org/wiki/Q3800087","display_name":"Pyrilamine","level":4,"score":0.9380244016647339},{"id":"https://openalex.org/C2778501154","wikidata":"https://www.wikidata.org/wiki/Q18349602","display_name":"Histaminergic","level":3,"score":0.8030624985694885},{"id":"https://openalex.org/C2781292560","wikidata":"https://www.wikidata.org/wiki/Q413486","display_name":"Diphenhydramine","level":3,"score":0.7617521286010742},{"id":"https://openalex.org/C13260007","wikidata":"https://www.wikidata.org/wiki/Q3825159","display_name":"Radial arm maze","level":4,"score":0.7126631736755371},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6152253150939941},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.5956363677978516},{"id":"https://openalex.org/C10335311","wikidata":"https://www.wikidata.org/wiki/Q309513","display_name":"Histamine H1 receptor","level":4,"score":0.5326558947563171},{"id":"https://openalex.org/C2779046751","wikidata":"https://www.wikidata.org/wiki/Q421076","display_name":"Tacrine","level":4,"score":0.49171096086502075},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4683498740196228},{"id":"https://openalex.org/C12515866","wikidata":"https://www.wikidata.org/wiki/Q50628021","display_name":"Water maze","level":3,"score":0.43476712703704834},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.42585843801498413},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3990212380886078},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3856663405895233},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3801374137401581},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37003999948501587},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.3229370713233948},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.2885585427284241},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2712213695049286},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21173545718193054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20720142126083374},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.16835254430770874},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08332926034927368},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003984","descriptor_name":"Dibenzazepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004155","descriptor_name":"Diphenhydramine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011738","descriptor_name":"Pyrilamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013619","descriptor_name":"Tacrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11749824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11749824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},{"id":"mag:173196971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11749824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1992064256","https://openalex.org/W2011052352","https://openalex.org/W2027022044","https://openalex.org/W2093249454","https://openalex.org/W2018806705","https://openalex.org/W2181511342","https://openalex.org/W3150653407","https://openalex.org/W2410342942","https://openalex.org/W1969968401","https://openalex.org/W2089478373"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"evaluate":[2],"effects":[3],"of":[4,15,33,50,68,98],"certain":[5,124],"H1-antagonists":[6],"on":[7,87],"spatial":[8,26,127],"memory":[9,27,45,57,92,102],"with":[10],"8-arm":[11],"radial":[12,19,51],"maze":[13,20,52],"performance":[14,21],"rats.":[16,29],"METHODS:":[17],"Eight-arm":[18],"was":[22,60,113],"used":[23],"to":[24,135],"measure":[25],"in":[28,126],"RESULTS:":[30],"Chronic":[31],"treatments":[32],"classical":[34],"H1-antagonists,":[35],"diphenhydramine":[36,69,106],"(5":[37],"mg/kg)":[38,42,72,108,112],"and":[39,73,90,129,138],"pyrilamine":[40,74,110],"(20":[41],"impaired":[43,62],"acquisition":[44,89],"process":[46,59],"regarding":[47],"both":[48,88,136],"parameters":[49],"performance.":[53],"In":[54],"addition,":[55],"the":[56,78],"retrieval":[58,91],"also":[61],"significantly":[63],"by":[64,105,115],"a":[65,95,123],"single":[66],"administration":[67],"(5,":[70],"10":[71],"(50":[75,111],"mg/kg).":[76,118],"However,":[77],"newly":[79],"developed":[80],"H1-antagonist,":[81],"epinastine":[82],"caused":[83],"no":[84],"appreciable":[85],"effect":[86],"even":[93],"at":[94],"high":[96],"dose":[97],"50":[99],"mg/kg.":[100],"The":[101],"deficit":[103],"induced":[104],"(10":[107],"or":[109],"reversed":[114],"tacrine":[116],"(1":[117],"CONCLUSION:":[119],"Histamine":[120],"H(1)-receptors":[121],"plays":[122],"role":[125],"cognition,":[128],"its":[130],"action":[131],"may":[132],"be":[133],"due":[134],"histaminergic":[137],"cholinergic":[139],"neurons.":[140]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
