{"id":"https://openalex.org/W172931916","doi":null,"title":"The Wnt pathway in ventral midbrain dopaminergic differentiation","display_name":"The Wnt pathway in ventral midbrain dopaminergic differentiation","publication_year":2010,"publication_date":"2010-12-17","ids":{"openalex":"https://openalex.org/W172931916","mag":"172931916"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26915662","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/The_Wnt_pathway_in_ventral_midbrain_dopaminergic_differentiation/26915662","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/40397","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007590218","display_name":"Diogo Ribeiro","orcid":"https://orcid.org/0000-0003-4400-8752","observed_orcids":["https://orcid.org/0000-0003-4400-8752"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Diogo Ribeiro","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4400-8752","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5007590218"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.4059999883174896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.4059999883174896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.21279999613761902,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.1665000021457672,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.7799999713897705},{"id":"https://openalex.org/keywords/ventral-midbrain","display_name":"ventral midbrain","score":0.7870000004768372},{"id":"https://openalex.org/keywords/dopaminergic-neuron-differentiation","display_name":"dopaminergic neuron differentiation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cell-replacement-therapy","display_name":"cell replacement therapy","score":0.7620000243186951},{"id":"https://openalex.org/keywords/wnt1","display_name":"Wnt1","score":0.8999999761581421},{"id":"https://openalex.org/keywords/lrp6","display_name":"LRP6","score":0.8799999952316284},{"id":"https://openalex.org/keywords/dkk1","display_name":"DKK1","score":0.8309999704360962},{"id":"https://openalex.org/keywords/wnt5a","display_name":"Wnt5a","score":0.9340000152587891},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.5400000214576721},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.44699999690055847},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.46399998664855957},{"id":"https://openalex.org/keywords/wnt-inhibitors","display_name":"Wnt inhibitors","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.8187216520309448},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.746035099029541},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5966144800186157},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5218738317489624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3964206576347351},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2992401719093323},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.26472336053848267},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.10403695702552795},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.08577841520309448}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26915662","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/The_Wnt_pathway_in_ventral_midbrain_dopaminergic_differentiation/26915662","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/40397","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/40397","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:172931916","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/handle/10616/40397","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/40397","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/40397","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1504655784","https://openalex.org/W1557541313","https://openalex.org/W1956332901","https://openalex.org/W1980020952","https://openalex.org/W1981437331","https://openalex.org/W1989194294","https://openalex.org/W1992865216","https://openalex.org/W1996984755","https://openalex.org/W2000572318","https://openalex.org/W2001992345","https://openalex.org/W2003028861","https://openalex.org/W2006046941","https://openalex.org/W2013548303","https://openalex.org/W2015602170","https://openalex.org/W2016488651","https://openalex.org/W2017668082","https://openalex.org/W2029042594","https://openalex.org/W2032924726","https://openalex.org/W2033291406","https://openalex.org/W2049859215","https://openalex.org/W2055557491","https://openalex.org/W2069693786","https://openalex.org/W2072335762","https://openalex.org/W2074210550","https://openalex.org/W2084275797","https://openalex.org/W2088327864","https://openalex.org/W2098067206","https://openalex.org/W2104793567","https://openalex.org/W2105688544","https://openalex.org/W2107499423","https://openalex.org/W2111334408","https://openalex.org/W2147015050","https://openalex.org/W2148512749","https://openalex.org/W2150589615","https://openalex.org/W2160933724","https://openalex.org/W2163170981","https://openalex.org/W2165781463","https://openalex.org/W2396242620","https://openalex.org/W2403316467"],"related_works":["https://openalex.org/W200372685","https://openalex.org/W2110212502","https://openalex.org/W1728508026","https://openalex.org/W2029115771","https://openalex.org/W2100519706","https://openalex.org/W1953170715","https://openalex.org/W2557539891","https://openalex.org/W3097779974","https://openalex.org/W2170404941","https://openalex.org/W2124161026"],"abstract_inverted_index":{"Parkinson\u2019s":[0],"disease":[1,7,32],"(PD)":[2],"is":[3,357,426,456],"a":[4,39,73,96,216,308,342,349,405,410,427,493,524,536,577,585,616,711,750],"debilitating":[5],"neurodegenerative":[6],"in":[8,13,62,185,191,219,226,248,256,269,287,348,393,398,420,429,448,458,478,496,513,539,549,589,596,643,706,714,730,740,748,785,816,854],"which":[9,108,147,416,698],"dopaminergic":[10,89,851,886],"(DA)":[11,90],"neurons":[12,54,91,113,485,544,568,629,719],"the":[14,31,36,45,60,66,120,123,140,164,172,231,239,242,251,262,265,281,284,296,300,324,361,389,421,434,444,459,464,479,497,540,550,554,602,620,644,715,727,737],"substantia":[15],"nigra":[16],"are":[17,27,57,71],"lost.":[18],"Current":[19],"treatments":[20],"such":[21,178,203,381],"as":[22,156,179,204,382],"administration":[23],"of":[24,83,98,111,122,152,163,174,230,241,253,264,283,338,378,391,401,413,423,446,466,481,499,542,553,587,601,604,622,627,646,691,696,717,723,736,753,764,788,920],"levodopa":[25],"(L-DOPA)":[26],"initially":[28],"effective":[29],"but":[30],"eventually":[33],"progresses,":[34],"highlighting":[35],"need":[37],"for":[38,154,610,649,760],"treatment":[40],"that":[41,128,318,353,366,454,618,664],"restores":[42],"and":[43,117,125,143,183,190,210,224,246,250,273,331,365,409,484,504,516,545,575,593,624,652,683,688,747,756,762,777,780,803,813,846,879,888,913,918],"maintains":[44],"otherwise":[46],"lost":[47,67],"functions.":[48],"Cell-replacement":[49],"therapy":[50],"(CRT),":[51],"where":[52],"DA":[53,69,112,130,187,194,220,243,254,271,288,310,332,355,371,395,414,430,449,467,482,500,502,525,543,567,591,628,659,679,692,704,718,741,754],"and/or":[55],"precursors":[56,255,505],"grafted":[58],"into":[59,103,119],"striatum":[61],"order":[63,77,597],"to":[64,78,150,234,259,305,369,387,441,463,598,637,654,656,674,686,702],"restore":[65],"striatal":[68],"transmission,":[70],"considered":[72],"promising":[74],"treatment.":[75],"In":[76,133,166,469,725],"implement":[79],"CRT,":[80,611],"large":[81,623,687],"numbers":[82,110,626,690,716],"correctly":[84],"specified":[85],"ventral":[86,518,884,922],"midbrain":[87,222,232,407,519,885,923],"(VM)":[88],"should":[92],"be":[93,115,151,235,374,635,670,774],"obtained.":[94],"Therefore,":[95],"lot":[97],"effort":[99],"has":[100,699],"been":[101,277,700],"put":[102],"identifying":[104],"cell":[105,193,205,514,783],"sources":[106],"from":[107,334,630,743],"high":[109],"can":[114,373,669,773],"generated":[116],"also":[118,709],"study":[121],"intrinsic":[124],"extrinsic":[126],"factors":[127,380,648],"regulate":[129],"neuron":[131,188,396,431,852],"development.":[132,450],"our":[134],"lab,":[135],"we":[136,148,169,439,472,532,612],"have":[137,170,613],"focused":[138],"on":[139],"Wnt":[141,175,197,266,343],"pathway":[142,176,198,286,364,739],"its":[144,227],"extracellular":[145],"modulators":[146],"believe":[149,770],"value":[153],"CRT":[155],"it":[157],"does":[158],"not":[159,276,474,507],"imply":[160],"genetic":[161],"modification":[162],"cells.":[165,639,768,926],"this":[167,260,346,731,771],"thesis,":[168,261],"investigated":[171],"role":[173,218,263,282,390,445,586],"components":[177],"Wnt1,":[180],"Wnt5a,":[181,697],"Lrp6":[182,268,301,392,424,855],"Dkk1":[184,447,455,588,882],"VM":[186,221,270,309,394,460,590,608,632,667,678,767],"development":[189,272,397],"stem":[192,292,745,782,925],"differentiation.":[195,432],"The":[196,212],"regulates":[199,883],"several":[200,707],"important":[201],"processes":[202],"proliferation,":[206],"fate":[207],"determination,":[208],"differentiation":[209,247,333,356,372,412,527,592,705,742,755,763,853,887,919],"patterning.":[211],"ligand":[213,298,325],"Wnt1":[214,237,297],"plays":[215],"crucial":[217],"patterning":[223,408],"specification:":[225],"absence":[228,422],"most":[229],"fails":[233],"formed;":[236],"promotes":[238],"specification":[240,274],"progenitor":[244],"domain":[245],"vivo,":[249,749],"proliferation":[252],"vitro.":[257],"Prior":[258],"receptor":[267,302,327],"had":[275,576],"elucidated.":[278],"To":[279],"determine":[280],"Wnt/\u03b2-catenin":[285,321,738],"specification,":[289],"mouse":[290,631],"embryonic":[291,744],"cells":[293,609,633,668,746],"(mESC)":[294],"lacking":[295],"or":[299,326,564],"were":[303,506,510,521,572,641],"induced":[304,653],"differentiate":[306,655],"towards":[307],"phenotype":[311],"using":[312,605],"established":[313],"protocols.":[314],"Our":[315,451,661],"results":[316,435,452,583,662,728],"revealed":[317,404,453,561],"an":[319,546,757],"impaired":[320],"pathway,":[322],"at":[323,486,489,559],"level,":[328],"improved":[329,358],"neurogenesis":[330],"mESC,":[335,438],"Moreover,":[336,694],"addition":[337,377,695],"Dickkopf":[339],"1":[340],"(Dkk1),":[341],"inhibitor,":[344],"mimicked":[345],"effect":[347],"mESC":[350],"line,":[351],"confirming":[352],"mESC-derived":[354],"by":[359,376],"impairing":[360],"Wnt/\u03b2-":[362],"catenin":[363],"current":[367,779],"protocols":[368],"induce":[370],"enhanced":[375],"soluble":[379],"Dkk1.":[383],"We":[384,769],"next":[385],"sought":[386],"investigate":[388],"vivo.":[399],"Analysis":[400,552],"Lrp6-/-":[402],"embryos":[403,558],"normal":[406],"decreased":[411],"neurons,":[415],"later":[417,530],"recovered.":[418],"Thus,":[419],"there":[425,491,509],"delay":[428],"Given":[433],"obtained":[436],"with":[437],"decided":[440],"further":[442],"assess":[443,657],"expressed":[457],"just":[461],"prior":[462],"onset":[465],"neurogenesis.":[468],"Dkk1+/-":[470],"mice":[471],"could":[473,533,634],"detect":[475,535],"any":[476],"changes":[477],"number":[480,498,541],"progenitors":[483,503],"E11.5.":[487],"However,":[488],"E13.5":[490],"was":[492],"significant":[494,712],"reduction":[495,538],"neurons.":[501,693],"affected,":[508],"no":[511],"differences":[512],"death":[515],"other":[517],"populations":[520],"unchanged,":[522],"suggesting":[523],"specific":[526],"impairment.":[528],"At":[529],"stages,":[531],"still":[534],"30%":[537],"abnormal":[547],"distribution":[548],"VM.":[551],"few":[555,563],"surviving":[556],"Dkk1-/-":[557],"E17.5":[560],"very":[562,578],"almost":[565],"absent":[566],"which,":[569],"when":[570],"present,":[571],"abnormally":[573],"distributed":[574],"immature":[579],"morphology.":[580],"Together,":[581],"these":[582],"suggest":[584],"morphogenesis.":[594,889],"Finally,":[595],"address":[599],"some":[600],"limitations":[603],"human":[606,638,665,765,921],"fetal":[607,666,766],"evaluated":[614],"whether":[615],"protocol":[617,759],"allows":[619],"generation":[621],"functional":[625],"applied":[636,776],"Cells":[640],"expanded":[642,672],"presence":[645],"DA-appropriate":[647],"2":[650,673,721],"weeks":[651,722],"their":[658,677],"potential.":[660],"show":[663],"successfully":[671,775],"3-fold,":[675],"retain":[676],"identity":[680],"during":[681],"expansion":[682,761,917],"give":[684],"rise":[685],"increasing":[689],"shown":[701],"promote":[703],"systems,":[708],"promoted":[710],"increase":[713],"after":[720],"expansion.":[724],"sum,":[726],"presented":[729],"thesis":[732],"describe":[733],"new":[734],"functions":[735],"novel":[751],"regulator":[752],"efficient":[758],"knowledge":[772],"improve":[778],"future":[781],"therapies":[784],"PD.":[786],"List":[787],"scientific":[789],"papers":[790],"I.":[791],"Caj\u00e1nek,":[792],"L.,":[793,800],"Ribeiro,":[794,836,865,896],"D.,":[795,837],"Liste,":[796],"I.,":[797],"Parish,":[798,904],"C.":[799],"Bryja,":[801],"V.":[802],"Arenas,":[804,847],"E.":[805,829,848],"(2009)":[806],"Wnt/\u03b2-Catenin":[807],"Signaling":[808],"Blockade":[809],"Promotes":[810],"Neuronal":[811],"Induction":[812],"Dopaminergic":[814],"Differentiation":[815],"Embryonic":[817],"Stem":[818,820],"Cells.":[819,821],"27:":[822],"2917\u20132927.":[823],"https://doi.org/10.1002/stem.210":[824],"II.":[825],"Castelo-Branco,":[826],"G.,":[827],"Andersson,":[828],"R.,":[830],"Minina,":[831],"E.,":[832],"Sousa,":[833],"K.":[834],"M.,":[835],"Kokubu,":[838],"C.,":[839],"Imai,":[840],"K.,":[841],"Prakash,":[842],"N.,":[843],"Wurst,":[844],"W.":[845],"(2010)":[849],"Delayed":[850],"mutant":[856],"mice.":[857],"Developmental":[858],"Dynamics.":[859],"239:":[860],"211\u2013221.":[861],"https://doi.org/10.1002/dvdy.22094":[862],"III.":[863],"Diogo":[864,895],"Kristina":[866],"Ellwanger,":[867],"D\u00e9sir\u00e9e":[868],"Glagow,":[869],"Spyridon":[870],"Theofilopoulos,":[871],"Nina":[872],"S.":[873],"Corsini,":[874],"Ana":[875],"Martin-Villalba,":[876],"Christof":[877],"Niehrs":[878],"Ernest":[880,914],"Arenas.":[881,915],"PLoS":[890],"ONE.":[891],"[Accepted]":[892],"https://pubmed.ncbi.nlm.nih.gov/21347250":[893],"IV.":[894],"Rocio":[897],"Laguna":[898],"Goya,":[899],"Tobias":[900],"Piroth,":[901],"Clare":[902],"L.":[903],"Malin":[905],"Parmar,":[906],"Olle":[907],"Lindvall,":[908],"Guido":[909],"Nikkhah,":[910],"Roger":[911],"Barker":[912],"Efficient":[916],"neural":[924],"[Manuscript]":[927]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}
