{"id":"https://openalex.org/W17291072","doi":null,"title":"Retroactivity to the Output of Transcription Devices: Quantification and Insulation.","display_name":"Retroactivity to the Output of Transcription Devices: Quantification and Insulation.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W17291072","mag":"17291072"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/95939","doi":null,"is_oa":false,"landing_page_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/95939/1/jayanthi_1.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S Jayanthi","orcid":"https://orcid.org/0000-0002-4292-3247","observed_orcids":["https://orcid.org/0000-0002-4292-3247"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S Jayanthi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4292-3247","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retroactivity","display_name":"retroactivity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/transcriptional-circuits","display_name":"transcriptional circuits","score":0.5260000228881836},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"synthetic biology","score":0.5509999990463257},{"id":"https://openalex.org/keywords/modularity","display_name":"modularity","score":0.7400000095367432},{"id":"https://openalex.org/keywords/hierarchical-design","display_name":"hierarchical design","score":0.7559999823570251},{"id":"https://openalex.org/keywords/disturbance-rejection","display_name":"disturbance rejection","score":0.878000020980835},{"id":"https://openalex.org/keywords/singular-perturbation","display_name":"singular perturbation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/biomolecular-circuits","display_name":"biomolecular circuits","score":0.5680000185966492},{"id":"https://openalex.org/keywords/dynamic-response","display_name":"dynamic response","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5240191221237183},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.3711856007575989},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3544154167175293},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.3417453169822693},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.3213258385658264},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.08415564894676208},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.07942944765090942}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/95939","doi":null,"is_oa":false,"landing_page_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/95939/1/jayanthi_1.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:17291072","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/bitstream/handle/2027.42/95939/jayanthi_1.pdf;sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W111213550","https://openalex.org/W598088444","https://openalex.org/W1492571996","https://openalex.org/W1498806721","https://openalex.org/W1518939299","https://openalex.org/W1526225007","https://openalex.org/W1540505601","https://openalex.org/W1575619134","https://openalex.org/W1593308984","https://openalex.org/W1596321532","https://openalex.org/W1642251103","https://openalex.org/W1816644759","https://openalex.org/W1918334909","https://openalex.org/W1966335196","https://openalex.org/W1970743380","https://openalex.org/W1973655646","https://openalex.org/W1979385177","https://openalex.org/W1980749266","https://openalex.org/W1981556685","https://openalex.org/W1982353649","https://openalex.org/W1983673069","https://openalex.org/W1991163038","https://openalex.org/W1996476332","https://openalex.org/W1996642492","https://openalex.org/W1997522747","https://openalex.org/W2000619385","https://openalex.org/W2003847712","https://openalex.org/W2007090643","https://openalex.org/W2007769474","https://openalex.org/W2008995486","https://openalex.org/W2014150977","https://openalex.org/W2014185980","https://openalex.org/W2016655140","https://openalex.org/W2032446791","https://openalex.org/W2034836218","https://openalex.org/W2037913229","https://openalex.org/W2038750939","https://openalex.org/W2041603328","https://openalex.org/W2041985017","https://openalex.org/W2046451925","https://openalex.org/W2052796757","https://openalex.org/W2060255660","https://openalex.org/W2064483836","https://openalex.org/W2065151746","https://openalex.org/W2068446438","https://openalex.org/W2070658593","https://openalex.org/W2071928210","https://openalex.org/W2077539492","https://openalex.org/W2081697327","https://openalex.org/W2088074649","https://openalex.org/W2099102896","https://openalex.org/W2105627149","https://openalex.org/W2106400237","https://openalex.org/W2108493072","https://openalex.org/W2110823478","https://openalex.org/W2113983551","https://openalex.org/W2114228460","https://openalex.org/W2117136688","https://openalex.org/W2123097315","https://openalex.org/W2128605063","https://openalex.org/W2132405406","https://openalex.org/W2132828256","https://openalex.org/W2133083422","https://openalex.org/W2133274430","https://openalex.org/W2135326887","https://openalex.org/W2136969641","https://openalex.org/W2142478420","https://openalex.org/W2144588155","https://openalex.org/W2152503338","https://openalex.org/W2155418451","https://openalex.org/W2156781574","https://openalex.org/W2164845193","https://openalex.org/W2166499263","https://openalex.org/W2169675068","https://openalex.org/W2186811768","https://openalex.org/W2341171179","https://openalex.org/W2461233813","https://openalex.org/W2528271650","https://openalex.org/W3190309845"],"related_works":["https://openalex.org/W2055956895","https://openalex.org/W4240428376","https://openalex.org/W2065151746","https://openalex.org/W2041886753","https://openalex.org/W2505145105","https://openalex.org/W2009996172","https://openalex.org/W1607323632","https://openalex.org/W2166499263","https://openalex.org/W7093433392","https://openalex.org/W2951937420"],"abstract_inverted_index":{"Traditional":[0],"engineering":[1],"often":[2],"relies":[3],"on":[4,114,121],"hierarchical":[5],"design":[6,91],"techniques":[7],"to":[8,84,98],"build":[9],"com-":[10],"plex":[11],"systems":[12,48],"from":[13],"simpler":[14],"subsystems.":[15],"This":[16],"technique":[17,111],"requires":[18],"modularity,":[19],"a":[20,30,54,78,115],"prop-":[21],"erty":[22],"that":[23,25,49,66],"states":[24],"the":[26,51,90],"input/output":[27],"characteristics":[28],"of":[29,53,92],"system":[31,55,79],"are":[32],"not":[33],"affected":[34],"by":[35],"interconnections.":[36],"In":[37,82],"this":[38],"work":[39],"we":[40,88],"investigate":[41],"retroactivity,":[42],"an":[43],"impedance-like":[44],"effect":[45],"in":[46,68,77,101],"biomolecular":[47],"makes":[50],"behavior":[52],"change":[56],"upon":[57],"intercon-":[58],"nection.":[59],"We":[60],"show,":[61],"through":[62],"analysis":[63],"and":[64,106],"experiments,":[65],"retroactivity":[67,104],"synthetic":[69],"biology":[70],"circuits":[71,86],"is":[72,112],"responsible":[73],"for":[74],"substantial":[75],"changes":[76],"dynamic":[80],"response.":[81],"order":[83],"construct":[85],"modularly,":[87],"propose":[89],"insulation":[93],"de-":[94],"vices,":[95],"which,":[96],"similar":[97],"insulating":[99],"amplifiers":[100],"electronics,":[102],"attenuate":[103],"effects":[105],"recover":[107],"modular":[108],"behavior.":[109],"Our":[110],"based":[113,120],"novel":[116],"disturbance":[117],"attenuation":[118],"approach":[119],"singular":[122],"perturbation":[123],"theory.":[124]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
