{"id":"https://openalex.org/W172888050","doi":null,"title":"Age-induced reduction of autophagy-related gene expression is associated with onset of Alzheimer's disease.","display_name":"Age-induced reduction of autophagy-related gene expression is associated with onset of Alzheimer's disease.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W172888050","mag":"172888050","pmid":"https://pubmed.ncbi.nlm.nih.gov/25628964","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4299720"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3272782","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4299720","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4299720","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070163946","display_name":"Yasuhiro Omata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Omata","raw_affiliation_strings":["Department of Occupational and Environmental Health, Graduate School of Medicine, Nagoya University Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Occupational and Environmental Health, Graduate School of Medicine, Nagoya University Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112271503","display_name":"Young\u2010Mi Lim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Young-Mi Lim","raw_affiliation_strings":["Animal Models of Aging, CAMD, National Center for Geriatrics and Gerontology Obu, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Models of Aging, CAMD, National Center for Geriatrics and Gerontology Obu, Aichi, Japan","institution_ids":["https://openalex.org/I4210160102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046810835","display_name":"Yukihiro Akao","orcid":"https://orcid.org/0000-0001-8902-5367","observed_orcids":["https://orcid.org/0000-0001-8902-5367"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukihiro Akao","raw_affiliation_strings":["United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University Gifu City, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University Gifu City, Gifu, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023779268","display_name":"Leo Tsuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Leo Tsuda","raw_affiliation_strings":["Animal Models of Aging, CAMD, National Center for Geriatrics and Gerontology Obu, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Models of Aging, CAMD, National Center for Geriatrics and Gerontology Obu, Aichi, Japan","institution_ids":["https://openalex.org/I4210160102"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3447,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.75174054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"3","issue":"3","first_page":"134","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.09700000286102295,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.824999988079071},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8949999809265137},{"id":"https://openalex.org/keywords/autophagy-related-gene-expression","display_name":"autophagy-related gene expression","score":0.8960000276565552},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8690000176429749},{"id":"https://openalex.org/keywords/atg1","display_name":"Atg1","score":0.7940000295639038},{"id":"https://openalex.org/keywords/atg8a","display_name":"Atg8a","score":0.9950000047683716},{"id":"https://openalex.org/keywords/atg18","display_name":"Atg18","score":1.0},{"id":"https://openalex.org/keywords/foxo","display_name":"FOXO","score":0.503000020980835},{"id":"https://openalex.org/keywords/sir2","display_name":"Sir2","score":0.9160000085830688},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9399999976158142},{"id":"https://openalex.org/keywords/neuronal-dysfunction","display_name":"neuronal dysfunction","score":0.7870000004768372},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6510000228881836},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.948639988899231},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.6378916501998901},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6258191466331482},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5889791250228882},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5771353244781494},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5522456765174866},{"id":"https://openalex.org/C2779695026","wikidata":"https://www.wikidata.org/wiki/Q4692577","display_name":"Aging brain","level":3,"score":0.5192782878875732},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.5184428691864014},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.466278076171875},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.46611979603767395},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.4511911869049072},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4504649043083191},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43440037965774536},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43411266803741455},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3981550633907318},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2995050251483917},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2839013934135437},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.27559879422187805},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25512757897377014},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24198272824287415},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.17993620038032532}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:3272782","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4299720","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25628964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25628964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of neurodegenerative disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4299720","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4299720/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Neurodegener Dis","raw_type":"Text"},{"id":"mag:172888050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25628964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:2187575087","doi":null,"is_oa":false,"landing_page_url":"http://www.ajnd.us/files/ajnd0002544.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3272782","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4299720","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1812073992","https://openalex.org/W1966825319","https://openalex.org/W1967809393","https://openalex.org/W1970661950","https://openalex.org/W1972567124","https://openalex.org/W1974279922","https://openalex.org/W1979081257","https://openalex.org/W1982397114","https://openalex.org/W1987416014","https://openalex.org/W1990632702","https://openalex.org/W1993902882","https://openalex.org/W2007636825","https://openalex.org/W2013215890","https://openalex.org/W2024782183","https://openalex.org/W2028536701","https://openalex.org/W2029695041","https://openalex.org/W2030664247","https://openalex.org/W2046250764","https://openalex.org/W2046705115","https://openalex.org/W2057035225","https://openalex.org/W2065031087","https://openalex.org/W2066727453","https://openalex.org/W2069097026","https://openalex.org/W2070071706","https://openalex.org/W2071221374","https://openalex.org/W2071841859","https://openalex.org/W2073956836","https://openalex.org/W2075829521","https://openalex.org/W2089230333","https://openalex.org/W2090496922","https://openalex.org/W2096124496","https://openalex.org/W2098845312","https://openalex.org/W2102776209","https://openalex.org/W2107493006","https://openalex.org/W2111607026","https://openalex.org/W2112329697","https://openalex.org/W2120180072","https://openalex.org/W2122770283","https://openalex.org/W2126785953","https://openalex.org/W2127457463","https://openalex.org/W2128655116","https://openalex.org/W2140664473","https://openalex.org/W2147231139","https://openalex.org/W2150168624","https://openalex.org/W2152222652","https://openalex.org/W2153188271","https://openalex.org/W2154315446"],"related_works":["https://openalex.org/W2187575087","https://openalex.org/W6977241352","https://openalex.org/W2075893141","https://openalex.org/W2325456151","https://openalex.org/W1967809393","https://openalex.org/W2006840724","https://openalex.org/W1966825319","https://openalex.org/W3120499196","https://openalex.org/W4312623056","https://openalex.org/W2071462548"],"abstract_inverted_index":{"Aging":[0],"is":[1,20,55,69,139,173],"a":[2,21,59,174],"major":[3],"risk":[4],"factor":[5],"for":[6,33,39],"Alzheimer's":[7],"disease":[8],"(AD).":[9],"Aggregation":[10],"of":[11,23,37,48,52,62,66,91,116,161,171,181],"amyloid":[12],"beta":[13],"(A\u03b2)":[14],"in":[15,77,99,127,177],"cerebral":[16],"cortex":[17],"and":[18,35,50,80,97,123,179],"hippocampus":[19],"hallmark":[22],"AD.":[24,182],"Many":[25],"factors":[26],"have":[27],"been":[28],"identified":[29],"as":[30,106,108],"causative":[31,60,175],"elements":[32],"onset":[34,178],"progression":[36,180],"AD;":[38],"instance,":[40],"tau":[41],"seems":[42],"to":[43,57,75],"mediate":[44],"the":[45,92,114,166],"neuronal":[46,155,159],"toxicity":[47],"A\u03b2,":[49],"downregulation":[51],"macroautophagy":[53],"(autophagy)":[54],"thought":[56],"be":[58],"element":[61,176],"AD":[63],"pathology.":[64],"Expression":[65],"autophagy-related":[67,93,136],"genes":[68,94],"reduced":[70,149],"with":[71,104,129,153],"age,":[72],"which":[73],"leads":[74],"increases":[76],"oxidative":[78],"stress":[79],"aberrant":[81],"protein":[82],"accumulation.":[83],"In":[84,112],"this":[85],"study,":[86],"we":[87],"found":[88,147],"that":[89,134,148,168],"expression":[90,138],"atg1,":[95],"atg8a,":[96],"atg18":[98,117],"Drosophila":[100],"melanogaster":[101],"was":[102,118],"regulated":[103,140],"aging":[105,143],"well":[107],"their":[109],"own":[110],"activities.":[111],"addition,":[113],"level":[115],"maintained":[119],"by":[120,141,158],"dfoxo":[121],"(foxo)":[122],"dsir2":[124],"(sir2)":[125],"activities":[126],"concert":[128],"aging.":[130],"These":[131,163],"results":[132],"indicate":[133],"some":[135],"gene":[137],"foxo/sir2-mediated":[142],"processes.":[144],"We":[145],"further":[146],"autophagy":[150,172],"activity":[151],"correlated":[152],"late-onset":[154],"dysfunction":[156,170],"caused":[157],"induction":[160],"A\u03b2.":[162],"data":[164],"support":[165],"idea":[167],"age-related":[169]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
