{"id":"https://openalex.org/W1727255336","doi":null,"title":"Atrial fibrillation after cardiac surgery : an analysis of risk factors, mechanisms, and survival effects","display_name":"Atrial fibrillation after cardiac surgery : an analysis of risk factors, mechanisms, and survival effects","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W1727255336","mag":"1727255336"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-1798","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1798","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1798","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086893879","display_name":"Giovanni Mariscalco","orcid":"https://orcid.org/0000-0001-8200-2269","observed_orcids":["https://orcid.org/0000-0001-8200-2269"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Giovanni Mariscalco","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8200-2269","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5086893879"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11930","display_name":"Cardiac, Anesthesia and Surgical Outcomes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.875},{"id":"https://openalex.org/keywords/cardiac-surgery","display_name":"cardiac surgery","score":0.7739999890327454},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.75},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.9020000100135803},{"id":"https://openalex.org/keywords/coronary-artery-bypass-grafting","display_name":"coronary artery bypass grafting","score":0.8240000009536743},{"id":"https://openalex.org/keywords/aortic-valve-replacement","display_name":"aortic valve replacement","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.9610000252723694},{"id":"https://openalex.org/keywords/off-pump-coronary-artery-bypass-grafting","display_name":"off-pump coronary artery bypass","score":0.7580000162124634},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.6010000109672546},{"id":"https://openalex.org/keywords/sotalol","display_name":"sotalol","score":0.765999972820282},{"id":"https://openalex.org/keywords/magnesium","display_name":"magnesium","score":0.8399999737739563},{"id":"https://openalex.org/keywords/postoperative-mortality","display_name":"postoperative mortality","score":0.7730000019073486},{"id":"https://openalex.org/keywords/long-term-survival","display_name":"long-term survival","score":0.703000009059906},{"id":"https://openalex.org/keywords/atrial-appendage","display_name":"atrial appendage","score":0.48899999260902405},{"id":"https://openalex.org/keywords/arrhythmia-mechanisms","display_name":"arrhythmia mechanisms","score":0.48399999737739563},{"id":"https://openalex.org/keywords/valvular-heart-disease","display_name":"valvular heart disease","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.7304294109344482},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.700628399848938},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5530279874801636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49980759620666504},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4122801125049591},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3757465183734894}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:DiVA.org:umu-1798","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1798","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:iris.unige.it:11567/926694","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11567/926694","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/book"},{"id":"mag:1727255336","doi":null,"is_oa":false,"landing_page_url":"http://umu.diva-portal.org/smash/get/diva2:142003/FULLTEXT01","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-1798","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1798","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":122,"referenced_works":["https://openalex.org/W21128474","https://openalex.org/W58578392","https://openalex.org/W68599434","https://openalex.org/W101547108","https://openalex.org/W158951522","https://openalex.org/W202227821","https://openalex.org/W203128385","https://openalex.org/W1496713467","https://openalex.org/W1758071420","https://openalex.org/W1965429601","https://openalex.org/W1966715154","https://openalex.org/W1971199131","https://openalex.org/W1974271755","https://openalex.org/W1976921482","https://openalex.org/W1976940506","https://openalex.org/W1980051680","https://openalex.org/W1987382099","https://openalex.org/W1988838208","https://openalex.org/W1988992598","https://openalex.org/W1990240357","https://openalex.org/W1990596490","https://openalex.org/W1990657636","https://openalex.org/W1991627898","https://openalex.org/W1993042579","https://openalex.org/W1994401913","https://openalex.org/W1995031715","https://openalex.org/W1995361007","https://openalex.org/W1996226626","https://openalex.org/W1996835220","https://openalex.org/W2001021177","https://openalex.org/W2004137064","https://openalex.org/W2004510000","https://openalex.org/W2005785764","https://openalex.org/W2008972555","https://openalex.org/W2011940469","https://openalex.org/W2013296985","https://openalex.org/W2017114673","https://openalex.org/W2021425365","https://openalex.org/W2024307818","https://openalex.org/W2030432410","https://openalex.org/W2034576097","https://openalex.org/W2036324891","https://openalex.org/W2038093356","https://openalex.org/W2041156861","https://openalex.org/W2041730779","https://openalex.org/W2042179255","https://openalex.org/W2045768968","https://openalex.org/W2045930638","https://openalex.org/W2046187712","https://openalex.org/W2053191524","https://openalex.org/W2053468117","https://openalex.org/W2055169036","https://openalex.org/W2058328280","https://openalex.org/W2058800184","https://openalex.org/W2059049831","https://openalex.org/W2060876261","https://openalex.org/W2062405644","https://openalex.org/W2065969137","https://openalex.org/W2067207951","https://openalex.org/W2070598889","https://openalex.org/W2073961713","https://openalex.org/W2075421127","https://openalex.org/W2075483955","https://openalex.org/W2078856783","https://openalex.org/W2081497884","https://openalex.org/W2082326103","https://openalex.org/W2084030938","https://openalex.org/W2084719078","https://openalex.org/W2085789330","https://openalex.org/W2086017238","https://openalex.org/W2086762446","https://openalex.org/W2087431627","https://openalex.org/W2088722322","https://openalex.org/W2090929330","https://openalex.org/W2091015211","https://openalex.org/W2092380622","https://openalex.org/W2096382911","https://openalex.org/W2098872681","https://openalex.org/W2109784377","https://openalex.org/W2110516088","https://openalex.org/W2110551960","https://openalex.org/W2112652982","https://openalex.org/W2113800342","https://openalex.org/W2114775432","https://openalex.org/W2118556143","https://openalex.org/W2124357096","https://openalex.org/W2136437896","https://openalex.org/W2143077267","https://openalex.org/W2146011843","https://openalex.org/W2150647527","https://openalex.org/W2155185788","https://openalex.org/W2161653527","https://openalex.org/W2164770054","https://openalex.org/W2165142491","https://openalex.org/W2165396712","https://openalex.org/W2170089420","https://openalex.org/W2172245650","https://openalex.org/W2215402147","https://openalex.org/W2266993741","https://openalex.org/W2267939447","https://openalex.org/W2313203550","https://openalex.org/W2321270707","https://openalex.org/W2323676296","https://openalex.org/W2329719527","https://openalex.org/W2341712066","https://openalex.org/W2341939697","https://openalex.org/W2346953662","https://openalex.org/W2358368113","https://openalex.org/W2395754775","https://openalex.org/W2397486082","https://openalex.org/W2405716921","https://openalex.org/W2407459081","https://openalex.org/W2417958212","https://openalex.org/W2418856511","https://openalex.org/W2418993795","https://openalex.org/W2424073111","https://openalex.org/W2424513194","https://openalex.org/W2462655393","https://openalex.org/W2770302683","https://openalex.org/W4242637714","https://openalex.org/W4294652390","https://openalex.org/W4321000870"],"related_works":["https://openalex.org/W2113595662","https://openalex.org/W1977306006","https://openalex.org/W2081497884","https://openalex.org/W2982850925","https://openalex.org/W2137313324","https://openalex.org/W2118613802","https://openalex.org/W2112874876","https://openalex.org/W4391014532","https://openalex.org/W2367946841","https://openalex.org/W4400828812"],"abstract_inverted_index":{"Background:":[0],"Despite":[1],"the":[2,16,71,73,80,209,300,333,353,393,425,437,444,451,458,471,486,502,509,551,558],"recent":[3],"improvements":[4],"in":[5,429,450,501,531],"surgical":[6],"techniques":[7],"and":[8,43,63,79,122,145,155,160,180,190,215,223,255,276,284,319,326,375,398,407,496],"postoperative":[9,24,44,77,103,170,233,422,505,570],"patient":[10,41,431,525],"care,":[11],"atrial":[12,211],"\\nfibrillation":[13],"(AF)":[14],"remains":[15],"most":[17],"frequent":[18],"complication":[19],"after":[20,541,547],"cardiac":[21,93],"surgery.":[22],"Although":[23,550],"AF":[25,60,74,100,152,156,171,253,301,310,361,390,404,417,423,441,477,517,537,562],"is":[26],"\\noften":[27],"regarded":[28],"as":[29],"a":[30,83,89,287,359,385,447,532,568],"benign":[31],"clinical":[32,266,297],"condition,":[33,356],"this":[34,381],"arrhythmia":[35],"has":[36,49],"significant":[37],"adverse":[38],"effects":[39,522],"on":[40,76,99,111,158,243,252,476],"\\nrecovery":[42],"survival.":[45,439],"Its":[46],"exact":[47],"pathophysiology":[48,503],"not":[50,413,435,546],"yet":[51],"been":[52],"elucidated.":[53],"The":[54,296,308],"present":[55],"\\nthesis":[56],"aims":[57],"to":[58,200,228,232,268,299,346,364,415,457,470,482,524,560],"analyze":[59],"risk":[61,153,342,387],"factors":[62,154,192,343],"their":[64,146,181,327],"interaction,":[65],"pre-existing":[66,490],"histological":[67,394,419],"explanatory":[68],"alterations":[69],"\\nof":[70],"atrium,":[72],"impact":[75],"survival":[78,104,124,187],"compliance":[81,298,521],"of":[82,221,250,336,389,427,465,504],"prophylactic":[84,302,518,533],"drug":[85,303],"regimen.":[86],"\\nMethods:":[87],"During":[88],"10-year":[90],"period,":[91,489],"consecutive":[92],"surgery":[94,238],"cases":[95],"with":[96,226,240,286,344,473],"complete":[97,241],"data":[98,125,242],"occurrence":[101],"\\nand":[102],"were":[105,109,126,149,163,184,198,213,247,259,278,468],"extracted.":[106],"All":[107],"patients":[108,175,197,239,264,467],"operated":[110],"for":[112,321,515],"coronary":[113,135],"or":[114,203],"valvular":[115,177,548],"surgery,":[116,544],"\\nwith":[117],"cardiopulmonary":[118],"bypass":[119,137],"(CPB).":[120],"Hospital":[121],"long-term":[123],"obtained":[127,189],"from":[128,208],"Swedish":[129],"\\npopulation":[130],"registry.":[131],"Study":[132,165,194,235,261],"I)":[133],"Isolated":[134],"artery":[136],"grafting":[138],"(CABG,":[139],"n=7056),":[140],"aortic":[141],"valve":[142],"\\nreplacement":[143],"(n=690)":[144],"combination":[147,182],"(n=688)":[148],"considered.":[150],"Independent":[151],"\\neffects":[157,475],"early":[159],"1-year":[161],"mortality":[162,540],"investigated.":[164],"II)":[166],"Patients":[167],"affected":[168],"by":[169,219],"\\namong":[172],"isolated":[173,322,542],"CABG":[174,263,291,452,466,543],"(n=7621),":[176],"surgeries":[178],"(n=995)":[179],"(n=879)":[183],"\\nstudied.":[185],"Long-term":[186],"was":[188,217,312,332,378,412],"prognostic":[191],"identified.":[193],"III)":[195],"Seventy":[196],"\\nrandomized":[199],"on-pump":[201],"(n=35)":[202,205],"off-pump":[204],"CABG.":[206],"Samples":[207],"right":[210],"appendage":[212],"\\ncollected":[214],"histology":[216],"evaluated":[218],"means":[220],"light":[222],"electronic":[224],"microscopy":[225],"reference":[227,345,456],"preexistent":[229],"\\nalterations":[230],"related":[231],"AF.":[234,338],"IV)":[236],"Cardiac":[237],"\\nsmoking":[244],"status":[245,374],"(n=3245)":[246],"reviewed.":[248],"Effects":[249],"smoking":[251,355,373,383],"development":[254],"interaction":[256,371,382],"among":[257],"\\nvariables":[258],"explored.":[260],"V)":[262],"without":[265,380],"contraindications":[267],"receive":[269],"oral":[270],"sotalol":[271],"\\n(80":[272],"mg":[273],"twice":[274],"daily)":[275],"magnesium":[277],"prospectively":[279],"enrolled":[280],"(n":[281,293],"=":[282,294],"49)":[283],"compared":[285,363],"matched":[288],"\\ncontemporary":[289],"control":[290],"group":[292,453],"844).":[295],"regimen":[304],"\\nwas":[305],"tested.":[306],"\\nResults:":[307],"overall":[309],"incidence":[311],"around":[313],"26%,":[314],"subdivided":[315],"into":[316],"23%,":[317],"40%":[318],"45%":[320],"CABG,":[323],"\\nvalve":[324],"procedures":[325],"combined":[328],"surgeries,":[329],"respectively.":[330],"Age":[331],"strongest":[334],"predictor":[335],"\\npostoperative":[337,416],"Coronary":[339],"disease":[340],"superimposed":[341],"myocardial":[347],"conditions":[348],"at":[349,485],"\\nCPB":[350],"weaning.":[351],"Considering":[352],"preoperative":[354],"smokers":[357],"demonstrated":[358],"reduced":[360],"\\nincidence":[362],"non-smokers":[365],"(20%":[366],"versus":[367],"27%,":[368],"p<0.001).":[369],"An":[370],"between":[372],"\\ninotropic":[376],"support":[377],"observed:":[379],"conferred":[384],"46%":[386],"reduction":[388],"\\n(p=0.011).":[391],"At":[392],"level,":[395],"myocyte":[396],"vacuolization":[397],"nuclear":[399],"derangement":[400],"represented":[401],"anatomical":[402],"\\nindependent":[403],"predictors":[405],"(p=0.002":[406],"p=0.016,":[408],"respectively).":[409],"CPB":[410,487,510],"exposure":[411],"associated":[414],"nor":[418],"changes.":[420],"Although,":[421],"increases":[424,538],"length":[426],"\\nhospitalization":[428],"all":[430],"groups,":[432],"it":[433],"did":[434],"affect":[436],"hospital":[438,565],"However,":[440],"independently":[442],"\\nimpaired":[443],"late":[445,539],"survival,":[446],"phenomenon":[448],"seen":[449],"only.":[454],"With":[455],"tested":[459],"sotalolmagnesium":[460],"\\ndrug":[461],"regimen,":[462],"only":[463],"55%":[464],"compliant":[469],"treatment,":[472],"marginal":[474],"occurrence.":[478],"\\nConclusions:":[479],"In":[480,507],"addition":[481],"age,":[483],"details":[484],"weaning":[488],"histopathological":[491],"changes,":[492],"\\nthe":[493],"hyperadrenergic":[494],"state":[495],"catecholamines":[497],"are":[498,553],"key":[499],"mechanisms":[500,552],"\\nAF.":[506],"particular,":[508],"period":[511],"hides":[512],"valuable":[513],"information":[514],"timely":[516],"stratifications.":[519],"\\nFurther,":[520],"due":[523],"selection":[526],"should":[527],"also":[528],"be":[529],"considered":[530],"therapy":[534],"\\nmodel.":[535],"Postoperative":[536],"but":[545],"\\nprocedures.":[549],"unclear,":[554],"our":[555],"results":[556],"draw":[557],"attention":[559],"possible":[561],"recurrence":[563],"\\nafter":[564],"discharge,":[566],"indicating":[567],"strict":[569],"surveillance.":[571]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}