{"id":"https://openalex.org/W1725965337","doi":null,"title":"Intratumor heterogeneity of EGFR mutations in lung cancer tissues and its correlation with the response to gefitinib","display_name":"Intratumor heterogeneity of EGFR mutations in lung cancer tissues and its correlation with the response to gefitinib","publication_year":2006,"publication_date":"2006-10-01","ids":{"openalex":"https://openalex.org/W1725965337","mag":"1725965337"},"language":"en","primary_location":{"id":"mag:1725965337","doi":null,"is_oa":false,"landing_page_url":"https://clincancerres.aacrjournals.org/content/12/19_Supplement/B25","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Clinical Cancer Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059682485","display_name":"Kikuya Kato","orcid":"https://orcid.org/0000-0003-1863-6253","observed_orcids":["https://orcid.org/0000-0003-1863-6253"]},"institutions":[{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kikuya Kato","raw_affiliation_strings":["Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1863-6253","affiliations":[{"raw_affiliation_string":"Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kazuya Taniguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuya Taniguchi","raw_affiliation_strings":["Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061233614","display_name":"Jiro Okami","orcid":"https://orcid.org/0000-0002-7633-9700","observed_orcids":["https://orcid.org/0000-0002-7633-9700"]},"institutions":[{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jiro Okami","raw_affiliation_strings":["Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7633-9700","affiliations":[{"raw_affiliation_string":"Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091248337","display_name":"Ken Kodama","orcid":"https://orcid.org/0000-0002-2508-9449","observed_orcids":["https://orcid.org/0000-0002-2508-9449"]},"institutions":[{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Kodama","raw_affiliation_strings":["Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2508-9449","affiliations":[{"raw_affiliation_string":"Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076968285","display_name":"Masahiko Higashiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiko Higashiyama","raw_affiliation_strings":["Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210151107"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.15686926,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"12","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intratumor-heterogeneity","display_name":"intratumoral heterogeneity","score":0.8949999809265137},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.8360000252723694},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.6769999861717224},{"id":"https://openalex.org/keywords/time-to-progression","display_name":"time to progression","score":0.8259999752044678},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.637552797794342},{"id":"https://openalex.org/C102306862","wikidata":"https://www.wikidata.org/wiki/Q6943735","display_name":"Mutation frequency","level":4,"score":0.6210461258888245},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5731714963912964},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.57032710313797},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5666731595993042},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5500596165657043},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.529723584651947},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5045820474624634},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46626147627830505},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.4346051812171936},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.420663982629776},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.420251727104187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.354642391204834},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24630507826805115},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.18629449605941772},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.18388640880584717},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17852193117141724},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1770535409450531},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1725965337","doi":null,"is_oa":false,"landing_page_url":"https://clincancerres.aacrjournals.org/content/12/19_Supplement/B25","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Clinical Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2069540737","https://openalex.org/W3012425929","https://openalex.org/W2161821474","https://openalex.org/W2087764235","https://openalex.org/W2030883899","https://openalex.org/W2147703884","https://openalex.org/W3012214105","https://openalex.org/W7067764277","https://openalex.org/W1989503742","https://openalex.org/W2068864761"],"abstract_inverted_index":{"B25":[0],"Cancer":[2],"tissues":[3,100,109,243,252,258,264],"consist":[4],"of":[5,16,35,79,123,148,154,157,163,200,206,212,231,233,246,253,259,266,283,307],"various":[6],"cancer":[7,99,137,286],"cells":[8,138,248,270,274,295],"with":[9,48,106,292],"different":[10,155],"genetic":[11],"alterations.":[12],"From":[13,228],"the":[14,25,52,61,76,90,124,145,161,164,229,236,284,297,318],"viewpoint":[15],"anti-cancer":[17],"drug":[18],"therapy,":[19],"it":[20],"is":[21,66,83],"important":[22],"to":[23,33,112,166,218,225,309],"assess":[24],"ratio":[26,239],"between":[27],"responder":[28,38,226,247,267],"and":[29,39,143,221,223,256,261,268,311],"non-responder":[30,40,219,269,273,294],"cells.":[31,173,227],"Due":[32],"lack":[34],"biomarkers":[36],"discriminating":[37],"cells,":[41,158,220],"such":[42],"studies":[43,53],"are":[44],"generally":[45],"difficult.":[46],"However,":[47],"molecular":[49],"target":[50,58],"drugs,":[51],"may":[54],"be":[55],"possible":[56],"using":[57,188],"molecules":[59],"as":[60],"biomarker.":[62],"In":[63],"particular,":[64],"gefitinib":[65],"an":[67,189],"ideal":[68],"example,":[69],"because":[70],"responders":[71],"carry":[72,113],"somatic":[73],"mutation(s)":[74],"in":[75,89,303,317],"kinase":[77],"domain":[78],"EGFR.":[80],"This":[81],"correlation":[82],"gaining":[84],"a":[85,184],"consensus":[86],"at":[87],"least":[88],"Asian":[91],"population.":[92],"We":[93],"collected":[94],"primary":[95],"non-small":[96],"cell":[97,126,203,238,287],"lung":[98],"from":[101],"twenty":[102],"Japanese":[103],"patients":[104],"treated":[105],"gefitinib.":[107],"All":[108],"were":[110,197,314],"confirmed":[111],"EGFR":[114,207,213],"mutations":[115],"by":[116,139,179],"PCR":[117],"direct":[118],"sequencing.":[119],"For":[120],"accurate":[121],"quantitation":[122],"responder/non-responder":[125,237],"ratio,":[127],"we":[128,159],"randomly":[129],"sampled":[130],"about":[131,171],"60":[132],"small":[133],"regions":[134,232],"containing":[135],"only":[136,245,254,298],"laser":[140],"microbeam":[141],"dissection,":[142],"determined":[144,178],"mutation":[146,175,208,214],"status":[147,176],"each":[149,194,234],"region.":[150],"To":[151],"prevent":[152],"contamination":[153],"types":[156],"minimized":[160],"size":[162],"region":[165],"100x100x40":[167],"micrometers,":[168],"which":[169],"contained":[170],"thirty":[172],"The":[174,290],"was":[177,240,296],"SNaP":[180],"shot":[181],"(Applied":[182],"Biosystems),":[183],"primer":[185,191],"extension":[186],"assay":[187],"oligonucleotide":[190],"designed":[192],"for":[193],"mutation.":[195],"Regions":[196],"classified":[198],"either":[199],"wild":[201],"type":[202],"(WT),":[204],"heterozygote":[205],"(HT)":[209],"or":[210],"homozygote":[211],"(HO).":[215],"WT":[216],"corresponded":[217],"HT":[222,260],"HO":[224],"number":[230],"category,":[235],"calculated.":[241],"Fourteen":[242],"consisted":[244,265],"(group":[249,271],"I):":[250],"twelve":[251],"HT,":[255],"two":[257],"HO.":[262],"Six":[263],"II):":[272],"occupied":[275],"7,":[276],"8,":[277],"10,":[278],"22,":[279],"67,":[280],"95":[281],"%":[282],"total":[285],"population,":[288],"respectively.":[289],"case":[291,302],"95%":[293],"PD":[299],"(progressive":[300],"disease)":[301],"this":[304],"collection.":[305],"Both":[306],"time":[308],"progression":[310],"overall":[312],"survival":[313],"significantly":[315],"reduced":[316],"group":[319],"II":[320],"(p":[321]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}