{"id":"https://openalex.org/W1723908101","doi":"https://doi.org/10.1128/jvi.64.5.2135-2140.1990","title":"Sequences in the U5-gag-pol region influence early and late pathogenic effects of Friend and Moloney murine leukemia viruses","display_name":"Sequences in the U5-gag-pol region influence early and late pathogenic effects of Friend and Moloney murine leukemia viruses","publication_year":1990,"publication_date":"1990-05-01","ids":{"openalex":"https://openalex.org/W1723908101","doi":"https://doi.org/10.1128/jvi.64.5.2135-2140.1990","mag":"1723908101","pmid":"https://pubmed.ncbi.nlm.nih.gov/2182908","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/249371"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.64.5.2135-2140.1990","doi":"https://doi.org/10.1128/jvi.64.5.2135-2140.1990","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.64.5.2135-2140.1990","pdf_url":"https://jvi.asm.org/content/jvi/64/5/2135.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jvi.asm.org/content/jvi/64/5/2135.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031967403","display_name":"Marc Sitbon","orcid":"https://orcid.org/0000-0003-3616-2338","observed_orcids":["https://orcid.org/0000-0003-3616-2338"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Sitbon","raw_affiliation_strings":["Laboratoire d'Immunologie et Oncologie des Maladies R\u00e9trovirales, H\u00f4pital Cochin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U152, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunologie et Oncologie des Maladies R\u00e9trovirales, H\u00f4pital Cochin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U152, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080295259","display_name":"Heinz Ellerbrok","orcid":"https://orcid.org/0000-0003-2695-7639","observed_orcids":["https://orcid.org/0000-0003-2695-7639"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H Ellerbrok","raw_affiliation_strings":["Laboratoire d'Immunologie et Oncologie des Maladies R\u00e9trovirales, H\u00f4pital Cochin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U152, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunologie et Oncologie des Maladies R\u00e9trovirales, H\u00f4pital Cochin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U152, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110895757","display_name":"Fran\u00e7oise Pozo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F Pozo","raw_affiliation_strings":["Laboratoire d'Immunologie et Oncologie des Maladies R\u00e9trovirales, H\u00f4pital Cochin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U152, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunologie et Oncologie des Maladies R\u00e9trovirales, H\u00f4pital Cochin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U152, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018936420","display_name":"Jane Nishio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J Nishio","raw_affiliation_strings":["Laboratoire d'Immunologie et Oncologie des Maladies R\u00e9trovirales, H\u00f4pital Cochin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U152, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunologie et Oncologie des Maladies R\u00e9trovirales, H\u00f4pital Cochin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U152, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110342373","display_name":"S. Fred Hayes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S F Hayes","raw_affiliation_strings":["Laboratoire d'Immunologie et Oncologie des Maladies R\u00e9trovirales, H\u00f4pital Cochin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U152, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunologie et Oncologie des Maladies R\u00e9trovirales, H\u00f4pital Cochin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U152, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112781528","display_name":"Leonard H. Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L H Evans","raw_affiliation_strings":["Laboratoire d'Immunologie et Oncologie des Maladies R\u00e9trovirales, H\u00f4pital Cochin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U152, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunologie et Oncologie des Maladies R\u00e9trovirales, H\u00f4pital Cochin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U152, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032220933","display_name":"Bruce W. Chesebro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B Chesebro","raw_affiliation_strings":["Laboratoire d'Immunologie et Oncologie des Maladies R\u00e9trovirales, H\u00f4pital Cochin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U152, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunologie et Oncologie des Maladies R\u00e9trovirales, H\u00f4pital Cochin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U152, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3748,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.80590169,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"64","issue":"5","first_page":"2135","last_page":"2140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/friend-murine-leukemia-virus","display_name":"Friend murine leukemia virus","score":0.9049999713897705},{"id":"https://openalex.org/keywords/moloney-murine-leukemia-virus","display_name":"Moloney murine leukemia virus","score":1.0},{"id":"https://openalex.org/keywords/long-terminal-repeat","display_name":"long terminal repeat","score":0.7239999771118164},{"id":"https://openalex.org/keywords/u3-region","display_name":"U3 region","score":0.765999972820282},{"id":"https://openalex.org/keywords/env-gene","display_name":"env gene","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hemolytic-anemia","display_name":"hemolytic anemia","score":0.9549999833106995},{"id":"https://openalex.org/keywords/erythroleukemia","display_name":"erythroleukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lymphoid-leukemia","display_name":"lymphoid leukemia","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pathogenicity","display_name":"pathogenicity","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7980450987815857},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.7867332696914673},{"id":"https://openalex.org/C2779562191","wikidata":"https://www.wikidata.org/wiki/Q673848","display_name":"Murine leukemia virus","level":3,"score":0.7567311525344849},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7194712162017822},{"id":"https://openalex.org/C199491388","wikidata":"https://www.wikidata.org/wiki/Q1869477","display_name":"Long terminal repeat","level":4,"score":0.6788034439086914},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6305074095726013},{"id":"https://openalex.org/C2781053568","wikidata":"https://www.wikidata.org/wiki/Q19000458","display_name":"Equine infectious anemia","level":3,"score":0.5493176579475403},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.46159860491752625},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4599645733833313},{"id":"https://openalex.org/C2779682186","wikidata":"https://www.wikidata.org/wiki/Q5504041","display_name":"Friend virus","level":3,"score":0.4422565698623657},{"id":"https://openalex.org/C2776175824","wikidata":"https://www.wikidata.org/wiki/Q1145668","display_name":"Hemolytic anemia","level":2,"score":0.43100011348724365},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33704283833503723},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20917010307312012},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19756042957305908},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14481806755065918}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005622","descriptor_name":"Friend murine leukemia virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005622","descriptor_name":"Friend murine leukemia virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007942","descriptor_name":"Leukemia, Experimental","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008979","descriptor_name":"Moloney murine leukemia virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008979","descriptor_name":"Moloney murine leukemia virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015683","descriptor_name":"Gene Products, gag","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015750","descriptor_name":"Genes, gag","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.64.5.2135-2140.1990","doi":"https://doi.org/10.1128/jvi.64.5.2135-2140.1990","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.64.5.2135-2140.1990","pdf_url":"https://jvi.asm.org/content/jvi/64/5/2135.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:237809","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC249371","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:249371","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/249371","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:2182908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2182908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/jvi.64.5.2135-2140.1990","doi":"https://doi.org/10.1128/jvi.64.5.2135-2140.1990","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.64.5.2135-2140.1990","pdf_url":"https://jvi.asm.org/content/jvi/64/5/2135.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1723908101.pdf"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1499029650","https://openalex.org/W1515273952","https://openalex.org/W1517128633","https://openalex.org/W1517732553","https://openalex.org/W1531346086","https://openalex.org/W1538974729","https://openalex.org/W1541422616","https://openalex.org/W1543183990","https://openalex.org/W1543411722","https://openalex.org/W1554493402","https://openalex.org/W1559992502","https://openalex.org/W1573822904","https://openalex.org/W1595151093","https://openalex.org/W1686094598","https://openalex.org/W1899631024","https://openalex.org/W1941739095","https://openalex.org/W1942505448","https://openalex.org/W1947717351","https://openalex.org/W1965372133","https://openalex.org/W1967856579","https://openalex.org/W1972940025","https://openalex.org/W1973945770","https://openalex.org/W1997110527","https://openalex.org/W2001936129","https://openalex.org/W2002756597","https://openalex.org/W2010340688","https://openalex.org/W2015639517","https://openalex.org/W2036334545","https://openalex.org/W2043886639","https://openalex.org/W2046255747","https://openalex.org/W2052115759","https://openalex.org/W2061311391","https://openalex.org/W2061942270","https://openalex.org/W2091847974","https://openalex.org/W2122467641","https://openalex.org/W2135090999","https://openalex.org/W2142638152","https://openalex.org/W2155444165","https://openalex.org/W2166744851","https://openalex.org/W2169131818"],"related_works":["https://openalex.org/W7098895143","https://openalex.org/W1500741456","https://openalex.org/W2061942270","https://openalex.org/W1538974729","https://openalex.org/W2186415239","https://openalex.org/W1775560270","https://openalex.org/W1884683054","https://openalex.org/W1530392303","https://openalex.org/W1517128633","https://openalex.org/W1557966788"],"abstract_inverted_index":{"Friend":[0],"replication-competent":[1],"murine":[2],"leukemia":[3],"virus":[4],"(F-MuLV),":[5],"clone":[6,49],"57,":[7],"induces":[8,30],"a":[9,15,204],"severe":[10,136,157],"early":[11,137,158],"hemolytic":[12,41,113,138,159],"anemia":[13,139,160],"and":[14,42,60,79,81,140,167,191,200],"later":[16],"erythroleukemia":[17,174],"after":[18],"inoculation":[19],"of":[20,45,76,100,105,115,120,129,135,145,150,173,179,187,194,208],"newborn":[21],"IRW":[22],"or":[23],"ICFW":[24],"mice,":[25],"whereas":[26],"Moloney":[27],"MuLV":[28],"(M-MuLV)":[29],"only":[31],"lymphoid":[32],"leukemia.":[33],"We":[34],"have":[35],"shown":[36],"previously":[37],"that":[38,125],"the":[39,57,66,97,101,106,112,121,126,143,148,164,177,180,185,189],"attenuated":[40],"erythroleukemogenic":[43],"abilities":[44],"an":[46],"F-MuLV":[47,77,130,146,165,181,195],"variant,":[48],"B3,":[50,147],"were":[51],"due":[52],"mostly":[53],"to":[54,197],"changes":[55],"in":[56,155],"env":[58,74,144,149],"gene":[59],"long":[61,102],"terminal":[62,103],"repeat,":[63],"respectively.":[64],"For":[65],"present":[67],"study,":[68],"we":[69,123],"derived":[70],"two":[71,85],"constructs":[72,86,117],"exchanging":[73,96],"fragments":[75],"57":[78],"M-MuLV":[80,151],"compared":[82],"them":[83],"with":[84,118,163,203],"described":[87],"by":[88],"Chatis":[89],"et":[90],"al.":[91],"(J.":[92],"Virol.":[93],"52:248-254,":[94],"1984)":[95],"U3":[98,168,182,190],"region":[99,128],"repeat":[104],"same":[107],"parental":[108],"viruses.":[109],"When":[110],"comparing":[111],"effect":[114],"these":[116],"those":[119],"parent,":[122],"found":[124],"U5-gag-pol":[127,166,192],"was":[131,152,201],"required":[132],"for":[133],"development":[134],"that,":[141],"unlike":[142],"fully":[153],"competent":[154],"inducing":[156],"when":[161],"associated":[162,202],"regions.":[169],"As":[170],"expected,":[171],"induction":[172],"depended":[175],"on":[176],"presence":[178,186],"region;":[183],"however,":[184],"both":[188],"regions":[193],"appeared":[196],"be":[198],"synergistic":[199],"more":[205],"rapid":[206],"appearance":[207],"erythroleukemia.":[209]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}