{"id":"https://openalex.org/W1720110446","doi":"https://doi.org/10.1096/fasebj.6.3.1346768","title":"Subtypes of \u03b1 1 \u2010 and \u03b1 2 \u2010adrenergic receptors","display_name":"Subtypes of \u03b1 1 \u2010 and \u03b1 2 \u2010adrenergic receptors","publication_year":1992,"publication_date":"1992-02-01","ids":{"openalex":"https://openalex.org/W1720110446","doi":"https://doi.org/10.1096/fasebj.6.3.1346768","mag":"1720110446","pmid":"https://pubmed.ncbi.nlm.nih.gov/1346768"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.6.3.1346768","doi":"https://doi.org/10.1096/fasebj.6.3.1346768","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.6.3.1346768","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104046994","display_name":"David B. Bylund","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David B. Bylund","raw_affiliation_strings":["Department of Pharmacology College of Medicine University of Nebraska Medical Center Omaha Nebraska 68198\u20106260 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology College of Medicine University of Nebraska Medical Center Omaha Nebraska 68198\u20106260 USA","institution_ids":["https://openalex.org/I1307117695","https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5104046994"],"corresponding_institution_ids":["https://openalex.org/I1307117695","https://openalex.org/I59130452"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":14.6804,"has_fulltext":false,"cited_by_count":363,"citation_normalized_percentile":{"value":0.9946261,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"3","first_page":"832","last_page":"839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha1-adrenergic-receptors","display_name":"alpha1-adrenoceptors","score":0.9570000171661377},{"id":"https://openalex.org/keywords/alpha2-adrenergic-receptors","display_name":"alpha2-adrenoceptors","score":0.9819999933242798},{"id":"https://openalex.org/keywords/adrenergic-receptor-subtypes","display_name":"adrenergic receptor subtypes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9620000123977661},{"id":"https://openalex.org/keywords/wb-4101","display_name":"WB4101","score":0.7670000195503235},{"id":"https://openalex.org/keywords/phentolamine","display_name":"phentolamine","score":0.968999981880188},{"id":"https://openalex.org/keywords/chloroethylclonidine","display_name":"chloroethylclonidine","score":0.996999979019165},{"id":"https://openalex.org/keywords/calcium-channel-activation","display_name":"calcium channel activation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/inositol-trisphosphate","display_name":"inositol trisphosphate","score":0.9919999837875366},{"id":"https://openalex.org/keywords/adenylyl-cyclase-inhibition","display_name":"adenylate cyclase inhibition","score":0.9570000171661377},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.8759999871253967},{"id":"https://openalex.org/keywords/gene-cloning","display_name":"gene cloning","score":0.6019999980926514},{"id":"https://openalex.org/keywords/radioligand-binding","display_name":"radioligand binding","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7503023147583008},{"id":"https://openalex.org/C40465926","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Adrenergic receptor","level":3,"score":0.6086462736129761},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5890440344810486},{"id":"https://openalex.org/C46688247","wikidata":"https://www.wikidata.org/wiki/Q17710475","display_name":"Alpha-1B adrenergic receptor","level":5,"score":0.559100329875946},{"id":"https://openalex.org/C2780253649","wikidata":"https://www.wikidata.org/wiki/Q420360","display_name":"Phentolamine","level":3,"score":0.5442895293235779},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.5395488142967224},{"id":"https://openalex.org/C121528942","wikidata":"https://www.wikidata.org/wiki/Q17710494","display_name":"Alpha-1A adrenergic receptor","level":5,"score":0.47147655487060547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46308237314224243},{"id":"https://openalex.org/C178059049","wikidata":"https://www.wikidata.org/wiki/Q17710464","display_name":"Alpha-1D adrenergic receptor","level":5,"score":0.4344486594200134},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4220730662345886},{"id":"https://openalex.org/C2909005528","wikidata":"https://www.wikidata.org/wiki/Q626478","display_name":"Radioligand Assay","level":3,"score":0.41469377279281616},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35287636518478394},{"id":"https://openalex.org/C169331234","wikidata":"https://www.wikidata.org/wiki/Q4897175","display_name":"Beta-3 adrenergic receptor","level":4,"score":0.27613013982772827},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26802271604537964},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1807228922843933},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000317","descriptor_name":"Adrenergic alpha-Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011942","descriptor_name":"Receptors, Adrenergic, alpha","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D011942","descriptor_name":"Receptors, Adrenergic, alpha","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1096/fasebj.6.3.1346768","doi":"https://doi.org/10.1096/fasebj.6.3.1346768","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.6.3.1346768","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:1346768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1346768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.459199994802475,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1099187024","display_name":"HETEROGENEITY OF ALPHA-2 ADRENERGIC RECEPTORS","funder_award_id":"5r01gm040784-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5634680776","display_name":null,"funder_award_id":"GM40784","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1489036681","https://openalex.org/W2172313765","https://openalex.org/W2041755700","https://openalex.org/W1829371640","https://openalex.org/W2461801837","https://openalex.org/W2026742720","https://openalex.org/W2094064194","https://openalex.org/W2053902105","https://openalex.org/W2035986648","https://openalex.org/W1985407755"],"abstract_inverted_index":{"The":[0,156],"adrenergic":[1,18],"receptors":[2],"are":[3,13],"members":[4],"of":[5,8,17,27,56,76,78,87,106,127,149,158,185,193],"the":[6,39,54,65,74,79,92,100,115,128,159,183,191,208,218],"superfamily":[7],"G":[9],"protein-coupled":[10],"receptors.":[11],"There":[12,213],"three":[14,29,36,176],"major":[15,30],"types":[16,31],"receptors:":[19],"alpha":[20,22,40,43,46,80,93,116,129,160,196],"1,":[21],"2,":[23],"and":[24,45,62,64,138,170,188,210,222],"beta.":[25],"Each":[26],"these":[28,107,150],"can":[32],"be":[33],"divided":[34],"into":[35],"subtypes.":[37],"Within":[38],"1-adrenergic":[41],"receptors,":[42],"1A":[44,81],"1B":[47,94],"subtypes":[48,109,126,162,177,199,221],"have":[49,118,132,144,178,200],"been":[50,119,134,145,164,179,201],"defined":[51],"pharmacologically":[52],"on":[53,166],"basis":[55],"reversible":[57],"antagonists,":[58],"such":[59],"as":[60,110,112],"WB4101":[61],"phentolamine,":[63],"irreversible":[66],"antagonist":[67],"chloroethylclonidine.":[68],"In":[69],"at":[70],"least":[71],"some":[72],"tissues":[73,137],"mechanism":[75],"action":[77],"subtype":[82],"is":[83,214],"related":[84],"to":[85,181],"activation":[86,184],"a":[88,113],"calcium":[89],"channel,":[90],"whereas":[91],"receptor":[95,108,131,198],"exerts":[96],"its":[97],"effect":[98],"through":[99],"second":[101],"messenger":[102],"inositol":[103],"trisphosphate.":[104],"Both":[105],"well":[111],"third,":[114],"1C,":[117],"identified":[120,202,220,224],"by":[121,203,225],"molecular":[122,204,226],"cloning.":[123,227],"Three":[124,195],"pharmacological":[125,219],"2-adrenergic":[130,197],"also":[133],"identified.":[135],"Prototypic":[136],"cell":[139],"lines":[140],"in":[141,206],"continuous":[142],"culture":[143],"developed":[146],"for":[147],"each":[148],"subtypes,":[151],"which":[152],"facilitated":[153],"their":[154],"study.":[155],"definition":[157],"2":[161],"has":[163],"based":[165],"radioligand":[167],"binding":[168],"data":[169],"more":[171],"limited":[172],"functional":[173],"data.":[174],"All":[175],"shown":[180],"inhibit":[182],"adenylate":[186],"cyclase":[187],"thus":[189],"reduce":[190],"levels":[192],"cAMP.":[194],"cloning":[205],"both":[207],"human":[209],"rat":[211],"species.":[212],"reasonable":[215],"agreement":[216],"between":[217],"those":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}