{"id":"https://openalex.org/W1720074926","doi":"https://doi.org/10.1111/jgh.12752","title":"Detailed analysis of epithelial\u2010mesenchymal transition and tumor budding identifies predictors of long\u2010term survival in pancreatic ductal adenocarcinoma","display_name":"Detailed analysis of epithelial\u2010mesenchymal transition and tumor budding identifies predictors of long\u2010term survival in pancreatic ductal adenocarcinoma","publication_year":2015,"publication_date":"2015-03-01","ids":{"openalex":"https://openalex.org/W1720074926","doi":"https://doi.org/10.1111/jgh.12752","mag":"1720074926","pmid":"https://pubmed.ncbi.nlm.nih.gov/25827809"},"language":"en","primary_location":{"id":"doi:10.1111/jgh.12752","doi":"https://doi.org/10.1111/jgh.12752","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jgh.12752","pdf_url":null,"source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110428530","display_name":"Ilona Kohler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ilona Kohler","raw_affiliation_strings":["Institute of Pathology University Medical Center Freiburg  Freiburg Germany","Institute of Pathology, University Medical Center Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology University Medical Center Freiburg  Freiburg Germany","institution_ids":["https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Institute of Pathology, University Medical Center Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074537923","display_name":"Peter Bronsert","orcid":"https://orcid.org/0000-0001-8558-0347","observed_orcids":["https://orcid.org/0000-0001-8558-0347"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Bronsert","raw_affiliation_strings":["Comprehensive Cancer Center Freiburg  Freiburg Germany","Institute of Pathology University Medical Center Freiburg  Freiburg Germany","Comprehensive Cancer Center Freiburg, Freiburg, Germany","Institute of Pathology, University Medical Center Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center Freiburg  Freiburg Germany","institution_ids":["https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Institute of Pathology University Medical Center Freiburg  Freiburg Germany","institution_ids":["https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Comprehensive Cancer Center Freiburg, Freiburg, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Pathology, University Medical Center Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056529795","display_name":"Sylvia Timme","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sylvia Timme","raw_affiliation_strings":["Institute of Pathology University Medical Center Freiburg  Freiburg Germany","Institute of Pathology, University Medical Center Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology University Medical Center Freiburg  Freiburg Germany","institution_ids":["https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Institute of Pathology, University Medical Center Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062987908","display_name":"Martin Werner","orcid":"https://orcid.org/0000-0002-6951-8022","observed_orcids":["https://orcid.org/0000-0002-6951-8022"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Werner","raw_affiliation_strings":["Comprehensive Cancer Center Freiburg  Freiburg Germany","German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ)  Heidelberg Germany","Institute of Pathology University Medical Center Freiburg  Freiburg Germany","Comprehensive Cancer Center Freiburg, Freiburg, Germany","German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany","Institute of Pathology, University Medical Center Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center Freiburg  Freiburg Germany","institution_ids":["https://openalex.org/I2801240073"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ)  Heidelberg Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Institute of Pathology University Medical Center Freiburg  Freiburg Germany","institution_ids":["https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Comprehensive Cancer Center Freiburg, Freiburg, Germany","institution_ids":[]},{"raw_affiliation_string":"German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Institute of Pathology, University Medical Center Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076332139","display_name":"Thomas Brabletz","orcid":"https://orcid.org/0000-0003-2983-9048","observed_orcids":["https://orcid.org/0000-0003-2983-9048"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Brabletz","raw_affiliation_strings":["Clinic for General and Visceral Surgery University Medical Center Freiburg  Freiburg Germany","Comprehensive Cancer Center Freiburg  Freiburg Germany","German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ)  Heidelberg Germany","Clinic for General and Visceral Surgery, University Medical Center Freiburg, Freiburg, Germany","Comprehensive Cancer Center Freiburg, Freiburg, Germany","German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for General and Visceral Surgery University Medical Center Freiburg  Freiburg Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Comprehensive Cancer Center Freiburg  Freiburg Germany","institution_ids":["https://openalex.org/I2801240073"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ)  Heidelberg Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Clinic for General and Visceral Surgery, University Medical Center Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Comprehensive Cancer Center Freiburg, Freiburg, Germany","institution_ids":[]},{"raw_affiliation_string":"German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4391767962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110013982","display_name":"Ulrich Theodor Hopt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich Theodor Hopt","raw_affiliation_strings":["Clinic for General and Visceral Surgery University Medical Center Freiburg  Freiburg Germany","Clinic for General and Visceral Surgery, University Medical Center Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for General and Visceral Surgery University Medical Center Freiburg  Freiburg Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Clinic for General and Visceral Surgery, University Medical Center Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050843400","display_name":"Oliver Schilling","orcid":"https://orcid.org/0000-0001-7678-7653","observed_orcids":["https://orcid.org/0000-0001-7678-7653"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Schilling","raw_affiliation_strings":["Institute for Molecular Medicine and Cell Research University of Freiburg  Freiburg Germany","Institute for Molecular Medicine and Cell Research, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine and Cell Research University of Freiburg  Freiburg Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Institute for Molecular Medicine and Cell Research, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042036234","display_name":"Dirk Bausch","orcid":"https://orcid.org/0000-0001-6511-1535","observed_orcids":["https://orcid.org/0000-0001-6511-1535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dirk Bausch","raw_affiliation_strings":["Clinic for Surgery UKSH Campus L\u00fcbeck  L\u00fcbeck Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for Surgery UKSH Campus L\u00fcbeck  L\u00fcbeck Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001389547","display_name":"Tobias Keck","orcid":"https://orcid.org/0000-0001-7651-6183","observed_orcids":["https://orcid.org/0000-0001-7651-6183"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tobias Keck","raw_affiliation_strings":["Clinic for Surgery UKSH Campus L\u00fcbeck  L\u00fcbeck Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for Surgery UKSH Campus L\u00fcbeck  L\u00fcbeck Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026516010","display_name":"Ulrich Friedrich Wellner","orcid":"https://orcid.org/0000-0002-8632-166X","observed_orcids":["https://orcid.org/0000-0002-8632-166X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ulrich Friedrich Wellner","raw_affiliation_strings":["Clinic for Surgery UKSH Campus L\u00fcbeck  L\u00fcbeck Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for Surgery UKSH Campus L\u00fcbeck  L\u00fcbeck Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5026516010"],"corresponding_institution_ids":[],"apc_list":{"value":4620,"currency":"USD","value_usd":4620},"apc_paid":null,"fwci":2.8696,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.9300673,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"30","issue":"S1","first_page":"78","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9679999947547913},{"id":"https://openalex.org/keywords/tumor-budding","display_name":"tumor budding","score":1.0},{"id":"https://openalex.org/keywords/long-term-survival","display_name":"long-term survival","score":0.8519999980926514},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.800000011920929},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9120000004768372},{"id":"https://openalex.org/keywords/lymph-node-ratio","display_name":"lymph node ratio","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tumor-host-interface","display_name":"tumor-host interface","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pancreatic-head-cancer","display_name":"pancreatic head cancer","score":0.6110000014305115},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.7250000238418579},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C2779188454","wikidata":"https://www.wikidata.org/wiki/Q16948689","display_name":"Tumor budding","level":5,"score":0.9027162790298462},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.7247583866119385},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.7245572805404663},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.644412636756897},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6285200715065002},{"id":"https://openalex.org/C2779012181","wikidata":"https://www.wikidata.org/wiki/Q2750567","display_name":"Cytokeratin","level":3,"score":0.6177761554718018},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5867404341697693},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5588264465332031},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4989888668060303},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4932340979576111},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4919566810131073},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.4561750590801239},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3865024447441101},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3810081481933594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28937602043151855},{"id":"https://openalex.org/C2992571226","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node metastasis","level":4,"score":0.25068968534469604}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/jgh.12752","doi":"https://doi.org/10.1111/jgh.12752","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jgh.12752","pdf_url":null,"source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmid:25827809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25827809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastroenterology and hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:freidok.uni-freiburg.de:124634","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/124634","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of gastroenterology and hepatology. - 30 (2015) , 78-84, ISSN: 1440-1746","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5,"display_name":"No poverty","id":"https://metadata.un.org/sdg/1"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1480706413","https://openalex.org/W1651458958","https://openalex.org/W1964081206","https://openalex.org/W1964825240","https://openalex.org/W1970912753","https://openalex.org/W1975098212","https://openalex.org/W1976523431","https://openalex.org/W1990575247","https://openalex.org/W1992663028","https://openalex.org/W2002369577","https://openalex.org/W2005701343","https://openalex.org/W2014691022","https://openalex.org/W2017325830","https://openalex.org/W2017465816","https://openalex.org/W2018575860","https://openalex.org/W2021115071","https://openalex.org/W2027181541","https://openalex.org/W2028919952","https://openalex.org/W2042965279","https://openalex.org/W2046089103","https://openalex.org/W2052706552","https://openalex.org/W2056232740","https://openalex.org/W2057067430","https://openalex.org/W2066146147","https://openalex.org/W2066185056","https://openalex.org/W2071096730","https://openalex.org/W2072640245","https://openalex.org/W2073708753","https://openalex.org/W2082055110","https://openalex.org/W2097946485","https://openalex.org/W2103510102","https://openalex.org/W2106545194","https://openalex.org/W2107925166","https://openalex.org/W2111564953","https://openalex.org/W2112625058","https://openalex.org/W2115792588","https://openalex.org/W2117277249","https://openalex.org/W2117692326","https://openalex.org/W2126664946","https://openalex.org/W2127496116","https://openalex.org/W2131335409","https://openalex.org/W2147775009","https://openalex.org/W2147807172","https://openalex.org/W2154589460","https://openalex.org/W2166603674"],"related_works":["https://openalex.org/W2110049629","https://openalex.org/W2040044246","https://openalex.org/W2078017434","https://openalex.org/W1985366394","https://openalex.org/W2333444352","https://openalex.org/W2000417457","https://openalex.org/W2339290343","https://openalex.org/W1990247221","https://openalex.org/W2062561309","https://openalex.org/W2003745302"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIM:":[2],"Pancreatic":[3],"ductal":[4],"adenocarcinoma":[5],"(PDAC)":[6],"is":[7,20,46],"characterized":[8],"by":[9,212],"aggressive":[10],"biology":[11],"and":[12,23,40,55,69,74,92,96,113,116,127,142,147,154,170,194,219],"poor":[13],"prognosis":[14,208],"even":[15],"after":[16],"resection.":[17],"Long-term":[18],"survival":[19,136,181],"very":[21],"rare":[22],"cannot":[24],"be":[25,210],"reliably":[26],"predicted.":[27],"Experimental":[28],"data":[29,98],"suggest":[30],"an":[31],"important":[32],"role":[33],"of":[34,42,52,61,72,79,110,121,134,150,159,179,204,215],"epithelial-mesenchymal":[35],"transition":[36],"(EMT)":[37],"in":[38,77,140,173,182,221],"invasion":[39,54],"metastasis":[41],"PDAC.":[43],"Tumor":[44],"budding":[45,76,156,196],"regarded":[47],"as":[48],"the":[49,67,80,164,198],"morphological":[50],"correlate":[51],"local":[53],"cancer":[56],"cell":[57],"dissemination.":[58],"The":[59],"aim":[60],"this":[62],"study":[63],"was":[64],"to":[65],"evaluate":[66],"biological":[68],"prognostic":[70],"implications":[71],"EMT":[73,151,161,193,220],"tumor":[75,111,155,174,195,222],"PDAC":[78],"pancreatic":[81],"head.":[82],"METHODS:":[83],"Patients":[84],"were":[85,99,130,176],"identified":[86,211],"from":[87],"a":[88,190],"prospectively":[89],"maintained":[90],"database,":[91],"baseline,":[93],"operative,":[94,124],"histopathological,":[95],"follow-up":[97],"extracted.":[100],"Serial":[101],"tissue":[102],"slices":[103],"stained":[104],"for":[105,108,119,132],"Pan-Cytokeratin":[106],"served":[107],"analysis":[109,120],"budding,":[112],"E-Cadherin,":[114],"Beta-Catenin,":[115],"Vimentin":[117],"staining":[118],"EMT.":[122],"Baseline,":[123],"standard":[125],"pathology,":[126],"immunohistochemical":[128,187],"parameters":[129],"evaluated":[131],"prediction":[133],"long-term":[135,180],"(\u2265":[137],"30":[138],"months)":[139],"uni-":[141],"multivariate":[143,183],"analysis.":[144,184],"RESULTS:":[145],"Intra-":[146],"intertumoral":[148],"patterns":[149],"marker":[152],"expression":[153,172],"provide":[157],"evidence":[158],"partial":[160],"induction":[162],"at":[163,197],"tumor-host":[165,199],"interface.":[166,200],"Lymph":[167],"node":[168,217],"ratio":[169,218],"E-Cadherin":[171],"buds":[175],"independent":[177],"predictors":[178],"CONCLUSIONS:":[185],"Detailed":[186],"assessment":[188,214],"confirms":[189],"relationship":[191],"between":[192],"A":[201],"small":[202],"group":[203],"patients":[205],"with":[206],"favorable":[207],"can":[209],"combined":[213],"lymph":[216],"buds.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
