{"id":"https://openalex.org/W171644397","doi":null,"title":"Rotavirus diversity and evolution in the post-vaccine world.","display_name":"Rotavirus diversity and evolution in the post-vaccine world.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W171644397","mag":"171644397","pmid":"https://pubmed.ncbi.nlm.nih.gov/22284787","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3738915"},"language":"en","primary_location":{"id":"pmid:22284787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22284787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},"volume":null,"type":"review","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3738915","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036655213","display_name":"John T. Patton","orcid":"https://orcid.org/0000-0003-1572-0732","observed_orcids":["https://orcid.org/0000-0003-1572-0732"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John T Patton","raw_affiliation_strings":["Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. jpatton@niaid.nih.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. jpatton@niaid.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036655213"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"],"apc_list":null,"apc_paid":null,"fwci":1.5467,"has_fulltext":false,"cited_by_count":135,"citation_normalized_percentile":{"value":0.81288614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"13","issue":"68","first_page":"85","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rotavirus","display_name":"rotavirus","score":0.9729999899864197},{"id":"https://openalex.org/keywords/rotavirus-evolution","display_name":"rotavirus evolution","score":0.6740000247955322},{"id":"https://openalex.org/keywords/rotateq","display_name":"RotaTeq","score":0.9750000238418579},{"id":"https://openalex.org/keywords/rotarix","display_name":"Rotarix","score":1.0},{"id":"https://openalex.org/keywords/rotavirus-surveillance","display_name":"rotavirus surveillance","score":0.5080000162124634},{"id":"https://openalex.org/keywords/childhood-diarrhea","display_name":"childhood diarrhea","score":0.40700000524520874},{"id":"https://openalex.org/keywords/vaccine-effectiveness","display_name":"vaccine effectiveness","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C2781367151","wikidata":"https://www.wikidata.org/wiki/Q164778","display_name":"Rotavirus","level":3,"score":0.7349955439567566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7060214281082153},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6176776885986328},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5533824563026428},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5466665625572205},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4965553879737854},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4832099676132202},{"id":"https://openalex.org/C44465124","wikidata":"https://www.wikidata.org/wiki/Q713623","display_name":"Clade","level":4,"score":0.4733025133609772},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4685189425945282},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4672080874443054},{"id":"https://openalex.org/C81977670","wikidata":"https://www.wikidata.org/wiki/Q585259","display_name":"Genetic diversity","level":3,"score":0.4379955530166626},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3924875855445862},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.24599716067314148},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1219886839389801},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.08261048793792725}],"mesh":[{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012400","descriptor_name":"Rotavirus Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012401","descriptor_name":"Rotavirus","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D012401","descriptor_name":"Rotavirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012401","descriptor_name":"Rotavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012401","descriptor_name":"Rotavirus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016865","descriptor_name":"Reassortant Viruses","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022243","descriptor_name":"Rotavirus Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:22284787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22284787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2732060","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3738915","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3738915","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3738915","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Discov Med","raw_type":"Text"},{"id":"mag:171644397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22284787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2732060","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3738915","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2935219440","display_name":"Modification Of The Antigenicity & Virulence Of Rotaviruses By Reverse Genetics","funder_award_id":"ZIAAI000788","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W73869089","https://openalex.org/W1554174530","https://openalex.org/W1589395984","https://openalex.org/W1650197172","https://openalex.org/W1838465562","https://openalex.org/W1952903862","https://openalex.org/W1964196308","https://openalex.org/W1967528793","https://openalex.org/W1972682766","https://openalex.org/W1975214829","https://openalex.org/W1978261180","https://openalex.org/W1978816007","https://openalex.org/W1985314879","https://openalex.org/W1987370447","https://openalex.org/W1999796523","https://openalex.org/W2002920916","https://openalex.org/W2005200745","https://openalex.org/W2006549154","https://openalex.org/W2006719680","https://openalex.org/W2015631630","https://openalex.org/W2016073315","https://openalex.org/W2016398809","https://openalex.org/W2022347005","https://openalex.org/W2024847513","https://openalex.org/W2025802471","https://openalex.org/W2029606630","https://openalex.org/W2029854306","https://openalex.org/W2033895498","https://openalex.org/W2034323018","https://openalex.org/W2035616418","https://openalex.org/W2039737871","https://openalex.org/W2040399924","https://openalex.org/W2044766785","https://openalex.org/W2045149404","https://openalex.org/W2047408758","https://openalex.org/W2047635732","https://openalex.org/W2049252323","https://openalex.org/W2056646962","https://openalex.org/W2058093400","https://openalex.org/W2062201966","https://openalex.org/W2068705108","https://openalex.org/W2072236708","https://openalex.org/W2072706782","https://openalex.org/W2077117880","https://openalex.org/W2083114710","https://openalex.org/W2085595248","https://openalex.org/W2090910360","https://openalex.org/W2097930670","https://openalex.org/W2099119539","https://openalex.org/W2100276305","https://openalex.org/W2102704779","https://openalex.org/W2103211789","https://openalex.org/W2106005103","https://openalex.org/W2106050401","https://openalex.org/W2107847785","https://openalex.org/W2109176401","https://openalex.org/W2109417543","https://openalex.org/W2110027469","https://openalex.org/W2110318366","https://openalex.org/W2111924954","https://openalex.org/W2118440094","https://openalex.org/W2121548069","https://openalex.org/W2123497124","https://openalex.org/W2127653958","https://openalex.org/W2131154800","https://openalex.org/W2132791342","https://openalex.org/W2133729485","https://openalex.org/W2135985984","https://openalex.org/W2137015911","https://openalex.org/W2140437331","https://openalex.org/W2143962003","https://openalex.org/W2144430726","https://openalex.org/W2147847383","https://openalex.org/W2149462395","https://openalex.org/W2150294366","https://openalex.org/W2152270920","https://openalex.org/W2156167673","https://openalex.org/W2157235080","https://openalex.org/W2157623048","https://openalex.org/W2157729395","https://openalex.org/W2159396395","https://openalex.org/W2160169493","https://openalex.org/W2162064817","https://openalex.org/W2163651604","https://openalex.org/W2170749337","https://openalex.org/W2336472430","https://openalex.org/W2342167269","https://openalex.org/W2467850362","https://openalex.org/W4231603137","https://openalex.org/W4234915916"],"related_works":["https://openalex.org/W1968209520","https://openalex.org/W2201595319","https://openalex.org/W2143962003","https://openalex.org/W4307339896","https://openalex.org/W2172251715","https://openalex.org/W1971112216","https://openalex.org/W2109176401","https://openalex.org/W2889363647","https://openalex.org/W7100093187","https://openalex.org/W7019676746"],"abstract_inverted_index":{"Rotaviruses":[0],"(RVs)":[1],"are":[2,15,27],"a":[3],"large":[4],"genetically":[5,144],"diverse":[6],"population":[7],"of":[8,18,32,55,60,64,70,95,114,124,143,151,167,178,186,205,215],"segmented":[9],"double-stranded":[10],"(ds)":[11],"RNA":[12],"viruses":[13],"that":[14,52,75,86,134,201],"important":[16],"causes":[17],"gastroenteritis":[19],"in":[20,43,174],"many":[21],"animal":[22],"species.":[23],"The":[24,68,148],"human":[25,56,77,125,194,216],"RVs":[26,57,126],"responsible":[28],"for":[29],"the":[30,53,76,96,111,115,121,139,163,176,183,203],"deaths":[31],"nearly":[33],"450,000":[34],"infants":[35],"and":[36,105,119,141,159,198,210],"young":[37],"children":[38],"each":[39],"year,":[40],"most":[41],"occurring":[42],"developing":[44],"countries.":[45],"Recent":[46],"large-scale":[47],"sequencing":[48],"efforts":[49],"have":[50,80],"revealed":[51],"genomes":[54],"typically":[58],"consist":[59],"phylogenetically":[61],"linked":[62],"constellations":[63,73],"eleven":[65],"dsRNA":[66],"segments.":[67],"presence":[69,140],"such":[71],"preferred":[72],"indicate":[74],"RV":[78,146,155,179],"genes":[79,98],"co-evolved":[81],"to":[82,90],"produce":[83],"protein":[84],"sets":[85],"work":[87],"optimally":[88],"together":[89],"support":[91],"virus":[92],"replication.":[93],"Two":[94],"viral":[97],"encode":[99],"virion":[100],"outer":[101],"capsid":[102],"proteins":[103],"(VP7":[104],"VP4)":[106],"whose":[107],"antigenic":[108,199],"properties":[109],"define":[110],"G/P":[112,122],"type":[113,123],"virus.":[116],"From":[117],"year-to-year":[118],"place-to-place,":[120],"associated":[127,137],"with":[128,138],"disease":[129],"can":[130,135],"fluctuate":[131],"dramatically,":[132],"phenomena":[133],"be":[136],"behavior":[142],"distinct":[145],"clades.":[147],"recent":[149],"introduction":[150],"two":[152],"live":[153],"attenuated":[154],"vaccines":[156,188],"[RotaTeq":[157],"(TM)":[158],"Rotarix":[160],"(TM)]":[161],"into":[162],"childhood":[164],"vaccination":[165],"programs":[166],"various":[168],"countries":[169],"has":[170],"been":[171],"highly":[172],"effective":[173],"reducing":[175],"incidence":[177],"diarrheal":[180],"disease.":[181],"Whether":[182],"widespread":[184],"use":[185],"these":[187],"will":[189,211],"introduce":[190],"selective":[191],"pressures":[192],"on":[193],"RVs,":[195],"triggering":[196],"genetic":[197],"changes":[200],"undermine":[202],"effectiveness":[204],"vaccinations":[206],"programs,":[207],"is":[208],"uncertain":[209],"require":[212],"continued":[213],"surveillance":[214],"RVs.":[217]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
