{"id":"https://openalex.org/W171363487","doi":"https://doi.org/10.1042/bj2740167","title":"Role of unsaturated derivatives of spermidine as substrates for spermine synthase and in supporting growth of SV-3T3 cells","display_name":"Role of unsaturated derivatives of spermidine as substrates for spermine synthase and in supporting growth of SV-3T3 cells","publication_year":1991,"publication_date":"1991-02-15","ids":{"openalex":"https://openalex.org/W171363487","doi":"https://doi.org/10.1042/bj2740167","mag":"171363487","pmid":"https://pubmed.ncbi.nlm.nih.gov/2001229","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1149934"},"language":"en","primary_location":{"id":"doi:10.1042/bj2740167","doi":"https://doi.org/10.1042/bj2740167","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2740167","pdf_url":"https://portlandpress.com/biochemj/article-pdf/274/1/167/602537/bj2740167.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/274/1/167/602537/bj2740167.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110184049","display_name":"Anthony E. Pegg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A E Pegg","raw_affiliation_strings":["Department of Cellular and Molecular Physiology, and of Pharmacology, The Pennsylvania State University College of Medicine, Hershey 17033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Physiology, and of Pharmacology, The Pennsylvania State University College of Medicine, Hershey 17033","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065824720","display_name":"S. NAGARAJAN","orcid":"https://orcid.org/0000-0001-7034-8158","observed_orcids":["https://orcid.org/0000-0001-7034-8158"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Nagarajan","raw_affiliation_strings":["Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, NY 14853, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, NY 14853, U.S.A","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081047458","display_name":"Sepehre Naficy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Naficy","raw_affiliation_strings":["Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, NY 14853, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, NY 14853, U.S.A","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035275755","display_name":"Bruce Ganem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Ganem","raw_affiliation_strings":["Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, NY 14853, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, NY 14853, U.S.A","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1266,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.33965468,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"274","issue":"1","first_page":"167","last_page":"171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spermine-synthase","display_name":"spermine synthase","score":0.7879999876022339},{"id":"https://openalex.org/keywords/polyamine-metabolism","display_name":"polyamine metabolism","score":0.6069999933242798},{"id":"https://openalex.org/keywords/stereospecificity","display_name":"stereospecificity","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.7210000157356262},{"id":"https://openalex.org/keywords/polyamine-transport","display_name":"polyamine transport","score":0.7839999794960022},{"id":"https://openalex.org/keywords/difluoromethylornithine","display_name":"difluoromethylornithine","score":0.9020000100135803},{"id":"https://openalex.org/keywords/spermidine","display_name":"spermidine","score":0.6710000038146973},{"id":"https://openalex.org/keywords/spermine","display_name":"spermine","score":0.7480000257492065},{"id":"https://openalex.org/keywords/polyamine-accumulation","display_name":"polyamine accumulation","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C2777497464","wikidata":"https://www.wikidata.org/wiki/Q418834","display_name":"Spermidine","level":3,"score":0.953938901424408},{"id":"https://openalex.org/C2776109719","wikidata":"https://www.wikidata.org/wiki/Q424597","display_name":"Spermine","level":3,"score":0.9516136646270752},{"id":"https://openalex.org/C2780115381","wikidata":"https://www.wikidata.org/wiki/Q421959","display_name":"Polyamine","level":2,"score":0.7861218452453613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.52178955078125},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5166440606117249},{"id":"https://openalex.org/C2776254738","wikidata":"https://www.wikidata.org/wiki/Q81406","display_name":"Alkene","level":3,"score":0.4220616817474365},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36723706126213074},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25676101446151733},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.06950727105140686}],"mesh":[{"descriptor_ui":"D000518","descriptor_name":"Eflornithine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013095","descriptor_name":"Spermidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013095","descriptor_name":"Spermidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013095","descriptor_name":"Spermidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013097","descriptor_name":"Spermine Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj2740167","doi":"https://doi.org/10.1042/bj2740167","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2740167","pdf_url":"https://portlandpress.com/biochemj/article-pdf/274/1/167/602537/bj2740167.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1149934","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1149934","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:2001229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2001229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj2740167","doi":"https://doi.org/10.1042/bj2740167","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2740167","pdf_url":"https://portlandpress.com/biochemj/article-pdf/274/1/167/602537/bj2740167.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1755016745","display_name":null,"funder_award_id":"GM 26290","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G312399290","display_name":"MODULATION OF POLYAMINE HOMEOSTASIS BY POLYAMINE ANALOGS","funder_award_id":"U01CA037606","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3482581258","display_name":null,"funder_award_id":"CA37606","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4596755758","display_name":"CHEMICAL AND BIOLOGICAL STUDIES WITH POLYAMINES","funder_award_id":"5r01am026754-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6708588899","display_name":"Investigations of Mammalian Aminopropyltransferases","funder_award_id":"R01GM026290","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W171363487.pdf","grobid_xml":"https://content.openalex.org/works/W171363487.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W328716559","https://openalex.org/W1536045402","https://openalex.org/W1560177405","https://openalex.org/W1577431525","https://openalex.org/W1579852010","https://openalex.org/W1783564941","https://openalex.org/W1844699750","https://openalex.org/W1966671509","https://openalex.org/W1968345395","https://openalex.org/W1975012397","https://openalex.org/W1995604250","https://openalex.org/W2011251553","https://openalex.org/W2024398712","https://openalex.org/W2032660482","https://openalex.org/W2033608520","https://openalex.org/W2056253308","https://openalex.org/W2060597942","https://openalex.org/W2074904803","https://openalex.org/W2079979154","https://openalex.org/W2080707821","https://openalex.org/W2084104179","https://openalex.org/W2107701857","https://openalex.org/W2108613214","https://openalex.org/W2125102543","https://openalex.org/W2146345243","https://openalex.org/W2161356660","https://openalex.org/W2203764179","https://openalex.org/W2262777201","https://openalex.org/W2281124822","https://openalex.org/W2338134387","https://openalex.org/W2339893430","https://openalex.org/W2340148597","https://openalex.org/W2398795634","https://openalex.org/W2401896515","https://openalex.org/W2406327503","https://openalex.org/W2486950037","https://openalex.org/W2794869410","https://openalex.org/W4238270754","https://openalex.org/W4302592996","https://openalex.org/W6600575473","https://openalex.org/W6601280964","https://openalex.org/W6611621389","https://openalex.org/W6795004367"],"related_works":["https://openalex.org/W2401896515","https://openalex.org/W2079979154","https://openalex.org/W2329314345","https://openalex.org/W2612732533","https://openalex.org/W2035604114","https://openalex.org/W2032660482","https://openalex.org/W2011251553","https://openalex.org/W2015763435","https://openalex.org/W2173292923","https://openalex.org/W2339893430"],"abstract_inverted_index":{"Synthetic":[0],"unsaturated":[1,79,169],"analogues":[2,81,170],"of":[3,24,35,39,68,77,88,97,107,136,167,211],"the":[4,22,36,50,55,65,71,78,85,95,104,134,152,168,174,193,204,208],"natural":[5,205],"polyamine":[6,159,194],"were":[7,59,91,101,117],"examined":[8],"as":[9,16],"possible":[10],"substrates":[11,191],"for":[12,18,45,133,192],"spermine":[13,46,72,89,122],"synthase":[14,73],"and":[15,54,84,115,147],"replacements":[17],"spermidine":[19,80,108,153,183],"in":[20,70,163,173,207],"supporting":[21],"growth":[23,96,146],"SV-3T3":[25,98,175],"cells.":[26],"It":[27],"was":[28,41,141,148],"found":[29],"that":[30,49,100,127,157,187,198],"N-(3-aminopropyl)-1,4-diamino-cis-but-2-ene":[31],"[the":[32],"cis":[33],"isomer":[34,52],"alkene":[37,56],"analogue":[38,57,87],"spermidine]":[40],"a":[42,121,178],"good":[43],"substrate":[44],"synthase,":[47],"but":[48,197],"trans":[51],"[N-(3-aminopropyl)-1,4-diamino-trans-but-2-ene]":[53],"[N-(3-aminopropyl)-1,4-diaminobut-2-yne]":[58],"not":[60,118,131,149],"substrates.":[61],"These":[62],"results":[63],"provide":[64],"first":[66],"demonstration":[67],"stereospecificity":[69],"reaction.":[74],"All":[75,166],"three":[76],"described":[82],"above":[83],"cis-alkene":[86],"[N1N4-bis-(3-aminopropyl)-1,4-diamino-cis-but-2-ene]":[90],"able":[92,143],"to":[93,144,151,177],"support":[94,145],"cells":[99,176],"prevented":[102],"from":[103],"endogenous":[105],"synthesis":[106],"by":[109],"treatment":[110],"with":[111],"alpha-difluoromethylornithine.":[112],"Since":[113],"N-(3-aminopropyl)-1,4-diamino-trans-but-2-ene]":[114],"N-(3-aminopropyl)-1,4-diaminobut-2-yne":[116],"converted":[119],"into":[120],"derivative,":[123,154],"it":[124,155],"is":[125,130],"apparent":[126],"this":[128,164,212],"conversion":[129],"needed":[132],"stimulation":[135],"growth.":[137],"However,":[138],"since":[139],"N1N4-bis-(3-aminopropyl)-1,4-diamino-cis-but-2-ene":[140],"also":[142],"degraded":[150],"appears":[156],"either":[158],"can":[160],"be":[161],"effective":[162,202],"respect.":[165],"tested":[171],"accumulated":[172],"much":[179],"greater":[180],"extent":[181],"than":[182,203],"itself.":[184],"This":[185],"indicates":[186],"these":[188],"compounds":[189],"are":[190,200],"transport":[195],"system,":[196],"they":[199],"less":[201],"polyamines":[206],"feedback":[209],"regulation":[210],"system.":[213]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
