{"id":"https://openalex.org/W171363484","doi":null,"title":"[Type IV collagenases (MMP-2 and MMP-9) and their substrates--intracellular proteins, hormones, cytokines, chemokines and their receptors].","display_name":"[Type IV collagenases (MMP-2 and MMP-9) and their substrates--intracellular proteins, hormones, cytokines, chemokines and their receptors].","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W171363484","mag":"171363484","pmid":"https://pubmed.ncbi.nlm.nih.gov/17718386"},"language":"pl","primary_location":{"id":"pmid:17718386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17718386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Postepy biochemii","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005128098","display_name":"El\u017cbieta Hrabec","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Elzbieta Hrabec","raw_affiliation_strings":["Zak\u0142ad Enzymologii Medycznej, Katedra Biochemii Medycznej, Uniwersytet Medyczny w Lodzi, L\u00f3d\u017a. ehrabec@zdn.am.lodz.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zak\u0142ad Enzymologii Medycznej, Katedra Biochemii Medycznej, Uniwersytet Medyczny w Lodzi, L\u00f3d\u017a. ehrabec@zdn.am.lodz.pl","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019011515","display_name":"Julia Naduk-Kik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia Naduk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078295366","display_name":"Ma\u0142gorzata Str\u0119k","orcid":"https://orcid.org/0000-0001-9902-0439","observed_orcids":["https://orcid.org/0000-0001-9902-0439"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ma\u0142gorzata Strek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065556433","display_name":"Zbigniew Hrabec","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zbigniew Hrabec","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9248,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.74177619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"53","issue":"1","first_page":"37","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8930000066757202},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":1.0},{"id":"https://openalex.org/keywords/type-iv-collagenase","display_name":"type IV collagenase","score":0.828000009059906},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.6949999928474426},{"id":"https://openalex.org/keywords/growth-factor-activation","display_name":"growth factor activation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7289999723434448},{"id":"https://openalex.org/keywords/immune-system","display_name":"immune system","score":0.5609999895095825},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7870000004768372},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.8740000128746033},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.8376960754394531},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7957330942153931},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7667377591133118},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.7003456950187683},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4915178716182709},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.4633958637714386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4567067325115204},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4256134033203125},{"id":"https://openalex.org/C2777738151","wikidata":"https://www.wikidata.org/wiki/Q1903925","display_name":"Tenascin","level":4,"score":0.413242906332016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2111344039440155}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010064","descriptor_name":"Embryo Implantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D036361","descriptor_name":"Peptide Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17718386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17718386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Postepy biochemii","raw_type":"English Abstract"},{"id":"mag:171363484","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17718386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2077123765","https://openalex.org/W4240895094","https://openalex.org/W2599889833","https://openalex.org/W2490219786","https://openalex.org/W2523756791","https://openalex.org/W2093312573","https://openalex.org/W2558574707","https://openalex.org/W2473988462","https://openalex.org/W2185233773","https://openalex.org/W2135124706"],"abstract_inverted_index":{"Matrix":[0],"metalloproteinases":[1],"(MMPs)":[2],"are":[3,119],"zinc-dependent":[4],"endopeptidases":[5],"that":[6,50,90,103],"cleave":[7,70],"protein":[8],"components":[9,61],"of":[10,57,73,107,129,138],"extracellular":[11,28,36,42,59],"matrix":[12,29,37,60],"such":[13],"as":[14],"collagens,":[15],"laminin,":[16],"fibronectin,":[17],"proteoglycans":[18],"and":[19,30,79,113,124,146],"contribute":[20],"to":[21],"cell":[22],"migration":[23],"by":[24,62,100],"eliminating":[25],"the":[26,35,58,105],"surrounding":[27],"basement":[31],"membrane":[32],"barriers.":[33],"However,":[34],"is":[38,97,109],"not":[39],"simply":[40],"an":[41],"scaffold":[43],"because,":[44],"for":[45,121],"example,":[46],"it":[47],"contains":[48],"sites":[49],"can":[51,64],"bind":[52],"growth":[53,80],"factors;":[54],"therefore,":[55],"degradation":[56],"MMPs":[63,68,108,118],"alter":[65],"cellular":[66],"behavior.":[67],"also":[69,98],"a":[71,136],"variety":[72,137],"non-ECM":[74],"proteins,":[75],"including":[76,141],"cytokines,":[77],"chemokines,":[78],"factors,":[81],"activating":[82],"or":[83,86],"inactivating":[84],"them,":[85],"generating":[87],"other":[88],"products":[89],"have":[91],"biological":[92],"consequences.":[93],"The":[94],"immune":[95],"system":[96],"influenced":[99],"MMPs.":[101],"For":[102],"reason,":[104],"function":[106],"much":[110],"more":[111],"complex":[112],"subtle":[114],"than":[115],"simple":[116],"demolition.":[117],"essential":[120],"embryonic":[122],"development":[123],"morphogenesis,":[125],"however,":[126],"exuberant":[127],"expression":[128],"these":[130],"enzymes":[131],"has":[132],"been":[133],"associated":[134],"with":[135],"destructive":[139],"diseases,":[140],"tumor":[142],"progression,":[143],"cardiovascular":[144],"diseases":[145],"autoimmune":[147],"diseases.":[148]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
