{"id":"https://openalex.org/W170946976","doi":null,"title":"Intravitreal toxicology and duration of efficacy of a novel antiviral lipid prodrug of ganciclovir in liposome formulation.","display_name":"Intravitreal toxicology and duration of efficacy of a novel antiviral lipid prodrug of ganciclovir in liposome formulation.","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W170946976","mag":"170946976","pmid":"https://pubmed.ncbi.nlm.nih.gov/10798672"},"language":"en","primary_location":{"id":"pmid:10798672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10798672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040724990","display_name":"Lingyun Cheng","orcid":"https://orcid.org/0000-0002-8156-5550","observed_orcids":["https://orcid.org/0000-0002-8156-5550"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Cheng","raw_affiliation_strings":["Shiley Eye Center, University of California, San Diego, La Jolla 92093-0946, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shiley Eye Center, University of California, San Diego, La Jolla 92093-0946, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009097053","display_name":"Karl Y. Hostetler","orcid":"https://orcid.org/0000-0002-1155-2885","observed_orcids":["https://orcid.org/0000-0002-1155-2885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Y Hostetler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009615900","display_name":"Sunan Chaidhawangul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Chaidhawangul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015604675","display_name":"Michael F. Gardner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M F Gardner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044272717","display_name":"James R. Beadle","orcid":"https://orcid.org/0000-0002-2690-6287","observed_orcids":["https://orcid.org/0000-0002-2690-6287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J R Beadle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060396124","display_name":"Kelly Keefe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K S Keefe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109065862","display_name":"G Bergeron-Lynn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Bergeron-Lynn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075998916","display_name":"GREGORY M. SEVERSON","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G M Severson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019172815","display_name":"Kelly A. Soules","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K A Soules","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A J Mueller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A J Mueller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101974691","display_name":"William R. Freeman","orcid":"https://orcid.org/0000-0001-9979-2500","observed_orcids":["https://orcid.org/0000-0001-9979-2500"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W R Freeman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.529,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.87142857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"41","issue":"6","first_page":"1523","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ganciclovir-prodrug","display_name":"ganciclovir prodrug","score":0.8460000157356262},{"id":"https://openalex.org/keywords/lipid-prodrugs","display_name":"lipid prodrugs","score":0.8740000128746033},{"id":"https://openalex.org/keywords/liposomal-formulation","display_name":"liposomal formulation","score":0.781000018119812},{"id":"https://openalex.org/keywords/intravitreal-injection","display_name":"intravitreal injection","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cytomegalovirus-retinitis","display_name":"cytomegalovirus retinitis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/antiviral-efficacy","display_name":"antiviral efficacy","score":0.7289999723434448},{"id":"https://openalex.org/keywords/ocular-toxicity","display_name":"ocular toxicity","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cataract","display_name":"cataract","score":0.7540000081062317},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.6639999747276306},{"id":"https://openalex.org/keywords/vitreous-body","display_name":"vitreous humor","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C2777965375","wikidata":"https://www.wikidata.org/wiki/Q417640","display_name":"Ganciclovir","level":4,"score":0.8936374187469482},{"id":"https://openalex.org/C2779742858","wikidata":"https://www.wikidata.org/wiki/Q180609","display_name":"Intravitreal administration","level":3,"score":0.7094095349311829},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.6752068400382996},{"id":"https://openalex.org/C2777016524","wikidata":"https://www.wikidata.org/wiki/Q630552","display_name":"Retinitis","level":4,"score":0.6175329089164734},{"id":"https://openalex.org/C2777324356","wikidata":"https://www.wikidata.org/wiki/Q4271835","display_name":"Cytomegalovirus retinitis","level":5,"score":0.5995514988899231},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5501978993415833},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5222569108009338},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3319207727909088},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.32632678747177124},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.28684574365615845},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.23647043108940125},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.16340622305870056}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006561","descriptor_name":"Herpes Simplex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006561","descriptor_name":"Herpes Simplex","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006561","descriptor_name":"Herpes Simplex","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009887","descriptor_name":"Ophthalmoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015774","descriptor_name":"Ganciclovir","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015774","descriptor_name":"Ganciclovir","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015774","descriptor_name":"Ganciclovir","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D015774","descriptor_name":"Ganciclovir","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015828","descriptor_name":"Eye Infections, Viral","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015828","descriptor_name":"Eye Infections, Viral","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015828","descriptor_name":"Eye Infections, Viral","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10798672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10798672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:170946976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10798672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1802017290","display_name":"Studies of Retinopathy of AIDS in the HAART Era","funder_award_id":"R01EY007366","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G7210171805","display_name":"PRODRUGS FOR THERAPY OF VIRAL RETINITIS IN AIDS","funder_award_id":"R01EY011832","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W121536396","https://openalex.org/W167631909","https://openalex.org/W314773953","https://openalex.org/W1971338866","https://openalex.org/W1974932175","https://openalex.org/W2003370883","https://openalex.org/W2006275825","https://openalex.org/W2008267706","https://openalex.org/W2022284496","https://openalex.org/W2024292816","https://openalex.org/W2047901258","https://openalex.org/W2057976869","https://openalex.org/W2068309442","https://openalex.org/W2075740239","https://openalex.org/W2091281345","https://openalex.org/W2095399072","https://openalex.org/W2108340827","https://openalex.org/W2133664045","https://openalex.org/W2148811378","https://openalex.org/W2151224739","https://openalex.org/W2161529378","https://openalex.org/W2168923499","https://openalex.org/W2318289184","https://openalex.org/W2326455829","https://openalex.org/W2418388941","https://openalex.org/W2502805807"],"related_works":["https://openalex.org/W176300871","https://openalex.org/W2103657369","https://openalex.org/W2023261618","https://openalex.org/W18595978","https://openalex.org/W2091438473","https://openalex.org/W2127662542","https://openalex.org/W1978694636","https://openalex.org/W2008267706","https://openalex.org/W2884255614","https://openalex.org/W2065539357"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"evaluate":[2],"the":[3,11,130,178,212,222,225,245,258],"intraocular":[4,64,287],"safety":[5,65],"and":[6,63,71,84,98,123,136,144,155,229],"antiviral":[7,54],"treatment":[8,88,227],"efficacy":[9,89],"of":[10,15,39,80,96,109,132,196,203,221,242,261],"sustained":[12],"lipid":[13],"prodrug":[14],"ganciclovir,":[16],"1-O-hexadecylpropanediol-3-phospho-ganciclovir":[17],"(HDP-P-GCV),":[18],"as":[19,45,266],"an":[20],"intravitreal":[21,74,78,94,107,116,168,191,209,269],"injectable":[22,270],"drug":[23],"system":[24,278],"for":[25,282,286],"viral":[26],"retinitis.":[27],"METHODS:":[28],"HDP-P-GCV":[29,97,110,133,152,204,264],"was":[30,49,56,66,90,119,142],"synthesized":[31],"by":[32,58,68,92,106],"coupling":[33],"1-O-hexadecyl-propanediol-3-phosphate":[34],"to":[35,235],"either":[36],"free":[37],"hydroxyl":[38],"ganciclovir":[40,251],"in":[41,61,150,174,185,211],"pyridine":[42],"with":[43,76,121,125,187,205,224,244,250],"dicyclohexylcarbodiimide":[44],"catalyst.":[46],"The":[47,53,87],"compound":[48],"formulated":[50],"into":[51],"liposomes.":[52],"activity":[55],"assessed":[57,67],"DNA":[59],"reduction":[60],"vitro,":[62,129],"ophthalmoscopy,":[69],"electrophysiology,":[70],"histology":[72],"after":[73],"injections,":[75],"resultant":[77,206],"concentrations":[79],"0.2,":[81],"0.632,":[82],"1.12,":[83],"2":[85,165],"mM.":[86],"evaluated":[91],"simultaneous":[93,226],"injection":[95,108,202],"herpes":[99],"simplex":[100],"virus":[101],"type":[102],"1":[103],"(HSV-1)":[104],"or":[105,252,272],"at":[111,161,177],"various":[112],"times":[113],"before":[114],"HSV-1":[115,135,213,262],"inoculation.":[117],"Retinitis":[118],"scored":[120],"ophthalmoscopy":[122],"compared":[124,249],"controls.":[126,255],"RESULTS:":[127],"In":[128,148,257],"IC50":[131],"against":[134],"human":[137],"cytomegalovirus":[138],"(HCMV)":[139],"infected":[140],"cells":[141],"0.02":[143],"0.6":[145],"microM,":[146],"respectively.":[147],"rabbits":[149],"vivo,":[151],"dispersed":[153],"evenly":[154],"maintained":[156],"a":[157,218,230,267],"good":[158],"vitreous":[159],"clarity":[160],"all":[162],"doses":[163],"except":[164],"mM":[166,189,208],"final":[167,190],"concentration.":[169,192],"Although":[170],"cataracts":[171],"were":[172,182,199],"observed":[173,184],"some":[175],"eyes":[176,186],"higher":[179],"doses,":[180],"they":[181],"not":[183],"0.2":[188,207],"No":[193],"other":[194],"indications":[195],"ocular":[197],"toxicity":[198],"observed.":[200],"Intravitreal":[201],"concentration":[210],"retinitis":[214,263],"rabbit":[215,259],"model":[216,260],"demonstrated":[217],"complete":[219],"protection":[220,241],"retina":[223,243],"strategy":[228],"4":[231],"(P":[232],"=":[233,237],"0.03)":[234],"6-(P":[236],"0.058)":[238],"week":[239],"significant":[240],"pretreatment":[246],"strategies":[247],"when":[248],"blank":[253],"liposome":[254,277],"CONCLUSIONS:":[256],"acts":[265],"long-lasting":[268],"anti-CMV":[271],"anti-HSV":[273],"compound.":[274],"This":[275],"self-assembling":[276],"could":[279],"be":[280],"applicable":[281],"many":[283],"compounds":[284],"available":[285],"diseases.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
