{"id":"https://openalex.org/W170915384","doi":null,"title":"Unraveling Mechanisms of Transcriptional Repression: Novel Insights from Brinker","display_name":"Unraveling Mechanisms of Transcriptional Repression: Novel Insights from Brinker","publication_year":2013,"publication_date":"2013-09-30","ids":{"openalex":"https://openalex.org/W170915384","mag":"170915384"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:19334","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/19334/1/Upadhyai_Priyanka_2013.pdf","pdf_url":"https://d-scholarship.pitt.edu/19334/1/Upadhyai_Priyanka_2013.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012276476","display_name":"Priyanka Upadhyai","orcid":"https://orcid.org/0000-0002-4319-7283","observed_orcids":["https://orcid.org/0000-0002-4319-7283"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Priyanka Upadhyai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4319-7283","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5012276476"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01114641,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.09740000218153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brinker","display_name":"Brinker","score":0.8920000195503235},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.984000027179718},{"id":"https://openalex.org/keywords/corepressors","display_name":"corepressors","score":0.9739999771118164},{"id":"https://openalex.org/keywords/groucho","display_name":"Groucho","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ctbp","display_name":"CtBP","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chromatin-modification","display_name":"chromatin modification","score":0.8050000071525574},{"id":"https://openalex.org/keywords/oogenesis","display_name":"oogenesis","score":0.843999981880188},{"id":"https://openalex.org/keywords/wing-imaginal-disc","display_name":"wing imaginal disc","score":0.8500000238418579},{"id":"https://openalex.org/keywords/egfr-signaling","display_name":"EGFR signaling","score":0.9200000166893005},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.8781498670578003},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.7190219163894653},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5864039659500122},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5582110285758972},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.465016633272171},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4644470512866974},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4496689736843109},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4429223835468292},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.41058826446533203},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.22272524237632751},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:19334","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/19334/1/Upadhyai_Priyanka_2013.pdf","pdf_url":"https://d-scholarship.pitt.edu/19334/1/Upadhyai_Priyanka_2013.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:170915384","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/19334/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":293,"referenced_works":["https://openalex.org/W947309","https://openalex.org/W85220410","https://openalex.org/W293846736","https://openalex.org/W1040915469","https://openalex.org/W1511545125","https://openalex.org/W1520825673","https://openalex.org/W1545962441","https://openalex.org/W1547269929","https://openalex.org/W1553325587","https://openalex.org/W1564308673","https://openalex.org/W1567442847","https://openalex.org/W1585562050","https://openalex.org/W1601315441","https://openalex.org/W1603742465","https://openalex.org/W1606360357","https://openalex.org/W1637612807","https://openalex.org/W1665675901","https://openalex.org/W1742557797","https://openalex.org/W1815642178","https://openalex.org/W1832829702","https://openalex.org/W1869366780","https://openalex.org/W1880648489","https://openalex.org/W1889767892","https://openalex.org/W1906734327","https://openalex.org/W1908701485","https://openalex.org/W1923015860","https://openalex.org/W1936346288","https://openalex.org/W1963687107","https://openalex.org/W1963736125","https://openalex.org/W1965856748","https://openalex.org/W1967153587","https://openalex.org/W1967234593","https://openalex.org/W1967422137","https://openalex.org/W1967638733","https://openalex.org/W1967709588","https://openalex.org/W1968366930","https://openalex.org/W1969021739","https://openalex.org/W1969408132","https://openalex.org/W1969917440","https://openalex.org/W1970316586","https://openalex.org/W1970642835","https://openalex.org/W1973972117","https://openalex.org/W1975613609","https://openalex.org/W1976290150","https://openalex.org/W1976519371","https://openalex.org/W1977308882","https://openalex.org/W1977455218","https://openalex.org/W1978139037","https://openalex.org/W1978327792","https://openalex.org/W1980730318","https://openalex.org/W1985063313","https://openalex.org/W1986325903","https://openalex.org/W1986510600","https://openalex.org/W1987438891","https://openalex.org/W1987599413","https://openalex.org/W1988379532","https://openalex.org/W1991062831","https://openalex.org/W1991395942","https://openalex.org/W1991439294","https://openalex.org/W1991766559","https://openalex.org/W1992854237","https://openalex.org/W1993414489","https://openalex.org/W1993521976","https://openalex.org/W1994528729","https://openalex.org/W1995303485","https://openalex.org/W1995812436","https://openalex.org/W1996813139","https://openalex.org/W1998359471","https://openalex.org/W1998363999","https://openalex.org/W1998746265","https://openalex.org/W1999570631","https://openalex.org/W2001212353","https://openalex.org/W2001488804","https://openalex.org/W2001770641","https://openalex.org/W2001898035","https://openalex.org/W2003038417","https://openalex.org/W2003168089","https://openalex.org/W2004032707","https://openalex.org/W2004320731","https://openalex.org/W2004743215","https://openalex.org/W2005415007","https://openalex.org/W2006788765","https://openalex.org/W2008201378","https://openalex.org/W2008843346","https://openalex.org/W2009112566","https://openalex.org/W2011181841","https://openalex.org/W2011263116","https://openalex.org/W2012674191","https://openalex.org/W2012703700","https://openalex.org/W2013740909","https://openalex.org/W2013865944","https://openalex.org/W2014157613","https://openalex.org/W2014361147","https://openalex.org/W2014908429","https://openalex.org/W2014941287","https://openalex.org/W2015132841","https://openalex.org/W2016350172","https://openalex.org/W2017995506","https://openalex.org/W2018438969","https://openalex.org/W2018649316","https://openalex.org/W2018804425","https://openalex.org/W2020674390","https://openalex.org/W2020977773","https://openalex.org/W2021125340","https://openalex.org/W2021554803","https://openalex.org/W2021647546","https://openalex.org/W2022035794","https://openalex.org/W2022099923","https://openalex.org/W2022620053","https://openalex.org/W2023865101","https://openalex.org/W2024301699","https://openalex.org/W2024352715","https://openalex.org/W2024675341","https://openalex.org/W2026441085","https://openalex.org/W2027813307","https://openalex.org/W2027971163","https://openalex.org/W2028163075","https://openalex.org/W2028673763","https://openalex.org/W2029627613","https://openalex.org/W2029746435","https://openalex.org/W2031782870","https://openalex.org/W2033522446","https://openalex.org/W2034139344","https://openalex.org/W2034156554","https://openalex.org/W2034217492","https://openalex.org/W2035432747","https://openalex.org/W2036639816","https://openalex.org/W2037128257","https://openalex.org/W2037602867","https://openalex.org/W2037877981","https://openalex.org/W2038614254","https://openalex.org/W2038676786","https://openalex.org/W2039968082","https://openalex.org/W2040633563","https://openalex.org/W2040706549","https://openalex.org/W2040850361","https://openalex.org/W2040879524","https://openalex.org/W2041232182","https://openalex.org/W2041892053","https://openalex.org/W2041966847","https://openalex.org/W2042279680","https://openalex.org/W2043562679","https://openalex.org/W2044854823","https://openalex.org/W2045580211","https://openalex.org/W2047734673","https://openalex.org/W2048066878","https://openalex.org/W2048122656","https://openalex.org/W2048546181","https://openalex.org/W2048917073","https://openalex.org/W2049838999","https://openalex.org/W2050867644","https://openalex.org/W2051619787","https://openalex.org/W2052112605","https://openalex.org/W2052443837","https://openalex.org/W2054729731","https://openalex.org/W2054961582","https://openalex.org/W2055807180","https://openalex.org/W2056453168","https://openalex.org/W2056493327","https://openalex.org/W2057228860","https://openalex.org/W2058283323","https://openalex.org/W2058694973","https://openalex.org/W2059321472","https://openalex.org/W2059607580","https://openalex.org/W2061257277","https://openalex.org/W2061888605","https://openalex.org/W2062076043","https://openalex.org/W2062412372","https://openalex.org/W2066170392","https://openalex.org/W2067991344","https://openalex.org/W2068028816","https://openalex.org/W2068089675","https://openalex.org/W2068930193","https://openalex.org/W2068952604","https://openalex.org/W2069328568","https://openalex.org/W2069532898","https://openalex.org/W2070108478","https://openalex.org/W2071202857","https://openalex.org/W2071990427","https://openalex.org/W2072751609","https://openalex.org/W2073026107","https://openalex.org/W2075087486","https://openalex.org/W2075422091","https://openalex.org/W2077132193","https://openalex.org/W2078523836","https://openalex.org/W2078587980","https://openalex.org/W2079348844","https://openalex.org/W2080506913","https://openalex.org/W2082533656","https://openalex.org/W2083279359","https://openalex.org/W2085509761","https://openalex.org/W2086350426","https://openalex.org/W2086876386","https://openalex.org/W2087950896","https://openalex.org/W2088510647","https://openalex.org/W2089894746","https://openalex.org/W2090536090","https://openalex.org/W2090551154","https://openalex.org/W2091739086","https://openalex.org/W2092386534","https://openalex.org/W2092476087","https://openalex.org/W2094636364","https://openalex.org/W2096590212","https://openalex.org/W2096898215","https://openalex.org/W2097469177","https://openalex.org/W2097751554","https://openalex.org/W2098756158","https://openalex.org/W2100256750","https://openalex.org/W2101883012","https://openalex.org/W2104582907","https://openalex.org/W2106217974","https://openalex.org/W2107870109","https://openalex.org/W2108557660","https://openalex.org/W2109319385","https://openalex.org/W2109533042","https://openalex.org/W2110399580","https://openalex.org/W2110632663","https://openalex.org/W2112571975","https://openalex.org/W2113702322","https://openalex.org/W2114692975","https://openalex.org/W2116236561","https://openalex.org/W2116287534","https://openalex.org/W2119714486","https://openalex.org/W2120422553","https://openalex.org/W2124025352","https://openalex.org/W2125453216","https://openalex.org/W2127262898","https://openalex.org/W2128033196","https://openalex.org/W2130967711","https://openalex.org/W2132332604","https://openalex.org/W2133084943","https://openalex.org/W2133938268","https://openalex.org/W2134771103","https://openalex.org/W2137035181","https://openalex.org/W2140485864","https://openalex.org/W2141248073","https://openalex.org/W2141991853","https://openalex.org/W2142321354","https://openalex.org/W2142366724","https://openalex.org/W2143087413","https://openalex.org/W2144414361","https://openalex.org/W2144492301","https://openalex.org/W2144792857","https://openalex.org/W2144806658","https://openalex.org/W2144925860","https://openalex.org/W2148591914","https://openalex.org/W2151240250","https://openalex.org/W2153424791","https://openalex.org/W2153598858","https://openalex.org/W2154284135","https://openalex.org/W2154454628","https://openalex.org/W2154563270","https://openalex.org/W2156086003","https://openalex.org/W2157131586","https://openalex.org/W2158610627","https://openalex.org/W2158680117","https://openalex.org/W2158834413","https://openalex.org/W2159494508","https://openalex.org/W2159540848","https://openalex.org/W2159696212","https://openalex.org/W2159935247","https://openalex.org/W2160345231","https://openalex.org/W2161007406","https://openalex.org/W2161597083","https://openalex.org/W2161932414","https://openalex.org/W2162082053","https://openalex.org/W2162729730","https://openalex.org/W2162857699","https://openalex.org/W2163154029","https://openalex.org/W2163170981","https://openalex.org/W2163585426","https://openalex.org/W2164924162","https://openalex.org/W2165924334","https://openalex.org/W2166496717","https://openalex.org/W2166831705","https://openalex.org/W2166971561","https://openalex.org/W2167684670","https://openalex.org/W2168617072","https://openalex.org/W2169595795","https://openalex.org/W2171056103","https://openalex.org/W2171483658","https://openalex.org/W2171667375","https://openalex.org/W2183372952","https://openalex.org/W2186780489","https://openalex.org/W2194804006","https://openalex.org/W2463934001","https://openalex.org/W6929598005","https://openalex.org/W6981296530","https://openalex.org/W6992757371","https://openalex.org/W7074230359","https://openalex.org/W7096815554","https://openalex.org/W7099134687","https://openalex.org/W7217628649"],"related_works":["https://openalex.org/W2150562812","https://openalex.org/W2008201378","https://openalex.org/W437704928","https://openalex.org/W2004032707","https://openalex.org/W7073529991","https://openalex.org/W2026830713","https://openalex.org/W1980843871","https://openalex.org/W1847082772","https://openalex.org/W2034434851","https://openalex.org/W1072901421"],"abstract_inverted_index":{"Transcriptional":[0],"repressors":[1,16],"bind":[2],"cis-regulatory":[3],"elements":[4],"of":[5,120,138,146,195,221,223,252],"target":[6,81],"genes":[7,82],"in":[8,25,61,83,189,237,240,256],"a":[9,34,41,65,96,118,158,224,241,249],"sequence":[10],"specific":[11],"manner.":[12],"To":[13,108],"antagonize":[14],"transcription,":[15],"primarily":[17],"function":[18,28,37,104],"by":[19,29,38,186],"recruiting":[20,39,54],"accessory":[21],"proteins,":[22],"co-repressors,":[23,56],"which":[24,204],"turn":[26],"largely":[27],"modifying":[30],"chromatin":[31],"structure.":[32],"Although":[33],"repressor":[35],"could":[36],"just":[40],"single":[42],"co-repressor,":[43],"many":[44],"recruit":[45,94,128],"more":[46,260],"than":[47,261],"one,":[48],"with":[49],"Brinker":[50],"(Brk)":[51],"from":[52],"Drosophila":[53],"the":[55,84,133,144,176,219,232],"CtBP":[57,130,171,209],"and":[58,150,172,227,230],"Groucho":[59],"(Gro),":[60],"addition":[62],"to":[63,79,93,100,116,127,156,174,208,234],"possessing":[64],"third":[66],"repression":[67],"domain,":[68],"3R.":[69],"Previous":[70],"studies":[71],"indicated":[72],"that":[73,102,124,142],"Gro":[74,101,147,179],"is":[75,148,151,163,231],"sufficient":[76,153],"for":[77,154,202,212],"Brk":[78,155,168,203],"repress":[80],"wing":[85],"imaginal":[86],"disc,":[87],"questioning":[88],"why":[89,253],"it":[90,162,200],"should":[91],"need":[92],"CtBP,":[95],"\u2019short-range\u2019":[97],"co-repressor":[98],"compared":[99],"can":[103,183],"over":[105],"longer":[106],"distances.":[107],"resolve":[109],"this":[110],"I":[111],"have":[112,132],"used":[113],"genomic":[114],"engineering":[115],"generate":[117],"series":[119],"endogenous":[121],"brk":[122],"mutants":[123,140],"are":[125],"unable":[126],"Gro,":[129],"and/or":[131,210],"3R":[134,173,211],"domain":[135],"deleted.":[136],"Analysis":[137],"these":[139],"reveals":[141],"while":[143],"recruitment":[145],"necessary":[149],"almost":[152],"make":[157],"morphologically":[159],"wild-type":[160],"fly,":[161],"insufficient":[164],"during":[165,181],"oogenesis":[166,182],"where":[167],"must":[169,205],"utilize":[170,259],"pattern":[175],"egg-shell":[177],"appropriately.":[178],"insufficiency":[180],"be":[184],"explained":[185],"its":[187,228,246],"downregulation":[188],"Brk-expressing":[190],"cells":[191],"through":[192],"phosphorylation":[193],"downstream":[194],"EGFR":[196],"signaling,":[197],"thus":[198],"making":[199],"unavailable":[201],"then":[206],"resort":[207],"repressive":[213],"activity.":[214],"The":[215],"present":[216],"study":[217],"dissects":[218],"mechanism":[220],"activity":[222],"transcription":[225,254],"factor":[226],"co-repressors":[229],"first":[233],"do":[235],"so":[236],"multicellular":[238],"eukaryotes":[239],"physiologically":[242],"relevant":[243],"manner;":[244],"additionally":[245],"findings":[247],"provide":[248],"better":[250],"understanding":[251],"factors":[255],"general":[257],"may":[258],"one":[262],"co-repressor.":[263]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
