{"id":"https://openalex.org/W170777045","doi":null,"title":"Interindividual variation in drug metabolism with focus on polymorphic cytochrome P 450 2C9","display_name":"Interindividual variation in drug metabolism with focus on polymorphic cytochrome P 450 2C9","publication_year":2005,"publication_date":"2005-09-09","ids":{"openalex":"https://openalex.org/W170777045","mag":"170777045"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26897818","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Interindividual_variation_in_drug_metabolism_with_focus_on_polymorphic_cytochrome_P450_2C9/26897818","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/38891","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072765929","display_name":"Mia Sandberg Lundblad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mia Sandberg Lundblad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5072765929"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2c9","display_name":"CYP2C9","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cytochrome-p450-polymorphisms","display_name":"cytochrome P450 polymorphisms","score":0.8550000190734863},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.7799999713897705},{"id":"https://openalex.org/keywords/metabolic-ratio","display_name":"metabolic ratio","score":0.847000002861023},{"id":"https://openalex.org/keywords/oral-contraceptives","display_name":"oral contraceptives","score":0.8999999761581421},{"id":"https://openalex.org/keywords/celecoxib","display_name":"celecoxib","score":0.7319999933242798},{"id":"https://openalex.org/keywords/intrinsic-clearance","display_name":"intrinsic clearance","score":0.4429999887943268},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.4560000002384186},{"id":"https://openalex.org/keywords/ethnic-differences-in-drug-metabolism","display_name":"ethnic differences in drug metabolism","score":0.5879999995231628},{"id":"https://openalex.org/keywords/sex-differences-in-drug-metabolism","display_name":"sex differences in drug metabolism","score":0.6809999942779541},{"id":"https://openalex.org/keywords/sulfonylureas","display_name":"sulfonylureas","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.7140101194381714},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.6054487228393555},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.5588120818138123},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5108510851860046},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.488812655210495},{"id":"https://openalex.org/C3946865","wikidata":"https://www.wikidata.org/wiki/Q5014962","display_name":"CYP2C9","level":4,"score":0.4607464075088501},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4478151798248291},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.44299909472465515},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.40548092126846313},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3792955279350281},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3151717185974121},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17088165879249573},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1655380129814148},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26897818","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Interindividual_variation_in_drug_metabolism_with_focus_on_polymorphic_cytochrome_P450_2C9/26897818","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/38891","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38891","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:170777045","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/handle/10616/38891","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/38891","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38891","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W81998461","https://openalex.org/W7019527241","https://openalex.org/W2098025302","https://openalex.org/W2221981480","https://openalex.org/W1481455433","https://openalex.org/W1997933847","https://openalex.org/W1550821665","https://openalex.org/W3169202519","https://openalex.org/W2066019936","https://openalex.org/W2161470395"],"abstract_inverted_index":{"Cytochromes":[0],"P450":[1,549,603],"(CYP)":[2],"are":[3],"enzymes,":[4],"mainly":[5],"catalysing":[6],"the":[7,18,29,77,89,95,113,144,168,175,244,248,280,335,349,365,388,406,458,471,479,501,509],"oxidation":[8,351,480],"of":[9,31,35,60,91,97,112,165,174,186,214,236,243,279,291,309,334,352,361,384,449,461,473,481,493,503,524,541,598,629,657],"xenobiotics,":[10],"in":[11,53,79,120,172,190,287,298,314,332,354,371,376,397,405,455,478,500,572,580,637],"order":[12],"to":[13,65,86,126,197,319,403,418,429,465,484],"facilitate":[14],"their":[15,54],"excretion":[16],"from":[17,330],"body.":[19],"CYP2C9":[20,80,92,114,293,304,477,496,542],"is":[21,26,209],"a":[22,49,106,229,257,357,444,519,632],"polymorphic":[23,601,662],"enzyme,":[24],"which":[25,47,69],"responsible":[27,72,347],"for":[28,143,348,640],"metabolism":[30,208,232,575],"about":[32],"10":[33],"%":[34],"all":[36],"known":[37],"drugs,":[38],"e.g":[39],"sulphonylureas,":[40],"anticoagulants,":[41],"angiotensin":[42],"II":[43],"blockers":[44],"and":[45,100,154,220,341,378,476,495,512,544,578,582,605,666],"NSAIDs,":[46],"show":[48],"considerable":[50,134],"interindividual":[51],"variation":[52,78,135],"metabolic":[55,81,109,148,170,184,259,521],"clearance.":[56],"The":[57,140,276,306,325,411,487,506,539],"primary":[58],"aim":[59],"this":[61,274],"PhD":[62],"thesis":[63],"was":[64,118,133,188,224,251,285,311,343,367,391,443],"investigate":[66],"possible":[67],"factors,":[68],"could":[70,178,272],"be":[71,179,426,498],"for,":[73],"or":[74],"contribute":[75],"to,":[76],"activity.":[82,522],"We":[83],"also":[84],"wanted":[85],"further":[87,350],"elucidate":[88],"impact":[90,540],"genotypes":[93],"on":[94,547],"turnover":[96],"both":[98,474],"exogenous":[99],"endogenous":[101],"substrates.":[102],"In":[103,438],"healthy":[104,218,372],"Caucasians":[105],"three-fold":[107],"higher":[108,157,183,258,370,396,634],"ratio":[110,185,260,507],"(MR)":[111],"probe":[115],"drug":[116,207,574,635],"losartan":[117,187,231],"found":[119],"volunteers":[121],"genotyped":[122,399,422],"as":[123,295,297,345,400,423],"CYP2C9*1/*3":[124,379],"compared":[125,196,318,402,464],"CYP2C9*1/*1":[127,159,176,377,419],"subjects":[128,141,242,374,398],"(p<0.05),":[129],"even":[130],"though":[131],"there":[132,442],"within":[136],"each":[137],"genotype":[138,409,460],"group.":[139],"homozygous":[142,639],"CYP2C9*3":[145,413],"allele":[146],"had":[147,228,256],"ratios":[149],"that":[150,205,226,490],"were":[151,415],"between":[152,240,508,576,661],"22":[153],"220":[155],"times":[156,369,395],"than":[158,233,262,375,393],"subjects.":[160,380,420],"No":[161,238],"novel":[162,270],"allelic":[163],"variants":[164],"CYP2C9,":[166],"explaining":[167],"low":[169,520],"activity":[171],"some":[173],"subjects,":[177,222],"identified.":[180],"A":[181,515,654],"two-fold":[182],"evident":[189],"women":[191,198,579],"taking":[192,200],"oral":[193,359,545],"contraceptives":[194,546],"(OCs)":[195],"not":[199,328],"OCs":[201],"(p<":[202],"0.05),":[203],"showing":[204],"CYP2C9-dependent":[206,573],"reduced":[210,313],"during":[211],"concomitant":[212],"intake":[213],"OC.":[215],"When":[216],"comparing":[217],"Swedish":[219,253],"Korean":[221,263],"it":[223],"discovered":[225],"Swedes":[227],"slower":[230],"Koreans,":[234],"regardless":[235],"genotype.":[237],"difference":[239],"female":[241],"two":[245,322,408],"populations,":[246],"having":[247],"same":[249],"genotype,":[250],"detected.":[252],"men,":[254],"though,":[255],"(MR=0.83)":[261],"men":[264,577],"(MR=0.54),":[265],"p<":[266],"0.001,":[267],"but":[268],"no":[269],"polymorphisms":[271],"explain":[273],"difference.":[275],"intrinsic":[277],"clearance":[278],"selective":[281],"COX-2":[282],"inhibitor":[283],"celecoxib":[284,386,389,599,630],"studied":[286],"human":[288,439],"liver":[289,440],"microsomes":[290,300,441],"different":[292],"genotypes,":[294],"well":[296],"yeast":[299],"with":[301,321,436,457,631],"recombinantly":[302],"expressed":[303],"variants.":[305],"formation":[307,447],"rate":[308,448],"OH-celecoxib":[310],"significantly":[312,445],"CYP":[315],"2C9*3":[316],"samples,":[317],"samples":[320,456],"functional":[323],"alleles.":[324],"CYP2C9*2-samples":[326],"did":[327],"differ":[329],"CYP2C9*1":[331],"any":[333],"systems":[336],"studied.":[337],"Alcohol":[338],"dehydrogenase":[339],"(ADH1":[340],"ADH2)":[342],"identified":[344],"being":[346],"OH-celecoxib,":[353],"vitro.":[355],"After":[356,381],"single":[358],"dose":[360],"200":[362],"mg":[363],"celecoxib,":[364],"exposure":[366,390,636],"three":[368],"CYP2C9*3/*3":[373,424],"one":[382],"week":[383],"repeated":[385],"administration,":[387],"more":[392,427],"seven":[394],"CYP2C9*3/*3,":[401],"individuals":[404,638],"other":[407],"groups.":[410],"heterozygous":[412],"carriers":[414],"almost":[416],"identical":[417],"Subjects":[421],"may":[425],"likely":[428],"experience":[430],"concentration-dependent":[431],"side-effects":[432],"after":[433],"long-term":[434],"treatment":[435],"celecoxib.":[437],"lower":[446],"epoxyeicosatrienoic":[450,658],"acids":[451,659],"(EETs)":[452],"by":[453,600],"34%":[454],"composite":[459],"CYP2C8":[462,466,475,494],"*3/*3/CYP2C9*2/*2":[463],"*1/*1/CYP2C9*1/*1.":[467],"Inhibition":[468],"experiments":[469],"confirmed":[470],"involvement":[472],"arachidonic":[482],"acid":[483],"vasoactive":[485],"metabolites.":[486],"results":[488],"imply":[489],"variant":[491],"alleles":[492],"might":[497],"involved":[499],"pathophysiology":[502],"cardiovascular":[504],"diseases.":[505],"parent":[510],"compound":[511],"its":[513],"metabolite.":[514],"high":[516],"MR":[517],"reflects":[518],"List":[523],"scientific":[525],"papers":[526],"I.":[527],"Sandberg":[528,559,586,616,644],"M,":[529,533,561,587,618,646],"Johansson":[530],"I,":[531],"Christensen":[532],"Rane":[534,653],"A,":[535],"Eliasson":[536,566,594,625,649],"E":[537,595,626],"(2004).":[538],"genetics":[543],"cytochrome":[548,602],"2C9":[550,604],"phenotype.":[551],"Drug":[552],"Metab":[553],"Dispos.":[554],"32(5):":[555],"484-9.":[556],"https://doi.org/10.1124/dmd.32.5.484":[557],"II.":[558],"Lundblad":[560,617,645],"Roh":[562],"HK,":[563],"Kang":[564],"JH,":[565],"E,":[567,650,652],"Bertilsson":[568],"L":[569],"(2005).":[570,627,655],"Differences":[571],"Sweden":[581],"Korea.":[583],"[Manuscript]":[584,642],"III.":[585],"Yasar":[588],"U,":[589],"Stromberg":[590],"P,":[591,622,624],"Hoog":[592],"JO,":[593],"(2002).":[596],"Oxidation":[597],"alcohol":[606],"dehydrogenase.":[607],"Br":[608],"J":[609],"Clin":[610],"Pharmacol.":[611],"54(4):":[612],"423-9.":[613],"https://doi.org/10.1046/j.1365-2125.2002.01660.x":[614],"IV.":[615],"Ohlsson":[619],"S,":[620],"Johanson":[621],"Lafolie":[623],"Accumulation":[628],"seven-fold":[633],"CYP2C9*3.":[641],"V.":[643],"Stark":[647],"K,":[648],"Oliw":[651],"Biosynthesis":[656],"varies":[660],"CYP2C":[663],"enzymes.":[664],"Biochemical":[665],"Biophysical":[667],"Research":[668],"Communications.":[669],"327.":[670],"https://doi.org/10.1016/j.bbrc.2004.12.116":[671]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}