{"id":"https://openalex.org/W170691192","doi":null,"title":"O Sistema Endocanabin\u00f3ide - uma perspetiva terap\u00eautica The Endocannabinoid system - a therapeutic perspective","display_name":"O Sistema Endocanabin\u00f3ide - uma perspetiva terap\u00eautica The Endocannabinoid system - a therapeutic perspective","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W170691192","mag":"170691192"},"language":"pt","primary_location":{"id":"pmh:oai:ojs.actafarmaceuticaportuguesa.com:article/5","doi":null,"is_oa":false,"landing_page_url":"https://actafarmaceuticaportuguesa.com/index.php/afp/article/view/5","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Farmac\u00eautica Portuguesa; v. 2 n. 2 (2013); 37-44","raw_type":"http://purl.org/coar/resource_type/c_6501"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://actafarmaceuticaportuguesa.com/index.php/afp/article/view/5/105","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090176261","display_name":"Bruno Miguel Fonseca","orcid":"https://orcid.org/0000-0002-8873-5591","observed_orcids":["https://orcid.org/0000-0002-8873-5591"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4387153674","display_name":"Instituto de Biologia Molecular e Celular","ror":"https://ror.org/005dkht93","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Bruno M. Fonseca","raw_affiliation_strings":["- Departamento de Ci\u00eancias Biol\u00f3gicas, Laborat\u00f3rio de Bioqu\u00edmica da Faculdade de Farm\u00e1cia da Universidade do Porto. Portugal#R##N#- Instituto de Biologia Molecular e Celular da Universidade do Porto. Portugal"],"raw_orcid":"https://orcid.org/0000-0002-8873-5591","affiliations":[{"raw_affiliation_string":"- Departamento de Ci\u00eancias Biol\u00f3gicas, Laborat\u00f3rio de Bioqu\u00edmica da Faculdade de Farm\u00e1cia da Universidade do Porto. Portugal#R##N#- Instituto de Biologia Molecular e Celular da Universidade do Porto. Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111481260","display_name":"Marissa Costa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4387153674","display_name":"Instituto de Biologia Molecular e Celular","ror":"https://ror.org/005dkht93","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Marissa Costa","raw_affiliation_strings":["- Departamento de Ci\u00eancias Biol\u00f3gicas, Laborat\u00f3rio de Bioqu\u00edmica da Faculdade de Farm\u00e1cia da Universidade do Porto. Portugal#R##N#- Instituto de Biologia Molecular e Celular da Universidade do Porto. Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"- Departamento de Ci\u00eancias Biol\u00f3gicas, Laborat\u00f3rio de Bioqu\u00edmica da Faculdade de Farm\u00e1cia da Universidade do Porto. Portugal#R##N#- Instituto de Biologia Molecular e Celular da Universidade do Porto. Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050483291","display_name":"Marta Almada","orcid":"https://orcid.org/0000-0001-6575-1698","observed_orcids":["https://orcid.org/0000-0001-6575-1698"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4387153674","display_name":"Instituto de Biologia Molecular e Celular","ror":"https://ror.org/005dkht93","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Marta Almada","raw_affiliation_strings":["- Departamento de Ci\u00eancias Biol\u00f3gicas, Laborat\u00f3rio de Bioqu\u00edmica da Faculdade de Farm\u00e1cia da Universidade do Porto. Portugal#R##N#- Instituto de Biologia Molecular e Celular da Universidade do Porto. Portugal"],"raw_orcid":"https://orcid.org/0000-0001-6575-1698","affiliations":[{"raw_affiliation_string":"- Departamento de Ci\u00eancias Biol\u00f3gicas, Laborat\u00f3rio de Bioqu\u00edmica da Faculdade de Farm\u00e1cia da Universidade do Porto. Portugal#R##N#- Instituto de Biologia Molecular e Celular da Universidade do Porto. Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061520709","display_name":"Ana Luiza Pelissari Pessanha de Paula Soares","orcid":"https://orcid.org/0000-0002-6501-3799","observed_orcids":["https://orcid.org/0000-0002-6501-3799"]},"institutions":[{"id":"https://openalex.org/I4210123791","display_name":"Centro Hospitalar do T\u00e2mega e Sousa","ror":"https://ror.org/0246qj146","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210123791"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana Luiza Pelissari Pessanha de Paula Soares","raw_affiliation_strings":["Servi\u00e7os Farmac\u00eauticos, Centro Hospitalar T\u00e2mega e Sousa \u2013 Unidade S. Gon\u00e7alo. Portugal"],"raw_orcid":"https://orcid.org/0000-0002-6501-3799","affiliations":[{"raw_affiliation_string":"Servi\u00e7os Farmac\u00eauticos, Centro Hospitalar T\u00e2mega e Sousa \u2013 Unidade S. Gon\u00e7alo. Portugal","institution_ids":["https://openalex.org/I4210123791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076327069","display_name":"Georgina Correia\u2010da\u2010Silva","orcid":"https://orcid.org/0000-0001-5787-9018","observed_orcids":["https://orcid.org/0000-0001-5787-9018"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4387153674","display_name":"Instituto de Biologia Molecular e Celular","ror":"https://ror.org/005dkht93","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Georgina Correia\u2010da\u2010Silva","raw_affiliation_strings":["- Departamento de Ci\u00eancias Biol\u00f3gicas, Laborat\u00f3rio de Bioqu\u00edmica da Faculdade de Farm\u00e1cia da Universidade do Porto. Portugal#R##N#- Instituto de Biologia Molecular e Celular da Universidade do Porto. Portugal"],"raw_orcid":"https://orcid.org/0000-0001-5787-9018","affiliations":[{"raw_affiliation_string":"- Departamento de Ci\u00eancias Biol\u00f3gicas, Laborat\u00f3rio de Bioqu\u00edmica da Faculdade de Farm\u00e1cia da Universidade do Porto. Portugal#R##N#- Instituto de Biologia Molecular e Celular da Universidade do Porto. Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066092179","display_name":"Nat\u00e9rcia A. A. Teixeira","orcid":"https://orcid.org/0000-0002-3664-1120","observed_orcids":["https://orcid.org/0000-0002-3664-1120","https://orcid.org/0000-0003-2308-8634"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4387153674","display_name":"Instituto de Biologia Molecular e Celular","ror":"https://ror.org/005dkht93","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Nat\u00e9rcia Teixeira","raw_affiliation_strings":["- Departamento de Ci\u00eancias Biol\u00f3gicas, Laborat\u00f3rio de Bioqu\u00edmica da Faculdade de Farm\u00e1cia da Universidade do Porto. Portugal#R##N#- Instituto de Biologia Molecular e Celular da Universidade do Porto. Portugal"],"raw_orcid":"https://orcid.org/0000-0002-3664-1120","affiliations":[{"raw_affiliation_string":"- Departamento de Ci\u00eancias Biol\u00f3gicas, Laborat\u00f3rio de Bioqu\u00edmica da Faculdade de Farm\u00e1cia da Universidade do Porto. Portugal#R##N#- Instituto de Biologia Molecular e Celular da Universidade do Porto. Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.215,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.55413643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"2","issue":"2","first_page":"37","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"endocannabinoid system","score":1.0},{"id":"https://openalex.org/keywords/endocannabinoids","display_name":"endocannabinoids","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cannabinoid-receptors","display_name":"cannabinoid receptors","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cb2-receptor","display_name":"CB2 receptor","score":1.0},{"id":"https://openalex.org/keywords/rimonabant","display_name":"rimonabant","score":0.7490000128746033},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.382999986410141},{"id":"https://openalex.org/keywords/appetite-stimulation","display_name":"appetite stimulation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/pain-management","display_name":"pain management","score":0.9779999852180481},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.6000000238418579},{"id":"https://openalex.org/keywords/cannabinoid-therapeutics","display_name":"cannabinoid therapeutics","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C2776433454","wikidata":"https://www.wikidata.org/wiki/Q412529","display_name":"Rimonabant","level":5,"score":0.9475950598716736},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.8544148206710815},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.7923554182052612},{"id":"https://openalex.org/C2780433416","wikidata":"https://www.wikidata.org/wiki/Q5032579","display_name":"Cannabinoid receptor antagonist","level":5,"score":0.6085427403450012},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.5767005085945129},{"id":"https://openalex.org/C2777056318","wikidata":"https://www.wikidata.org/wiki/Q79817","display_name":"Cannabis","level":2,"score":0.5321169495582581},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5072829127311707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44467711448669434},{"id":"https://openalex.org/C2777846614","wikidata":"https://www.wikidata.org/wiki/Q19904200","display_name":"Synthetic cannabinoids","level":4,"score":0.4310513138771057},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4215969443321228},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4205493927001953},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40581411123275757},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.28731220960617065},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2630281448364258},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.25826168060302734},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.23534327745437622},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2291342318058014},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.16528919339179993},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12601307034492493}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ojs.actafarmaceuticaportuguesa.com:article/5","doi":null,"is_oa":false,"landing_page_url":"https://actafarmaceuticaportuguesa.com/index.php/afp/article/view/5","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Farmac\u00eautica Portuguesa; v. 2 n. 2 (2013); 37-44","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"mag:170691192","doi":null,"is_oa":true,"landing_page_url":"http://actafarmaceuticaportuguesa.com/index.php/afp/article/view/5/105","pdf_url":null,"source":{"id":"https://openalex.org/S4306500332","display_name":"Acta Farmac\u00eautica Portuguesa","issn_l":"2182-3340","issn":["2182-3340"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Acta Farmac\u00eautica Portuguesa","raw_type":null},{"id":"mag:2341420510","doi":null,"is_oa":false,"landing_page_url":"https://www.actafarmaceuticaportuguesa.com/index.php/afp/article/download/5/105","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"mag:170691192","doi":null,"is_oa":true,"landing_page_url":"http://actafarmaceuticaportuguesa.com/index.php/afp/article/view/5/105","pdf_url":null,"source":{"id":"https://openalex.org/S4306500332","display_name":"Acta Farmac\u00eautica Portuguesa","issn_l":"2182-3340","issn":["2182-3340"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Acta Farmac\u00eautica Portuguesa","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1520490569","https://openalex.org/W1832918544","https://openalex.org/W1897520831","https://openalex.org/W1934194241","https://openalex.org/W1971698096","https://openalex.org/W1979491557","https://openalex.org/W1989073099","https://openalex.org/W1992882144","https://openalex.org/W1993018268","https://openalex.org/W1993041600","https://openalex.org/W2005828463","https://openalex.org/W2007924093","https://openalex.org/W2025896767","https://openalex.org/W2036412371","https://openalex.org/W2046870314","https://openalex.org/W2049942115","https://openalex.org/W2056188558","https://openalex.org/W2060589571","https://openalex.org/W2067724628","https://openalex.org/W2091315563","https://openalex.org/W2104497132","https://openalex.org/W2108265345","https://openalex.org/W2113565543","https://openalex.org/W2114062911","https://openalex.org/W2118125637","https://openalex.org/W2133811076","https://openalex.org/W2135015648","https://openalex.org/W2149110258","https://openalex.org/W2162112945","https://openalex.org/W2167743125","https://openalex.org/W2171530795","https://openalex.org/W2316290048","https://openalex.org/W2320064572","https://openalex.org/W2418287198"],"related_works":["https://openalex.org/W2341420510","https://openalex.org/W1976854280","https://openalex.org/W2336815228","https://openalex.org/W1971036356","https://openalex.org/W2414051968","https://openalex.org/W1961870250","https://openalex.org/W77775636","https://openalex.org/W2593492730","https://openalex.org/W1982092263","https://openalex.org/W2352146179"],"abstract_inverted_index":{"Although":[0],"the":[1,13,21,30,35,42,49,52,56,71,90,100,116,145,154,159],"medicinal":[2],"use":[3,65],"of":[4,15,23,51,62,125,148,161],"Cannabis":[5],"sativa":[6],"derivatives":[7,78],"is":[8],"well":[9],"known":[10],"since":[11],"antiquity,":[12],"study":[14],"their":[16,46],"properties":[17],"expanded":[18],"recently":[19],"with":[20,103],"discovery":[22,50],"an":[24],"endogenous":[25,31],"cannabinoid":[26,36],"system,":[27],"which":[28],"comprises":[29],"cannabis-like":[32],"ligands":[33],"(endocannabinoids),":[34],"receptors":[37],"(CB1":[38],"and":[39,41,66,86,122,153],"CB2)":[40],"enzymes":[43],"involved":[44],"in":[45,151],"metabolism.":[47],"Since":[48],"endocannabinoid":[53],"system":[54,150],"(ECS),":[55],"scientific":[57],"community":[58],"focused":[59],"on":[60,115],"research":[61],"its":[63],"clinical":[64,123],"achieved":[67],"important":[68],"findings":[69],"during":[70],"last":[72],"decade.":[73],"In":[74],"some":[75],"countries,":[76],"cannabis":[77],"are":[79,130],"a":[80],"pharmacological":[81],"option":[82],"for":[83,99,138,158],"appetite":[84],"stimulation":[85],"pain":[87],"treatment.":[88],"However,":[89],"first":[91],"ECS-based":[92],"drug":[93],"rimonabant":[94],"(a":[95],"CB1":[96],"antagonist),":[97],"approved":[98],"treatment":[101],"obesity":[102],"associated":[104],"risk":[105],"factors,":[106],"was":[107],"withdrawn":[108],"due":[109],"to":[110],"safety":[111],"concerns.":[112],"Nowadays,":[113],"based":[114],"growing":[117],"evidences":[118],"resulting":[119],"from":[120],"preclinical":[121],"studies":[124],"ECS":[126],"modulators,":[127],"these":[128],"drugs":[129,162],"currently":[131],"pointed":[132],"out":[133],"as":[134],"novel":[135],"therapeutic":[136],"approaches":[137],"several":[139],"pathophysiological":[140],"conditions.":[141],"Here,":[142],"we":[143],"review":[144],"potential":[146],"role":[147],"(endo)cannabinoid":[149],"therapeutics":[152],"recent":[155],"designed":[156],"strategies":[157],"development":[160],"that":[163],"target":[164],"this":[165],"system.":[166]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}