{"id":"https://openalex.org/W1705440780","doi":null,"title":"Malignant melanoma and other malignancies of the nasal cavity and the paranasal sinuses in Sweden","display_name":"Malignant melanoma and other malignancies of the nasal cavity and the paranasal sinuses in Sweden","publication_year":2014,"publication_date":"2014-10-15","ids":{"openalex":"https://openalex.org/W1705440780","mag":"1705440780"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26920657","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Malignant_melanoma_and_other_malignancies_of_the_nasal_cavity_and_the_paranasal_sinuses_in_Sweden/26920657","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/42102","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043342248","display_name":"Mattias Jangard","orcid":"https://orcid.org/0000-0003-3772-2026","observed_orcids":["https://orcid.org/0000-0003-3772-2026"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mattias Jangard","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3772-2026","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5043342248"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sinonasal-malignant-melanoma","display_name":"sinonasal malignant melanoma","score":0.9440000057220459},{"id":"https://openalex.org/keywords/sinonasal-malignancies","display_name":"sinonasal malignancies","score":0.9309999942779541},{"id":"https://openalex.org/keywords/nasal-cavity","display_name":"nasal cavity","score":0.6460000276565552},{"id":"https://openalex.org/keywords/paranasal-sinuses","display_name":"paranasal sinuses","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mucosal-melanoma","display_name":"mucosal melanoma","score":0.800000011920929},{"id":"https://openalex.org/keywords/cutaneous-melanoma","display_name":"cutaneous melanoma","score":0.8169999718666077},{"id":"https://openalex.org/keywords/incidence-trends","display_name":"incidence trends","score":0.7590000033378601},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5460000038146973},{"id":"https://openalex.org/keywords/adenoid-cystic-carcinoma","display_name":"adenoid cystic carcinoma","score":0.8090000152587891},{"id":"https://openalex.org/keywords/kit-mutations","display_name":"KIT mutations","score":0.703000009059906},{"id":"https://openalex.org/keywords/nras-mutation","display_name":"NRAS mutation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tert-promoter-mutation","display_name":"TERT promoter mutation","score":0.9589999914169312},{"id":"https://openalex.org/keywords/molecular-alterations","display_name":"molecular alterations","score":0.8059999942779541},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.5659999847412109},{"id":"https://openalex.org/keywords/sweden","display_name":"Sweden","score":0.32199999690055847},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8298077583312988},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7879579663276672},{"id":"https://openalex.org/C2777955602","wikidata":"https://www.wikidata.org/wiki/Q281473","display_name":"Paranasal sinuses","level":2,"score":0.7673482894897461},{"id":"https://openalex.org/C2778801703","wikidata":"https://www.wikidata.org/wiki/Q156104","display_name":"Nasal cavity","level":2,"score":0.7667595744132996},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6021714806556702},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.526436448097229},{"id":"https://openalex.org/C2781186586","wikidata":"https://www.wikidata.org/wiki/Q6931266","display_name":"Mucosal melanoma","level":3,"score":0.47662651538848877},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.45590537786483765},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.44593220949172974},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.44341424107551575},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.43264269828796387},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28715622425079346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23862922191619873},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.07101860642433167},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26920657","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Malignant_melanoma_and_other_malignancies_of_the_nasal_cavity_and_the_paranasal_sinuses_in_Sweden/26920657","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/42102","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/42102","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1705440780","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/handle/10616/42102/Thesis_Mattias_Jangard.pdf?sequence=5","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/42102","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/42102","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":139,"referenced_works":["https://openalex.org/W81622822","https://openalex.org/W1498900250","https://openalex.org/W1506121355","https://openalex.org/W1509970002","https://openalex.org/W1516437155","https://openalex.org/W1545177819","https://openalex.org/W1551295720","https://openalex.org/W1553272316","https://openalex.org/W1932933996","https://openalex.org/W1938081271","https://openalex.org/W1964915268","https://openalex.org/W1965318403","https://openalex.org/W1965652319","https://openalex.org/W1967627564","https://openalex.org/W1970051943","https://openalex.org/W1970283942","https://openalex.org/W1970977508","https://openalex.org/W1974949377","https://openalex.org/W1976913222","https://openalex.org/W1977824195","https://openalex.org/W1981921145","https://openalex.org/W1983856113","https://openalex.org/W1984372402","https://openalex.org/W1984374449","https://openalex.org/W1984408439","https://openalex.org/W1985817586","https://openalex.org/W1987372760","https://openalex.org/W1988397037","https://openalex.org/W1989121777","https://openalex.org/W1990024884","https://openalex.org/W1991170787","https://openalex.org/W1995624758","https://openalex.org/W1995949628","https://openalex.org/W1996102225","https://openalex.org/W1996429288","https://openalex.org/W1997948610","https://openalex.org/W1999441881","https://openalex.org/W2001719099","https://openalex.org/W2003650710","https://openalex.org/W2006662296","https://openalex.org/W2008493391","https://openalex.org/W2009154923","https://openalex.org/W2009416122","https://openalex.org/W2011464588","https://openalex.org/W2017771787","https://openalex.org/W2018155127","https://openalex.org/W2018567163","https://openalex.org/W2019960405","https://openalex.org/W2021376884","https://openalex.org/W2022425138","https://openalex.org/W2022521283","https://openalex.org/W2022728211","https://openalex.org/W2023021073","https://openalex.org/W2023835369","https://openalex.org/W2025973123","https://openalex.org/W2030209169","https://openalex.org/W2031579870","https://openalex.org/W2033087055","https://openalex.org/W2034737120","https://openalex.org/W2035283749","https://openalex.org/W2035679542","https://openalex.org/W2038337571","https://openalex.org/W2039969555","https://openalex.org/W2044433401","https://openalex.org/W2051478656","https://openalex.org/W2053520756","https://openalex.org/W2055243185","https://openalex.org/W2064462464","https://openalex.org/W2065786604","https://openalex.org/W2070871778","https://openalex.org/W2071771423","https://openalex.org/W2074193309","https://openalex.org/W2074380451","https://openalex.org/W2075740340","https://openalex.org/W2076697417","https://openalex.org/W2077517114","https://openalex.org/W2078616035","https://openalex.org/W2080193946","https://openalex.org/W2080833419","https://openalex.org/W2084990201","https://openalex.org/W2085007067","https://openalex.org/W2088379306","https://openalex.org/W2088740373","https://openalex.org/W2090362980","https://openalex.org/W2092097506","https://openalex.org/W2094009840","https://openalex.org/W2097779490","https://openalex.org/W2097843794","https://openalex.org/W2097995306","https://openalex.org/W2098215116","https://openalex.org/W2098647445","https://openalex.org/W2099200814","https://openalex.org/W2100215079","https://openalex.org/W2101203594","https://openalex.org/W2101470318","https://openalex.org/W2103549763","https://openalex.org/W2104500293","https://openalex.org/W2106726562","https://openalex.org/W2108246221","https://openalex.org/W2108934985","https://openalex.org/W2109078042","https://openalex.org/W2109545379","https://openalex.org/W2110801273","https://openalex.org/W2113322325","https://openalex.org/W2114274255","https://openalex.org/W2117692326","https://openalex.org/W2120807471","https://openalex.org/W2123363005","https://openalex.org/W2124783653","https://openalex.org/W2124784168","https://openalex.org/W2128542677","https://openalex.org/W2129234309","https://openalex.org/W2131756199","https://openalex.org/W2134471382","https://openalex.org/W2136403421","https://openalex.org/W2139888313","https://openalex.org/W2146216556","https://openalex.org/W2147416239","https://openalex.org/W2147474070","https://openalex.org/W2148547284","https://openalex.org/W2149260165","https://openalex.org/W2151227303","https://openalex.org/W2154683287","https://openalex.org/W2154841567","https://openalex.org/W2156266404","https://openalex.org/W2160037270","https://openalex.org/W2161948433","https://openalex.org/W2162066233","https://openalex.org/W2163523630","https://openalex.org/W2164758365","https://openalex.org/W2166262263","https://openalex.org/W2168302736","https://openalex.org/W2169552173","https://openalex.org/W2171968985","https://openalex.org/W2324111213","https://openalex.org/W2388163742","https://openalex.org/W2414931042","https://openalex.org/W3034355295","https://openalex.org/W4255101987"],"related_works":["https://openalex.org/W4255101987","https://openalex.org/W1192295383","https://openalex.org/W4323348189","https://openalex.org/W2052964994","https://openalex.org/W3010779032","https://openalex.org/W4397032846","https://openalex.org/W3107916668","https://openalex.org/W20256478","https://openalex.org/W2620396993","https://openalex.org/W2028829769"],"abstract_inverted_index":{"Background:":[0],"Malignancies":[1],"emerging":[2],"in":[3,28,48,53,78,93,100,103,119,168,182,302,419,533,568,597,622,684,695,705,716,743,797,828],"the":[4,8,54,79,83,94,104,123,129,135,162,176,183,186,199,202,228,232,246,257,266,278,295,306,314,325,333,352,366,376,401,405,414,422,430,445,451,464,478,487,519,529,550,558,591,626,633,638,717,750,771],"nasal":[5,95,326,377,634],"cavity":[6,635],"and":[7,13,20,23,82,106,143,234,250,269,273,275,287,291,342,345,361,397,440,463,573,578,580,610,738,760,789,794,821],"paranasal":[9,101,328,627],"sinuses":[10,102,628],"are":[11,89,240],"rare":[12],"accounts":[14],"for":[15,194,217,359,385,456,461,469,500,515,566,646,660,668],"5%":[16],"of":[17,25,32,56,60,70,111,122,131,137,164,175,219,230,237,248,260,271,280,294,354,372,447,477,523,531,547,590,620,673,681,721,749,770,803],"all":[18,26,71],"head":[19,105],"neck":[21,107],"malignancies":[22,27,322,356,374,742],"0.1%":[24],"Sweden.":[29,49],"The":[30,109,191,338,379,454,492,511],"incidence":[31,110,136,156,163,344,353,446,455,465,530],"sinonasal":[33,37,355,764,798,829],"malignancy":[34],"(SNM),":[35],"except":[36,358],"malignant":[38,72,113,222,765],"melanoma":[39,114,145],"(SNMM),":[40],"has":[41,214],"been":[42],"reported":[43],"to":[44,117,128,264,276,630],"decrease":[45],"since":[46,651,708],"1960":[47,335,416,538],"Despite":[50],"similar":[51],"improvement":[52],"prognosis":[55],"other":[57],"malignancies,":[58],"treatment":[59,192,439],"SNM":[61,249,274],"still":[62],"yields":[63],"a":[64,147,152,506,617,656,677,692,746,767,801],"poor":[65,499],"survival":[66,346,382,496,508,512],"outcome.":[67],"About":[68],"1\u20132%":[69],"melanomas":[73,88,139],"originate":[74],"from":[75,313,324,421,537,625,632],"mucosal":[76,87,138,799,830],"membranes":[77],"genitourinary,":[80],"digestive":[81],"respiratory":[84],"regions,":[85],"whereas":[86],"most":[90,488],"frequently":[91],"located":[92],"cavity,":[96,327],"followed":[97,207,391],"by":[98,208,392,585],"sites":[99],"region.":[108],"cutaneous":[112],"(CMM)":[115],"continues":[116],"increase":[118],"many":[120],"parts":[121],"world,":[124],"possibly":[125],"due":[126],"mainly":[127,204],"effects":[130],"sun-related":[132],"behaviour;":[133],"however,":[134],"such":[140],"as":[141,170,483,543,545,561,563],"vulvar":[142],"ano-rectal":[144],"display":[146],"more":[148],"complicated":[149],"pattern":[150],"with":[151,221,320,387,395,467],"stable":[153],"or":[154,330],"decreasing":[155],"rate.":[157],"We":[158,349,428,472,526,615,697],"now":[159],"know":[160],"that":[161,351,474,528,546,699],"SNMM":[165,180,272,360,396,411,448,532,644,700],"is":[166,254],"increasing":[167],"Sweden,":[169],"we":[171,309,408,553,564,641],"have":[172,197,675],"documented":[173],"one":[174],"largest":[177,559],"consecutively":[178],"studied":[179],"groups":[181],"world.":[184],"Nevertheless,":[185],"underlying":[187],"mechanism":[188],"remains":[189],"unclear.":[190],"options":[193],"these":[195,373,598,661,709],"patients":[196,220,312,386,412],"remained":[198],"same":[200],"over":[201],"years;":[203],"radical":[205],"surgery":[206],"radiotherapy.":[209],"Alternatively,":[210],"recent":[211],"molecular-targeted":[212],"therapy":[213],"become":[215],"available":[216],"sub-groups":[218],"melanomas.":[223],"Such":[224],"therapeutic":[225,524,714],"advances":[226],"stress":[227],"importance":[229],"investigating":[231],"aetiology":[233],"molecular":[235,281,706],"characteristics":[236,268],"SNMM,":[238,251],"which":[239],"not":[241,542],"yet":[242],"well.":[243],"Aims:":[244],"Given":[245],"rarity":[247],"relevant":[252],"knowledge":[253],"limited.":[255],"Therefore,":[256],"overall":[258],"aim":[259],"this":[261,443,669,685],"thesis":[262],"was":[263,383,458,486],"examine":[265],"clinical":[267],"features":[270],"determine":[277],"occurrence":[279],"alterations.":[282],"They":[283],"include":[284],"KIT,":[285,792],"NRAS":[286,575,613,793],"BRAF":[288,581,608,795],"mutation":[289,292,609,827],"frequencies":[290],"frequency":[293,619,679,694],"TERT":[296,647,687,824],"(Telomerase":[297],"Reverse":[298],"Transcriptase)":[299],"promotor":[300,648,825],"gene":[301,649,826],"SNMM.":[303,696],"Results:":[304],"In":[305,404,442,549,637],"first":[307],"project,":[308,552],"identified":[310,409,584],"3221":[311],"Swedish":[315,424,751,772],"National":[316,423],"Cancer":[317,425],"Registry":[318,426],"diagnosed":[319],"primary":[321,434,490,556],"arising":[323],"sinuses,":[329],"both,":[331],"during":[332,365,413,450,518],"period":[334,415],"through":[336,417,539],"2011.":[337],"anatomical":[339,435],"site,":[340],"gender":[341],"age,":[343,433],"were":[347,480,498,664],"scrutinized.":[348],"found":[350,473,616,654],"decreased":[357],"adenoid":[362,388],"cystic":[363,389],"cancer":[364,390],"study":[367,452,520,748,769,802],"period.":[368,453],"More":[369],"than":[370,460,509],"50%":[371],"involved":[375],"cavity.":[378],"five-year":[380,493],"relative":[381],"highest":[384],"adenocarcinoma.":[393],"Those":[394],"undifferentiated":[398],"carcinoma":[399],"had":[400,505,612],"poorest":[402],"prognosis.":[403],"second":[406],"project":[407,640],"186":[410],"2000":[418,540],"Sweden":[420,534,744],"(SCR).":[427],"investigated":[429],"incidence,":[431],"gender,":[432],"sites,":[436],"geographic":[437],"distribution,":[438],"survival.":[441],"population":[444],"increased":[449,466,535],"females":[457,504],"higher":[459,618],"males,":[462],"age":[468],"both":[470,501,516],"genders.":[471],"about":[475],"70%":[476],"tumours":[479,594,601,623,631,645,701],"clinically":[481],"described":[482],"amelanotic.":[484],"Surgery":[485],"common":[489],"treatment.":[491],"disease-":[494],"specific":[495],"rates":[497],"genders,":[502],"but":[503,541],"better":[507],"males.":[510],"rate":[513],"improved":[514],"genders":[517],"period,":[521],"regardless":[522],"strategy.":[525],"conclude":[527],"significantly":[536],"rapidly":[544],"CMM.":[548],"third":[551],"analysed":[554,642],"56":[555,592,804],"SNMMs,":[557],"number,":[560],"far":[562],"know,":[565],"mutations":[567,596,621,659,683,689,796],"KIT":[569,603],"(exons":[570,576],"11,":[571],"13":[572],"17),":[574],"1":[577],"2)":[579],"(exon":[582],"15)":[583],"using":[586],"direct":[587],"sequencing.":[588],"Twelve":[589],"(21%)":[593],"contained":[595],"oncogenes,":[599],"2":[600,606],"harboured":[602,607],"mutations,":[604,650],"another":[605],"8":[611],"mutations.":[614],"originating":[624],"compared":[629],"(p=0.027).":[636],"fourth":[639],"49":[643],"former":[652],"investigators":[653],"only":[655],"few":[657],"driver":[658,682],"patients,":[662],"who":[663],"never":[665],"previously":[666],"examined":[667],"mutation.":[670],"Recent":[671],"studies":[672],"CMM":[674],"shown":[676],"high":[678],"(>70%)":[680],"gene.":[686],"promoter":[688],"occur":[690],"at":[691],"moderate":[693],"suggest":[698],"should":[702],"be":[703,713],"included":[704],"characterization,":[707],"alterations":[710],"probably":[711],"will":[712],"targets":[715],"near":[718],"future.":[719],"List":[720],"scientific":[722],"papers":[723],"I.":[724],"Elliot":[725],"A,":[726,783,818],"Jangard":[727,756,815],"M,":[728,757,816],"Marklund":[729],"L,":[730],"Dickman":[731],"P,":[732],"H\u00e5kansson":[733],"N,":[734],"Hammarstedt-":[735],"Nordenvall":[736],"L":[737],"Stj\u00e4rne":[739],"P.":[740],"Sinonasal":[741],"1960-2010;":[745],"nationwide":[747,768],"population.":[752],"[Accepted]":[753],"https://doi.org/10.4193/Rhino14070":[754],"II.":[755],"Hansson":[758,790,822],"J,":[759],"Ragnarsson-Olding":[761,787,819],"B.":[762],"Primary":[763],"melanoma:":[766,800],"population,":[773],"1960-2000.":[774],"Rhinology,":[775],"2013.":[776],"51(1):":[777],"p.":[778],"22-30.":[779],"https://doi.org/10.4193/Rhino12.075":[780],"III.":[781],"Zebary":[782,817],"Jangard,":[784],"Omholt":[785],"K,":[786],"B,":[788,820],"J.":[791,823],"cases.":[805],"Br":[806],"J":[807],"Cancer.":[808],"2013":[809],"Aug":[810],"6;":[811],"109:559-64.":[812],"https://doi.org/10.1038/bjc.2013.373":[813],"IV.":[814],"melanoma.":[831],"[Submitted]":[832]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
