{"id":"https://openalex.org/W170453741","doi":"https://doi.org/10.18926/amo/30684","title":"Pharmacokinetic analysis of adriamycin (doxorubicin) and related fluorescent compounds in Ehrlich tumor-bearing mouse plasma and tissues.","display_name":"Pharmacokinetic analysis of adriamycin (doxorubicin) and related fluorescent compounds in Ehrlich tumor-bearing mouse plasma and tissues.","publication_year":1982,"publication_date":"1982-04-01","ids":{"openalex":"https://openalex.org/W170453741","doi":"https://doi.org/10.18926/amo/30684","mag":"170453741","pmid":"https://pubmed.ncbi.nlm.nih.gov/7136849"},"language":"en","primary_location":{"id":"pmid:7136849","doi":"https://doi.org/10.18926/amo/30684","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7136849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica Okayama","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ousar.lib.okayama-u.ac.jp/30684","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079652012","display_name":"Shinya Shinozawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Shinozawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Fukuda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Fukuda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Y Araki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Araki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"T Oda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Oda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8052,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.72305389,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"36","issue":"2","first_page":"125","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.03849999979138374,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.9459999799728394},{"id":"https://openalex.org/keywords/plasma-distribution","display_name":"plasma distribution","score":0.5400000214576721},{"id":"https://openalex.org/keywords/drug-metabolites","display_name":"drug metabolites","score":0.6470000147819519},{"id":"https://openalex.org/keywords/fluorescent-materials","display_name":"fluorescent materials","score":0.5040000081062317},{"id":"https://openalex.org/keywords/ehrlich-ascites-carcinoma","display_name":"Ehrlich ascites carcinoma","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tumor-bearing-mice","display_name":"tumor-bearing mice","score":0.5440000295639038},{"id":"https://openalex.org/keywords/tissue-to-plasma-ratio","display_name":"tissue-to-plasma ratio","score":0.6320000290870667},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.49000000953674316},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.9279999732971191},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.8510000109672546},{"id":"https://openalex.org/keywords/lung","display_name":"lung","score":0.7329999804496765},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8805114030838013},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6893295049667358},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6815640926361084},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6443221569061279},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.6341491341590881},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5693551301956177},{"id":"https://openalex.org/C3019775314","wikidata":"https://www.wikidata.org/wiki/Q1781748","display_name":"Tissue distribution","level":2,"score":0.565796434879303},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5077170133590698},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38873225450515747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3330855369567871},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.31828439235687256},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2705515921115875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18158504366874695},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1619466245174408},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002286","descriptor_name":"Carcinoma, Ehrlich Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002286","descriptor_name":"Carcinoma, Ehrlich Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:7136849","doi":"https://doi.org/10.18926/amo/30684","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7136849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica Okayama","raw_type":"Journal Article"},{"id":"pmh:oai:EPrintsOUDIR.lib.okayama-u.ac.jp:30684","doi":"https://doi.org/10.18926/amo/30684","is_oa":false,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/30684","pdf_url":null,"source":{"id":"https://openalex.org/S4377196325","display_name":"Okayama University Scientific Achievement Repository (Okayama University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I163770644","host_organization_name":"Okayama University","host_organization_lineage":["https://openalex.org/I163770644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Okayama","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01081:0000646100","doi":"https://doi.org/10.18926/amo/30684","is_oa":true,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/30684","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Okayama","raw_type":"journal article"},{"id":"mag:170453741","doi":"https://doi.org/10.18926/amo/30684","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7136849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01081:0000646100","doi":"https://doi.org/10.18926/amo/30684","is_oa":true,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/30684","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Okayama","raw_type":"journal article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2415721110","https://openalex.org/W2429115404","https://openalex.org/W2082781151","https://openalex.org/W2011500160","https://openalex.org/W2510211892","https://openalex.org/W2047672219","https://openalex.org/W2002415621","https://openalex.org/W2415390689","https://openalex.org/W2100411451","https://openalex.org/W2470702409"],"abstract_inverted_index":{"Pharmacokinetic":[0],"analysis":[1],"of":[2,7,64],"the":[3,20,54,76,94,100,121,128,140],"distribution":[4],"and":[5,13,39,59,71,79,104,113,131,146],"concentration":[6],"adriamycin":[8],"(ADM)":[9],"in":[10,53,57,75,99,127],"mouse":[11],"plasma":[12,58,67],"tissues":[14],"was":[15],"carried":[16],"out":[17],"by":[18],"differentiating":[19],"unmetabolized":[21],"form":[22],"from":[23],"metabolized":[24,49],"ones":[25],"using":[26],"high-performance":[27],"liquid":[28],"chromatography":[29],"after":[30,119],"a":[31,82],"single":[32],"intravenous":[33],"injection.":[34],"Marked":[35],"differences":[36],"between":[37],"ADM":[38,41,45,70,73,97,125],"total":[40,69,124],"equivalent":[42],"values":[43,74,98,126],"(total":[44],"values)":[46],"or":[47],"its":[48],"forms":[50],"were":[51,88,106,133],"observed":[52],"pharmacokinetic":[55],"behavior":[56],"tissue":[60,65],"distributions.":[61],"The":[62],"ratios":[63,95,122],"per":[66],"for":[68,72,96,123],"liver,":[77,101],"kidney":[78],"heart":[80,103],"showed":[81],"two-digit":[83],"magnitude":[84],"each":[85],"time":[86],"they":[87],"examined.":[89],"Twenty":[90,117],"four":[91],"h":[92,138],"later,":[93,139],"kidney,":[102],"lung":[105,130],"at":[107],"high":[108],"levels;":[109],"43.1,":[110],"48.1,":[111],"57.9":[112],"45.5":[114,145],"times,":[115],"respectively.":[116,149],"min":[118],"injection":[120],"spleen,":[129],"tumors":[132],"comparatively":[134],"small,":[135],"but":[136],"24":[137],"ratio":[141],"had":[142],"increased":[143],"36.5,":[144],"6.8":[147],"times":[148]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
