{"id":"https://openalex.org/W170249944","doi":null,"title":"Stimulation of the scavenger receptor on monocytes-macrophages evokes release of arachidonic acid metabolites and reduced oxygen species.","display_name":"Stimulation of the scavenger receptor on monocytes-macrophages evokes release of arachidonic acid metabolites and reduced oxygen species.","publication_year":1986,"publication_date":"1986-08-01","ids":{"openalex":"https://openalex.org/W170249944","mag":"170249944","pmid":"https://pubmed.ncbi.nlm.nih.gov/3090368"},"language":"en","primary_location":{"id":"pmid:3090368","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3090368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004330962","display_name":"Hartung Hp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H P Hartung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019657720","display_name":"R.G. Kladetzky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R G Kladetzky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014420805","display_name":"Bodo Clemens Melnik","orcid":"https://orcid.org/0000-0002-4501-1809","observed_orcids":["https://orcid.org/0000-0002-4501-1809"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Melnik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5107857171","display_name":"Michael G. Hennerici","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Hennerici","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8662,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.8597008,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"55","issue":"2","first_page":"209","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.09279999881982803,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scavenger-receptors","display_name":"scavenger receptors","score":0.9900000095367432},{"id":"https://openalex.org/keywords/modified-low-density-lipoprotein","display_name":"modified low-density lipoprotein","score":0.8830000162124634},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8140000104904175},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9100000262260437},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.9330000281333923},{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prostaglandin-e","display_name":"prostaglandin E","score":0.8870000243186951},{"id":"https://openalex.org/keywords/6-keto-prostaglandin-f1-alpha","display_name":"6-keto-prostaglandin F1alpha","score":0.925000011920929},{"id":"https://openalex.org/keywords/thromboxane-b2","display_name":"thromboxane B2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/leukotriene-c4","display_name":"leukotriene C4","score":1.0},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":1.0},{"id":"https://openalex.org/keywords/respiratory-burst","display_name":"respiratory burst","score":0.9350000023841858},{"id":"https://openalex.org/keywords/atherogenesis","display_name":"atherogenesis","score":0.824999988079071},{"id":"https://openalex.org/keywords/acetylated-ldl","display_name":"acetylated LDL","score":0.7720000147819519},{"id":"https://openalex.org/keywords/malondialdehyde-modified-ldl","display_name":"malondialdehyde-modified LDL","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cyclooxygenase","display_name":"cyclooxygenase","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C41443022","wikidata":"https://www.wikidata.org/wiki/Q27796666","display_name":"Scavenger receptor","level":4,"score":0.7345055937767029},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.7138065695762634},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.6624090671539307},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.589083731174469},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4761088788509369},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.44512060284614563},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4291324019432068},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.42605364322662354},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42372629046440125},{"id":"https://openalex.org/C99971728","wikidata":"https://www.wikidata.org/wiki/Q838181","display_name":"Respiratory burst","level":2,"score":0.4215339422225952},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4127883315086365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2935856282711029},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.2929375171661377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14372029900550842},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.11682096123695374},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.061762869358062744}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010529","descriptor_name":"Peritoneal Cavity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018110","descriptor_name":"Receptors, Lipoprotein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051116","descriptor_name":"Receptors, Scavenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051122","descriptor_name":"Scavenger Receptors, Class B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3090368","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3090368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:170249944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3090368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2885283717","https://openalex.org/W2428742751","https://openalex.org/W2118246515","https://openalex.org/W7098184720","https://openalex.org/W183027691","https://openalex.org/W3139808032","https://openalex.org/W2395990237","https://openalex.org/W2085080298","https://openalex.org/W7096246668","https://openalex.org/W2177477421"],"abstract_inverted_index":{"Mouse":[0],"peritoneal":[1,27],"macrophages":[2,28,77],"are":[3],"endowed":[4],"with":[5,78,168],"a":[6],"scavenger":[7,122,173],"receptor":[8,18,123,174],"recognizing":[9],"modified":[10,82,165],"low":[11],"density":[12],"lipoproteins":[13],"(LDL).":[14],"Metabolic":[15],"sequelae":[16],"of":[17,39,58,76,94,107,128,145,172,185,199],"occupancy":[19],"distinct":[20],"from":[21,89],"lipoprotein":[22],"processing":[23],"were":[24,29,111],"examined.":[25],"Adherent":[26],"kept":[30],"in":[31,68,138,153,162,201],"short":[32],"term":[33],"culture.":[34],"Release":[35],"into":[36],"culture":[37],"supernatants":[38],"the":[40,69,126,179,196],"arachidonic":[41,101],"acid":[42,102],"derived":[43],"eicosanoids":[44,161],"prostaglandin":[45],"E,":[46],"6-keto-prostaglandin":[47],"F1a,":[48],"thromboxane":[49],"B2,":[50],"and":[51,56,64,131,140,160],"leukotriene":[52,115],"C4":[53,116],"was":[54,72,96,118,135],"assessed,":[55],"production":[57],"reduced":[59,157],"oxygen":[60,158],"species":[61,159],"superoxide":[62,129],"anion":[63,130],"hydrogen":[65,132],"peroxide,":[66],"generated":[67,156],"oxidative":[70],"burst,":[71],"monitored":[73],"after":[74,142,150],"challenge":[75],"acetylated":[79],"or":[80],"malondialdehyde":[81],"LDL.":[83,166],"Modified":[84],"LDL":[85],"at":[86],"concentrations":[87],"ranging":[88],"50":[90],"to":[91,98,164],"250":[92],"micrograms":[93],"protein/ml":[95],"noted":[97],"augment":[99],"macrophage":[100],"metabolism":[103],"within":[104],"6":[105],"hours":[106],"addition.":[108],"Cyclo-oxygenase":[109],"derivatives":[110],"synthesized":[112],"predominantly,":[113],"but":[114],"generation":[117],"also":[119,155],"observed.":[120],"Further,":[121],"occupation":[124],"triggered":[125],"release":[127],"peroxide":[133],"which":[134],"more":[136],"rapid":[137],"onset":[139],"plateaued":[141],"60":[143],"minutes":[144],"incubation.":[146],"Human":[147],"monocyte-derived":[148],"macrophages,":[149],"4":[151],"days":[152],"culture,":[154],"response":[163],"Along":[167],"our":[169],"previous":[170],"finding":[171],"mediated":[175],"lysosomal":[176],"enzyme":[177],"liberation,":[178],"present":[180],"study":[181],"indicates":[182],"novel":[183],"functions":[184],"these":[186],"binding":[187],"sites.":[188],"Our":[189],"observations":[190],"may":[191],"shed":[192],"new":[193],"light":[194],"on":[195],"possible":[197],"role":[198],"monocyte-macrophages":[200],"atherogenesis.":[202]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
