{"id":"https://openalex.org/W16997778","doi":null,"title":"[Malformations and fetal death in the Spanish antiepileptic drug and pregnancy registry: results at 6 years].","display_name":"[Malformations and fetal death in the Spanish antiepileptic drug and pregnancy registry: results at 6 years].","publication_year":2009,"publication_date":"2009-07-01","ids":{"openalex":"https://openalex.org/W16997778","mag":"16997778","pmid":"https://pubmed.ncbi.nlm.nih.gov/19798601"},"language":"es","primary_location":{"id":"pmid:19798601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19798601","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologia (Barcelona, Spain)","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005969623","display_name":"Meritxell Mart\u00ednez Ferri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096566","display_name":"University Hospital M\u00fatua de Terrassa","ror":"https://ror.org/011335j04","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096566","https://openalex.org/I4210130102"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Meritxell Mart\u00ednez Ferri","raw_affiliation_strings":["Hospital Universitario M\u00fatua de Terrasa, Barcelona. 19216mmf@comb.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario M\u00fatua de Terrasa, Barcelona. 19216mmf@comb.es","institution_ids":["https://openalex.org/I4210096566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018582266","display_name":"Pilar Pe\u00f1a Mayor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Pe\u00f1a Mayor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026454768","display_name":"Isabel P\u00e9rez L\u00f3pez-Fraile","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I P\u00e9rez L\u00f3pez-Fraile","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037882466","display_name":"Mar\u00eda Dolores Castro Vilanova","orcid":"https://orcid.org/0000-0002-9831-1944","observed_orcids":["https://orcid.org/0000-0002-9831-1944"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M D Castro Vilanova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084402585","display_name":"Antonio Escart\u00edn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Escart\u00edn Siquier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027905664","display_name":"M. Martin Moro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Mart\u00edn Moro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068889490","display_name":"Mar\u00eda Isabel Forcadas Berdus\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Forcadas Berdusan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3093,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.63632521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":"6","first_page":"360","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9710000157356262},{"id":"https://openalex.org/keywords/major-congenital-anomalies","display_name":"major congenital malformations","score":0.8410000205039978},{"id":"https://openalex.org/keywords/fetal-death","display_name":"fetal death","score":0.8460000157356262},{"id":"https://openalex.org/keywords/perinatal-death","display_name":"perinatal death","score":0.7239999771118164},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.8619999885559082},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.6420000195503235},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.9309999942779541},{"id":"https://openalex.org/keywords/epilepsy-in-pregnancy","display_name":"epilepsy in pregnancy","score":0.7590000033378601},{"id":"https://openalex.org/keywords/folic-acid-supplementation","display_name":"folic acid supplementation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/lamotrigine","display_name":"lamotrigine","score":0.7940000295639038},{"id":"https://openalex.org/keywords/carbamazepine","display_name":"carbamazepine","score":1.0},{"id":"https://openalex.org/keywords/low-birth-weight","display_name":"low birth weight","score":0.7369999885559082},{"id":"https://openalex.org/keywords/medication-safety-in-pregnancy","display_name":"drug safety in pregnancy","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8701165914535522},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6961858868598938},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.667041540145874},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.6385489702224731},{"id":"https://openalex.org/C3019607859","wikidata":"https://www.wikidata.org/wiki/Q727096","display_name":"Congenital malformations","level":3,"score":0.6383988261222839},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5787492990493774},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.4439363479614258},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.14654338359832764},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005313","descriptor_name":"Fetal Death","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013030","descriptor_name":"Spain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015337","descriptor_name":"Multicenter Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19798601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19798601","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologia (Barcelona, Spain)","raw_type":"English Abstract"},{"id":"mag:16997778","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19798601","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2053871705","https://openalex.org/W7099155145","https://openalex.org/W2119186079","https://openalex.org/W2146629358","https://openalex.org/W2800992563","https://openalex.org/W2904464888","https://openalex.org/W2087716543","https://openalex.org/W2574419237","https://openalex.org/W2939870019","https://openalex.org/W2143268844"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Pregnancy":[1],"registries":[2],"provide":[3],"trustworthy":[4],"information":[5,132,190],"about":[6],"the":[7,27,34,43,51,69,81,87,90,93,134,146,157,175,182,203,225,234,313],"risks":[8],"associated":[9],"to":[10,40,66,206,214,338],"antiepileptic":[11],"drugs":[12],"(AEDs).":[13],"EURAP":[14,41,71],"is":[15],"a":[16,168],"Prospective":[17],"International":[18],"Registry":[19,83,150],"which":[20,37],"include":[21],"patients":[22,77,273],"who":[23],"takes":[24],"AEDs":[25,67,120,235,279,314],"at":[26,86,89,231,254,280,310],"time":[28],"of":[29,33,45,53,92,107,113,116,133,139,148,159,170,185,202,211,247,259,271,288,303],"conception.":[30],"The":[31,245,269],"data":[32],"Spanish":[35,70],"centers":[36],"are":[38],"contributing":[39],"reflects":[42],"reality":[44],"our":[46,324],"milieu.":[47],"OBJECTIVES:":[48],"To":[49],"study":[50],"incidence":[52,158],"major":[54,160],"congenital":[55,161,195],"malformations":[56,162],"(MCM)":[57],"/and/or":[58],"fetal-perinatal":[59],"death":[60],"(MFP)":[61],"and":[62,84,95,100,121,127,131,163,208,233,243,283,312,331],"determine":[63],"his":[64],"relationship":[65],"in":[68,80,151,174,191,199,298,323],"registry.":[72],"METHODS:":[73],"After":[74,136],"informed":[75],"consent,":[76],"were":[78,109,178,197,265,274,284],"included":[79,173],"prospective":[82,179],"evaluated:":[85],"beginning,":[88],"end":[91],"second":[94],"third":[96],"trimester,":[97],"after":[98,103],"delivery":[99],"one":[101],"year":[102],"birth.":[104],"A":[105],"variety":[106],"variables":[108,226],"collected:":[110],"demographic,":[111],"type":[112],"epilepsy,":[114],"frequency":[115],"seizures":[117],"during":[118],"pregnancy,":[119],"dose,":[122,128],"potential":[123],"toxics,":[124],"folate":[125],"use":[126],"obstetric":[129],"complications":[130],"newborn.":[135],"6":[137],"years":[138],"recruitment":[140],"(June":[141],"2001-October":[142],"2007)":[143],"we":[144,187],"analyzed":[145,227],"results":[147],"this":[149],"Spain":[152],"with":[153,220,241,278,296,320,336],"special":[154],"attention":[155],"on":[156,275,292],"foetal-perinatal":[164],"death.":[165],"RESULTS:":[166],"Of":[167,224],"whole":[169],"540":[171],"cases":[172],"Registry,":[176],"490":[177],"(included":[180],"before":[181],"16th":[183],"week),":[184],"these":[186],"had":[188],"complete":[189],"368":[192],"cases.":[193],"Major":[194],"maLformations":[196],"present":[198,300],"5%":[200],"(n=13)":[201],"child":[204],"exposed":[205,213],"monotherapy":[207,276,306],"12%":[209],"(n=6)":[210],"those":[212,295],"polytherapy":[215,218],"(p=0.08).":[216],"All":[217],"combinations":[219],"MCM,":[221],"contained":[222],"valproate.":[223],"only":[228,308],"low":[229,281],"weight":[230,309],"birth":[232,311],"used":[236,315],"showed":[237],"statistically":[238,267,318],"significant":[239,319],"association":[240,317],"MCM":[242,248],"MFP.":[244],"percentage":[246],"was":[249],"superior":[250,258],"for":[251],"valproate,":[252],"particularly":[253,294],"doses":[255,282],"equal":[256],"or":[257],"1000":[260],"mg/day":[261],"(16%),":[262],"although":[263],"differences":[264,335],"not":[266,333],"significant.":[268],"majority":[270],"ours":[272],"(83%)":[277],"taking":[285],"5":[286],"mg":[287],"folate.":[289],"CONCLUSIONS:":[290],"Patients":[291],"polytherapy,":[293],"valproate":[297],"combination":[299],"more":[301,327],"risk":[302,328],"MCM.":[304],"For":[305],"exposures":[307],"have":[316],"MC/MFP.":[321],"Valproate":[322],"series":[325],"presents":[326],"than":[329],"lamotrigine":[330],"does":[332],"show":[334],"regard":[337],"carbamazepine.":[339]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}