{"id":"https://openalex.org/W1699500024","doi":"https://doi.org/10.1016/j.str.2015.06.009","title":"Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles","display_name":"Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles","publication_year":2015,"publication_date":"2015-07-17","ids":{"openalex":"https://openalex.org/W1699500024","doi":"https://doi.org/10.1016/j.str.2015.06.009","mag":"1699500024","pmid":"https://pubmed.ncbi.nlm.nih.gov/26190576","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4526357"},"language":"en","primary_location":{"id":"doi:10.1016/j.str.2015.06.009","doi":"https://doi.org/10.1016/j.str.2015.06.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.str.2015.06.009","pdf_url":"http://www.cell.com/article/S0969212615002348/pdf","source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0969212615002348/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024840454","display_name":"Yu Feng","orcid":"https://orcid.org/0000-0003-4239-8320","observed_orcids":["https://orcid.org/0000-0003-4239-8320"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Feng","raw_affiliation_strings":["Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051323344","display_name":"David Degen","orcid":"https://orcid.org/0000-0002-2916-0564","observed_orcids":["https://orcid.org/0000-0002-2916-0564"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Degen","raw_affiliation_strings":["Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100408866","display_name":"Xinyue Wang","orcid":"https://orcid.org/0000-0001-6990-783X","observed_orcids":["https://orcid.org/0000-0001-6990-783X","https://orcid.org/0000-0001-9793-8211","https://orcid.org/0009-0000-9181-0663","https://orcid.org/0009-0001-6199-821X"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinyue Wang","raw_affiliation_strings":["Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048367157","display_name":"Matthew Gigliotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Gigliotti","raw_affiliation_strings":["Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100319123","display_name":"Shuang Liu","orcid":"https://orcid.org/0000-0003-3287-2404","observed_orcids":["https://orcid.org/0000-0003-3287-2404"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuang Liu","raw_affiliation_strings":["Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100433501","display_name":"Yu Zhang","orcid":"https://orcid.org/0000-0002-1778-8389","observed_orcids":["https://orcid.org/0000-0002-1778-8389","https://orcid.org/0009-0009-7401-5225"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Zhang","raw_affiliation_strings":["Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083870648","display_name":"Deepankar Das","orcid":"https://orcid.org/0000-0003-4504-0367","observed_orcids":["https://orcid.org/0000-0003-4504-0367"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepankar Das","raw_affiliation_strings":["Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019655524","display_name":"Trevor Michalchuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trevor Michalchuk","raw_affiliation_strings":["Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107898385","display_name":"Yon W. Ebright","orcid":"https://orcid.org/0000-0002-3835-3683","observed_orcids":["https://orcid.org/0000-0002-3835-3683"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yon\u00a0W. Ebright","raw_affiliation_strings":["Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067431961","display_name":"Meliza T. Talaue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meliza Talaue","raw_affiliation_strings":["Center for Biodefense, New Jersey Medical School, Rutgers University, Newark, NJ 07101, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biodefense, New Jersey Medical School, Rutgers University, Newark, NJ 07101, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050607880","display_name":"Nancy D Connell","orcid":"https://orcid.org/0000-0003-0489-3777","observed_orcids":["https://orcid.org/0000-0003-0489-3777"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Connell","raw_affiliation_strings":["Center for Biodefense, New Jersey Medical School, Rutgers University, Newark, NJ 07101, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biodefense, New Jersey Medical School, Rutgers University, Newark, NJ 07101, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087284111","display_name":"Richard H. Ebright","orcid":"https://orcid.org/0000-0001-8915-7140","observed_orcids":["https://orcid.org/0000-0001-8915-7140"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard\u00a0H. Ebright","raw_affiliation_strings":["Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: ebright@waksman.rutgers.edu","Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: ebright@waksman.rutgers.edu","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Waksman Institute and Department of Chemistry & Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087284111"],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":{"value":9350,"currency":"USD","value_usd":9350},"apc_paid":null,"fwci":2.053,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.86363359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"23","issue":"8","first_page":"1470","last_page":"1481"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.10999999940395355,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.03460000082850456,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.8289999961853027},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.6650000214576721},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.6990000009536743},{"id":"https://openalex.org/keywords/resistance-determinants","display_name":"resistance determinants","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cross-resistance","display_name":"cross-resistance","score":0.9419999718666077},{"id":"https://openalex.org/keywords/scaffold-hopping","display_name":"scaffold hopping","score":0.722000002861023},{"id":"https://openalex.org/keywords/structure-based-drug-design","display_name":"structure-based drug design","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.6556121110916138},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5131138563156128},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4584614038467407},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4572126865386963},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.4462220370769501},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.433544397354126},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.433024525642395},{"id":"https://openalex.org/C26261996","wikidata":"https://www.wikidata.org/wiki/Q2382392","display_name":"Bacterial transcription","level":5,"score":0.4313352704048157},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4226975440979004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39702507853507996},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.24491849541664124},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23191052675247192},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16491836309432983},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11508935689926147}],"mesh":[{"descriptor_ui":"D000578","descriptor_name":"Amidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000578","descriptor_name":"Amidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006898","descriptor_name":"Hydroxylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006898","descriptor_name":"Hydroxylamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012321","descriptor_name":"DNA-Directed RNA Polymerases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D012321","descriptor_name":"DNA-Directed RNA Polymerases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012321","descriptor_name":"DNA-Directed RNA Polymerases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.str.2015.06.009","doi":"https://doi.org/10.1016/j.str.2015.06.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.str.2015.06.009","pdf_url":"http://www.cell.com/article/S0969212615002348/pdf","source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},{"id":"pmid:26190576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26190576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure (London, England : 1993)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3933253","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4526357","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4526357","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4526357","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Structure","raw_type":"Text"},{"id":"pmh:oai:alma.01RUT_INST:11679583490004646","doi":null,"is_oa":false,"landing_page_url":"https://scholarship.libraries.rutgers.edu/esploro/outputs/journalArticle/Structural-basis-of-transcription-inhibition-by/991031733050804646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401388","display_name":"Rutgers University Community Repository (Rutgers University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102322142","host_organization_name":"Rutgers, The State University of New Jersey","host_organization_lineage":["https://openalex.org/I102322142"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"doi:10.1016/j.str.2015.06.009","doi":"https://doi.org/10.1016/j.str.2015.06.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.str.2015.06.009","pdf_url":"http://www.cell.com/article/S0969212615002348/pdf","source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1765023576","display_name":null,"funder_award_id":"GM 041376","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3847374230","display_name":"BACTERIAL TRANSCRIPTION COMPLEXES","funder_award_id":"R37GM041376","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000873568","display_name":"Prokaryotic Transcription Termination R37GM041376-R01GM041376 - Competitive Renewal Resubmission 1","funder_award_id":"R01GM041376","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320338284","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1699500024.pdf"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1539796472","https://openalex.org/W1557661275","https://openalex.org/W1558827136","https://openalex.org/W1570409675","https://openalex.org/W1582312374","https://openalex.org/W1810878477","https://openalex.org/W1869062106","https://openalex.org/W1974141130","https://openalex.org/W1980640885","https://openalex.org/W1982183474","https://openalex.org/W1982491379","https://openalex.org/W1983600437","https://openalex.org/W1987351852","https://openalex.org/W1987609716","https://openalex.org/W1995664303","https://openalex.org/W2003327066","https://openalex.org/W2022654406","https://openalex.org/W2029978813","https://openalex.org/W2038061439","https://openalex.org/W2038211892","https://openalex.org/W2046192268","https://openalex.org/W2049917954","https://openalex.org/W2061376845","https://openalex.org/W2063758560","https://openalex.org/W2067559823","https://openalex.org/W2068372433","https://openalex.org/W2072021660","https://openalex.org/W2073391911","https://openalex.org/W2078802973","https://openalex.org/W2097688085","https://openalex.org/W2098126135","https://openalex.org/W2101110349","https://openalex.org/W2105453216","https://openalex.org/W2107552671","https://openalex.org/W2107861779","https://openalex.org/W2124026197","https://openalex.org/W2138023605","https://openalex.org/W2139241849","https://openalex.org/W2142618175","https://openalex.org/W2163341755","https://openalex.org/W2180229411","https://openalex.org/W2404966432","https://openalex.org/W2443442445","https://openalex.org/W2804007336","https://openalex.org/W2950711796","https://openalex.org/W4251566758"],"related_works":["https://openalex.org/W7101028744","https://openalex.org/W1980640885","https://openalex.org/W2049917954","https://openalex.org/W2097688085","https://openalex.org/W2097514264","https://openalex.org/W3013357028","https://openalex.org/W1987351852","https://openalex.org/W2119721460","https://openalex.org/W2333306656","https://openalex.org/W2122176985"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}