{"id":"https://openalex.org/W1699190458","doi":null,"title":"Etude des m\u00e9canismes mol\u00e9culaires par lesquels les m\u00e9thyltransf\u00e9rases de l'ADN \u00e9tablissent les profils de m\u00e9thylation","display_name":"Etude des m\u00e9canismes mol\u00e9culaires par lesquels les m\u00e9thyltransf\u00e9rases de l'ADN \u00e9tablissent les profils de m\u00e9thylation","publication_year":2005,"publication_date":"2005-05-31","ids":{"openalex":"https://openalex.org/W1699190458","mag":"1699190458"},"language":"fr","primary_location":{"id":"pmh:oai:dipot.ulb.ac.be:2013/211004","doi":null,"is_oa":true,"landing_page_url":"https://dipot.ulb.ac.be/dspace/bitstream/2013/211004/4/00a22aef-2eca-4668-b5c4-4862e15b8862.txt","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dipot.ulb.ac.be/dspace/bitstream/2013/211004/4/00a22aef-2eca-4668-b5c4-4862e15b8862.txt","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065632278","display_name":"Rachel Deplus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachel Deplus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5038483344","display_name":"Fran\u00e7ois Fuks","orcid":"https://orcid.org/0000-0003-4637-7287","observed_orcids":["https://orcid.org/0000-0003-4637-7287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Fuks","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4637-7287","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.9729999899864197},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8610000014305115},{"id":"https://openalex.org/keywords/histone-deacetylation","display_name":"histone deacetylation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chromatin-condensation","display_name":"chromatin condensation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.5860000252723694},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.4819999933242798},{"id":"https://openalex.org/keywords/x-chromosome-inactivation","display_name":"X chromosome inactivation","score":0.5649999976158142},{"id":"https://openalex.org/keywords/genomic-imprinting","display_name":"genomic imprinting","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.4749999940395355},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.5799999833106995},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.546999990940094},{"id":"https://openalex.org/keywords/dna-methylation-patterns","display_name":"DNA methylation patterns","score":0.35600000619888306}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7312239408493042},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4533807337284088},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.3627352714538574}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dipot.ulb.ac.be:2013/211004","doi":null,"is_oa":true,"landing_page_url":"https://dipot.ulb.ac.be/dspace/bitstream/2013/211004/4/00a22aef-2eca-4668-b5c4-4862e15b8862.txt","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1699190458","doi":null,"is_oa":false,"landing_page_url":"https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211004/Holdings","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dipot.ulb.ac.be:2013/211004","doi":null,"is_oa":true,"landing_page_url":"https://dipot.ulb.ac.be/dspace/bitstream/2013/211004/4/00a22aef-2eca-4668-b5c4-4862e15b8862.txt","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":238,"referenced_works":["https://openalex.org/W116365591","https://openalex.org/W161079426","https://openalex.org/W1486257535","https://openalex.org/W1490231232","https://openalex.org/W1504303645","https://openalex.org/W1509466986","https://openalex.org/W1516326873","https://openalex.org/W1521333964","https://openalex.org/W1522855936","https://openalex.org/W1528728961","https://openalex.org/W1533942477","https://openalex.org/W1544893850","https://openalex.org/W1550720320","https://openalex.org/W1552218246","https://openalex.org/W1554666790","https://openalex.org/W1556996865","https://openalex.org/W1559742681","https://openalex.org/W1577875429","https://openalex.org/W1603793127","https://openalex.org/W1605104953","https://openalex.org/W1635667563","https://openalex.org/W1659768997","https://openalex.org/W1660631781","https://openalex.org/W1665024321","https://openalex.org/W1670921079","https://openalex.org/W1673514954","https://openalex.org/W1709424591","https://openalex.org/W1826726872","https://openalex.org/W1838266191","https://openalex.org/W1903792504","https://openalex.org/W1939097055","https://openalex.org/W1942778846","https://openalex.org/W1951075546","https://openalex.org/W1951809136","https://openalex.org/W1965344790","https://openalex.org/W1966273969","https://openalex.org/W1966593231","https://openalex.org/W1967064280","https://openalex.org/W1968048144","https://openalex.org/W1968449865","https://openalex.org/W1969076105","https://openalex.org/W1973759523","https://openalex.org/W1974112332","https://openalex.org/W1974747095","https://openalex.org/W1976403210","https://openalex.org/W1976608804","https://openalex.org/W1976874039","https://openalex.org/W1977479343","https://openalex.org/W1978419388","https://openalex.org/W1978735852","https://openalex.org/W1979216378","https://openalex.org/W1981276210","https://openalex.org/W1981442074","https://openalex.org/W1981536428","https://openalex.org/W1981828788","https://openalex.org/W1982172428","https://openalex.org/W1982598635","https://openalex.org/W1984566498","https://openalex.org/W1984667030","https://openalex.org/W1990381590","https://openalex.org/W1990861922","https://openalex.org/W1991745061","https://openalex.org/W1993257254","https://openalex.org/W1997345702","https://openalex.org/W1997998562","https://openalex.org/W1999946050","https://openalex.org/W2000580034","https://openalex.org/W2000711026","https://openalex.org/W2000816728","https://openalex.org/W2001221569","https://openalex.org/W2001224651","https://openalex.org/W2001488045","https://openalex.org/W2004172747","https://openalex.org/W2004705005","https://openalex.org/W2004988279","https://openalex.org/W2006095114","https://openalex.org/W2006987944","https://openalex.org/W2010697949","https://openalex.org/W2011221870","https://openalex.org/W2013050589","https://openalex.org/W2014109329","https://openalex.org/W2015132841","https://openalex.org/W2015996771","https://openalex.org/W2016961672","https://openalex.org/W2018258194","https://openalex.org/W2019757555","https://openalex.org/W2019767302","https://openalex.org/W2019996598","https://openalex.org/W2022394909","https://openalex.org/W2023195681","https://openalex.org/W2024106659","https://openalex.org/W2027297574","https://openalex.org/W2028817220","https://openalex.org/W2032246157","https://openalex.org/W2032594275","https://openalex.org/W2034022735","https://openalex.org/W2034980302","https://openalex.org/W2035090622","https://openalex.org/W2035391407","https://openalex.org/W2036479240","https://openalex.org/W2036565444","https://openalex.org/W2039274160","https://openalex.org/W2040239915","https://openalex.org/W2042169129","https://openalex.org/W2042794853","https://openalex.org/W2042966777","https://openalex.org/W2046020893","https://openalex.org/W2046241907","https://openalex.org/W2046387526","https://openalex.org/W2051060234","https://openalex.org/W2055171335","https://openalex.org/W2057089696","https://openalex.org/W2058733797","https://openalex.org/W2059976468","https://openalex.org/W2060446375","https://openalex.org/W2060990349","https://openalex.org/W2061639735","https://openalex.org/W2061946349","https://openalex.org/W2062093164","https://openalex.org/W2063486767","https://openalex.org/W2064297857","https://openalex.org/W2064775435","https://openalex.org/W2068494490","https://openalex.org/W2069624136","https://openalex.org/W2069752613","https://openalex.org/W2071285517","https://openalex.org/W2071298219","https://openalex.org/W2074140050","https://openalex.org/W2074144048","https://openalex.org/W2075087486","https://openalex.org/W2075421336","https://openalex.org/W2076845646","https://openalex.org/W2077053535","https://openalex.org/W2079891060","https://openalex.org/W2081054663","https://openalex.org/W2081091627","https://openalex.org/W2081597769","https://openalex.org/W2083308605","https://openalex.org/W2083485306","https://openalex.org/W2084223479","https://openalex.org/W2084748297","https://openalex.org/W2085297752","https://openalex.org/W2086908959","https://openalex.org/W2087083968","https://openalex.org/W2090540942","https://openalex.org/W2091098061","https://openalex.org/W2091196623","https://openalex.org/W2091513322","https://openalex.org/W2091658754","https://openalex.org/W2091972243","https://openalex.org/W2092492901","https://openalex.org/W2092586481","https://openalex.org/W2094473285","https://openalex.org/W2095115211","https://openalex.org/W2096796564","https://openalex.org/W2097411118","https://openalex.org/W2099067892","https://openalex.org/W2100325414","https://openalex.org/W2101825944","https://openalex.org/W2101904615","https://openalex.org/W2103206259","https://openalex.org/W2104882487","https://openalex.org/W2105365305","https://openalex.org/W2106642338","https://openalex.org/W2107038650","https://openalex.org/W2107733280","https://openalex.org/W2107972234","https://openalex.org/W2109047753","https://openalex.org/W2109143388","https://openalex.org/W2109738692","https://openalex.org/W2110237282","https://openalex.org/W2110399580","https://openalex.org/W2111041465","https://openalex.org/W2112167962","https://openalex.org/W2112481194","https://openalex.org/W2114221123","https://openalex.org/W2114599216","https://openalex.org/W2115147255","https://openalex.org/W2116646376","https://openalex.org/W2116862022","https://openalex.org/W2117059020","https://openalex.org/W2118008591","https://openalex.org/W2119787118","https://openalex.org/W2121417064","https://openalex.org/W2122054853","https://openalex.org/W2122116522","https://openalex.org/W2122348846","https://openalex.org/W2122558768","https://openalex.org/W2122580718","https://openalex.org/W2122686086","https://openalex.org/W2123337810","https://openalex.org/W2123927456","https://openalex.org/W2124105093","https://openalex.org/W2125600565","https://openalex.org/W2126003594","https://openalex.org/W2126298144","https://openalex.org/W2126371676","https://openalex.org/W2128071342","https://openalex.org/W2128280445","https://openalex.org/W2128951060","https://openalex.org/W2130808015","https://openalex.org/W2131011930","https://openalex.org/W2132619798","https://openalex.org/W2135925928","https://openalex.org/W2136270288","https://openalex.org/W2140332969","https://openalex.org/W2141942950","https://openalex.org/W2142785868","https://openalex.org/W2143658931","https://openalex.org/W2143817569","https://openalex.org/W2144449731","https://openalex.org/W2144691110","https://openalex.org/W2148253564","https://openalex.org/W2149790281","https://openalex.org/W2149858761","https://openalex.org/W2149902033","https://openalex.org/W2151411596","https://openalex.org/W2151447730","https://openalex.org/W2153466675","https://openalex.org/W2153781529","https://openalex.org/W2153900602","https://openalex.org/W2154648145","https://openalex.org/W2155120106","https://openalex.org/W2159882433","https://openalex.org/W2160839840","https://openalex.org/W2161343890","https://openalex.org/W2165880713","https://openalex.org/W2170940855","https://openalex.org/W2171715925","https://openalex.org/W2171996338","https://openalex.org/W2216831825","https://openalex.org/W2328946792","https://openalex.org/W2338927555","https://openalex.org/W2522073038","https://openalex.org/W2591932503","https://openalex.org/W2977348998","https://openalex.org/W3217574651","https://openalex.org/W4240795757"],"related_works":["https://openalex.org/W1675555070","https://openalex.org/W1633163167","https://openalex.org/W2171567935","https://openalex.org/W631235277","https://openalex.org/W7139802267","https://openalex.org/W172845450","https://openalex.org/W2058332934","https://openalex.org/W7148786744","https://openalex.org/W4414495232","https://openalex.org/W4392540118"],"abstract_inverted_index":{"La":[0,79,244,263],"m\u00e9thylation":[1,45,57,80,141,158,194,325],"des":[2,94,100,195,233,256,286,320],"cytosines":[3],"de":[4,9,12,38,46,55,58,65,81,91,107,110,112,134,142,151,160,165,176,185,188,215,222,242,254,272,283,313,323,326],"l\u2019ADN":[5,47,59,82,327],"est":[6,37,61,83,246,266],"un":[7,18,125,203,289],"niveau":[8],"contr\u00f4le":[10],"essentiel":[11],"la":[13,44,50,56,73,92,135,140,157,163,166,183,193,216,219,273,324],"transcription":[14,93],"g\u00e9nique.":[15],"Elle":[16],"joue":[17],"r\u00f4le":[19],"primordial":[20],"dans":[21,120,182,302,332],"plusieurs":[22,146],"\u00e9tapes":[23],"du":[24,28,103,275,305],"d\u00e9veloppement":[25,304],"comme":[26],"l\u2019inactivation":[27],"chromosome":[29],"X":[30],"et":[31,96,192,250],"l\u2019empreinte":[32],"g\u00e9nomique.":[33],"De":[34],"plus,":[35],"il":[36,149],"plus":[39,41,152,154,267],"en":[40,99,153,252,278],"\u00e9vident":[42],"que":[43,156,329],"participe":[48],"\u00e0":[49,132,145,270],"canc\u00e9rogen\u00e8se.":[51],"Actuellement,":[52],"le":[53,97,231,303],"monde":[54],"n\u2019en":[60],"encore":[62,76],"qu\u2019\u00e0":[63],"l'aube":[64],"son":[66,186,330],"histoire.":[67],"En":[68,309],"effet,":[69],"les":[70,117,333],"m\u00e9canismes":[71,321],"mol\u00e9culaires":[72,322],"gouvernant":[74],"sont":[75],"peu":[77],"connus.":[78],"caract\u00e9ris\u00e9e":[84],"par":[85,139],"deux":[86,122,179,240],"concept":[87],"cl\u00e9s":[88],":le":[89,295],"verrouillage":[90],"g\u00e8nes":[95],"ciblage":[98,232],"r\u00e9gions":[101],"sp\u00e9cifiques":[102],"g\u00e9nome.":[104],"Au":[105],"cours":[106],"notre":[108,228,311],"travail":[109,312],"th\u00e8se":[111],"doctorat,":[113],"nous":[114,128,129,200,225,237,280],"avons":[115,169,201,226,238,281],"poursuivi":[116],"avanc\u00e9es":[118],"r\u00e9alis\u00e9es":[119],"ces":[121,207],"domaines.":[123],"Dans":[124,218],"premier":[126],"temps,":[127],"sommes":[130],"attach\u00e9s":[131],"l\u2019\u00e9tude":[133,253],"r\u00e9pression":[136],"transcriptionnelle":[137],"entra\u00een\u00e9e":[138],"l\u2019ADN.":[143],"Gr\u00e2ce":[144,269],"\u00e9tudes":[147],"r\u00e9centes,":[148],"para\u00eet":[150],"clair":[155],"agit":[159],"paire":[161],"avec":[162,178,258],"structure":[164],"chromatine.":[167],"Nous":[168],"donc":[170],"concentr\u00e9":[171],"nos":[172],"recherches":[173],"sur":[174,230],"l\u2019interconnexion":[175],"celle-ci":[177],"machineries":[180,208],"impliqu\u00e9es":[181],"r\u00e9gulation":[184],"degr\u00e9":[187],"compaction":[189],":la":[190],"d\u00e9sac\u00e9tylation":[191],"histones.":[196],"Par":[197],"diverses":[198],"exp\u00e9rimentations,":[199],"d\u00e9montr\u00e9":[202],"lien":[204],"\u00e9troit":[205],"entre":[206],"r\u00e9pressives":[209],"pour":[210],"l\u2019imposition":[211],"d\u2019un":[212],"\u00e9tat":[213],"silencieux":[214],"transcription.":[217],"deuxi\u00e8me":[220],"partie":[221],"ce":[223],"travail,":[224],"dirig\u00e9":[227],"attention":[229],"Dnmt.":[234],"Pour":[235],"cela,":[236],"men\u00e9":[239],"strat\u00e9gies":[241],"front.":[243],"premi\u00e8re":[245],"une":[247,317],"approche":[248,265],"cibl\u00e9e":[249],"consiste":[251],"l\u2019association":[255],"Dnmt":[257],"l\u2019oncoprot\u00e9ine":[259],"bien":[260],"connue,":[261],"Myc.":[262],"seconde":[264],"large.":[268],"l\u2019utilisation":[271],"technique":[274],"double":[276],"hybride":[277],"levure,":[279],"identifi\u00e9":[282],"nouveaux":[284],"partenaires":[285],"Dnmt,":[287],"dont":[288],"qui":[290],"pourrait":[291],"s\u2019av\u00e9r\u00e9":[292],"particuli\u00e8rement":[293],"int\u00e9ressant":[294],"prot\u00e9ine":[296],"Cart1":[297],"(cartilage":[298],"homeoproteine":[299],"1)":[300],"impliqu\u00e9e":[301],"syst\u00e8me":[306],"nerveux":[307],"central.":[308],"conclusion,":[310],"doctorat":[314],"devrait":[315],"permettre":[316],"meilleure":[318],"compr\u00e9hension":[319],"ainsi":[328],"implication":[331],"divers":[334],"processus":[335],"physiologiques":[336],"mais":[337],"aussi":[338],"pathologiques":[339],"auxquels":[340],"elle":[341],"participe.":[342]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}