{"id":"https://openalex.org/W1698934341","doi":"https://doi.org/10.1128/jb.171.10.5410-5421.1989","title":"Characterization of Acinetobacter calcoaceticus catM, a repressor gene homologous in sequence to transcriptional activator genes","display_name":"Characterization of Acinetobacter calcoaceticus catM, a repressor gene homologous in sequence to transcriptional activator genes","publication_year":1989,"publication_date":"1989-10-01","ids":{"openalex":"https://openalex.org/W1698934341","doi":"https://doi.org/10.1128/jb.171.10.5410-5421.1989","mag":"1698934341","pmid":"https://pubmed.ncbi.nlm.nih.gov/2793826","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/210378"},"language":"en","primary_location":{"id":"doi:10.1128/jb.171.10.5410-5421.1989","doi":"https://doi.org/10.1128/jb.171.10.5410-5421.1989","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.171.10.5410-5421.1989","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/210378","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030250396","display_name":"Ellen L. Neidle","orcid":"https://orcid.org/0000-0003-1665-5303","observed_orcids":["https://orcid.org/0000-0003-1665-5303"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E L Neidle","raw_affiliation_strings":["Department of Biology, Yale University, New Haven, Connecticut 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yale University, New Haven, Connecticut 06511","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109920747","display_name":"Chris Hartnett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Hartnett","raw_affiliation_strings":["Department of Biology, Yale University, New Haven, Connecticut 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yale University, New Haven, Connecticut 06511","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020257818","display_name":"L. Nicholas Ornston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L N Ornston","raw_affiliation_strings":["Department of Biology, Yale University, New Haven, Connecticut 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yale University, New Haven, Connecticut 06511","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":1.9794,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.85341859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"171","issue":"10","first_page":"5410","last_page":"5421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.7289999723434448,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.7289999723434448,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10324","display_name":"Microbial bioremediation and biosurfactants","score":0.23999999463558197,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12688","display_name":"Microbial metabolism and enzyme function","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acinetobacter-calcoaceticus","display_name":"Acinetobacter calcoaceticus","score":1.0},{"id":"https://openalex.org/keywords/catechol-degradation","display_name":"catechol degradation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/catechol-1-2-dioxygenase","display_name":"catechol 1,2-dioxygenase","score":0.9229999780654907},{"id":"https://openalex.org/keywords/benzoate-degradation","display_name":"benzoate degradation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/transcriptional-repressor","display_name":"transcriptional repressor","score":0.7319999933242798},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cis-cis-muconate","display_name":"cis,cis-muconate","score":0.8450000286102295},{"id":"https://openalex.org/keywords/gene-clusters","display_name":"gene clusters","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8600930571556091},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.749272346496582},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6550660729408264},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.6079066395759583},{"id":"https://openalex.org/C5527404","wikidata":"https://www.wikidata.org/wiki/Q2357310","display_name":"Structural gene","level":4,"score":0.5188571214675903},{"id":"https://openalex.org/C33498276","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Regulator gene","level":4,"score":0.46242445707321167},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4587779939174652},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45383456349372864},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.451764851808548},{"id":"https://openalex.org/C2775859738","wikidata":"https://www.wikidata.org/wiki/Q4674168","display_name":"Acinetobacter calcoaceticus","level":4,"score":0.44757041335105896},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.3482448160648346},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.34798336029052734},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2701537013053894},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.20176208019256592},{"id":"https://openalex.org/C2778523567","wikidata":"https://www.wikidata.org/wiki/Q310457","display_name":"Acinetobacter","level":3,"score":0.08776476979255676},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000150","descriptor_name":"Acinetobacter","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jb.171.10.5410-5421.1989","doi":"https://doi.org/10.1128/jb.171.10.5410-5421.1989","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.171.10.5410-5421.1989","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1296138","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/210378","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:210378","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/210378","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmid:2793826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2793826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1296138","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/210378","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G261216223","display_name":null,"funder_award_id":"GM 33377","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320309086","display_name":"Celgene","ror":"https://ror.org/0527yg379"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320338281","display_name":"Army Research Office","ror":"https://ror.org/05epdh915"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W194917975","https://openalex.org/W236661653","https://openalex.org/W371084363","https://openalex.org/W1413884192","https://openalex.org/W1509557781","https://openalex.org/W1522298664","https://openalex.org/W1524688180","https://openalex.org/W1526230021","https://openalex.org/W1527394822","https://openalex.org/W1542067597","https://openalex.org/W1544658322","https://openalex.org/W1560866854","https://openalex.org/W1568390953","https://openalex.org/W1577152142","https://openalex.org/W1580575171","https://openalex.org/W1581681869","https://openalex.org/W1605869353","https://openalex.org/W1731959810","https://openalex.org/W1745838399","https://openalex.org/W1775749144","https://openalex.org/W1845621439","https://openalex.org/W1854033468","https://openalex.org/W1855595511","https://openalex.org/W1948027265","https://openalex.org/W1972010400","https://openalex.org/W1979053604","https://openalex.org/W1980279189","https://openalex.org/W1997133285","https://openalex.org/W1997621667","https://openalex.org/W2020584576","https://openalex.org/W2028622989","https://openalex.org/W2029195137","https://openalex.org/W2039077305","https://openalex.org/W2039851076","https://openalex.org/W2052503008","https://openalex.org/W2061202321","https://openalex.org/W2074231493","https://openalex.org/W2106737096","https://openalex.org/W2109068357","https://openalex.org/W2112858624","https://openalex.org/W2117987081","https://openalex.org/W2118172868","https://openalex.org/W2122161443","https://openalex.org/W2138270253","https://openalex.org/W2150066221","https://openalex.org/W2156758701","https://openalex.org/W2161524167","https://openalex.org/W2163822801","https://openalex.org/W2175899208","https://openalex.org/W2896851218","https://openalex.org/W2896859644","https://openalex.org/W4237636790"],"related_works":["https://openalex.org/W2098305009","https://openalex.org/W1581681869","https://openalex.org/W2009340955","https://openalex.org/W2169334907","https://openalex.org/W1580575171","https://openalex.org/W1509557781","https://openalex.org/W1978539693","https://openalex.org/W2006103378","https://openalex.org/W2114521600","https://openalex.org/W1626863135"],"abstract_inverted_index":{"Two":[0],"structural":[1,52,170,277],"genes":[2,35,53,176,278],"needed":[3],"for":[4,55,280],"catechol":[5,14,123],"degradation,":[6,29],"catA":[7,32,65,90,225,231,262],"and":[8,18,30,33,66,74,91,107,139],"catB,":[9],"encode":[10,153],"the":[11,31,51,56,71,95,161,168,175,187,219,261,273,276],"respective":[12],"enzymes":[13],"1,2-dioxygenase":[15],"(EC":[16,21],"1.13.11.1)":[17],"muconate":[19],"cycloisomerase":[20],"5.5.1.1).":[22],"Catechol":[23],"is":[24,265],"an":[25,268],"intermediate":[26],"in":[27,70,94,160,186,226,239,253],"benzoate":[28,59,236,281],"catB":[34,67,138],"are":[36,210],"clustered":[37],"within":[38],"a":[39,154,180,196,199,240,254],"17-kilobase-pair":[40],"(kbp)":[41],"region":[42,274],"of":[43,50,58,80,105,113,163,167,174,198,202,230],"Acinetobacter":[44],"calcoaceticus":[45],"chromosomal":[46],"DNA":[47,252],"containing":[48,275],"all":[49],"required":[54,251],"conversion":[57],"to":[60,152,194,284],"tricarboxylic":[61],"acid":[62],"cycle":[63],"intermediates.":[64],"were":[68,75,98],"transcribed":[69,93,140],"same":[72,96],"direction":[73,97],"separated":[76],"by":[77,179,215,234],"3.8":[78],"kbp":[79,258],"DNA.":[81],"The":[82,190],"3.8-kbp":[83],"sequence":[84],"revealed":[85],"that":[86,267],"directly":[87],"downstream":[88],"from":[89,137,142,243,260],"potentially":[92],"two":[99],"open":[100,115,130],"reading":[101,116,131],"frames":[102,117],"encoding":[103],"polypeptides":[104],"48":[106],"36":[108],"kilodaltons":[109],"(kDa).":[110],"Genetic":[111],"disruption":[112],"these":[114],"did":[118],"not":[119,218],"discernably":[120],"alter":[121],"either":[122,235],"metabolism":[124],"or":[125,237],"its":[126],"regulation.":[127],"A":[128],"third":[129],"frame,":[132],"beginning":[133],"123":[134],"bp":[135],"upstream":[136,259],"divergently":[141],"this":[143,285],"gene,":[144,270],"was":[145,150,177,217,232],"designated":[146],"catM.":[147],"This":[148,249],"gene":[149],"found":[151],"28-kDa":[155],"trans-acting":[156],"repressor":[157,191],"protein":[158,192],"that,":[159],"absence":[162],"cis,cis-muconate,":[164],"prevented":[165],"expression":[166,173],"cat":[169],"genes.":[171],"Constitutive":[172],"caused":[178],"mutation":[181],"substituting":[182],"Arg-156":[183],"with":[184,207],"His-156":[185],"catM-encoded":[188],"repressor.":[189],"proved":[193],"be":[195],"member":[197],"diverse":[200],"family":[201],"procaryotic":[203],"regulatory":[204],"proteins":[205],"which,":[206],"rare":[208],"exception,":[209],"transcriptional":[211,221],"activators.":[212],"Repression":[213],"mediated":[214],"catM":[216,245],"sole":[220],"control":[222],"exercised":[223],"over":[224],"A.":[227],"calcoaceticus.":[228],"Expression":[229],"elicited":[233],"cis,cis-muconate":[238],"genetic":[241],"background":[242],"which":[244],"had":[246],"been":[247],"deleted.":[248],"induction":[250],"segment":[255],"lying":[256,271],"1":[257],"gene.":[263],"It":[264],"likely":[266],"additional":[269],"outside":[272],"necessary":[279],"metabolism,":[282],"contributes":[283],"control.":[286]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}