{"id":"https://openalex.org/W169756770","doi":null,"title":"Molecular Functions of MLL PHD3 Binding to Its Ligands Cyp33 and H3K4Me3","display_name":"Molecular Functions of MLL PHD3 Binding to Its Ligands Cyp33 and H3K4Me3","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W169756770","mag":"169756770"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.luc.edu:luc_diss-1539","doi":null,"is_oa":true,"landing_page_url":"https://ecommons.luc.edu/luc_diss/540","pdf_url":"https://ecommons.luc.edu/luc_diss/540","source":{"id":"https://openalex.org/S4306402030","display_name":"Loyola eCommons (Loyola University of Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1925986","host_organization_name":"Loyola University Chicago","host_organization_lineage":["https://openalex.org/I1925986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ecommons.luc.edu/luc_diss/540","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068206979","display_name":"Gayathree Raman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gayathree Raman","raw_affiliation_strings":["#N#        Loyola University, Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#        Loyola University, Chicago","institution_ids":["https://openalex.org/I1925986"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068206979"],"corresponding_institution_ids":["https://openalex.org/I1925986"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7124000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7124000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.12409999966621399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.08449999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mll","display_name":"MLL","score":0.7860000133514404},{"id":"https://openalex.org/keywords/phd3","display_name":"PHD3","score":0.871999979019165},{"id":"https://openalex.org/keywords/h3k4me3","display_name":"H3K4me3","score":0.8159999847412109},{"id":"https://openalex.org/keywords/histone-methyltransferase","display_name":"histone methyltransferase","score":0.8970000147819519},{"id":"https://openalex.org/keywords/histone-demethylase","display_name":"histone demethylase","score":0.7419999837875366},{"id":"https://openalex.org/keywords/jarid1a","display_name":"JARID1A","score":0.9900000095367432},{"id":"https://openalex.org/keywords/jarid1b","display_name":"JARID1B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/h3k4-trimethylation","display_name":"H3K4 trimethylation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7900000214576721},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-expansion","display_name":"hematopoietic progenitor expansion","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.6869999766349792},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C2780914512","wikidata":"https://www.wikidata.org/wiki/Q25323943","display_name":"H3K4me3","level":5,"score":0.7513219118118286},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7500408887863159},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6021739840507507},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5132448673248291},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49713805317878723},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4572578966617584},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4154576063156128},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4102831780910492},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3952903151512146},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3788515329360962},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.363537460565567},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3436223864555359},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1705171763896942},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.14004549384117126}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ecommons.luc.edu:luc_diss-1539","doi":null,"is_oa":true,"landing_page_url":"https://ecommons.luc.edu/luc_diss/540","pdf_url":"https://ecommons.luc.edu/luc_diss/540","source":{"id":"https://openalex.org/S4306402030","display_name":"Loyola eCommons (Loyola University of Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1925986","host_organization_name":"Loyola University Chicago","host_organization_lineage":["https://openalex.org/I1925986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.953.3311","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.953.3311","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ecommons.luc.edu/cgi/viewcontent.cgi?article%3D1539%26context%3Dluc_diss","raw_type":"text"},{"id":"mag:169756770","doi":null,"is_oa":false,"landing_page_url":"https://ecommons.luc.edu/cgi/viewcontent.cgi?article=1539&context=luc_diss","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ecommons.luc.edu:luc_diss-1539","doi":null,"is_oa":true,"landing_page_url":"https://ecommons.luc.edu/luc_diss/540","pdf_url":"https://ecommons.luc.edu/luc_diss/540","source":{"id":"https://openalex.org/S4306402030","display_name":"Loyola eCommons (Loyola University of Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1925986","host_organization_name":"Loyola University Chicago","host_organization_lineage":["https://openalex.org/I1925986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309973","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W169756770.pdf","grobid_xml":"https://content.openalex.org/works/W169756770.grobid-xml"},"referenced_works_count":117,"referenced_works":["https://openalex.org/W203170764","https://openalex.org/W1511815964","https://openalex.org/W1625536075","https://openalex.org/W1967381498","https://openalex.org/W1968677867","https://openalex.org/W1976021347","https://openalex.org/W1976129849","https://openalex.org/W1976439451","https://openalex.org/W1979515634","https://openalex.org/W1982315838","https://openalex.org/W1986396604","https://openalex.org/W1989610407","https://openalex.org/W1992048312","https://openalex.org/W1992902970","https://openalex.org/W2000474359","https://openalex.org/W2000952899","https://openalex.org/W2002698073","https://openalex.org/W2003053220","https://openalex.org/W2003177342","https://openalex.org/W2004499293","https://openalex.org/W2006560497","https://openalex.org/W2008525795","https://openalex.org/W2008730812","https://openalex.org/W2010743730","https://openalex.org/W2015604871","https://openalex.org/W2015735594","https://openalex.org/W2018626566","https://openalex.org/W2021606478","https://openalex.org/W2021856943","https://openalex.org/W2024532072","https://openalex.org/W2025973422","https://openalex.org/W2027216468","https://openalex.org/W2027913461","https://openalex.org/W2027966582","https://openalex.org/W2031986168","https://openalex.org/W2032295900","https://openalex.org/W2039904177","https://openalex.org/W2041944666","https://openalex.org/W2042871287","https://openalex.org/W2046463189","https://openalex.org/W2048249977","https://openalex.org/W2050373816","https://openalex.org/W2054621094","https://openalex.org/W2056228735","https://openalex.org/W2058001379","https://openalex.org/W2059171174","https://openalex.org/W2059255388","https://openalex.org/W2061433452","https://openalex.org/W2062120260","https://openalex.org/W2062134218","https://openalex.org/W2063756611","https://openalex.org/W2065178008","https://openalex.org/W2065422635","https://openalex.org/W2069157717","https://openalex.org/W2069591815","https://openalex.org/W2069918359","https://openalex.org/W2074978329","https://openalex.org/W2077654571","https://openalex.org/W2078404121","https://openalex.org/W2080896401","https://openalex.org/W2083782960","https://openalex.org/W2085092579","https://openalex.org/W2085697457","https://openalex.org/W2086409037","https://openalex.org/W2089313343","https://openalex.org/W2090805227","https://openalex.org/W2090977067","https://openalex.org/W2091151146","https://openalex.org/W2092912586","https://openalex.org/W2093950264","https://openalex.org/W2094799740","https://openalex.org/W2094808650","https://openalex.org/W2098769593","https://openalex.org/W2100722219","https://openalex.org/W2103233056","https://openalex.org/W2104460981","https://openalex.org/W2105740818","https://openalex.org/W2105798364","https://openalex.org/W2106497229","https://openalex.org/W2108282427","https://openalex.org/W2108498698","https://openalex.org/W2108502557","https://openalex.org/W2110726136","https://openalex.org/W2112087352","https://openalex.org/W2115482702","https://openalex.org/W2116229314","https://openalex.org/W2118681186","https://openalex.org/W2119795320","https://openalex.org/W2121115564","https://openalex.org/W2121910267","https://openalex.org/W2122574122","https://openalex.org/W2123552387","https://openalex.org/W2125921110","https://openalex.org/W2126334907","https://openalex.org/W2126917138","https://openalex.org/W2127015656","https://openalex.org/W2127414497","https://openalex.org/W2127976626","https://openalex.org/W2139008292","https://openalex.org/W2143658931","https://openalex.org/W2145307719","https://openalex.org/W2146641795","https://openalex.org/W2147713614","https://openalex.org/W2149736989","https://openalex.org/W2150056778","https://openalex.org/W2153991114","https://openalex.org/W2154218976","https://openalex.org/W2156213441","https://openalex.org/W2156798579","https://openalex.org/W2157646587","https://openalex.org/W2158773950","https://openalex.org/W2161465043","https://openalex.org/W2163344214","https://openalex.org/W2170848572","https://openalex.org/W2171739003","https://openalex.org/W2329118646","https://openalex.org/W2334485043"],"related_works":["https://openalex.org/W2056228735","https://openalex.org/W2094808650","https://openalex.org/W7098467214","https://openalex.org/W1994598503","https://openalex.org/W1838219589","https://openalex.org/W2583220517","https://openalex.org/W2058001379","https://openalex.org/W2908320038","https://openalex.org/W4417014824","https://openalex.org/W4239979687"],"abstract_inverted_index":{"Mixed":[0],"Lineage":[1],"Leukemia":[2],"protein":[3],"(MLL)":[4],"is":[5,14,49,59,83,121,336],"required":[6],"for":[7,56,110,291,300],"proper":[8],"embryonic":[9],"development,":[10],"and":[11,140,156,162,208,238,299,316,328,340],"hematopoiesis.":[12],"It":[13],"a":[15,30,50,124,152,266,311],"SET":[16],"domain":[17],"containing":[18],"histone":[19,24,31,288,318],"methyl":[20,267],"transferase":[21],"that":[22,33,279],"trimethylates":[23],"H3":[25],"on":[26,137,141,217],"lysine":[27],"4":[28],"(H3K4Me3),":[29],"modification":[32],"correlates":[34],"with":[35,52],"active":[36],"transcription.":[37],"The":[38,78],"3rd":[39],"PHD":[40],"finger":[41],"of":[42,63,68,74,80,89,106,133,135,143,160,179,212,223,234,251,261,295,303,324,332,344],"MLL":[43,48,64,75,90,100,108,144,170,181,198,218,227,235,252,281,296,325,333,345],"binds":[44],"to":[45,84,93,99,129,184,196,226,245,255,274,284,287],"H3K4me3.":[46],"Thus":[47],"\"writer\"":[51],"an":[53],"embedded":[54],"\"reader\"":[55],"H3K4Me3.":[57],"Cyp33":[58,69,97,136,147,194,315,339],"another":[60],"known":[61],"ligand":[62],"PHD3.":[65,346],"Over":[66],"expression":[67,149],"results":[70],"in":[71,115,123,151,154,158,203,230,232,240,258,265,320],"transcriptional":[72,177,293,330],"repression":[73],"target":[76,145,171,219,236,297,326,334],"genes.":[77,146],"aim":[79],"this":[81,120],"study":[82,130],"determine":[85,175],"the":[86,103,107,131,164,169,176,180,197,204,210,214,246,280,292,301,321,329,342],"biological":[87],"function":[88],"PHD3":[91,101,109,182,199,228,253,282],"binding":[92,98,104,183,192,195,225,254,283],"H3K4Me3":[94,111,155,185,191,224,241,256,285],"or":[95,186,193],"Cyp33.":[96],"reduces":[102],"affinity":[105],"by":[112,200,338],"5.7":[113],"fold":[114],"vitro.":[116],"To":[117,174],"know":[118],"if":[119],"true":[122],"cellular":[125],"system,":[126],"we":[127,188,308],"sought":[128],"effect":[132,211],"excess":[134],"H3K4":[138,165,289],"trimethylation":[139],"transcription":[142,233,322],"over":[148],"resulted":[150,229,257],"decrease":[153,231,239],"increase":[157],"recruitment":[159],"JARID1A":[161],"JARID1B,":[163],"specific":[166],"demethylases,":[167],"at":[168],"gene":[172,220],"promoters.":[173],"outcome":[178,331],"Cyp33,":[187],"abrogated":[189],"either":[190],"point":[201],"mutations":[202],"MLL-N":[205,247],"coding":[206],"sequence":[207],"assessed":[209],"expressing":[213],"mutant":[215],"proteins":[216],"expression.":[221],"Abrogation":[222],"genes":[237,298,335],"marks":[242],"when":[243,272],"compared":[244,273],"wt.":[248],"Also,":[249],"abrogation":[250],"decreased":[259],"expansion":[260,302],"mouse":[262],"hematopoietic":[263,304],"progenitors":[264],"cellulose":[268],"colony":[269],"formation":[270],"assay":[271],"wt":[275],"MLL-N.":[276],"This":[277],"indicates":[278],"contributes":[286],"trimethylation,":[290],"activation":[294],"progenitors.":[305],"Taken":[306],"together,":[307],"have":[309],"identified":[310],"novel":[312],"link":[313],"between":[314],"JARID1":[317],"demethylases":[319],"regulation":[323],"genes;":[327],"influenced":[337],"H3K4Me3,":[341],"ligands":[343]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}