{"id":"https://openalex.org/W1697565460","doi":null,"title":"Relaci\u00f3n del efecto analg\u00e9sico de fentanilo agudo con la regulaci\u00f3n a la alta de los receptores 5-HT1A cerebrales en la rata","display_name":"Relaci\u00f3n del efecto analg\u00e9sico de fentanilo agudo con la regulaci\u00f3n a la alta de los receptores 5-HT1A cerebrales en la rata","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1697565460","mag":"1697565460"},"language":"en","primary_location":{"id":"pmh:oai:dialnet.unirioja.es:ART0001307597","doi":null,"is_oa":false,"landing_page_url":"https://dialnet.unirioja.es/servlet/oaiart?codigo=6772829","pdf_url":null,"source":{"id":"https://openalex.org/S4306401293","display_name":"Dialnet (Universidad de la Rioja)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168974976","host_organization_name":"Universidad de La Rioja","host_organization_lineage":["https://openalex.org/I168974976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista de la Sociedad Espa\u00f1ola del Dolor (SED), ISSN 1134-8046, Vol. 11, N\u00ba. 5, 2004, pags. 270-281","raw_type":"text (article)"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019471743","display_name":"Inmaculada Bellido-Est\u00e9vez","orcid":"https://orcid.org/0000-0002-9362-8635","observed_orcids":["https://orcid.org/0000-0002-9362-8635"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bellido Est\u00e9vez, Inmaculada","raw_affiliation_strings":["Facultad de Medicina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Castro S\u00e1nchez, M. Jose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Castro S\u00e1nchez, M. Jose","raw_affiliation_strings":["Hospital Carlos Haya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Carlos Haya","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078996783","display_name":"A. G\u00f3mez\u2010Luque","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G\u00f3mez Luque, Aurelio","raw_affiliation_strings":["Facultad de Medicina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075544170","display_name":"Felipe S\u00e1nchez de la Cuesta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S\u00e1nchez de la Cuesta, Felipe","raw_affiliation_strings":["Facultad de Medicina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.75,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.75,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.12729999423027039,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.07999999821186066,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.8679999709129333},{"id":"https://openalex.org/keywords/5-ht1a-receptor","display_name":"5-HT1A receptor","score":0.9290000200271606},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.3869999945163727},{"id":"https://openalex.org/keywords/receptor-upregulation","display_name":"receptor up-regulation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.546999990940094},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.8320000171661377},{"id":"https://openalex.org/keywords/thermal-nociception","display_name":"thermal nociception","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mechanical-nociception","display_name":"mechanical nociception","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6110000014305115},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.9610000252723694},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9409999847412109},{"id":"https://openalex.org/keywords/heteroreceptors","display_name":"heteroreceptors","score":0.5870000123977661},{"id":"https://openalex.org/keywords/opioid-antagonists","display_name":"opioid antagonists","score":0.5120000243186951},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.4009999930858612},{"id":"https://openalex.org/keywords/autoradiography","display_name":"autoradiography","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.6258338689804077},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5682536363601685},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5487428903579712},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5290906429290771},{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.4730733335018158},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4530491530895233},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23947179317474365},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.238503098487854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.03694060444831848}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dialnet.unirioja.es:ART0001307597","doi":null,"is_oa":false,"landing_page_url":"https://dialnet.unirioja.es/servlet/oaiart?codigo=6772829","pdf_url":null,"source":{"id":"https://openalex.org/S4306401293","display_name":"Dialnet (Universidad de la Rioja)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168974976","host_organization_name":"Universidad de La Rioja","host_organization_lineage":["https://openalex.org/I168974976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista de la Sociedad Espa\u00f1ola del Dolor (SED), ISSN 1134-8046, Vol. 11, N\u00ba. 5, 2004, pags. 270-281","raw_type":"text (article)"},{"id":"pmh:oai:hispana.mcu.es:6006185","doi":null,"is_oa":false,"landing_page_url":"http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1134-80462004000500003","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"},{"id":"pmh:oai:scielo:S1134-80462004000500003","doi":null,"is_oa":false,"landing_page_url":"http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1134-80462004000500003","pdf_url":null,"source":{"id":"https://openalex.org/S4306402135","display_name":"Scientific Electronic library online (Sciences Carlos III Health Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801357902","host_organization_name":"Instituto de Salud Carlos III","host_organization_lineage":["https://openalex.org/I2801357902"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista de la Sociedad Espa\u00c3\u00b1ola del Dolor v.11 n.5 2004","raw_type":"journal article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1488489801","https://openalex.org/W1515279996","https://openalex.org/W1626809853","https://openalex.org/W1854871069","https://openalex.org/W1968547286","https://openalex.org/W1969553615","https://openalex.org/W1970361438","https://openalex.org/W1971385193","https://openalex.org/W1974090265","https://openalex.org/W1978137535","https://openalex.org/W1978656927","https://openalex.org/W1989530345","https://openalex.org/W1991406422","https://openalex.org/W1993656420","https://openalex.org/W1999864585","https://openalex.org/W2000134021","https://openalex.org/W2001888260","https://openalex.org/W2009185989","https://openalex.org/W2021832717","https://openalex.org/W2022743480","https://openalex.org/W2026426748","https://openalex.org/W2038994511","https://openalex.org/W2042545626","https://openalex.org/W2059131799","https://openalex.org/W2060356750","https://openalex.org/W2061595171","https://openalex.org/W2065585933","https://openalex.org/W2066612487","https://openalex.org/W2066702812","https://openalex.org/W2070018013","https://openalex.org/W2070290419","https://openalex.org/W2073987850","https://openalex.org/W2074861537","https://openalex.org/W2080440538","https://openalex.org/W2086269051","https://openalex.org/W2095360380","https://openalex.org/W2098580856","https://openalex.org/W2102247119","https://openalex.org/W2120945887","https://openalex.org/W2123273353","https://openalex.org/W2127453348","https://openalex.org/W2138859916","https://openalex.org/W2146695343","https://openalex.org/W2153853866","https://openalex.org/W2155667685","https://openalex.org/W2256167805","https://openalex.org/W2264183971"],"related_works":["https://openalex.org/W2932372515","https://openalex.org/W2144268968","https://openalex.org/W2005752860","https://openalex.org/W2098580856","https://openalex.org/W1967498912","https://openalex.org/W2017576189","https://openalex.org/W1787763039","https://openalex.org/W2064932969","https://openalex.org/W2142628949","https://openalex.org/W2062202390"],"abstract_inverted_index":{"5-HT1A":[0,16,33,70,103,134,219,236,291,337],"agonists":[1,10,285,301],"have":[2],"analgesic":[3,6,44,85,96,142,180,280,296],"effects.":[4],"The":[5,118,179],"effect":[7,45,86,143,181,281,297],"of":[8,37,46,69,102,111,121,130,133,164,182,195,207,218,230,254,271,282,306,330,335,342,349],"\u00b5":[9,30,202,284,300,331],"can":[11],"be":[12,186],"blocked":[13],"by":[14,190],"selective":[15,290],"antagonists.":[17],"In":[18,92],"order":[19,320],"to":[20,94,321],"determine":[21,323],"the":[22,26,43,57,63,66,88,115,131,145,157,165,167,176,205,211,216,222,228,234,252,260,269,272,278,294,324,328,340,347,350],"mechanism":[23,325],"that":[24,136,241,286],"produces":[25],"synergies":[27],"observed":[28,288,298],"between":[29],"and":[31,53,59,65,83,152,160,172,175,204,215,245,257,293,302,339],"serotoninergic":[32],"receptors":[34,71,135,203,220,237,256,332,338],"in":[35,56,72,263,319,346],"terms":[36],"their":[38,112],"antinociceptive":[39],"effect,":[40,97],"we":[41,106],"determined":[42],"fentanyl":[47,98,122,184,249],"after":[48],"ap-plying":[49],"a":[50,81,108,126],"painful":[51],"thermal":[52],"mechanical":[54],"stimulus":[55],"rat,":[58],"related":[60],"it":[61],"with":[62,87,140,289],"affinity":[64],"maximum":[67],"density":[68,132],"thirteen":[73],"brain":[74,224,344],"areas":[75],"using":[76],"autoradiographic":[77],"techniques.":[78],"Fentanyl":[79],"showed":[80],"dose-":[82],"time-dependant":[84],"two":[89,191],"nociceptive":[90,273,351],"stimuli.":[91],"addition":[93],"its":[95,141,193],"caused":[99,125],"an":[100],"up-regulation":[101,217,334],"receptors,":[104],"since":[105],"found":[107],"dose-dependant":[109],"increase":[110,129,206],"density,":[113],"but":[114],"same":[116],"affinity.":[117],"highest":[119],"dose":[120],"(12.8":[123],"\u00b5g.kg-1)":[124],"statistically":[127],"significant":[128],"was":[137],"positively":[138],"associated":[139],"on":[144,200],"terminal":[146,223,266],"cortical":[147],"external":[148],"(+64%),":[149],"internal":[150],"(+69%)":[151],"piriform":[153],"(+113%)":[154],"frontoparietal":[155],"areas,":[156,225,267],"CA1":[158],"(+111%)":[159],"DGm":[161],"(+60%)":[162],"regions":[163],"hippocampus,":[166],"amygdalin":[168],"nuclei":[169],"PMCo":[170],"(+101%)":[171],"AHiAL":[173],"(+91%)":[174],"hypo-thalamus":[177],"(+127%).":[178],"acute":[183],"would":[185,250,258,276],"explained,":[187],"at":[188,210,221],"least,":[189],"mechanisms:":[192],"stimulation":[194,229,253,329],"opiate":[196,201,283],"neurotransmission":[197],"acting":[198],"directly":[199],"5-HT":[208,308],"levels":[209],"central":[212],"nervous":[213],"system":[214],"hence":[226],"facilitating":[227],"such":[231,265,310],"receptors.":[232],"Since":[233],"post-synaptic":[235,336],"act":[238],"as":[239,311],"heteroreceptors":[240],"inhibit":[242,259],"non-serotoninergic":[243],"neurons":[244],"cause":[246,333],"neuronal":[247,261],"hyperpolarization,":[248],"facilitate":[251],"these":[255],"activity":[262],"all":[264],"preventing":[268],"transmission":[270],"stimulus.":[274,352],"This":[275],"explain":[277],"reduced":[279],"is":[287],"antagonists":[292],"increased":[295],"when":[299],"other":[303],"drugs":[304],"capable":[305],"increasing":[307],"levels,":[309],"ISRS,":[312],"are":[313,317],"co-administered.":[314],"Further":[315],"studies":[316],"required":[318],"accurately":[322],"through":[326],"which":[327],"role":[341],"each":[343],"area":[345],"perception":[348]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
