{"id":"https://openalex.org/W169718174","doi":null,"title":"Novel function of C4a anaphylatoxin. Release from monocytes of protein which inhibits monocyte chemotaxis.","display_name":"Novel function of C4a anaphylatoxin. Release from monocytes of protein which inhibits monocyte chemotaxis.","publication_year":1993,"publication_date":"1993-06-01","ids":{"openalex":"https://openalex.org/W169718174","mag":"169718174","pmid":"https://pubmed.ncbi.nlm.nih.gov/8506953","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886998"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886998","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886998","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"T Tsuruta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Tsuruta","raw_affiliation_strings":["Division of Molecular Pathology, Graduate School of Medical Sciences, Kumamoto University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Pathology, Graduate School of Medical Sciences, Kumamoto University, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078140561","display_name":"Takashi Yamamoto","orcid":"https://orcid.org/0000-0002-6516-2903","observed_orcids":["https://orcid.org/0000-0002-6516-2903","https://orcid.org/0000-0003-0484-7287","https://orcid.org/0009-0000-7380-0592","https://orcid.org/0009-0008-7027-2286"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Yamamoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S Matsubara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Matsubara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051254986","display_name":"Shigeharu Nagasawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Nagasawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071545998","display_name":"Sumio Tanase","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Tanase","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Tanaka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Tanaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K Takagi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Takagi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110125131","display_name":"T. Kambara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Kambara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.421,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.56863291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"142","issue":"6","first_page":"1848","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-c4","display_name":"complement C4","score":0.847000002861023},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.6430000066757202},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.44200000166893005},{"id":"https://openalex.org/keywords/carboxypeptidase-b","display_name":"carboxypeptidase B","score":0.8090000152587891},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.5619999766349792},{"id":"https://openalex.org/keywords/u937-cells","display_name":"U937 cells","score":0.7829999923706055},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/proteolytic-processing","display_name":"proteolytic processing","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C90630246","wikidata":"https://www.wikidata.org/wiki/Q17854107","display_name":"C4A","level":3,"score":0.8716282844543457},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.822097659111023},{"id":"https://openalex.org/C90582226","wikidata":"https://www.wikidata.org/wiki/Q424292","display_name":"Anaphylatoxin","level":4,"score":0.8092889785766602},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.6403539180755615},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.5724305510520935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4557497203350067},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4395178258419037},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3262789845466614},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32099735736846924},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29833781719207764},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.226118266582489},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.20745563507080078},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15707382559776306},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11307409405708313},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002918","descriptor_name":"Chymotrypsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015934","descriptor_name":"Complement C4a","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015934","descriptor_name":"Complement C4a","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015934","descriptor_name":"Complement C4a","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1886998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886998","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:8506953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8506953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:169718174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8506953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886998","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W87082738","https://openalex.org/W113901703","https://openalex.org/W183757317","https://openalex.org/W1255332801","https://openalex.org/W1489791952","https://openalex.org/W1583648061","https://openalex.org/W1677371761","https://openalex.org/W1847565797","https://openalex.org/W1896082656","https://openalex.org/W1978700752","https://openalex.org/W1981182529","https://openalex.org/W1987446470","https://openalex.org/W2001870721","https://openalex.org/W2024875771","https://openalex.org/W2025958411","https://openalex.org/W2045810087","https://openalex.org/W2066882468","https://openalex.org/W2073027205","https://openalex.org/W2077883691","https://openalex.org/W2081538722","https://openalex.org/W2083192361","https://openalex.org/W2084093106","https://openalex.org/W2103685679","https://openalex.org/W2169063940","https://openalex.org/W2275007566","https://openalex.org/W2411523723","https://openalex.org/W4313310264"],"related_works":["https://openalex.org/W1992786987","https://openalex.org/W1525207872","https://openalex.org/W2012285989","https://openalex.org/W1571287173","https://openalex.org/W2288452716","https://openalex.org/W2089366412","https://openalex.org/W2094311680","https://openalex.org/W1995604283","https://openalex.org/W1912783631","https://openalex.org/W2046458530"],"abstract_inverted_index":{"The":[0,43,105,128],"complement":[1],"C4-derived":[2],"anaphylatoxin,":[3],"C4a,":[4],"possesses":[5],"a":[6,158],"strong":[7],"chemotaxis":[8,107],"inhibitory":[9,37,45,95,108,161],"capacity":[10,46,96],"to":[11,28,31,39,117,138],"blood":[12,68],"monocytes":[13,156],"at":[14,90],"concentrations":[15],"as":[16,18],"low":[17],"10(-16)":[19,82],"mol/L.":[20],"In":[21],"our":[22],"study,":[23],"treatment":[24,118],"with":[25,81,119,160],"carboxypeptidase":[26],"B":[27],"convert":[29],"it":[30],"C4a":[32,48,84,150],"des":[33],"Arg77":[34],"decreased":[35],"the":[36,50,63,94,100,133,153],"activity":[38,102,162],"less":[40],"than":[41,99],"1/1,000.":[42],"extraordinary":[44],"of":[47,52,66,103,132,157],"suggests":[49],"presence":[51],"an":[53],"amplification":[54],"mechanism":[55],"in":[56],"this":[57],"inhibition.":[58],"Indeed,":[59],"we":[60],"found":[61],"that":[62,149],"conditioned":[64],"media":[65],"peripheral":[67],"mononuclear":[69],"cells":[70],"or":[71,88],"monocyte/macrophage":[72],"lineage":[73],"cell":[74],"lines":[75],"(U937":[76],"and":[77,121,123],"THP-1":[78],"cells)":[79],"preincubated":[80],"mol/L":[83],"for":[85,163],"5":[86],"minutes":[87],"more":[89],"37":[91],"C":[92],"possessed":[93],"100,000-fold":[97],"stronger":[98],"original":[101],"C4a.":[104,127],"monocyte-derived":[106],"factor":[109,114,135],"seemed":[110],"monocyte-specific.":[111],"This":[112],"cell-derived":[113],"was":[115,136],"sensitive":[116],"trypsin":[120],"chymotrypsin":[122],"immunologically":[124],"distinct":[125],"from":[126,155],"apparent":[129],"molecular":[130],"size":[131],"monocyte":[134,164],"estimated":[137],"be":[139],"approximately":[140],"20":[141],"kd":[142],"by":[143],"gel":[144],"filtration.":[145],"These":[146],"results":[147],"indicate":[148],"anaphylatoxin":[151],"induces":[152],"release":[154],"protein":[159],"chemotaxis.":[165]},"counts_by_year":[{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
