{"id":"https://openalex.org/W169696105","doi":null,"title":"Activation of blood platelets in chronic hepatitis and liver cirrhosis P-selectin expression on blood platelets and secretory activity of beta-thromboglobulin and platelet factor-4.","display_name":"Activation of blood platelets in chronic hepatitis and liver cirrhosis P-selectin expression on blood platelets and secretory activity of beta-thromboglobulin and platelet factor-4.","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W169696105","mag":"169696105","pmid":"https://pubmed.ncbi.nlm.nih.gov/11462931"},"language":"en","primary_location":{"id":"pmid:11462931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11462931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077813829","display_name":"Anatol Panasiuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146122375","display_name":"Medical University of Bia\u0142ystok","ror":"https://ror.org/00y4ya841","country_code":"PL","type":"education","lineage":["https://openalex.org/I146122375"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"A Panasiuk","raw_affiliation_strings":["Department of Infectious Diseases, Medical Academy of Bialystok, 14 Zurawia St., 15-523 Bialystok, Poland. apanasiuk@wp.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Medical Academy of Bialystok, 14 Zurawia St., 15-523 Bialystok, Poland. apanasiuk@wp.pl","institution_ids":["https://openalex.org/I146122375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087014477","display_name":"Danuta Prokopowicz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Prokopowicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037502891","display_name":"Janusz \u017bak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Zak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008078529","display_name":"Joanna Matowicka-Karna","orcid":"https://orcid.org/0000-0003-4438-9110","observed_orcids":["https://orcid.org/0000-0003-4438-9110"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Matowicka-Karna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014881076","display_name":"Joanna Osada","orcid":"https://orcid.org/0000-0002-2756-9518","observed_orcids":["https://orcid.org/0000-0002-2756-9518"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Osada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109316234","display_name":"Jolanta Wysocka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Wysocka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3492,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.57723471,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"48","issue":"39","first_page":"818","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.19679999351501465,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/chronic-hepatitis","display_name":"chronic hepatitis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":1.0},{"id":"https://openalex.org/keywords/p-selectin","display_name":"P-selectin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/beta-thromboglobulin","display_name":"beta-thromboglobulin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/platelet-factor-4","display_name":"platelet factor 4","score":0.8899999856948853},{"id":"https://openalex.org/keywords/platelet-morphology","display_name":"platelet morphology","score":0.7680000066757202},{"id":"https://openalex.org/keywords/thrombin-stimulation","display_name":"thrombin stimulation","score":0.847000002861023},{"id":"https://openalex.org/keywords/hepatitis-b","display_name":"hepatitis B","score":0.5630000233650208},{"id":"https://openalex.org/keywords/hepatitis-c","display_name":"hepatitis C","score":0.9929999709129333},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.839837372303009},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.7809918522834778},{"id":"https://openalex.org/C2781318281","wikidata":"https://www.wikidata.org/wiki/Q3639099","display_name":"Beta-thromboglobulin","level":4,"score":0.608565628528595},{"id":"https://openalex.org/C159973064","wikidata":"https://www.wikidata.org/wiki/Q3740205","display_name":"Platelet factor 4","level":3,"score":0.5995948314666748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5978564620018005},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.596034586429596},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.5854127407073975},{"id":"https://openalex.org/C56701166","wikidata":"https://www.wikidata.org/wiki/Q4046137","display_name":"P-selectin","level":4,"score":0.5358508825302124},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.5356048941612244},{"id":"https://openalex.org/C2779102576","wikidata":"https://www.wikidata.org/wiki/Q5113984","display_name":"Chronic liver disease","level":3,"score":0.5020925998687744},{"id":"https://openalex.org/C190481736","wikidata":"https://www.wikidata.org/wiki/Q6803639","display_name":"Mean platelet volume","level":3,"score":0.4546222984790802},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41782069206237793},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3715607523918152}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001620","descriptor_name":"beta-Thromboglobulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010978","descriptor_name":"Platelet Factor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019007","descriptor_name":"P-Selectin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:11462931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11462931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"},{"id":"mag:169696105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11462931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W277608805","https://openalex.org/W2048823992","https://openalex.org/W2989771100","https://openalex.org/W2413587500","https://openalex.org/W1989513167","https://openalex.org/W1988637814","https://openalex.org/W2964550213","https://openalex.org/W4237062016","https://openalex.org/W1969096821","https://openalex.org/W2124687626"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Blood":[1],"platelets":[2,19,27,53,130,189],"are":[3,213,238],"cells":[4],"that":[5,224],"quite":[6],"often":[7],"undergo":[8],"damage":[9],"in":[10,20,28,67,91,120,172,182,208,226,231,245,253],"chronic":[11,49,74,227,232],"liver":[12,34,50,79,150,160,228,233,236],"diseases.":[13,229],"Endotoxemia":[14],"and":[15,33,59,76,109,116,131,141,166,178,235],"hyperkinetic":[16],"circulation":[17],"influence":[18,47],"an":[21],"active":[22],"manner.":[23],"The":[24,38,63,162],"role":[25],"of":[26,31,40,48,70,81,148,159,164,215],"the":[29,41,46,68,98,146,157,209,254],"development":[30],"hepatitis":[32,75],"fibrosis":[35],"is":[36,248],"speculative.":[37],"aim":[39],"study":[42],"was":[43,65,175,190,199],"to":[44,243],"determine":[45],"diseases":[51,234],"on":[52,128,187],"morphologic":[54],"parameters,":[55,218],"their":[56],"secretory":[57],"activity":[58],"P-selectin":[60,126,185,197],"expression.":[61],"METHODOLOGY:":[62],"examination":[64],"completed":[66],"group":[69],"29":[71],"patients":[72],"with":[73,78,145,156,195,219],"27":[77],"cirrhosis":[80,237],"postinflammatory":[82],"etiology":[83],"(HBV,":[84],"HCV).":[85],"Liver":[86],"biopsies":[87],"were":[88,97,112,135],"carried":[89],"out":[90],"all":[92],"patients.":[93],"Thirty-two":[94],"healthy":[95,183,255],"individuals":[96],"control":[99],"group.":[100],"Platelets":[101],"morphological":[102,217],"parameters":[103],"(number,":[104],"volume,":[105,140],"platelet":[106,117,142,167,216],"crit,":[107],"micro-":[108],"macrothrombocyte":[110],"fraction)":[111],"estimated.":[113],"beta-thromboglobulin":[114,165],"concentration":[115,163],"factor":[118,168],"4":[119,169],"blood":[121,173],"serum":[122,174],"as":[123,125],"well":[124],"expression":[127,186,198],"resting":[129,188],"after":[132],"thrombin":[133],"activation":[134],"also":[136],"examined.":[137],"RESULTS:":[138],"Number,":[139],"crit":[143],"decreased":[144],"advancement":[147],"a":[149],"disease.":[151],"Megathrombocyte":[152],"fraction":[153,222],"increased":[154],"inversely":[155],"severity":[158],"damage.":[161],"alpha-granule":[170],"contents":[171],"higher":[176,204,249],"2-":[177],"7-times,":[179],"respectively":[180],"than":[181,207,252],"controls.":[184,256],"considerably":[191],"higher.":[192],"After":[193],"stimulation":[194],"thrombin,":[196],"equal":[200],"(chronic":[201],"hepatitis)":[202],"or":[203],"(liver":[205,250],"cirrhosis)":[206,251],"control.":[210],"CONCLUSIONS:":[211],"There":[212],"changes":[214],"accompanying":[220],"megathrombocyte":[221],"increase":[223],"occur":[225],"Thrombocytes":[230],"more":[239],"activated.":[240],"Platelet":[241],"sensitivity":[242],"stimuli":[244],"these":[246],"ailments":[247]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}